I-TASSER results

I-TASSER results for job id Rv0597c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (411 residues)
MGVVERAIAPSVLAALADTPVVVVNGARQVGKTTLVARLDYPGSSEVVSLDDVANRDAAR
DDPRAFVSRPVDTLVIDEAQLEPGLFRAIKAEVDRDRRPGRFLLTGSARLLSAPDMADAL
VGRVEIIELWPFSQGERAGIADGFVDALFTAPRELIHGSDMRRADLVDRIATGGFPDIVA
RSPSRRRAWFDNYLTTATQSVIREISPIERLAEMPRVLRLCAARTGAELNVSALANDLSI
PARTTAGYLALLEAAFLIHRVPAWSTNLSRKVIRRPKLVVSDSGLACHLLGVTGATLDRP
GRPLGPLLETFVANEIRKQLTWSTERPSLWHFRDRGGAEVDLVLEHPDGRVCGIEVKATS
TPRAEDLRGLRYLAERLDDRFQFGVLLTAAPEATPFGPTLAALPVSTLWAG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGVVERAIAPSVLAALADTPVVVVNGARQVGKTTLVARLDYPGSSEVVSLDDVANRDAARDDPRAFVSRPVDTLVIDEAQLEPGLFRAIKAEVDRDRRPGRFLLTGSARLLSAPDMADALVGRVEIIELWPFSQGERAGIADGFVDALFTAPRELIHGSDMRRADLVDRIATGGFPDIVARSPSRRRAWFDNYLTTATQSVIREISPIERLAEMPRVLRLCAARTGAELNVSALANDLSIPARTTAGYLALLEAAFLIHRVPAWSTNLSRKVIRRPKLVVSDSGLACHLLGVTGATLDRPGRPLGPLLETFVANEIRKQLTWSTERPSLWHFRDRGGAEVDLVLEHPDGRVCGIEVKATSTPRAEDLRGLRYLAERLDDRFQFGVLLTAAPEATPFGPTLAALPVSTLWAG
Prediction	CCCCCCCHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHCCCCEEEHCCCHHHHHHHHHHHHHHHHCCCCCEEEHCHHHCCCHHHHHHHHHHCCCCCCEEEEHCCCCHHHHCCCCCCCCCEEEEEEHCCCCHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEHCCCCCCCHHHHHCCCCCEEEHCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCEEEEEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEHCCCEEEEEHHHHHCC
Conf.Score	997566489999999857997999958988889999999865785898789999999999989999985899689853564986999999999858898689998687577655565556886899997688999998756875677765665445665545899999999898689987796899999999999999999999856776899999999999975788899999999888689999999999998544546888885667655788668768999999989986787656776789999999999999986556787688887589977999999799589999997699997899999999999869866679999699865776895899886776659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGVVERAIAPSVLAALADTPVVVVNGARQVGKTTLVARLDYPGSSEVVSLDDVANRDAARDDPRAFVSRPVDTLVIDEAQLEPGLFRAIKAEVDRDRRPGRFLLTGSARLLSAPDMADALVGRVEIIELWPFSQGERAGIADGFVDALFTAPRELIHGSDMRRADLVDRIATGGFPDIVARSPSRRRAWFDNYLTTATQSVIREISPIERLAEMPRVLRLCAARTGAELNVSALANDLSIPARTTAGYLALLEAAFLIHRVPAWSTNLSRKVIRRPKLVVSDSGLACHLLGVTGATLDRPGRPLGPLLETFVANEIRKQLTWSTERPSLWHFRDRGGAEVDLVLEHPDGRVCGIEVKATSTPRAEDLRGLRYLAERLDDRFQFGVLLTAAPEATPFGPTLAALPVSTLWAG
Prediction	573243611540262066330000000110000000100046441100104215125203510430256354100000003264014001000142344021000100011124433421121012020100001001413642143224444413533523352023001101000002333532342243002100230144224233241022002000311233032430253142335002300300130010130221245334424444220100000000002023422122122000000000000002012133441200001233420010003267430000000124534551251034017416651210000012543142653000000100128
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHCCCCEEEHCCCHHHHHHHHHHHHHHHHCCCCCEEEHCHHHCCCHHHHHHHHHHCCCCCCEEEEHCCCCHHHHCCCCCCCCCEEEEEEHCCCCHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEHCCCCCCCHHHHHCCCCCEEEHCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCEEEEEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEHCCCEEEEEHHHHHCC
MGVVERAIAPSVLAALADTPVVVVNGARQVGKTTLVARLDYPGSSEVVSLDDVANRDAARDDPRAFVSRPVDTLVIDEAQLEPGLFRAIKAEVDRDRRPGRFLLTGSARLLSAPDMADALVGRVEIIELWPFSQGERAGIADGFVDALFTAPRELIHGSDMRRADLVDRIATGGFPDIVARSPSRRRAWFDNYLTTATQSVIREISPIERLAEMPRVLRLCAARTGAELNVSALANDLSIPARTTAGYLALLEAAFLIHRVPAWSTNLSRKVIRRPKLVVSDSGLACHLLGVTGATLDRPGRPLGPLLETFVANEIRKQLTWSTERPSLWHFRDRGGAEVDLVLEHPDGRVCGIEVKATSTPRAEDLRGLRYLAERLDDRFQFGVLLTAAPEATPFGPTLAALPVSTLWAG

