I-TASSER results

I-TASSER results for job id Rv0613c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (855 residues)
MAEAFDATQAVARILAEHGPLSEDDIARRLLDSGVADPDAVLRALRLETEWPARQLVDDR
WVWLPTLLAGRVFTHRLGADEAVHDMLGVTPDLDPITTLCEHEEYGRLADGSAARIVLAG
YDEELLERRGIPDEAIDPGGALLLEPGTLATLGAAAGDLVGVRLTAAGLVLERIGTAGAD
TSVGARLAELVDPDEPAFFPAAVWTACVDDPAAFTEPVAPLREILDQHGLTHEDDWLAPG
GFNFDAWRFENRCELLAFRHDLDPNDAVALYTLIKLHETMSLLLEATDPDELPRDVLATA
AETATETGSDSLVDLLGDIGAALADPLLAELLVAETVGTDSGGAAALGLLTEMLEPKVPR
AARVAVRWLRAVALDRIGDVEAAERELLAAESMDTEWPLPLLDLARIASDRGDAERGLAL
LRRAGTEPDHPLVRLLERHRAQPRRDLGRNEACWCGSGRKYKKCHLGREALPLAERVDWL
YAKASQHALSGDWTGLLAEVSYERFRYADSDDEDALAAALADPLVLDAVLFEGGAFAEFL
EVRGSLLPDDERLLAEQWLLVERSVFEVEHVQPGEGVIVRDVRTGDTHEVHERAASRQLR
AGQLICARPVPAGDTMVFFGGIEPVALHERAVLIELLDDEPDPVTLVAQLSRRFAPPTLV
NTEGDSLAICEASVRVDDPAGIQGALDGVYDRVDGEEPPRWIEHVTNDGMLRVRATLVLD
GDTLRVETNSEPRMDRVLATLTRLDPAMTVLDDDRRPLRNTREAAALAEQMPVTGAGAPD
PDSPELAAALEEFIRDYETSWLDQPIPALDGHTPRQAADDPTRRADLIKLLDTFPAGAGA
RGGMDADRLRTALGL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAEAFDATQAVARILAEHGPLSEDDIARRLLDSGVADPDAVLRALRLETEWPARQLVDDRWVWLPTLLAGRVFTHRLGADEAVHDMLGVTPDLDPITTLCEHEEYGRLADGSAARIVLAGYDEELLERRGIPDEAIDPGGALLLEPGTLATLGAAAGDLVGVRLTAAGLVLERIGTAGADTSVGARLAELVDPDEPAFFPAAVWTACVDDPAAFTEPVAPLREILDQHGLTHEDDWLAPGGFNFDAWRFENRCELLAFRHDLDPNDAVALYTLIKLHETMSLLLEATDPDELPRDVLATAAETATETGSDSLVDLLGDIGAALADPLLAELLVAETVGTDSGGAAALGLLTEMLEPKVPRAARVAVRWLRAVALDRIGDVEAAERELLAAESMDTEWPLPLLDLARIASDRGDAERGLALLRRAGTEPDHPLVRLLERHRAQPRRDLGRNEACWCGSGRKYKKCHLGREALPLAERVDWLYAKASQHALSGDWTGLLAEVSYERFRYADSDDEDALAAALADPLVLDAVLFEGGAFAEFLEVRGSLLPDDERLLAEQWLLVERSVFEVEHVQPGEGVIVRDVRTGDTHEVHERAASRQLRAGQLICARPVPAGDTMVFFGGIEPVALHERAVLIELLDDEPDPVTLVAQLSRRFAPPTLVNTEGDSLAICEASVRVDDPAGIQGALDGVYDRVDGEEPPRWIEHVTNDGMLRVRATLVLDGDTLRVETNSEPRMDRVLATLTRLDPAMTVLDDDRRPLRNTREAAALAEQMPVTGAGAPDPDSPELAAALEEFIRDYETSWLDQPIPALDGHTPRQAADDPTRRADLIKLLDTFPAGAGARGGMDADRLRTALGL
Prediction	CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEHCCCCCEEHHHHHHHCCCHCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEHCCCCHHHHHHHCCCCCCCCCCCEEEHCCCCHHHCCCCCCCEEEEEEHCCEEEEEHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHCCCCCCCEHCCCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEHCCCEEEEEEHCCCCEEEEEHCCCCCCCCCCEEEEEEEEHCCCEEEEHCCEEHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEHCCCHHHHHHHHHHHHHCCCCCCCHHHEEEHCCCCCEEEEEEEEHCCEEEEEHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
