I-TASSER results

I-TASSER results for job id Rv0614

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (330 residues)
MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPRLGSHRTLRPRWPPYAA
ASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLPGPRTSGTAAERVARHAQA
QTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPETPSIDDTIIGNDNRDTGVRLV
DVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMILGGDPANLTGQGLADNVQRFVQ
SLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTNDWIDRTAQFASGAIVFSIGVLTAE
TGAGVVAAAAGGVGAATAGVSLLQCLVGSK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPRLGSHRTLRPRWPPYAAASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLPGPRTSGTAAERVARHAQAQTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPETPSIDDTIIGNDNRDTGVRLVDVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMILGGDPANLTGQGLADNVQRFVQSLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTNDWIDRTAQFASGAIVFSIGVLTAETGAGVVAAAAGGVGAATAGVSLLQCLVGSK
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEHCCCCCCEHHHHHHCCCCHHHHHHHHHHHHHCCC
Conf.Score	998888776556788998877887556646777777788888777877667888986677765654444445666678664445456789999887765557899999877889888887765578999999999999999999999874888888899999888888888888878999984578999999999999999999999999988888756889877788776888999999879999986455444456778899999998578857999998865444444544444566774445566546654556889999987789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPRLGSHRTLRPRWPPYAAASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLPGPRTSGTAAERVARHAQAQTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPETPSIDDTIIGNDNRDTGVRLVDVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMILGGDPANLTGQGLADNVQRFVQSLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTNDWIDRTAQFASGAIVFSIGVLTAETGAGVVAAAAGGVGAATAGVSLLQCLVGSK
Prediction	653231525243354454245031100303245233134313442353441444132221043314202441102441123132343121410361001002133444443533434541642334023203403421450054045214414524025334364344546455220100113454664524424236346544244431345145112454334236541153035105513673343121423244053323305204440434402430241011000101010214321000000122111222132003103558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEHCCCCCCEHHHHHHCCCCHHHHHHHHHHHHHCCC
MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPRLGSHRTLRPRWPPYAAASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLPGPRTSGTAAERVARHAQAQTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPETPSIDDTIIGNDNRDTGVRLVDVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMILGGDPANLTGQGLADNVQRFVQSLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTNDWIDRTAQFASGAIVFSIGVLTAETGAGVVAAAAGGVGAATAGVSLLQCLVGSK

4oojA

0.15

0.14

0.91

0.71

MUSTER

VDVIKF-------KEPERCD-----YLYVDENNKVHI---LLPIVGGDEIGLDNTCQTAVELITFFYGSAHSGVTKYSAEHQLSEYKRQLEEDIKAI-----NSQKKISPHAYDDLLKEKIERLQQIEKYIELIQVLKKQYDEQNDIRQ--LRTGGIPQLPSGVKEIIKSSENAFAVRLSPYDNDKFTRFDDPISKYDTPSRQAPIYEGLGYRLRSTLFPEDPTPINKKSLRDKVKSTVLSHYK-DEDRIDGEKKDEKLNELITNLQNELV----KELVKSDPQYSKLSL--SKDPRGKEINYDYLVNSLMLVDNDSEIGDWIDTILDAT

5gaoE

0.14

0.13

0.91

0.78

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTK

4fzrA

0.17

0.14

0.82

0.62

wdPPAS

-------------------HR----ILVIAG-CSEGFVP----AAG-HEVLSEN---PTVTGAGLSLDPEVLSWDREGNRTTPREEKPLLEHIGRG-------------YGRLVLRRDEALALAERWK--PDLVLTETYSLTGPLVAATLGIPWIEQSIRLASPELIKGLTDFPDPLLSID--------VCPPSEPGTTKRYVPYNGRNDQVPSWVFEERKQPRLCLTLSLLQALSQELPKLGFDLPEGVLAAGQFP--LSAIPACDVVVHH---GGHGTTLTCLSEGVPQVSVPVIAEVWDSARLLHAAGGVEVPSVLAACARIRDDSS

