I-TASSER results

I-TASSER results for job id Rv0622

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (315 residues)
MSFCVYCGAELADPTRCGACGAYKIGSTWHRTTTPTVGAATTATGWRPDPTGRHEGRYFV
AGQPTDLVREGDAEAVDPLGQQQLDQSGAVGVSPSAVSGWVRSGHRRLWWALAGVVAFLG
LVGAGVVGTLFLNRDRESIDDKYLAALRRSGLTGEFNSDANAIARGKQVCRQLQDGGEQQ
GMPVDQVAVQYYCPQFSDGFHILETITVTGSFTLKDESPNVYAPAITVSGSGCSGSAGYA
DIDRGTQVTVKNGQGDILATAFLQAGQGGRFLCTFPFSFEITEGEDRYVVSVSRRGEMSY
SFADLKANGLSLVLG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFCVYCGAELADPTRCGACGAYKIGSTWHRTTTPTVGAATTATGWRPDPTGRHEGRYFVAGQPTDLVREGDAEAVDPLGQQQLDQSGAVGVSPSAVSGWVRSGHRRLWWALAGVVAFLGLVGAGVVGTLFLNRDRESIDDKYLAALRRSGLTGEFNSDANAIARGKQVCRQLQDGGEQQGMPVDQVAVQYYCPQFSDGFHILETITVTGSFTLKDESPNVYAPAITVSGSGCSGSAGYADIDRGTQVTVKNGQGDILATAFLQAGQGGRFLCTFPFSFEITEGEDRYVVSVSRRGEMSYSFADLKANGLSLVLG
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHCCEEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCEEEHCCCCEEEEEEEEHCCCCCCEEEEEEEEEHCCCCCCEEEEEHCCCCCEEHCHHHHHHCCEEEEHC
Conf.Score	986666676568888755566654577766777766777766678888987666665776688754444478754588776666654456778888777766775568999999999999999999999999878999987999999987776666776545666789999985788777876544455554755554545566688999999858888766777777887555777755678997589986886589999865777776578999998668887579999857776675888987588579869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFCVYCGAELADPTRCGACGAYKIGSTWHRTTTPTVGAATTATGWRPDPTGRHEGRYFVAGQPTDLVREGDAEAVDPLGQQQLDQSGAVGVSPSAVSGWVRSGHRRLWWALAGVVAFLGLVGAGVVGTLFLNRDRESIDDKYLAALRRSGLTGEFNSDANAIARGKQVCRQLQDGGEQQGMPVDQVAVQYYCPQFSDGFHILETITVTGSFTLKDESPNVYAPAITVSGSGCSGSAGYADIDRGTQVTVKNGQGDILATAFLQAGQGGRFLCTFPFSFEITEGEDRYVVSVSRRGEMSYSFADLKANGLSLVLG
Prediction	721001001303462312312324234323444333334323132132424142512111034125314626352344434530452252323252344444432211000102100000000120001000244554154400200352213441455141223045005405735564433124100430023115003003214041202034644532444344434304243214204661403042562331020303536444210302030512644510301035335132326405435041407
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHCCEEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCEEEHCCCCEEEEEEEEHCCCCCCEEEEEEEEEHCCCCCCEEEEEHCCCCCEEHCHHHHHHCCEEEEHC
MSFCVYCGAELADPTRCGACGAYKIGSTWHRTTTPTVGAATTATGWRPDPTGRHEGRYFVAGQPTDLVREGDAEAVDPLGQQQLDQSGAVGVSPSAVSGWVRSGHRRLWWALAGVVAFLGLVGAGVVGTLFLNRDRESIDDKYLAALRRSGLTGEFNSDANAIARGKQVCRQLQDGGEQQGMPVDQVAVQYYCPQFSDGFHILETITVTGSFTLKDESPNVYAPAITVSGSGCSGSAGYADIDRGTQVTVKNGQGDILATAFLQAGQGGRFLCTFPFSFEITEGEDRYVVSVSRRGEMSYSFADLKANGLSLVLG

