I-TASSER results

I-TASSER results for job id Rv0610c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (385 residues)
MDDELRGLLARYARGELSADDARRAILRYPKWRVAEIDGELETVALDDGTPMLIAESSAS
DGREYSGLELVRDIAPLVGGLSFDPDEPWGSAFRPGALPELQNWARTVELEDAVAKPGPG
QRDLLYEGPWWVAVSPGTGRPAVHRADGLDVITIMTAPDAAATFRRTERHRGLDVVRLGP
ALWGDLAKRSDFDGVRLNPLRPLAQLWPPHVPAMLVAGCDPRPNAEPLPARTVAEIHLWL
DQHGARQEKRELSNRATPVGEVTVARAWWNYDRREIAFTRVAPASDTEGLGSVPSRILCA
GKLRQSIQSKLAGLPRLTWRADAWHRQRAALAVGWALELEKLVCGERVPFAALRTPEGAH
LWHLEPQAFTARAIRKLRDRAASFR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDDELRGLLARYARGELSADDARRAILRYPKWRVAEIDGELETVALDDGTPMLIAESSASDGREYSGLELVRDIAPLVGGLSFDPDEPWGSAFRPGALPELQNWARTVELEDAVAKPGPGQRDLLYEGPWWVAVSPGTGRPAVHRADGLDVITIMTAPDAAATFRRTERHRGLDVVRLGPALWGDLAKRSDFDGVRLNPLRPLAQLWPPHVPAMLVAGCDPRPNAEPLPARTVAEIHLWLDQHGARQEKRELSNRATPVGEVTVARAWWNYDRREIAFTRVAPASDTEGLGSVPSRILCAGKLRQSIQSKLAGLPRLTWRADAWHRQRAALAVGWALELEKLVCGERVPFAALRTPEGAHLWHLEPQAFTARAIRKLRDRAASFR
Prediction	CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEHCCCCEEEEEHCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEHCCCEEEEHCCCCCCCCCHCCCCCEEEEEEHCCCHHHHHHHHHHHCCCEEEEHCHHHHHHHHHCCCCCCCHCCCCHHHHHHCCCCCCCCEHCCCCCCCCCCCCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEHCCCCCCCCEEHCCCHHHHHHHHHHHHHHHHHCC
Conf.Score	9778999999987667776788999987786545544675556664789756776467777766554577788777656777899998766678876677887766655555545789986544444765789758989865444678758988757755666666665457656775445555555456788754565557788788887534444788898888888643445555555555567788876567876557777654345654455665567777777777764344356788999998757887544444677777778888877777766466666433468887655555765678999999998766659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDDELRGLLARYARGELSADDARRAILRYPKWRVAEIDGELETVALDDGTPMLIAESSASDGREYSGLELVRDIAPLVGGLSFDPDEPWGSAFRPGALPELQNWARTVELEDAVAKPGPGQRDLLYEGPWWVAVSPGTGRPAVHRADGLDVITIMTAPDAAATFRRTERHRGLDVVRLGPALWGDLAKRSDFDGVRLNPLRPLAQLWPPHVPAMLVAGCDPRPNAEPLPARTVAEIHLWLDQHGARQEKRELSNRATPVGEVTVARAWWNYDRREIAFTRVAPASDTEGLGSVPSRILCAGKLRQSIQSKLAGLPRLTWRADAWHRQRAALAVGWALELEKLVCGERVPFAALRTPEGAHLWHLEPQAFTARAIRKLRDRAASFR
Prediction	7555033001310424142640230014125121351444042111452111000333254344140141033003101104133652113113331143044004214145113643434330115110000012332320234141110000010241223143255333130030121002200644515423142032005112330100000003343526313131003010002532345545514643233131100300132533300123014254352124123200001302530453023033011314213442000000000304301124301010030362120110324211140044037414628
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEHCCCCEEEEEHCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEHCCCEEEEHCCCCCCCCCHCCCCCEEEEEEHCCCHHHHHHHHHHHCCCEEEEHCHHHHHHHHHCCCCCCCHCCCCHHHHHHCCCCCCCCEHCCCCCCCCCCCCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEHCCCCCCCCEEHCCCHHHHHHHHHHHHHHHHHCC
MDDELRGLLARYARGELSADDARRAILRYPKWRVAEIDGELETVALDDGTPMLIAESSASDGREYSGLELVRDIAPLVGGLSFDPDEPWGSAFRPGALPELQNWARTVELEDAVAKPGPGQRDLLYEGPWWVAVSPGTGRPAVHRADGLDVITIMTAPDAAATFRRTERHRGLDVVRLGPALWGDLAKRSDFDGVRLNPLRPLAQLWPPHVPAMLVAGCDPRPNAEPLPARTVAEIHLWLDQHGARQEKRELSNRATPVGEVTVARAWWNYDRREIAFTRVAPASDTEGLGSVPSRILCAGKLRQSIQSKLAGLPRLTWRADAWHRQRAALAVGWALELEKLVCGERVPFAALRTPEGAHLWHLEPQAFTARAIRKLRDRAASFR