Conf.Score	988877689999999997899999999999998899888999999975788754457885564678877664444577888887666788877888887578765444688877898577778999998998777888876996787455558888868999984885899975788888589999999867788764679999999857788767887499999997985567645677898455555789999999989987888999999999999999998767566666666556655555566678899889999987578889999999875888557899999999875655788999999998888876899999999987766876665899999999876667888888765678876646777776578777788888888888568888887576545589999999999999998556889999999988887566646789998876555456655776699999997557999999999999858865899999969968999995589689998677777778886999999865997999844677688899999999986777688999999875776656777875466777887466578999999877655778865444455557886689999994868999986999999999999998555665546665554556889999985767778888887999999999999999999756556658999999886857899999999998765677766778999999889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAEAFDATQAVARILAEHGPLSEDDIARRLLDSGVADPDAVLRALRLETEWPARQLVDDRWVWLPTLLAGRVFTHRLGADEAVHDMLGVTPDLDPITTLCEHEEYGRLADGSAARIVLAGYDEELLERRGIPDEAIDPGGALLLEPGTLATLGAAAGDLVGVRLTAAGLVLERIGTAGADTSVGARLAELVDPDEPAFFPAAVWTACVDDPAAFTEPVAPLREILDQHGLTHEDDWLAPGGFNFDAWRFENRCELLAFRHDLDPNDAVALYTLIKLHETMSLLLEATDPDELPRDVLATAAETATETGSDSLVDLLGDIGAALADPLLAELLVAETVGTDSGGAAALGLLTEMLEPKVPRAARVAVRWLRAVALDRIGDVEAAERELLAAESMDTEWPLPLLDLARIASDRGDAERGLALLRRAGTEPDHPLVRLLERHRAQPRRDLGRNEACWCGSGRKYKKCHLGREALPLAERVDWLYAKASQHALSGDWTGLLAEVSYERFRYADSDDEDALAAALADPLVLDAVLFEGGAFAEFLEVRGSLLPDDERLLAEQWLLVERSVFEVEHVQPGEGVIVRDVRTGDTHEVHERAASRQLRAGQLICARPVPAGDTMVFFGGIEPVALHERAVLIELLDDEPDPVTLVAQLSRRFAPPTLVNTEGDSLAICEASVRVDDPAGIQGALDGVYDRVDGEEPPRWIEHVTNDGMLRVRATLVLDGDTLRVETNSEPRMDRVLATLTRLDPAMTVLDDDRRPLRNTREAAALAEQMPVTGAGAPDPDSPELAAALEEFIRDYETSWLDQPIPALDGHTPRQAADDPTRRADLIKLLDTFPAGAGARGGMDADRLRTALGL
Prediction	654434224001400364111445201410362313315400520442341101200431100000003100000101152033200312120300120043551431351320120024143410463504454044410000111103423233000000001332020231542444441142024104554142020000100110241024013103300452403142110002201033131421021004327043510200100130132023103314434224421342343343234421231024003101211123211320032435322001000310354344312000200111015323403511542442441445222113310412443442443341143352444321242254343464541555450024204401521244434323422331143024102343034202311322132243333320220000000000102444102300443354144602400430250200001023035521010100036440302144334503100000000012423100000000003630430251045324234013203621223402424233021130203044254035204412531544634300211346423202020204432010002145005301400340133342243334214424425422543444445435423530250024003520351034214415721033006366125303500440145443322000410163056
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840