3waiA2

0.13

0.11

0.88

0.71

MUSTER

NPF----GIGNKYNNVPGASS-----AENESYAEFVAEKLNV--------------KYVVSYAMAVWAEGDLPLAEKYYGGYFYYSPTGTFGYANSQWDIPLNSIIIPLRIPSELYYSTMEAKLHLFDGSGLSHYRMIYESDYPAEWKSYSSQVNLNNESQVLQTALYEAVMRARYGVSPTMGTQEVLYKYAYTQLYEK---------------KMGIPVKIAPSGYVKGAVVTGKVSANVTEVSVNATIKTNQNRTFEYWQTVEVKNGTYTVVLPYSHNSDYPITPYHIKAGNVKEITIYESQVQNGEIQLDL-

5gaoE

0.12

0.09

0.76

0.70

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAARAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------------

3hxjA

0.12

0.09

0.74

0.64

wdPPAS

---------------------------KWEFLIGNSIDSSPILAK---------NGTIYLGSS------NKNLYAINTDGSVFFKSGEIIECRPSIGKD--------TIYFGSDKVYAINPDGTEKWRF----DTSDFTIFEDILYVTSDGHLYAINTD------GTEK--RFKTKKAIYATPI--VS--------EDG--TIYVGSNDNYLYAINPDGTEFKTNDAITSAASIGKDGT--YFGSDKVYAINPDGTEKWNFYAGYWTVTRPAIIYVTSLD-PDGTEKWRFKTGKRDTIYFGSYD---GHLYAI-G

4bedB

0.15

0.14

0.93

0.72

wMUSTER

HALPPLCPSPAAKRFACCVHGMATFP-QWHRLSLRKHGAVVGLPYWDWTPELLTVSTIHDTGRDIPNPFIGSKIEFEGENVHTKRDINRDRLFQGSTKTHHNWFIEQALLALEQDFEVQFEIMHNGVHTWVGGKEPYGIGHLHYASYDPLFYI--HHSQTDRIWAIWQSLQRFRGLSGSEANCAVNLMKTPLKP-----FSFGAP------YNLNDHTHDFSKPEDTFDYQK--G---YDTLEAGWSIR-NRQEHSRVFAGFLLEGFGTS--ATVDFQVCRTAGDGYFTVLGGEKRLYKYDTETLDKMNLRHDEI

3zfsC

0.17

0.12

0.71

0.56

wPPAS

LGY-IVSARSTDREIQ-AQDGGIGLLAYALDEGIIAVVAGPGEEFWKPQPM-----------------------AMSS---DELKAYTFSPNVMMLKKAVRQYGIEK-----------LGTVA-------------IPCQ---TMGIRTYPFGVRFLADKIKLLVG--YC----MENFKLGVSMEL--VEKM--DIGKGKFWVYT---DDVLTLPLKETHGYEQ------AGC-YVAELADVPDGWSVITRTDAGSIFEAGLFETKPIE----------EVKPGLGLLELAAQKKEKAEKNIAARKE------MG

3hxjA

0.12

0.09

0.76

0.78

dPPAS2

---------------------------KWEFLIGNSIDSSPILAK---------NGTIYLGSS------NKNLYAINTDGSVFFKSGEIIECRPSIGKDYFGSDKVYAINPDGTEKWRFDTSDFTIFEDILYV-----TSDGHLYAINTDG----------------TEKWRFKTKKAIYATPI--VS--------EDG--TIYVGSNDNYLYAINPDGTEFKTNDAITSAASIGKDGTI-YFGSDKVYAINPDGTEKWNFYAGYWTVTRPAISEDGTIYVTSLDG-HLYAINPDGTEKWRFKTGKRIESSPVIG

5ay6A

0.16

0.13

0.85

0.71

PPAS

VGV----NANLRSEQPVAAAVSYK-VGTAGSPSKTNVVDSATNSVYSSTGIANGNNEYLVDIKENGVIVATGKVAYDAATNELVSSTIDYKGASPVTGTTTRINAAGTTVNLADLGIVNASGADDAEVVAGKLYDPSTWSMSDYAKDNSKGVKPDFESDSKGGQR--TV---LKGPGPNQAKPGDLAN--------GNGQISTGIIEFTGKLKNTGSLFGTTSPTIKSSGYIAPTVTPPAVQPPTPPTWA-DALGIDEQEVQIDLASAAGGLTQY--------NSQSVVQSVNTN--------------------

