I-TASSER results

I-TASSER results for job id Rv0621

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (354 residues)
MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFCERCGSPIGVVPWPSEE
SGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARNDREEPSSARGAATTGVPF
AQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGDVESNSALEVTVADGRRDVAA
GSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSGAPALAATRKGRSDRSAARGGSA
RTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYVRVGIANRWVPQVSSKRVGLVAAGK
TWTSADILRDHLALRQRFGGARLVWSGHWTTFSGPDFWVTVVGPAQPTAAEANR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFCERCGSPIGVVPWPSEESGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARNDREEPSSARGAATTGVPFAQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGDVESNSALEVTVADGRRDVAAGSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSGAPALAATRKGRSDRSAARGGSARTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYVRVGIANRWVPQVSSKRVGLVAAGKTWTSADILRDHLALRQRFGGARLVWSGHWTTFSGPDFWVTVVGPAQPTAAEANR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCEEEEEEEEEHCCCCCCEEHCCCEEEEEEHCCCCCCCEEHCCCCCCEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCEEEEEEHCCCCCCEHCCHCCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCEEEEEHCCCCCCHHHHCC
Conf.Score	988778888888888888877667888587578888888644455568877888898888998888886555467888888888765345777756899999888888888888888888888776789998757778986899579999987578998766567768999978987654786588998676799867999997798754587667898667767899898888888888888888888899888877769999999999666778875478555555446778566675578999999999999985885999858886556798589998578999788659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFCERCGSPIGVVPWPSEESGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARNDREEPSSARGAATTGVPFAQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGDVESNSALEVTVADGRRDVAAGSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSGAPALAATRKGRSDRSAARGGSARTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYVRVGIANRWVPQVSSKRVGLVAAGKTWTSADILRDHLALRQRFGGARLVWSGHWTTFSGPDFWVTVVGPAQPTAAEANR
Prediction	754544443433413433443243110100002023443323103402441343322464444565434433222000000000000010000000143454555445445444544554645424414542413143143544203020303240552322324512010214743001011203542040345441312031344221222541555433333355455444454454554344444444544545332242034216523430354035210000003324041434304234004202501651440100203303304443000000014274465158
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCEEEEEEEEEHCCCCCCEEHCCCEEEEEEHCCCCCCCEEHCCCCCCEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCEEEEEEHCCCCCCEHCCHCCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCEEEEEHCCCCCCHHHHCC
MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFCERCGSPIGVVPWPSEESGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARNDREEPSSARGAATTGVPFAQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGDVESNSALEVTVADGRRDVAAGSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSGAPALAATRKGRSDRSAARGGSARTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYVRVGIANRWVPQVSSKRVGLVAAGKTWTSADILRDHLALRQRFGGARLVWSGHWTTFSGPDFWVTVVGPAQPTAAEANR

4fweA4

0.15

0.13

0.86

0.96

wPPAS

-TGSVGADYLLPKDYHNKS-----GA---AA-FGIK-EAKDRIGGRVWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITFAGDHTLLTPGYSVIIEKLAEGLDIQLKSP----VQCIDYSGDEVQVTTT------DGTGYSAQKVLVTVP-QKGAI---QFN-PPLS-SLGAGIIEKIALQFP-YRFWD-SKVQGADFFGHVPPSASKRGMDPQKKHS---AGEAVASVRTLDDKQQQCMATLRELFEQEVPDPTKYFVTRWSTD--IQ--M-VKTGGSGEAYDIIAE--------IQGTVFFAGEATNRHFPQT---VTGAYLSGVREASK

5gaoE

0.18

0.14

0.79

1.92

dPPAS2

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------------------------------------

5gaoE

0.18

0.14

0.79

1.27

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------------------------------------

4uxeA

0.11

0.09

0.84

1.16

dPPAS2

-----------------------------------PSQFIRRDIAQTVNGSLTLTQQTNLSAPLVSSSTGEFGGSLAANRTFTIRNTGAPTSIVFEKGPASGANPAQSSIGNQFGGGSDTTRSTVFEVGDDTSHHFYSQRNKDGNIAFNINGTVPININASGLNVNGTATF--GRSVTANGEFISKSANFFIRNDASNTYFLLTAAGDQTGGFNGLQSGQITIGEGLIIAKGVTINSGGVNSRIRSQGTKTSDLYTRAPTSDTVGFWSIDINDSATYNQFPGYFKVEKTNEVTGLERGEEVK---------------SPGTLTQFGN-----TLDSLYQDWITYPTTPEARTTR