3d0rB

0.15

0.13

0.89

0.55

MUSTER

IEGRMRVLFVSSPIGHLFLIQLAWGFRTA---------GHDVLIAVAEHADR-AAAAGLEVAPDYSAVKVFEQVAKDNPRFAETVATRPAIDLE-EWGVQIAAVNRP-LVDGTMALVDDYRPDLVVYEQGATVAADRAGVPAVQRNQSAWRTRGMHRS-IASFLTDLMDKHQVSLPE--PVATIESF----PPSLLLEAEPE---GWFMWVPY--GGGAVLGDRLPPVPARAIT--TIELQAFGIGAVEPIIA-GEVDA-DFVLALGDLDISPGTLPNVRAVGWTPLHTL--LRT-VVHHGGGGTVMTAIDAGIP-APDPRDQHTAREAVSRRGIGLVST----SDKVDADLLRR-----LIG---DESLRTAAREVREEMVALP

3d0rB

0.14

0.13

0.90

0.57

dPPAS

M----RVLFVSSGIGHLFPLIQLAWGFRTAGHDVLIAVAEHADRAAAAGLEVVDV------APDYSAVKVFEQVAKDNPRFAETVATRPAIDLEEWGVQIAAVNRPLVDGTMALVDD---------YRPDLVVYEQGAVGLLAADRAGVPAVQRNQSAWRTRGMHRSIAS--------FLTDLMDKHQVSLPEPVATIESFP-PSLLLEAEPEGWFMRWVPYGGGAVLGDRAITMGTIELQAFGIGAVEPIIAAAGEVDADFVLALGDLDISGTLPRNVRAVGWTPLHTLLRTCTAVVHHGGGGTVMTAIDAGIPQLPRDQFQHTAREAVSRRGIGLVST----SDKVDADLLRR--------LIGDESLRTAAREVREEMVALP

3h1bA

0.21

0.14

0.68

0.48

wdPPAS

MGPEIVKLKKILREKEVPLDVMRKGMEKVAFKAADDI--QVEQVTVA-GCAAEWVRAPGCQAG------------KAI--LYL------GGGYVMGSI----------NTHRSMV------GEI------------------SRAS-QAAALLL--APDGVAAYRWLLDQ-GFKPQHL--SISGD----S---G------GGLVLA------VLVSA----RDQGLPMPASAIPI---WADMTCTNDSFKTRAEADPMVAPGGINKMAARYDAKH----YASPNANLKGL---PPLLIHVG-----------RDEVL--LDDSIKLDAKAKADG-------------VK-STLEIWDDMHVWHAEGKQAIVRVGEFMREQWAA--

4luqA

0.19

0.17

0.89

0.50

wMUSTER

MTDLIESLISYSDDWQVTRQEARRVIAAIPDATIAALDGSLIKLFQRVGPPELLIASIA--GRTTMQRYQARNALIRS--LINNPLGTQTDNW--IYFPTITFFDICADLADAAGRAAAGATGVASQAI-----GPFSGVGAT----GVNPTDLPSIADQLKLLNKDPAT----VTKYNPLLGAYLSQLSPQD--KLNQAQPIPDAYPGNPPAKVMSAAARKYDLTP---QLIG-AIILAEQRTRDEDAKDYQ--AVSIKSANTSIG--------LGQVVVSTAIKYELF----TDLLGQPVRRGLSRKAVATL--LA--SDEFNIFATARYIRYVANLASQQDLRKLPKTRGAFPSDLRAYAGNPRNWPRDNVRALASEYTS-R

4ypvA

0.33

0.21

0.64

0.43

wPPAS

MDPQAKGLLDAMAANDLPVKEAREMYRGIQDLPIGKT--EDRKIPGPAGDPVRIYTPVAAGG---AAL-------PVLGG--------WGD----------------LETHDALC------RSF---G---KVVAVD--RLA-HRA-AAE--------DCLAAVKWVETNAGVDANRI--AVAGD----S---G---N-LAVVSQL------A--------LAAKGPRIA---FQL-LVTDTNVDTASYRENAS--GYF--LERDGIWFDYDRTDP---RVAPAASLAGL---RAYVITAG-------------P-L--KDEGRAYAEALKAAG-------------VP-TEYV--EGMH-FNLQARDAVKAAAKALKEALA---