2ixsA

0.17

0.14

0.85

0.75

Env-PPAS

FGFSAVTLLALAG---------LKPGDHWADSTTPRLGVQKIMDWSG----AYWAKPYATGSR--EDFRK---KTL----RQWVDNGFAV-LNPDNLNIATNSQLNEYCL-SDEAAQAIRSYGTDAFESALVDFKASDTVRARAEALRAAMISVDL-------ADGDEF--LLSPAG--QN-PLLKKMVEEFMPRFAPGAKVLYIGDTRGKHTRFEKRIFEETLGLTFDPH-----GRMPDL-----VLHDKVRKWLFLMEAVKSKDEERHRTLRELFATPVAGL-VFVNCFENREAMRQWLPEL-AWETEAWVA

3wajA2

0.13

0.11

0.86

0.69

MUSTER

-------------------------GIGNKYNN--VPGASSFFTA--ENESYKLNVKYVVSYAMAVWAEGDLPLAEKYYGGYFYYSPTGTFGYANSQWDIPLNSIIIPLRIPSELYYSTMEAKLHLFDGSGLSHYRMIYESDYPAEWKSYSSQVNLNNESQVLQTALYEAVMRARYGVSPTMGTQEVLYKYAYTQLYEK---------------KMGIPVKIAPSGYVKGAVVTGKVSANVTEVSVNATIKTNQNRTFEYWQTVEVKNGTYTVVLPYSHNSDYPITPYHIKAGNVKEITIYESQVQNGEIQLDL-

3hxjA

0.10

0.08

0.77

0.59

dPPAS

---------------------------KWEFLIGNSIDSSPILAK---------NGTIYLGSS------NKNLYAINTDGSVKWFFKSGEIIECRPSIGKDGT-----IYFGSDKVYAINPDGTEKWRF----DTSDFTIFEDILYVTSDGHLYAINTDG-------TEKWRFKTKKAIYATPI------------VSEDGTIYVGSNDNYLYAINPDGTEFKTNDAITSAASIGKDGTI-YFGSDKVYAINPDGTEKWNFYAGYWTVTRPAISEDGTIYVTSLDG-HLYAINPDGTEKWRFKTGKRIESSPVIG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.30

Estimated TM-score = 0.26±0.08

Estimated RMSD = 17.1±2.7Å

Download Model 2

C-score=-4.68

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4maeA	0.548	4.57	0.045	0.718
2	4mh1A	0.547	4.63	0.070	0.718
3	4cvbA	0.546	4.66	0.062	0.718
4	3hxjA	0.543	4.60	0.055	0.718
5	4aahA	0.541	4.73	0.080	0.718
6	2d0vA	0.539	4.58	0.076	0.714
7	1flgA	0.538	4.61	0.073	0.711
8	1kv9A	0.536	4.59	0.057	0.711
9	1yiqA1	0.536	4.64	0.073	0.714
10	4wjsA	0.531	4.64	0.044	0.702

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3k71E	UUU	Rep, Mult	212,241,243,247
2	0.06	3	4h5iA	K	Rep, Mult	233,269,271,272,312,313
3	0.04	2	4po7A	III	Rep, Mult	189,229,232,233,234,241,243,246,248,268,269,270,271,310
4	0.04	2	1adlA	O	Rep, Mult	46,233
5	0.04	2	2vdoA	III	Rep, Mult	209,211,230,245,246,268
6	0.02	1	1um0A	FMN	Rep, Mult	258,266
7	0.02	1	4cy5A	III	Rep, Mult	235,236,237,239,258,259,273,295
8	0.02	1	3ef2B	CA	Rep, Mult	234,235
9	0.02	1	1y10C	CA	Rep, Mult	210,216
10	0.02	1	3ihiB	SO4	Rep, Mult	263,295
11	0.02	1	2nupB	ZN	Rep, Mult	4,7,17,20
12	0.02	1	2vc2A	180	Rep, Mult	238,239,250,261,292,293
13	0.02	1	1fiuA	MG	Rep, Mult	241,273
14	0.02	1	3ol2A	UUU	Rep, Mult	157,158
15	0.02	1	4a09B	CA	Rep, Mult	184,233,313
16	0.02	1	3fcsC	IMD	Rep, Mult	214,215,240,241
17	0.02	1	2ebsA	XYS	Rep, Mult	266,284,286,308
18	0.02	1	3m9gA	ZN	Rep, Mult	216,255
19	0.02	1	3mksD	C1C	Rep, Mult	262,265,290,291,292,298,300,301
20	0.02	1	1flgB	CA	Rep, Mult	243,246,267,269