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Sec.Str
Seq

CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEHCCCCCEEHHHHHHHCCCHCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEHCCCCHHHHHHHCCCCCCCCCCCEEEHCCCCHHHCCCCCCCEEEEEEHCCEEEEEHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHCCCCCCCEHCCCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEHCCCEEEEEEHCCCCEEEEEHCCCCCCCCCCEEEEEEEEHCCCEEEEHCCEEHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEHCCCHHHHHHHHHHHHHCCCCCCCHHHEEEHCCCCCEEEEEEEEHCCEEEEEHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
MAEAFDATQAVARILAEHGPLSEDDIARRLLDSGVADPDAVLRALRLETEWPARQLVDDRWVWLPTLLAGRVFTHRLGADEAVHDMLGVTPDLDPITTLCEHEEYGRLADGSAARIVLAGYDEELLERRGIPDEAIDPGGALLLEPGTLATLGAAAGDLVGVRLTAAGLVLERIGTAGADTSVGARLAELVDPDEPAFFPAAVWTACVDDPAAFTEPVAPLREILDQHGLTHEDDWLAPGGFNFDAWRFENRCELLAFRHDLDPNDAVALYTLIKLHETMSLLLEATDPDELPRDVLATAAETATETGSDSLVDLLGDIGAALADPLLAELLVAETVGTDSGGAAALGLLTEMLEPKVPRAARVAVRWLRAVALDRIGDVEAAERELLAAESMDTEWPLPLLDLARIASDRGDAERGLALLRRAGTEPDHPLVRLLERHRAQPRRDLGRNEACWCGSGRKYKKCHLGREALPLAERVDWLYAKASQHALSGDWTGLLAEVSYERFRYADSDDEDALAAALADPLVLDAVLFEGGAFAEFLEVRGSLLPDDERLLAEQWLLVERSVFEVEHVQPGEGVIVRDVRTGDTHEVHERAASRQLRAGQLICARPVPAGDTMVFFGGIEPVALHERAVLIELLDDEPDPVTLVAQLSRRFAPPTLVNTEGDSLAICEASVRVDDPAGIQGALDGVYDRVDGEEPPRWIEHVTNDGMLRVRATLVLDGDTLRVETNSEPRMDRVLATLTRLDPAMTVLDDDRRPLRNTREAAALAEQMPVTGAGAPDPDSPELAAALEEFIRDYETSWLDQPIPALDGHTPRQAADDPTRRADLIKLLDTFPAGAGARGGMDADRLRTALGL

4c0oA

0.12

0.11

0.95

1.29

MUSTER

-GAKPTLQLVYQAVQALYHDPDASFWLGELQRSVHA-WEISDQLLQIRQDVESCYFA---AQTMKMKIQTSF--YELPTDSHASLRDSL---LTHIQNLKDLSPVIVTQLALAIADLALQMPQTLVEKYS-NDVTSLPFLLEILTVLPEEVHSRS------LRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD--EKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNL--HEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVADLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAKSVDPEN---NPTLVEVLEGVVRLPETAVRYTSIELVGEMSEVVDRN--PQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLSPEAAVGLLKGTALV------LARLPLDKITECLSELCSVQVMALKKLLSQSSDPTVFLLAVIFRHTNPI--VHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGRQGLLDMLQALCIPTFQLLE-QQNGLQ---NHPDTVDDLFRLATRFIPVTLLRSQVVIPI-TLDHMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDQVDRPTFCRWLENSLKGLPTVTHKQLTDFHKQVTS

4c0oA

0.10

0.98

1.05

dPPAS

-GAKPTLQLVYQAVQALYHDPDPSGKERASFWLGERSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSL-----LTHIQNLKDLSPVIVTQLALAIADLALQMPVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSL------RIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD--EKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVM--ALKKLLSQSSDPTVFLDRLAVIFRHTNPIVHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDQVDRPTFCRWLENSLKGLPTVTHKQLTDFHKQVTS