4uxeA

0.11

0.10

0.92

1.09

PPAS

TLTQQTNLSAPLVSSSTGEFGGSLAANRTFTIRNTGAPTSIVFEKGPASGANPAQSSIRVWGNQFGGGSDTTRSTVFEVG-----DTSHHFYSQRNKDGNNGTVPININASGLNVNGTATFGRSVTANGEFISKSANAFRAING------------DYGFFIRNDASNTYFLLTAAGDQTGGFN-GLRPLLINNQSG---QITIGEGLIIAKGVTINSGGLTVNSRIRSQGTKTSDLYTRAPTSDTVGFWSIDIND--SATYNQFPGYFKVEKTNEVTG-LPYLERGEEVKSPGLTQFGNTLDS---LYQDWITYPTTPERTTRWTRTWKTKNSWSSFVQVDGGNPPQPSDSDN

5cdcB

0.11

0.08

0.67

1.10

dPPAS2

---------KPRNQQQVCPLQNVPAW-----GYSLYKGIDMSVPLAY-DPNNELGDLKDVFPSAVDEMA---------IGYVCGNPAVKHVLTWKTTDAIQKPIANGDDWGGVIPVGMPCYSKSIRTIKISETENRETEVIDAATMCYRITVVKTAGVIPVKPTVNNIGPDQDQLTGAVAPS--DNNYKYILDLTNDTEVTIRVPNKMFLKTAGIYGANSTKLMAPDTVSDVEPKPLTSGPTQVYRPPPTASAAVEVLNVELQ-------------------------------------------------------------------------------------------

3wpaA

0.10

0.07

0.73

1.04

dPPAS2

--------------------------------------------------------------NVAQGNQTNVGDALTALDNAINTAATTSKSTVSNGQNIVVSKSKNADGSDNYEVSTAKDLTVDSVKAGDTVLNNAGITIGNNAVVLNNTGLTI-SGGPSVTLAGIDAGNK-TIQNVANAVNATDAVNKGQLDSAINNVNNN--------VNELANNAVKYDDASKDKITLGGGATGTTITNVKDGTVAQGSKDAVNGGQLWNVQQQVDQNTTDISNIKND-----INNGTVGLVQQAGK-----------------DAPVTVAKDTGGTTTDGN--RVVTGVKEGAVNATSK

4fj6A2

0.13

0.12

0.91

0.86

MUSTER

QAGDDGSAPGLVTTNNGT------LGVYDIRYNSSVDLQEKIDIGVSRSTDKGQTWEPRVATFKQTDGLPHGQNGVGDPSILVDEKTNTIWVVAAWTHGGNERAWWNSPGTPDETAQLLVKSEDDGKTWSEPINITSQVKDPSWYFLLQGPGRGITQDGTLVFP----IQFIDATRVPNAGYSKDRGKTWHLHNLARTNTTEAQEPGVLLNRDNRGGSRAVATTKDLGKTWTEHPSSRSALQESVCASLIKVNAKDNITGKDLLLFSNPNTTKG------RNHITIKASLD------GGLTWPTEHQV---LLDEAEGWGYSCLS------IDKETVGIFYESSVAHTFQAVKD

5gaoE

0.18

0.14

0.79

0.96

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------------------------------------

4fweA4

0.14

0.13

0.90

wdPPAS

-TGSVGADQYLLPKDYHNKSVIIIGAGPAG--FGIK-EAKDRIGGRVWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITFAGDHTLLTPGYSVIIEKLAEGLDIQLKSP----VQCIDYSGDEVQVTTT------DGTGYSAQKVLVTV--PLALLQKGAIQFNPPS-SLGAGIIEKIALQFP-YRFWD--SKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSV-------IAGEAVASVRTLDDKQLQQCMATLRELFKEQEVPDPTKYFV--TRWSTDP-GEAYDIIAEDIQG-TVFFAGEATNRHFPQT---VTGAYLSGVREASK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.62