3r0vA

0.20

0.13

0.63

0.58

dPPAS2

-----------------------------------------QTVPSSDGT--PIAFERSGSGP-----PVV-----LVGGALST----------------RAGGAPLAERLAP-------HFTVIYD-------RRGRGDSG--DTPPY------AVEREIEDLAAIIDAAGGAAFVFG-SSGAGLSL------------LAAASGLPITRLAVFEPPYAVDDSRPPVPPDYQTRLDALLAE-GRRGDAVTYFTEGVGVPPDLVAQQQAPWPGEAVAHTLPDNTIPTARFASISIPTL--------V---DGG------ASPAWIRHTAQELADTI------------PNARYVTLENQT--HTVPDAIAPVLVEFFT-------

4gtnA

0.20

0.16

0.78

0.49

PPAS

LRANIQQALNHITKNILTQAQMEDVMRSI-------MQGNAQIGAL------MMGESID----EITAAARVMREL-----IKIDVSDI------QYLV-------------DIVGTGGDGQNLF----NVSTASSFAAGATAKHSSDLLEQAGINLDLDMQQTERCIREM-GVGFLFAPKAMKYAVGPRREL-GIR-SIFNLLGPLTNPAGVKRFVIGVSDRPIAE-LGAEHVMVVH----KDGL-----EISLSQTYIAELKEVTEWV-LNPEDVNIPS-QTLSGLIV-ED-------SNASLKLIKDALGRKK---SDIGEKAANMIALNAGAGIYVSGLA-------TSYK--QGVALDIIY---QALEKMSILSEFTKALK

4zrsA

0.20

0.14

0.71

0.68

Env-PPAS

MTPELRAKLESLGR-DLTPEMLGGTTQIFAMATGSDPEVETRDLEYGEDPRLDLFRKADTRD------------APVL--VFV-----HGGGFVMGDK-RLAETPFYDNIGVFAAQQG------------FVGVTITY-RPA-HQFSGPE--------DLAAVVRWLKANVGGDPDKI--VLSGQ---------------AGAAHV------ASYIA-HKAHHATEGGGIAGAILMSGIYDTL-----------TATPN---EFLIAYYGDDPKGWG--PASSAGLINTE--IPLMLTVS-----------------EFDPEDFQRQAAQFVCAWGMAHA--------AYPEMHYLVGHN--HLSPAQSIGTEIKAIGRMVAGFR

4gtnA

0.19

0.15

0.80

0.55

MUSTER

LRANIQQALNHITKNILTQAQMEDVMRSI-------MQGNATIGAL------MMGESID----EITAARVMRELAIKIDVSDIQYLVDIVGTGGDGQ--NLFNVSTASSFVIAAA----GA---------TIAKHGNS-------SDLLEQAGINLDLDMQQTERCIREM-GVGFLFAPKAMKYAVGPRREL-GIRFNLLGPLTN--PAGVKRFVIGVFSDRPIAE-LGAEHVMVVH---SKDGL----------ISLASQTYIAELK-----GEVTEWVLNPE--DVNIPSQTLSGLIVEDSNASLKLIKDALGRKKSDIGEKAANMIALNAGAGIYVSGLA-------TSYK--QGVALDIIY---QALEKMSILSEFTKALK

2wpxA

0.17

0.13

0.76

0.55

dPPAS

TVGQWLDLMALAAETGPRANVDMVGSLRFAPPWVVRSGGRALRLALPDGAPLLVHPGRRRRGIGRALWAHARELARKHDRTTLTATVVESLPSGPAQDPGPAAFAAAMGA-------HRSDIPAGTHQWLDLDRHDPLADGVPAVPAGYSLVTWGTITPDEYAVPVSELELRA------------------AQEVRTSYARQFETMRVGRGRRAYH---------------TGAVH----DATG------------ALAGYTSVSKTTGNPAYALQGMTVVHREHRGHALGTL---LKLANLEYVLRHE--PEVRLVTANAED---NHPMIAVNAALGFE--PYDRWVFWTAEAGPS----------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.41