4hnwA

0.12

0.09

0.80

0.88

wdPPAS

GKQYKKSLKLLDAILKKD-GSH----VDSLALKGLGEKDDAASYVAN-----IRKI-ESACHVLGIYMR----TKEYKSIKWFTAALNNGSTKQIYRDL------------ATLQSQIGDF-KNALVSR---------KKYWEAFLGNWTSLAVA-GER-AINTLSQFEKL----EGKISDSEKYEHSECL------YKNDIMYKAASDNQDKLQNVLKHLNDIEPCV-LERKATIYMKLG------QLKDASIVYRTLIKRNPDNFKYYKLLEVSLGIQGDNKLK---KALYGKLEQFYPRCTFLQDKEELSKKLREYVLPQLESNVKPLYQRRKSKVSPLLEKIVLDYLSGLDPTQDPIPFIWTNYYLSQHFLFLKDFPKAQEYIDAALDHTPTLVEFYILKARILKHLGLMDTAAGILEEGDLQDRFINCKTVKYFLRANNSLFTKNDD----SVNGIKDLHLVEASWFIVEQAEAYYRLYLDRKKKLDDLASEQIANDIKENQWLKYKGLALKRFNAIPKFYKQFEDDQLDFHSYCMRKGT---------PRAYLEM---------------LEWGKALYTKPMYV--RAMKEASK----LYFQM----------------DRLKRSQKKKAKKEAAAMNKRKETEAKSVAAYP-NDVFGEKLI------ETSTPDFATEFYNNYSMQV-REDERDYI---------------------LDFEF--NYRIGKLALCFASLNKFAKRFGTTSGLFGSM--AIVLLHATRND-----TPFDPILKKVVTKSLINGLLFLYRYRDDVIGSSNLKEMIIEPHSQNEILQYY--YP--------------------

4c0oA

0.12

0.11

0.93

1.25

wMUSTER

AKPTLQLVYQAVQALYH-DP-RASFWLGELQRSVHA-WEISDQLLQIRQDVESCYFA----QTMKMKIQTSF--YELPTDSHAS--LRDS--LTHIQNLKDLSPVIVTQLALAIADLALQMPSGCVQTL---VEKYSNDVTSL--PFLLEILTVLPEEV-------------HSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCV--TDEKMLMKVFRCLGSWFNLGVLDSNFEVLQQDKTSSNLHESDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVARED--LDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVL----AKSVDPEN---NPTLVEVLEGVVRLPETAVRYTSIELVGEMSEVVDRN--PQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLSPEAAVGLLKGTALV------LARLPLDKITCLSELCS-VQVMALKKLLSQSSDPTVFLLAVIFRHTNP--IVHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEERQGLLDMLQA--CIPTFQLLE-QQNGL----NHPDTVDDLFRLATRFIPVTLLRSQVVIPI-TLDHRDANCSVMRTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDQVDRPTFCRWLENSLKGLPTVTHKQLTDFHKQVTS