Estimated TM-score = 0.32±0.11

Estimated RMSD = 15.5±3.3Å

Download Model 2

C-score=-4.07

Download Model 3

C-score=-4.44

Download Model 4

C-score=-4.42

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4fweA	0.662	4.86	0.120	0.890
2	2x0lA	0.647	5.03	0.127	0.887
3	2iidA	0.642	4.87	0.087	0.878
4	4iv9A	0.637	5.40	0.082	0.915
5	4uirA	0.635	5.11	0.081	0.890
6	3bnmB	0.625	4.92	0.092	0.859
7	2jb2A2	0.625	4.82	0.091	0.853
8	1b5qB	0.617	5.00	0.119	0.850
9	3x0vA	0.615	5.01	0.079	0.864
10	3we0A	0.614	5.53	0.093	0.898

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	2jb3B	BE2	Rep, Mult	64,246,339,341
2	0.08	4	4gu0C	FAD	Rep, Mult	37,38,45,60,61,62,63,64,135,136,171,172,289,327,328,339,340,341
3	0.06	3	1f8sA	BE2	Rep, Mult	265,267,272,273,277
4	0.04	2	3tgxA	MAN	Rep, Mult	301,302
5	0.04	2	1jqyF	A32	Rep, Mult	291,292
6	0.02	1	2bxsA	MLG	Rep, Mult	106,221,232,235,246,338
7	0.02	1	3fz3A	CA	Rep, Mult	200,322,323
8	0.02	1	1ugiC	IMD	Rep, Mult	289,308
9	0.02	1	2o011	CLA	Rep, Mult	159,160
10	0.02	1	1eccB	MN	Rep, Mult	173,339
11	0.02	1	1i75B	NOJ	Rep, Mult	284,353
12	0.02	1	4p6vB	RBF	Rep, Mult	264,267
13	0.02	1	2qx6A	ML1	Rep, Mult	329,343
14	0.02	1	3b4pA	AZI	Rep, Mult	292,325
15	0.02	1	1f8sC	BE2	Rep, Mult	312,346,347

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	1f8rA	0.641	4.90	0.091	0.878	1.4.3.2	NA
2	0.066	2iveA	0.592	5.10	0.130	0.828	1.3.3.4	NA
3	0.066	3i6dB	0.595	5.04	0.082	0.828	1.3.3.4	NA
4	0.066	2vvmA	0.598	5.01	0.095	0.825	1.4.3.4	NA
5	0.066	2jaeA	0.624	4.88	0.089	0.856	1.4.3.2	NA
6	0.060	1sezA	0.598	5.21	0.079	0.848	1.3.3.4	NA
7	0.060	2yr4A	0.612	5.46	0.071	0.890	1.13.12.9	NA
8	0.060	1gpeB	0.515	6.18	0.067	0.802	1.1.3.4	62,327,339
9	0.060	3bi2B	0.626	4.89	0.089	0.859	1.5.3.11	NA
10	0.060	2uzzB	0.512	5.60	0.068	0.757	1.5.3.-	NA
11	0.060	3cn8B	0.629	4.90	0.086	0.862	1.5.3.17	171
12	0.060	1pn0C	0.538	5.53	0.063	0.791	1.14.13.7	174
13	0.060	1b37B	0.617	5.01	0.119	0.850	1.5.3.15,1.5.3.14	NA
14	0.060	3lovA	0.578	5.21	0.100	0.819	1.3.3.4	172,307
15	0.060	1pj6A	0.512	5.54	0.079	0.749	1.5.3.10	NA
16	0.060	2z5xA	0.607	4.81	0.078	0.836	1.4.3.4	3
17	0.060	1vrqB	0.513	5.46	0.042	0.749	1.5.3.1	NA
18	0.060	1cf3A	0.510	6.57	0.051	0.831	1.1.3.4	NA
19	0.060	1ng3A	0.510	5.38	0.058	0.737	1.4.3.19,1.5.3.-	NA
20	0.060	1reoA	0.637	4.95	0.081	0.878	1.4.3.2	NA
21	0.060	1fohC	0.536	5.48	0.078	0.777	1.14.13.7	NA
22	0.060	2wdqA	0.513	5.93	0.063	0.777	1.3.99.1	NA
23	0.060	1rsgA	0.616	5.01	0.094	0.845	1.5.3.11	NA
24	0.060	2jb2A	0.624	4.88	0.089	0.856	1.4.3.2	42