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2ecfA	0.484	5.21	0.080	0.686	3.4.14.5	NA
2	0.060	1a4gA	0.475	4.71	0.060	0.644	3.2.1.18	141
3	0.060	3g0bB	0.468	5.13	0.049	0.657	3.4.14.5	267
4	0.060	1yiqA	0.493	5.44	0.042	0.718	1.1.99.-	NA
5	0.060	2ebsB	0.485	4.88	0.080	0.660	3.2.1.150	NA
6	0.060	1s0kA	0.491	5.52	0.053	0.721	3.2.1.18	260
7	0.060	3fsnB	0.478	4.85	0.025	0.648	5.2.1.7	255
8	0.060	1g72A	0.541	4.65	0.091	0.714	1.1.99.8	NA
9	0.060	1simA	0.472	5.66	0.044	0.714	3.2.1.18	NA
10	0.060	2bixA	0.473	4.99	0.036	0.651	1.14.99.-	NA
11	0.060	1w6sC	0.533	4.73	0.083	0.714	1.1.99.8	NA
12	0.060	2agsA	0.486	5.28	0.045	0.705	3.2.1.18	197,271
13	0.060	2f10A	0.474	5.13	0.063	0.673	3.2.1.18	NA
14	0.060	1qksB	0.503	4.73	0.061	0.673	1.7.2.1	NA
15	0.060	1kv9A	0.536	4.59	0.057	0.711	1.1.99.-	NA
16	0.060	3c75J	0.475	5.25	0.063	0.679	1.4.99.3	238,250,272
17	0.060	1jofA	0.481	4.68	0.031	0.648	5.5.1.5	NA
18	0.060	1ri6A	0.488	4.57	0.064	0.648	3.1.1.31	NA
19	0.060	1orvA	0.466	5.12	0.036	0.651	3.4.14.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.491	4.70	0.07	0.65	4pk1A	GO:0007155 GO:0009279 GO:0016020 GO:0016021 GO:0019867 GO:0042802 GO:0043165 GO:0051205 GO:0071709 GO:1990063
1	0.07	0.548	4.57	0.04	0.72	4maeA	GO:0005509 GO:0016020 GO:0016491 GO:0016614 GO:0052930 GO:0052931 GO:0052932 GO:0052933 GO:0052934 GO:0052935 GO:0052936 GO:0055114
2	0.07	0.541	4.73	0.08	0.72	4aahA	GO:0005509 GO:0005886 GO:0015945 GO:0016020 GO:0016491 GO:0016614 GO:0030288 GO:0046872 GO:0052930 GO:0052931 GO:0052932 GO:0052933 GO:0055114
3	0.07	0.546	4.66	0.06	0.72	4cvbA	GO:0046872
4	0.07	0.541	4.67	0.07	0.72	1lrwA	GO:0005509 GO:0015945 GO:0016020 GO:0016491 GO:0016614 GO:0030288 GO:0042597 GO:0046872 GO:0052930 GO:0052931 GO:0052932 GO:0052933 GO:0055114
5	0.07	0.540	4.53	0.08	0.71	4tqoA	GO:0005509 GO:0015946 GO:0016020 GO:0016614 GO:0018468 GO:0030288 GO:0046872 GO:0055114
6	0.07	0.539	4.58	0.08	0.71	2d0vA	GO:0005509 GO:0016020 GO:0016614 GO:0030288 GO:0046872 GO:0055114
7	0.07	0.533	4.73	0.08	0.71	1w6sC	GO:0005509 GO:0005886 GO:0015945 GO:0016020 GO:0016491 GO:0016614 GO:0030288 GO:0046872 GO:0052930 GO:0052931 GO:0052932 GO:0052933 GO:0055114
8	0.07	0.536	4.59	0.06	0.71	1kv9A	GO:0005509 GO:0009055 GO:0016020 GO:0016491 GO:0016614 GO:0020037 GO:0030288 GO:0042597 GO:0046872 GO:0055114 GO:0070968
9	0.07	0.538	4.61	0.07	0.71	1flgA	GO:0005509 GO:0006069 GO:0016020 GO:0016491 GO:0016614 GO:0018468 GO:0030288 GO:0042597 GO:0046872 GO:0052934 GO:0052935 GO:0052936 GO:0055114
10	0.07	0.495	5.18	0.05	0.70	1kb0A	GO:0005509 GO:0009055 GO:0016020 GO:0016491 GO:0016614 GO:0020037 GO:0030288 GO:0042597 GO:0046872 GO:0055114