3ea5B

0.12

0.11

0.87

0.97

wPPAS

M----S-TAEFAQLLENS-P-IRLTSETQLKKLSNDNFLQFAGLSSQV-------LIDER--ILAALTLKNELVSK-KTQQFAQRWITVSPETNALTALVSIEPRIANAAAQLIAIADIELPHELMKIM----DNTGAEQPENVKRASLLALGSADPQSQVSSSNN--LIVQGAQSTETSKAVRLAALNALAD--NYLMQVVCEATQAEDIEVQAAAFGCLCKIMSKY------TFMKP----MEQ--LYALTIATMKSP----NDKVASMTVEFWSTICEEEIDIAYELAQFPQ----SPLQSYNFALSSIKDVVPNLLNLLTRSMSAGACLQLFAQNNHILEPVLEFVEQNITADNWRNREAAVMAFGSIKVQRTYYVHQALPSILNLMN-DQS-ETTAWCIGRIADSVAESIDPQQHLPGV-------VQACLIG---QDHPKVATN----SWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTM-TDTVAETSASISTFVMD--------KLGQTMSVDENQLTLEDAQSLQELQSNILTVLAIRKSPSSVEPVADMLMG---FRLLEKKDSAFIEDDVFAISALAAS-----LGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIAD----ISNSLEEDFR-----------RYSDAMMNVLAQMISNPNARRELKPAVLS----VFGDIASNGADF------IPYLNDIMALCVAA--QNTKPENGTLEALDYQILEAVLDAYVGIVAGLHDKPEGTIFQFIAQVAEDPQLYSEDA-AAMFPDGSIKQFYGQ----DWVIDYIKRTRSGQLFSQA--REQQKRQLSL

4ui9O

0.11

0.08

0.71

1.00

dPPAS2

LQGPDITVSKLLKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEHKTSVVGLFLR-HMILSKLSFSQVFK--L-----YTALQQYFQSDENKKPLS---------QKQAEFFLSQ------------------QASLLKNDETK-------------------ALTPASLQKELNNLLKFNPDFYLSYLNNLRVQDVFSSTH---SLLHYFDRLILTGAESKSGEEGYGRSLRYAALNLAALHCRFGH------YQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRNKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEQVALCHLAELHAEQGCFAAASEVLKHLPPNSQHAQLWMLCDQKIQFDRAMNDGK---------YHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALLQYLASETVLNLAFAQLIL--------GI---------------------------------------------------PEQALSLLHMAIEPILADGAILDKGRAM-------------------------FLVAKCQVASAASYDQPK--------------------------------KAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARLYHTLG----------KTQERNRCAMLFRQLHQELPSVPINHL----------------------------------------------

4c0oA

0.12

0.11

0.95

1.37

PPAS

-GAKPTLQLVYQAVQALYHDPDKERASFWLGEL--RSVHAWEISDQLLQIRQ----DVESCYFAAQTMKMKIQTSFYEHASLRDSLLDLSPVIVTQLALAIADLALQMPS--------KGCVQTLVEKYS-NDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYS------STVVSLLMTCVEKAGTD--EKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHESDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVARED--LDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETD---DFGEFRMRVSDLVKDLIFLI----GSMECFAQLYSTLKEGNPPWEVTEAVLFIAAVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLSPEAAVGLLKGTALV------LARLPLDKITECLSELCSVQVMALKKLLSQSSDPTVFLLAVIFRHTNP--IVHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQ---NHPDTVDDLFRLATRF-PVTLLRSQVVIPI-TLDHMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDQVDRPTFCRWLENSLKGLPTVTHKQLTDFHKQVTS

2ipcA3

0.16

0.06

0.36

0.82

Env-PPAS

AEKATDLYYKMAEIAKKRGLPAEPG---------------------VRKEPTGDYTVEERSVHL---------TLQ--GIAKAEKLLGISPENMELAHML----IQAIR-----AKELYHRDRDYI---------VQDGQVIIVDEFT--------GRLMPGRRYGEGLAIEAKEGVRIERE-NQTLAQLLQFDD--VLSRQREVIYAQRRLILLGKDEEVKEAAIGMVEETVASLAENPEVHPEDWDLEGLKATLLDTAPQLQDFPFAELRALKAEEAVERLVEAALKAYEAREAELSPPLMRAVERFVILNVVDNAWKEHLHNVLRQGIFLRGYGQKDPFQIEATRLFNEMVAFIKSEVAKFLFRL----KVE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5ifeC