2qenA

0.18

0.12

0.64

1.16

wdPPAS

MDIFDREESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDC-KLSLREVFRELNDLGEELGEFIVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFRE----VNLDVPENEIEEAVELLDGIPGWLVVDFGRAMKRTLEVAKGLIMGELEELR--RRSPRYVDILRAIALGYNR---WSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI------------------------------------------------------------------------------------------------------------------------

2qenA

0.16

0.11

0.65

0.78

MUSTER

MDIFDREESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCLEPRKLREVFRELNDLGEELGEFVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP----ENEIEEAVELLDGIPGWLVVFGVEYLRNFGRAMKRTLEVAKGLIMGLEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.11

0.64

0.73

dPPAS

------EESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRELSLREVFRELNDLGEELGEFIVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP----ENEIEEAVELLDGIPGWLVVEYLRNGDFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.11

0.64

1.05

wMUSTER

TRIFDREESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCEPRKLLREVFRELNDLGEELGEFVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFRE----VNLDVPENEIEEAVELLDGIPGWLVVDFGRAMKRTLEVAKGLIMGELEELR--RRSPRYVDILRAIALGYNR---WSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.11

0.64

1.44

wPPAS

MDIFDREESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCPRKLSLREVFRELNDLGEELGEFVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFRE----VNLDVPENEIEEAVELLDGIPGWLVVDFGRAMKRTLEVAKGLIMGELEELR--RRSPRYVDILRAIAL----YNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLR-I-----------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.11

0.64

1.41

dPPAS2

-------ESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRELSLREVFRELNDLGEELGEFIVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP----ENEIEEAVELLDGIPGWLVVEYLRNGDFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.11

0.65

1.31

PPAS

MDIFDREESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRKLSLREVFRELNDLGEELGEFIVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP----ENEIEEAVELLDGIPGWLVVEYLRNGDFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI------------------------------------------------------------------------------------------------------------------------

2fnaA

0.17

0.11

0.65

1.19

Env-PPAS

KDFFDR--EKEIEKLKGRAPITLVLGLRRTGKSSIIKIGINELNLPYIYLDYKDFLLELQKEINKLVKRDNVIIVLDEAQELVNLLPALAYAYDNLKR--IKFISGSEGYLRVEDPESPLFGRFSTVELKPFSREEAIEF----LRRGFQEADIDFKDYEVVYEKIPGWLTYFGFIYLDNKNLDFAINQTLEYAKKLILKEFENFLHGREIARKRYLNIRTLSKWSDVKRALELEEGIEISDSEIYNYLTQLTKHSWIIK-------------EGEKYCPSEPLISLAFS-------------------------------------------------------------------------------------------------------------------------