3wj8A

0.15

0.12

0.81

0.72

wMUSTER

LGSFPQVDHHQA---KGQLAEV----IH---NTMR------VPWVA--RVM-SQFPHIPHAWAALKPN---------------IETRYAEDGADLIRLNSIVPGPVMPNPTPKLLRLGWTESKIEELKTALDLLNYGNPKYLILITAFNEAWHE-----RDTGGRAPQKLRGRD-------------AERIPYGLPNSVEKFNLLDIEKASDRTQTVLRD---RDAFLHHGPASNYRVLGVWP------DYLEIALRDSLAPVALSAEYDE--TARRIRKIAREHVKGPAGVAWRDMT-EKLSAEQIAGLTGLDITIAIIRLKQAFSGPE

3wj8A

0.17

0.13

0.77

0.60

wPPAS

LGSFPDHHQA-KGQAE-H--RVP--WV---ARVMSQF-PHFIPHA---AALKP-----RYAEDGADLIRLN---SIVPGPVMPN----PTPKLLRLGW----------TESKIEELKTALDLLNYGNPKYLILITAFNEAWHER----------------DTGGRAPQKLRGRDA--------ERIPYGLPNSVEKFNLLDIEKA-----SDRTQTVL--RDIRDAFLHHGPASNYRVLGVWPD---EIAL----RDSLAPVALSAEYDET---ARRIRKIAREHVKG-FDKPAGVAWRDMTEKLSAEQIAGLDITIAIIRLKQAFSGPE

4wj1A

0.12

0.09

0.75

0.98

dPPAS2

--------------------------------------------------EELQYELPGLERKAHECESTRPEGPGDATKPDELATTASVYSKLAS---------AAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAAELSRQNGSDAPPPAAEAVVPD----------------------SGIPGPLAIPSEYPSAAAAADEDWEAAARIIHSGDTQALSKYDQWRDYQSTLEGHGHFANPAEGW-AGAAAETCAEAQRRLSTWWA-DGAECGRLAQEATTFVDAHDKLVANHPTLENVREFEETEWASEWDRQNAWALQEQSE

5gaoE

0.14

0.13

0.91

0.90

PPAS

AAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTK

2v9tB

0.15

0.09

0.62

0.61

Env-PPAS

-------G-SLHC-----PAACSNNIVDCRGKGLTEIPTNLPERLEQNT-IK-VIPPGAF--SPYKKLRRID-LSNNQISELAPD---AFQGLRSLNSLVLYGN----------------------------KITE---------------LPKSLFEGLFSLQLLLL----NANKINCL---------------RVDAFQD-------L-HNLNLLSLYDNKLQTIAKGTFSPLR----AI-----QTMHLAQNPFIC-----DCHLKWL----ADYLHTNPIETSGARCTSP-------------RRLANKRIGQIKSKKFRC-----

5b2oA

0.12

0.97

0.69

MUSTER

IP--PY--LDNNNRKPPKCQ-----SLILNPKFLDNQYPQYLQELKKLQSIQNYLDSFETDLKVLKSSKDQPYFVEYKSSNASGQRDYKDLDARILQF--IFDRVKASDELLLNEIYFQAKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQRQRARDSRLIMPEYRYDKKLHKYNNTGRFDDDNQKPRQKRYQLLNDLAGVLQVSPNFLKGSDDDLFISKWLVEHIRGFKKEDSLKIQKDNRGLLNHKINIARNTKGKKEIFNLICKIEKHGLAYELGVLPNEASKPEFDRKIKKFNSIYSFAQIQQIAFAER