0.11

0.10

0.91

1.21

MUSTER

LKP--DDIQYFDKLLVDVDEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGP---LFNQILP--LLMSPTLEDQERHLL------VKVIDRILYKLD-------DLVRPYVHKILVVIEPLLIDEDYYARVEGREI-----ISNLAKAAGLATMISTMRPDI---DNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSSWQARHTGIKIVQQIAILMG----------CAI-----HLRSLVEIIEHGLVQQKVRTISALAIAALAEAATPGIESFDSLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQ-----HRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGA---LKAIVNVIGMHKMTIKDLLPR--TPILKNRHEKVQENCIDLVGRIADRGAEYVSAREW----MRICFELLELLKAHKKTVNTFGYIAKAIGPHDVLATLQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQN------GVLKSLSFLF------------EYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVSPHVIQAVMGALEGL---GPCRMLQYRKVRDVYWKIYNSIYIGSQIYNDDKNTYIRYELDY

4w8yA

0.09

0.08

0.89

0.91

dPPAS

ALKIENHEERSKKILSSGNIQDKVKQADALSSK----TQRFIIREPVIDFLGRFHV------------GYPVFIHPIST--------EIKRYETLEKYIDLGRSNRGERFVNEFLERVSKLEGDVLKEVFEDASNKFKGEESKQWAYIWQFY-------------------------PVKLKEGVKEFAKSELKLKEEEAEKFAEEFVNLPADTRFPDHAIWTHLDLTSLSVKDPTLLRIKIPFIA-NSRKQLDLWASSHLLSMLMYKALEVIVDKFGPEHVIYPSLRDQPFFLKFYLGENIGDGKEAEKIEEEIKKRIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIVREYFTVSIYQVTENAGLSDEDVKKWLKFAEKKENSRVLERIAIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDHDNLKSLWLDEEPLCPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNWRKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESGLSIDEEKVKEVVDFLNAAYK---EIGNPPKYYAILVMDGISGEVLGEISTRIHPNIRDYVEIPEAKYYSTPQVHV--AISQALANFSIREVRSVVKDEKALEVAYKIRKEFGKSFENGSLLPGWKLSAGILIVHYKHPLYDALEKARDLLNNKAKN-------VPGKDTLAIGLLKRSGSYYISLVGWELIRVFYNSELRKKLLERFIYHVLREVDTWPIDEMLKFEV------------IRHIKEETKELREKIYGEIKDLLEHVRGNN------EVEKVRGLFTFLKIITDAEVFP--------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.03

Estimated TM-score = 0.59±0.14

Estimated RMSD = 11.0±4.6Å

Download Model 2

C-score=-2.37

Download Model 3

C-score=-3.37

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.71

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4c0oA	0.909	2.71	0.119	0.964
2	2x19B	0.789	4.33	0.085	0.915
3	3icqT	0.769	5.07	0.078	0.936
4	3gjxA	0.762	5.20	0.064	0.932
5	3m1iC	0.753	5.57	0.065	0.940
6	2x1gF	0.749	5.31	0.089	0.916
7	4fgvA	0.736	5.47	0.074	0.911
8	1wa5C	0.659	6.09	0.073	0.856
9	3a6pA	0.649	6.93	0.064	0.889
10	4xriA	0.641	5.79	0.063	0.809

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	8	2ysoA	ZN	Rep, Mult	453,455,461,465
2	0.04	2	1mj2B	CA	Rep, Mult	302,306
3	0.04	2	1f59A	III	Rep, Mult	627,630,631,634,635,662,666,670
4	0.02	1	4fnnA	STE	Rep, Mult	114,117
5	0.02	1	1o6pA	III	Rep, Mult	544,585,589
6	0.02	1	5ezmA	MPG	Rep, Mult	298,301
7	0.02	1	3q2qA	CA	Rep, Mult	306,309
8	0.02	1	1sl0A	MG	Rep, Mult	581,642
9	0.02	1	4clvB	ZN	Rep, Mult	588,592
10	0.02	1	1f61A	MG	Rep, Mult	58,101
11	0.02	1	1u6g0	III	Rep, Mult	339,340,383,384
12	0.02	1	5aeiA	III	Rep, Mult	109,112,139,142,145,146,149,150,205,208,212,215,216,254,257,258,261,262,299,302,305,306,309,345,348
13	0.02	1	1o6pA	III	Rep, Mult	634,637,638,666,669,672,673
14	0.02	1	4tnkD	CLA	Rep, Mult	183,190
15	0.02	1	3cigA	UUU	Rep, Mult	541,544,545,586
16	0.02	1	2cg5B	COA	Rep, Mult	514,515
17	0.02	1	4y282	CLA	Rep, Mult	578,579