Estimated TM-score = 0.25±0.07

Estimated RMSD = 18.1±2.4Å

Download Model 2

C-score=-4.64

Download Model 3

C-score=-4.55

Download Model 4

C-score=-4.87

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3uu1A	0.574	5.10	0.115	0.800
2	1o17D	0.572	4.98	0.095	0.782
3	2elcA	0.568	4.95	0.109	0.774
4	1kgzB	0.563	5.00	0.106	0.774
5	4gtnA	0.562	5.31	0.099	0.797
6	1vquA	0.553	5.14	0.121	0.774
7	4hkmA	0.519	4.94	0.099	0.709
8	2wk5B	0.513	5.05	0.104	0.712
9	4muoA	0.508	5.14	0.103	0.714
10	4ga4A	0.507	5.30	0.122	0.720

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	8	1exvA	700	Rep, Mult	6,9,10,13,47
2	0.07	6	2iegA	FRY	Rep, Mult	8,9,10,21,25
3	0.04	3	2tpt0	III	Rep, Mult	6,9,10,13,44,45,54,184,185,186
4	0.04	3	3njbB	IOD	Rep, Mult	371,372,375
5	0.04	3	4izvA	1HC	Rep, Mult	365,366,367
6	0.02	2	3pe7A	CA	Rep, Mult	286,288
7	0.02	2	3thuA	MG	Rep, Mult	241,243,261,275
8	0.01	1	1gxbD	POP	Rep, Mult	10,12,20,21,22,23
9	0.01	1	3pfeA	IMD	Rep, Mult	346,353
10	0.01	1	1zxyA	MG	Rep, Mult	241,248
11	0.01	1	7mdhC	ZN	Rep, Mult	159,210
12	0.01	1	3vggA	GLC	Rep, Mult	180,184
13	0.01	1	2pokA	BGC	Rep, Mult	225,226,232,235,320,321,322
14	0.01	1	3hl2D	NUC	Rep, Mult	376,380
15	0.01	1	3e3nF	AMP	Rep, Mult	8,12,56
16	0.01	1	5d8pD	FE2	Rep, Mult	357,365
17	0.01	1	1zykB	BE2	Rep, Mult	16,17,20,59
18	0.01	1	2qjjA	MG	Rep, Mult	241,243,261,288
19	0.01	1	3m4oA	C7P	Rep, Mult	332,333,336
20	0.01	1	2o014	CLA	Rep, Mult	103,377