4wj1A

0.11

0.08

0.75

0.76

dPPAS

--------------------------------------------------EELQYELPGLERKAHECESTRPEGPGDATKPDELATTASVYSKLAS---------AAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQKAAELSRQNGSDAPPPAAEAVVPD----------------------SGIPGPLAIPSEYPSAAAAADEDWEAAARIIHSGDTQALSKYDQWRDYQSTLEGHGRHFANPAEGWAGAAAETCAEAQRRLSTWWA-DGAECGRLAQEATTFVDAHDKLVANHPTLENVREFEETEWASEWDRQNAWALQEQSE

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.29

Estimated TM-score = 0.26±0.08

Estimated RMSD = 17.2±2.7Å

Download Model 2

C-score=-4.70

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wj8A	0.706	3.31	0.110	0.821
2	3bjxA	0.687	3.22	0.154	0.803
3	2cseW	0.392	6.32	0.051	0.624
4	4ezcA	0.374	5.90	0.075	0.573
5	5cioA	0.373	6.69	0.049	0.636
6	3fahA2	0.373	6.58	0.063	0.630
7	1jroB	0.372	6.41	0.068	0.615
8	3b9zA	0.370	6.29	0.044	0.594
9	3cmmC	0.370	6.33	0.026	0.594
10	1no3A2	0.369	6.45	0.050	0.588

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3wj8A	B2P	Rep, Mult	31,33,233,234,235,314,315
2	0.06	3	2xgxA	AKG	Rep, Mult	134,138
3	0.04	2	4dcaA	MG	Rep, Mult	170,181
4	0.04	2	1hu9A	4HM	Rep, Mult	93,96,97,101,136,282
5	0.04	2	2wieA	CVM	Rep, Mult	141,145
6	0.04	2	4ogqF	3WM	Rep, Mult	127,131,134,141
7	0.02	1	4d2bA	78N	Rep, Mult	145,148
8	0.02	1	1wx2A	CU	Rep, Mult	112,117
9	0.02	1	3nz4A	TCA	Rep, Mult	121,128
10	0.02	1	3o58Y	III	Rep, Mult	112,116,125
11	0.02	1	3attA	MG	Rep, Mult	181,184
12	0.02	1	3r4iB	CA	Rep, Mult	140,181
13	0.02	1	1dgjA	FES	Rep, Mult	168,169,170,173,174,175,177,290
14	0.02	1	2o011	CLA	Rep, Mult	36,130
15	0.02	1	2b0qA	MG	Rep, Mult	165,181
16	0.02	1	3d6aA	MG	Rep, Mult	86,90

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1jroB	0.372	6.41	0.068	0.615	1.1.1.204	NA
2	0.060	3b9jJ	0.229	6.73	0.065	0.388	1.17.1.4,1.17.3.2	60,141
3	0.060	2e9eA	0.307	6.60	0.055	0.500	1.11.1.7	NA
4	0.060	2sqcA	0.343	6.87	0.021	0.618	5.4.99.17	NA
5	0.060	3fvyA	0.342	5.91	0.060	0.530	3.4.14.4	144,152
6	0.060	1up8A	0.353	6.26	0.071	0.576	1.11.1.18	NA
7	0.060	3btaA	0.339	6.34	0.026	0.558	3.4.24.69	NA
8	0.060	1fo4A	0.334	6.38	0.072	0.558	1.17.1.4	NA
9	0.060	1ygeA	0.373	6.28	0.044	0.582	1.13.11.12	NA
10	0.060	1qi9B	0.339	6.41	0.041	0.558	1.11.1.10	NA
11	0.060	1rm6A	0.353	6.65	0.053	0.600	1.3.99.20	NA
12	0.060	2e1qA	0.351	6.86	0.044	0.624	1.17.3.2,1.17.1.4	NA
13	0.060	2iukA	0.370	6.44	0.051	0.591	1.13.11.12	NA
14	0.060	3bjxA	0.687	3.22	0.154	0.803	3.8.1.10	84
15	0.060	1jrpB	0.372	6.40	0.038	0.615	1.17.1.4	148
16	0.060	1vlbA	0.359	6.50	0.029	0.600	1.2.99.7	NA
17	0.060	3d2jA	0.344	6.65	0.034	0.579	1.21.3.3	176
18	0.060	1h0hA	0.349	6.59	0.035	0.591	1.2.1.2	NA
19	0.060	3cmmC	0.370	6.33	0.026	0.594	6.3.2.19	63