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.09	0.662	4.86	0.12	0.89	4fweA	GO:0003677 GO:0005634 GO:0005654 GO:0006349 GO:0006351 GO:0006355 GO:0007275 GO:0008270 GO:0016491 GO:0016568 GO:0032452 GO:0034648 GO:0034649 GO:0034720 GO:0043046 GO:0044030 GO:0046872 GO:0050660 GO:0055114
1	0.09	0.646	5.16	0.13	0.90	2dw4A	GO:0000122 GO:0000784 GO:0000790 GO:0001085 GO:0001701 GO:0002039 GO:0003677 GO:0003682 GO:0003700 GO:0004407 GO:0005634 GO:0005654 GO:0005667 GO:0006351 GO:0006355 GO:0006357 GO:0006482 GO:0007275 GO:0007596 GO:0008134 GO:0008283 GO:0010569 GO:0010725 GO:0016491 GO:0016568 GO:0016575 GO:0019899 GO:0021983 GO:0030374 GO:0030851 GO:0032091 GO:0032451 GO:0032452 GO:0032453 GO:0032454 GO:0033169 GO:0033184 GO:0034644 GO:0034648 GO:0034720 GO:0042162 GO:0043234 GO:0043392 GO:0043426 GO:0043433 GO:0043518 GO:0044212 GO:0045648 GO:0045654 GO:0045892 GO:0045944 GO:0046886 GO:0050660 GO:0050681 GO:0051091 GO:0051572 GO:0051573 GO:0055001 GO:0055114 GO:0061752 GO:0071480 GO:1902166 GO:1903827 GO:1990391 GO:2000179 GO:2000648
2	0.08	0.641	4.90	0.09	0.88	1f8rA	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0055114
3	0.08	0.647	5.03	0.13	0.89	2x0lA	GO:0000122 GO:0000784 GO:0000790 GO:0001085 GO:0001701 GO:0002039 GO:0003677 GO:0003682 GO:0003700 GO:0004407 GO:0005634 GO:0005654 GO:0005667 GO:0006351 GO:0006355 GO:0006357 GO:0006482 GO:0007275 GO:0007596 GO:0008134 GO:0008283 GO:0010569 GO:0010725 GO:0016491 GO:0016568 GO:0016575 GO:0019899 GO:0021983 GO:0030374 GO:0030851 GO:0032091 GO:0032451 GO:0032452 GO:0032453 GO:0032454 GO:0033169 GO:0033184 GO:0034644 GO:0034648 GO:0034720 GO:0042162 GO:0043234 GO:0043392 GO:0043426 GO:0043433 GO:0043518 GO:0044212 GO:0045648 GO:0045654 GO:0045892 GO:0045944 GO:0046886 GO:0050660 GO:0050681 GO:0051091 GO:0051572 GO:0051573 GO:0055001 GO:0055114 GO:0061752 GO:0071480 GO:1902166 GO:1903827 GO:1990391 GO:2000179 GO:2000648
4	0.08	0.637	5.40	0.08	0.92	4iv9A	GO:0004497 GO:0009851 GO:0016491 GO:0050361 GO:0055114
5	0.07	0.616	5.01	0.09	0.84	1rsgA	GO:0015940 GO:0016491 GO:0046208 GO:0046592 GO:0052901 GO:0052902 GO:0052903 GO:0052904 GO:0055114
6	0.07	0.641	4.88	0.08	0.88	3kveA	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0044179 GO:0046872 GO:0055114
7	0.07	0.617	5.02	0.11	0.85	3kpfA	GO:0016491 GO:0052893 GO:0052896 GO:0052897 GO:0052898 GO:0052900 GO:0055114
8	0.07	0.637	4.95	0.08	0.88	1reoA	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0044179 GO:0055114
9	0.07	0.598	5.01	0.10	0.82	2vvmA	GO:0005777 GO:0016491 GO:0055114
10	0.07	0.637	4.87	0.08	0.87	4e0vB	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0044179 GO:0055114