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	2elcD	0.570	4.90	0.116	0.777	2.4.2.18	23
2	0.067	1kgzB	0.563	5.00	0.106	0.774	2.4.2.18	NA
3	0.067	1k8eD	0.572	4.98	0.095	0.782	2.4.2.18	NA
4	0.067	1vquA	0.553	5.14	0.121	0.774	2.4.2.18	5
5	0.060	2wk5A	0.512	5.00	0.091	0.704	2.4.2.4	11
6	0.060	1n1hA	0.399	7.06	0.040	0.675	2.7.7.48	NA
7	0.060	1f6wA	0.385	6.40	0.055	0.610	3.1.1.13,3.1.1.3	2
8	0.060	1brwA	0.500	5.28	0.084	0.709	2.4.2.2	NA
9	0.060	2dsjA	0.485	5.45	0.117	0.696	2.4.2.2	NA
10	0.060	2azdB	0.446	6.40	0.076	0.701	2.4.1.1	12
11	0.060	2e9bA	0.416	6.96	0.054	0.699	3.2.1.41	NA
12	0.060	2fhbA	0.362	7.15	0.029	0.629	3.2.1.41	NA
13	0.060	2pflA	0.386	6.72	0.043	0.634	2.3.1.54	200,205
14	0.060	3cf4A	0.391	6.29	0.065	0.603	1.2.99.2	NA
15	0.060	1ygpA	0.453	6.17	0.050	0.704	2.4.1.1	40,178
16	0.060	1zvwA	0.564	5.01	0.122	0.779	2.4.2.18	NA
17	0.060	3h5qA	0.474	5.67	0.066	0.696	2.4.2.2	18
18	0.060	2veoB	0.409	6.00	0.059	0.626	3.1.1.3	46
19	0.060	1azyA	0.487	5.64	0.069	0.709	2.4.2.4	11
20	0.060	2qezF	0.387	7.06	0.037	0.665	4.3.1.7	29
21	0.060	3gpbA	0.445	6.31	0.088	0.696	2.4.1.1	NA
22	0.060	2fhcA	0.413	7.33	0.058	0.730	3.2.1.41	5,47
23	0.060	1aknA	0.387	6.42	0.061	0.616	3.1.1.13,3.1.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.593	4.92	0.13	0.81	5c2lA	GO:0000162 GO:0000287 GO:0003824 GO:0004048 GO:0005576 GO:0005829 GO:0005886 GO:0008152 GO:0008652 GO:0009073 GO:0016740 GO:0016757 GO:0040007 GO:0046872
1	0.07	0.568	4.95	0.11	0.77	2elcA	GO:0000162 GO:0000287 GO:0004048 GO:0008152 GO:0008652 GO:0009073 GO:0016740 GO:0016757 GO:0046872
2	0.07	0.563	5.00	0.11	0.77	1kgzB	GO:0000162 GO:0000287 GO:0004048 GO:0008152 GO:0008652 GO:0009073 GO:0016740 GO:0016757 GO:0046872
3	0.07	0.573	4.97	0.09	0.78	2gvqD	GO:0000162 GO:0000287 GO:0003824 GO:0004048 GO:0005829 GO:0008152 GO:0008652 GO:0009073 GO:0016740 GO:0016757 GO:0046872
4	0.07	0.555	5.10	0.12	0.77	4hkmB	GO:0000162 GO:0000287 GO:0003824 GO:0004048 GO:0005829 GO:0008152 GO:0008652 GO:0009073 GO:0016740 GO:0016757 GO:0046872
5	0.07	0.560	5.01	0.11	0.77	1vquA	GO:0000162 GO:0000287 GO:0004048 GO:0008152 GO:0008652 GO:0009073 GO:0016740 GO:0016757 GO:0046872
6	0.07	0.561	5.24	0.10	0.79	4gtnA	GO:0000162 GO:0000287 GO:0004048 GO:0008152 GO:0008652 GO:0009073 GO:0016740 GO:0016757 GO:0046872
7	0.07	0.508	5.14	0.10	0.71	4muoA	GO:0003677 GO:0003723 GO:0005829 GO:0008152 GO:0016740 GO:0016757
8	0.07	0.511	5.38	0.12	0.73	4ga5A	GO:0003824 GO:0004645 GO:0005829 GO:0006196 GO:0006206 GO:0006213 GO:0006220 GO:0008152 GO:0009032 GO:0016208 GO:0016740 GO:0016757 GO:0016763 GO:0042301 GO:0046125
9	0.07	0.512	5.00	0.09	0.70	2wk5A	GO:0000002 GO:0001525 GO:0004645 GO:0005161 GO:0005829 GO:0006206 GO:0006213 GO:0006220 GO:0006260 GO:0006935 GO:0007275 GO:0008083 GO:0008152 GO:0009032 GO:0016154 GO:0016740 GO:0016757 GO:0016763 GO:0030154 GO:0043097 GO:0046135
10	0.07	0.485	5.45	0.12	0.70	2dsjA	GO:0004645 GO:0006206 GO:0006213 GO:0008152 GO:0016154 GO:0016740 GO:0016757 GO:0016763
11	0.06	0.314	6.66	0.08	0.51	3undB	GO:0003824 GO:0005737 GO:0008152 GO:0008676 GO:0009058 GO:0009103 GO:0016740 GO:0019294
12	0.06	0.277	6.93	0.05	0.46	5dm3A	GO:0003824 GO:0004356 GO:0006542 GO:0006807 GO:0016874
13	0.06	0.279	6.80	0.06	0.47	4pxdA	GO:0000256 GO:0006144 GO:0008152 GO:0009442 GO:0016787 GO:0016813 GO:0030145 GO:0042803 GO:0046872 GO:0047652
14	0.06	0.229	6.35	0.06	0.36	2izpA	GO:0005576 GO:0009405
15	0.06	0.203	6.18	0.05	0.31	1delA	GO:0000166 GO:0005524 GO:0016301 GO:0016310 GO:0016740 GO:0047507
16	0.06	0.226	5.51	0.07	0.33	4ttpA	GO:0000166 GO:0004140 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740
17	0.06	0.237	5.47	0.04	0.34	2pyuA	GO:0000166 GO:0000287 GO:0005829 GO:0006163 GO:0009117 GO:0009143 GO:0016787 GO:0017111 GO:0046872 GO:0047429
18	0.06	0.234	5.76	0.03	0.35	4xboA	GO:0002128 GO:0003723 GO:0005737 GO:0005829 GO:0006396 GO:0008033 GO:0008168 GO:0008173 GO:0016740 GO:0032259 GO:0052665 GO:0052666

Consensus prediction of GO terms

Molecular Function	GO:0016763	GO:0043169
GO-Score	0.58	0.58
Biological Processes	GO:0006520	GO:1901607	GO:0046219	GO:0046394	GO:0006568
GO-Score	0.58	0.58	0.58	0.58	0.58
Cellular Component	GO:0044444
GO-Score	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.