2fnaA

0.17

0.11

0.65

0.74

MUSTER

KDFFDR--EKEIEKLKGRAPITLVLGLRRTGKSSIIKIGINELNLPYIYLDYKDFLLELQKEINKLVKRLPSLIVLDEAQELVNLLPALAYAYDNLKR--IKFISGSEGYLRVEDPESPLFGRFSTVELKPFSREEAIEF----LRRGFQEADIDFKDYEVVYEKIPGWLTYFGFIYLDNKNLDFAINQTLEYAKKLILKEFENFLHGRARKRYLNIRTLSKCGKWSDVRALELEEGIEISDSEIYNYLTQLTKHSWIIK-------------EGEKYCPSEPLISLAFS-------------------------------------------------------------------------------------------------------------------------

2fnaA

0.18

0.12

0.66

0.72

dPPAS

KDFFDREKEIEKLKGL-RAPITLVLGLRRTGKSSIIKIGINELNLPYIYLDLKDFLLELQKEINKLVKRDNVIIVLDEAQELVNLLPALAYAYDNLKR--IKFISGSEGLLYDYDPESPLFGRFSTVELKPFSREEAIEF----LRRGFQEADIDFKDYEVVYEKIPGWLTYFGFIYLDNKNLDFAINQTLEYAKKLILKEFENFLHGREIARKRYLNIRTLGKWSDVKRALELEEGIEISDSEIYNYLTQLTKHSWIIK-------------EGEKYCPSEPLISLAFS-------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.91

Estimated TM-score = 0.29±0.09

Estimated RMSD = 16.8±2.9Å

Download Model 2

C-score=-3.98

Download Model 3

C-score=-4.29

Download Model 4

C-score=-4.23

Download Model 5

C-score=-4.57

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1vt4I	0.614	4.45	0.071	0.783
2	2qenA	0.588	2.53	0.147	0.647
3	3iytA	0.579	4.68	0.092	0.759
4	2fnaA	0.577	2.61	0.183	0.637
5	2a5yB2	0.549	4.35	0.128	0.698
6	1w5tB	0.517	4.44	0.116	0.669
7	5irlA	0.496	5.70	0.088	0.706
8	5g4fA	0.486	5.63	0.071	0.693
9	3cf1B	0.480	5.19	0.069	0.657
10	5kneA	0.476	5.72	0.090	0.664

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.26	27	5e7pB	ADP	Rep, Mult	1,28,29,30,31,32,33,34,176,177
2	0.10	10	1r6bX	MG	Rep, Mult	32,33,105
3	0.10	10	3glfC	BEF	Rep, Mult	28,29,32,33,78,177
4	0.02	2	3glfH	QNA	Rep, Mult	362,363,364,365,368
5	0.01	1	3glfD	UUU	Rep, Mult	94,119,123
6	0.01	1	3shfA	GBL	Rep, Mult	216,217,252

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2ph5A	0.369	6.59	0.043	0.584	2.5.1.44	85
2	0.060	1ii0B	0.376	6.71	0.079	0.586	3.6.3.16	32
3	0.060	1q8iA	0.286	7.34	0.024	0.504	2.7.7.7	NA
4	0.060	2e8yA	0.358	7.71	0.059	0.664	3.2.1.41	77
5	0.060	3glfG	0.449	4.84	0.140	0.579	2.7.7.7	217
6	0.060	1nsfA	0.374	3.80	0.119	0.450	3.6.4.6	32
7	0.060	1moqA	0.287	6.63	0.063	0.457	2.6.1.16	289
8	0.060	2dewX	0.378	7.05	0.065	0.640	3.5.3.15	NA
9	0.060	1oyyA	0.383	6.37	0.077	0.591	3.6.4.12	32,35,78
10	0.060	2gv9B	0.365	7.14	0.048	0.620	2.7.7.7	NA
11	0.060	1llwA	0.389	7.38	0.045	0.676	1.4.7.1	NA
12	0.060	1ofdA	0.340	7.70	0.044	0.618	1.4.7.1	NA
13	0.060	2jkvA	0.365	6.82	0.057	0.589	1.1.1.44	NA
14	0.060	1jxaA	0.381	7.28	0.059	0.654	2.6.1.16	NA
15	0.060	1uaaA	0.378	5.87	0.062	0.550	3.6.4.12	NA
16	0.060	3k1dA	0.373	7.47	0.036	0.659	2.4.1.18	83,106
17	0.060	1in5A	0.458	4.75	0.130	0.591	3.6.4.12	NA
18	0.060	1wd8A	0.364	6.85	0.059	0.601	3.5.3.15	282
19	0.060	1w36B	0.393	6.09	0.047	0.586	3.1.11.5	32