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1z1wA	0.334	7.50	0.042	0.470	3.4.11.-	NA
2	0.060	1dceA	0.346	6.09	0.069	0.450	2.5.1.60	NA
3	0.060	2vdcA	0.353	8.73	0.054	0.568	1.4.1.13	NA
4	0.060	1fo4A	0.318	8.57	0.033	0.501	1.17.1.4	NA
5	0.060	1yq2A	0.286	8.48	0.052	0.446	3.2.1.23	541,556
6	0.060	1ug9A	0.292	8.53	0.037	0.460	3.2.1.70	254
7	0.060	1t3tA	0.287	9.09	0.039	0.475	6.3.5.3	532
8	0.060	1b0pA	0.308	9.61	0.062	0.537	1.2.7.1	NA
9	0.060	2pffB	0.314	8.90	0.040	0.505	2.3.1.86	613
10	0.060	3b9jJ	0.164	6.45	0.048	0.221	1.17.1.4,1.17.3.2	304
11	0.060	3b9jC	0.186	8.99	0.049	0.304	1.17.3.2,1.17.1.4	NA
12	0.060	2pdaA	0.298	9.83	0.042	0.529	1.2.7.1	308
13	0.060	3h09B	0.287	8.57	0.035	0.452	3.4.21.72	NA
14	0.060	2ckjA	0.308	8.36	0.045	0.478	1.17.1.4,1.17.3.2	NA
15	0.060	2gtqA	0.326	7.74	0.040	0.471	3.4.11.2	NA
16	0.060	3ecqB	0.342	8.78	0.031	0.544	3.2.1.97	247
17	0.060	3ffzA	0.292	8.79	0.035	0.468	3.4.24.69	NA
18	0.060	2gv9B	0.304	8.16	0.053	0.461	2.7.7.7	334,337
19	0.060	3hkzJ	0.288	8.78	0.039	0.457	2.7.7.6	605