11	0.07	0.486	4.63	0.08	0.64	4immA	GO:0009279 GO:0016020 GO:0043165 GO:0046872 GO:0051205
12	0.07	0.474	4.89	0.09	0.67	4hdjA	GO:0009279 GO:0016020 GO:0043165 GO:0051205
13	0.07	0.493	5.44	0.04	0.72	1yiqA	GO:0005509 GO:0009055 GO:0016020 GO:0016491 GO:0016614 GO:0020037 GO:0042597 GO:0046872 GO:0055114 GO:0070968
14	0.06	0.300	7.16	0.02	0.55	4b6eA	GO:0000166 GO:0001172 GO:0002020 GO:0003723 GO:0003824 GO:0003968 GO:0004197 GO:0004252 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0005576 GO:0006351 GO:0006355 GO:0006508 GO:0006810 GO:0006811 GO:0008026 GO:0008152 GO:0008233 GO:0008234 GO:0008236 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0017124 GO:0019012 GO:0019013 GO:0019028 GO:0019031 GO:0019062 GO:0019079 GO:0019087 GO:0020002 GO:0030430 GO:0030683 GO:0033644 GO:0033650 GO:0034220 GO:0039502 GO:0039503 GO:0039520 GO:0039545 GO:0039547 GO:0039563 GO:0039645 GO:0039654 GO:0039663 GO:0039694 GO:0039707 GO:0042025 GO:0042802 GO:0044164 GO:0044165 GO:0044167 GO:0044186 GO:0044191 GO:0044220 GO:0044385 GO:0046718 GO:0046872 GO:0051259 GO:0055036 GO:0060153 GO:0075509 GO:0075512
15	0.06	0.332	4.96	0.06	0.48	1itvA	GO:0001501 GO:0001503 GO:0001934 GO:0004175 GO:0004222 GO:0004252 GO:0005518 GO:0005576 GO:0005578 GO:0005615 GO:0006508 GO:0007566 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0022617 GO:0030198 GO:0030225 GO:0030574 GO:0031012 GO:0035987 GO:0042802 GO:0043065 GO:0043066 GO:0043388 GO:0045742 GO:0046872 GO:0048013 GO:0050900 GO:0051549 GO:0070062 GO:0090200 GO:1900122 GO:2001243 GO:2001258 GO:2001268
16	0.06	0.286	6.72	0.04	0.51	1jlnA	GO:0001701 GO:0004721 GO:0004725 GO:0005615 GO:0005737 GO:0005886 GO:0006470 GO:0007399 GO:0010633 GO:0016020 GO:0016021 GO:0016311 GO:0016787 GO:0016791 GO:0019901 GO:0030054 GO:0030182 GO:0035335 GO:0038128 GO:0070373
17	0.06	0.275	6.35	0.03	0.46	3tkkA	GO:0016811 GO:0046872
18	0.06	0.253	6.38	0.03	0.43	1rpmA	GO:0001937 GO:0004721 GO:0004725 GO:0005001 GO:0005737 GO:0005887 GO:0005911 GO:0005913 GO:0006470 GO:0007155 GO:0007156 GO:0007165 GO:0010596 GO:0010842 GO:0016020 GO:0016021 GO:0016311 GO:0016525 GO:0016787 GO:0016791 GO:0030027 GO:0031175 GO:0031290 GO:0035335 GO:0042493 GO:0042802 GO:0045296 GO:0045909 GO:0048471

Consensus prediction of GO terms

Molecular Function	GO:0052933	GO:0046872
GO-Score	0.37	0.37
Biological Processes	GO:0044710
GO-Score	0.37
Cellular Component	GO:0030288	GO:0016021	GO:1990063	GO:0005886
GO-Score	0.13	0.12	0.12	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.