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.11	0.706	3.28	0.12	0.82	4n2xA	GO:0016787 GO:0019120 GO:0033976
1	0.10	0.695	3.16	0.15	0.81	3bjxA	GO:0019120
2	0.06	0.265	6.65	0.04	0.44	5bxpA	GO:0004553 GO:0004563 GO:0005975 GO:0008152 GO:0016020 GO:0016021 GO:0016787 GO:0016798 GO:0047403
3	0.06	0.316	6.29	0.05	0.52	3gh4A	GO:0004553 GO:0004563 GO:0005975
4	0.06	0.296	6.98	0.06	0.54	4em6A	GO:0004347 GO:0005737 GO:0006094 GO:0006096 GO:0016853
5	0.06	0.392	6.32	0.05	0.62	2cseW	GO:0000166 GO:0004386 GO:0005524 GO:0006370 GO:0006397 GO:0016787 GO:0019012 GO:0019028 GO:0039625 GO:0046872
6	0.06	0.290	6.89	0.05	0.51	3k01A
7	0.06	0.275	6.95	0.04	0.48	5br4A	GO:0004022 GO:0005829 GO:0005975 GO:0006004 GO:0008198 GO:0008912 GO:0016491 GO:0019301 GO:0019317 GO:0042355 GO:0042846 GO:0046872 GO:0051143 GO:0055114
8	0.06	0.276	6.69	0.04	0.47	4bkqA	GO:0004318 GO:0006629 GO:0006631 GO:0006633 GO:0016491 GO:0051287 GO:0055114
9	0.06	0.285	6.88	0.03	0.49	4m9dB	GO:0000166 GO:0000287 GO:0004019 GO:0005525 GO:0005737 GO:0006164 GO:0016874 GO:0044208 GO:0046872
10	0.06	0.273	6.62	0.05	0.46	4fc6B	GO:0005102 GO:0005777 GO:0005778 GO:0006629 GO:0006631 GO:0006636 GO:0008670 GO:0016491 GO:0019166 GO:0044255 GO:0055114
11	0.06	0.300	6.77	0.03	0.51	3hlfA	GO:0016740 GO:0016746 GO:0016787 GO:0017000 GO:0030639 GO:0050832
12	0.06	0.266	6.77	0.03	0.46	3c8nA	GO:0004497 GO:0005618 GO:0005829 GO:0005886 GO:0005975 GO:0016491 GO:0016614 GO:0016705 GO:0045454 GO:0052749 GO:0055114 GO:0070967
13	0.06	0.264	6.89	0.05	0.45	3txxB	GO:0005737 GO:0006520 GO:0006596 GO:0016597 GO:0016740 GO:0016743 GO:0033388 GO:0033390 GO:0050231
14	0.06	0.290	6.44	0.07	0.48	4c20B	GO:0005737 GO:0005975 GO:0005996 GO:0006004 GO:0008736 GO:0016853 GO:0016861 GO:0019317 GO:0030145 GO:0042355 GO:0046872
15	0.06	0.241	6.73	0.02	0.41	2b69A	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403
16	0.06	0.328	6.14	0.06	0.51	3iylY	GO:0046872
17	0.06	0.351	6.17	0.05	0.56	3k1qC	GO:0046872
18	0.06	0.249	6.89	0.03	0.44	2amxA	GO:0009168 GO:0019239

Consensus prediction of GO terms

Molecular Function	GO:0016824
GO-Score	0.39
Biological Processes	GO:0006096	GO:0006094
GO-Score	0.06	0.06
Cellular Component	GO:0016021	GO:0005737
GO-Score	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.