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.762	5.20	0.06	0.93	3gjxA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005487 GO:0005634 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0046825 GO:0051028
1	0.21	0.877	3.34	0.11	0.96	4ol0B	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
2	0.20	0.769	5.07	0.08	0.94	3icqT	GO:0000049 GO:0003723 GO:0005525 GO:0005634 GO:0005635 GO:0005643 GO:0005737 GO:0005829 GO:0006409 GO:0006605 GO:0006810 GO:0008033 GO:0008536 GO:0015932 GO:0016363 GO:0071528
3	0.20	0.707	5.50	0.08	0.87	4bsmA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
4	0.18	0.835	3.90	0.11	0.94	4c0qA	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
5	0.14	0.764	5.39	0.07	0.94	3wyfC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
6	0.14	0.749	5.31	0.09	0.92	2x1gF	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
7	0.14	0.756	4.53	0.09	0.88	3zjyE	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
8	0.13	0.748	5.53	0.07	0.93	5difC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
9	0.12	0.723	5.70	0.09	0.91	2xwuB	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
10	0.11	0.721	3.88	0.10	0.81	4c0qB	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
11	0.11	0.608	6.25	0.07	0.80	1qgkA	GO:0000059 GO:0000060 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006309 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0007079 GO:0007080 GO:0008139 GO:0008270 GO:0008536 GO:0008565 GO:0015031 GO:0016020 GO:0016032 GO:0019054 GO:0019899 GO:0019904 GO:0030953 GO:0031291 GO:0031965 GO:0034399 GO:0040001 GO:0043234 GO:0044822 GO:0045184 GO:0051879 GO:0070062 GO:0071782 GO:0075733 GO:0090307
12	0.11	0.667	5.66	0.07	0.84	3gb8A	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
13	0.11	0.717	4.92	0.08	0.86	3zkvA	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
14	0.09	0.649	6.93	0.06	0.89	3a6pA	GO:0000049 GO:0003723 GO:0003729 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0031047 GO:0035281 GO:0042565 GO:0044822 GO:0070883 GO:0090631 GO:1900370
15	0.07	0.604	6.28	0.07	0.79	2q5dB	GO:0000059 GO:0000060 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006309 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0007079 GO:0007080 GO:0008139 GO:0008270 GO:0008536 GO:0008565 GO:0015031 GO:0016020 GO:0016032 GO:0019054 GO:0019899 GO:0019904 GO:0030953 GO:0031291 GO:0031965 GO:0034399 GO:0040001 GO:0043234 GO:0044822 GO:0045184 GO:0051879 GO:0070062 GO:0071782 GO:0075733 GO:0090307
16	0.07	0.641	5.79	0.06	0.81	4xriA	GO:0005622 GO:0006886 GO:0008536
17	0.07	0.599	6.28	0.08	0.79	3nd2A	GO:0000059 GO:0000060 GO:0000176 GO:0005087 GO:0005634 GO:0005643 GO:0005737 GO:0006606 GO:0006607 GO:0006610 GO:0006612 GO:0006656 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965 GO:0034399 GO:0043547 GO:0051028 GO:0051292 GO:0060188
18	0.06	0.268	6.77	0.04	0.36	2iw3B	GO:0000166 GO:0001933 GO:0003723 GO:0003746 GO:0005524 GO:0005737 GO:0005840 GO:0006412 GO:0006414 GO:0006415 GO:0006469 GO:0010494 GO:0016887 GO:0019843 GO:0022626 GO:0042788
19	0.06	0.225	7.46	0.05	0.32	2hivA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0005737 GO:0006260 GO:0006273 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
20	0.06	0.214	8.90	0.04	0.35	3o8lA	GO:0000166 GO:0003824 GO:0003872 GO:0005524 GO:0005737 GO:0006002 GO:0006096 GO:0008022 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0046872 GO:0061615
21	0.06	0.131	6.79	0.03	0.18	4rk9A	GO:0005215 GO:0006810
22	0.06	0.123	5.98	0.04	0.16	2htmC	GO:0003824 GO:0005737 GO:0009228 GO:0009229 GO:0016740 GO:0016783

Consensus prediction of GO terms

Molecular Function	GO:0008565	GO:0008536	GO:0003723	GO:0035639	GO:0032561	GO:0032550	GO:0022891	GO:0005487	GO:0019904	GO:0004872	GO:0042802	GO:0008139
GO-Score	0.59	0.49	0.49	0.40	0.40	0.40	0.40	0.37	0.37	0.35	0.35	0.35
Biological Processes	GO:0034470	GO:0006399	GO:0006409	GO:0043487	GO:1902583	GO:0019058	GO:0046794	GO:0000819	GO:0042176	GO:0000122	GO:0010824	GO:0000056	GO:0051028	GO:0000055	GO:0046825	GO:0042493	GO:0035048
GO-Score	0.40	0.40	0.40	0.39	0.39	0.39	0.39	0.39	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.37	0.35
Cellular Component	GO:0031965	GO:0034399	GO:0005642	GO:0005730	GO:0015030	GO:0000776	GO:0030529	GO:0005829
GO-Score	0.59	0.40	0.37	0.37	0.37	0.37	0.37	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.