11	0.07	0.628	4.88	0.10	0.86	4gdpB	GO:0015940 GO:0016491 GO:0046208 GO:0046592 GO:0052901 GO:0052902 GO:0052903 GO:0052904 GO:0055114
12	0.07	0.624	4.88	0.09	0.86	2jaeA	GO:0000166 GO:0001716 GO:0016491 GO:0055114
13	0.07	0.599	5.00	0.09	0.84	3rhaA	GO:0016491 GO:0050232 GO:0055114
14	0.07	0.607	4.95	0.09	0.84	1o5wC	GO:0005739 GO:0005741 GO:0006584 GO:0008131 GO:0016020 GO:0016021 GO:0016491 GO:0042135 GO:0042424 GO:0042428 GO:0042443 GO:0050660 GO:0051378 GO:0055114
15	0.07	0.592	4.84	0.09	0.81	3ng7X	GO:0000166 GO:0016491 GO:0018531 GO:0055114
16	0.07	0.607	4.93	0.12	0.84	4i58A	GO:0000166 GO:0016491 GO:0055114
17	0.07	0.585	4.98	0.08	0.81	3qj4A	GO:0002931 GO:0005576 GO:0005615 GO:0016491 GO:0055114 GO:0071869 GO:0071871 GO:1902074
18	0.07	0.607	4.81	0.08	0.84	2z5xA	GO:0005739 GO:0005741 GO:0006576 GO:0006584 GO:0008131 GO:0016020 GO:0016021 GO:0016491 GO:0042133 GO:0042135 GO:0042420 GO:0042428 GO:0042443 GO:0050660 GO:0051378 GO:0055114
19	0.07	0.605	4.87	0.09	0.84	4a79A	GO:0005739 GO:0005740 GO:0005741 GO:0005743 GO:0008131 GO:0009055 GO:0009636 GO:0010044 GO:0010269 GO:0014063 GO:0016020 GO:0016021 GO:0016491 GO:0021762 GO:0032496 GO:0042420 GO:0042493 GO:0042803 GO:0045471 GO:0045964 GO:0048545 GO:0050660 GO:0050665 GO:0051412 GO:0055114 GO:0070062
20	0.07	0.598	4.99	0.10	0.84	2yg3B	GO:0000166 GO:0016491 GO:0055114
21	0.07	0.592	5.10	0.13	0.83	2iveA	GO:0004729 GO:0005737 GO:0006779 GO:0006782 GO:0006783 GO:0016020 GO:0016491 GO:0055114
22	0.07	0.601	5.30	0.09	0.86	1sezA	GO:0004729 GO:0005739 GO:0006779 GO:0006782 GO:0006783 GO:0016491 GO:0055114
23	0.07	0.582	5.17	0.09	0.82	3lovA	GO:0000166 GO:0004729 GO:0006779 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0032453	GO:0000166	GO:0050662	GO:0016491	GO:0003723	GO:0016811	GO:0033558	GO:0035258	GO:0044877	GO:0001071	GO:0000975	GO:0003713	GO:0043565	GO:0043425
GO-Score	0.47	0.47	0.47	0.35	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32
Biological Processes	GO:0070076	GO:0055114	GO:0006366	GO:0051090	GO:0046885	GO:0000018	GO:0006476	GO:0032880	GO:0060319	GO:0034613	GO:0060341	GO:0051101	GO:0051100	GO:0035270	GO:0072091	GO:0051570	GO:0031061	GO:0045995	GO:0043516	GO:0033182	GO:0045892	GO:0021536	GO:0043009	GO:1902230	GO:0031058	GO:0050817	GO:0032846	GO:0043393	GO:1902165	GO:0042060	GO:0032352	GO:0009411	GO:0007599	GO:0044093	GO:0042692	GO:0008284	GO:0045652	GO:0031398	GO:0045646	GO:0071479	GO:0045893	GO:0000724	GO:0071482	GO:1902254	GO:0048468	GO:0048732	GO:0002573	GO:2000779	GO:0045639	GO:2000177	GO:0051569	GO:0010332
GO-Score	0.47	0.35	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32
Cellular Component	GO:0000781	GO:0000785	GO:0044454
GO-Score	0.32	0.32	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.