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.19	0.588	2.53	0.15	0.65	2qenA	GO:0000166 GO:0005524
1	0.16	0.379	4.59	0.06	0.47	3sfzA	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0097190 GO:1902510 GO:2001235
2	0.07	0.614	4.45	0.07	0.78	4v4lA	GO:0002921 GO:0005524 GO:0006915 GO:0006919 GO:0007291 GO:0007423 GO:0008635 GO:0008656 GO:0010332 GO:0012501 GO:0021556 GO:0033353 GO:0034352 GO:0035006 GO:0035070 GO:0035071 GO:0042594 GO:0043065 GO:0043293 GO:0043531 GO:0046668 GO:0046672 GO:0048813 GO:0050700 GO:0051260 GO:0051291 GO:0070050 GO:0070328 GO:0097190 GO:0097199 GO:1901053
3	0.07	0.584	5.02	0.09	0.79	3j2tA	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007399 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043065 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0072432 GO:0097190 GO:0097193 GO:1902510 GO:2001235
4	0.07	0.582	2.58	0.18	0.64	2fnaA	GO:0000166 GO:0005524
5	0.07	0.552	4.49	0.12	0.71	4m9sB	GO:0000166 GO:0005524 GO:0005634 GO:0005739 GO:0005829 GO:0006915 GO:0008361 GO:0008635 GO:0008656 GO:0009792 GO:0010954 GO:0016020 GO:0016505 GO:0030155 GO:0042981 GO:0043065 GO:0043066 GO:0043281 GO:0043531 GO:0048471 GO:0048598 GO:0051432 GO:0051434 GO:0061133 GO:1902742 GO:2001056
6	0.06	0.321	6.11	0.06	0.48	3eifA	GO:0004252 GO:0005618 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016787
7	0.06	0.387	4.46	0.07	0.49	1z6tB	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007399 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043065 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0072432 GO:0097190 GO:0097193 GO:1902510 GO:2001235
8	0.06	0.326	6.71	0.05	0.52	2esdA	GO:0008152 GO:0008886 GO:0016491 GO:0016620 GO:0047100 GO:0055114
9	0.06	0.298	6.97	0.03	0.50	4nsxA	GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0030529 GO:0031167 GO:0032040 GO:0034388 GO:0042254 GO:0042274
10	0.06	0.293	6.32	0.06	0.46	4ixmA	GO:0000166 GO:0003924 GO:0005525 GO:0005829 GO:0006974 GO:0042802 GO:0046914
11	0.06	0.299	6.74	0.08	0.48	5a1vK	GO:0000139 GO:0005179 GO:0005198 GO:0005576 GO:0005615 GO:0005737 GO:0005794 GO:0006810 GO:0006886 GO:0006888 GO:0006890 GO:0006891 GO:0015031 GO:0016020 GO:0016192 GO:0030117 GO:0030126 GO:0030157 GO:0030663 GO:0031410 GO:0070062
12	0.06	0.287	6.97	0.11	0.48	4ci8A	GO:0000226 GO:0002244 GO:0005509 GO:0005737 GO:0005829 GO:0005856 GO:0005874 GO:0005875 GO:0007052 GO:0007405 GO:0007420 GO:0008017 GO:0015631 GO:0048471 GO:0097431 GO:1990023
13	0.06	0.292	7.14	0.03	0.49	3mkqA	GO:0005198 GO:0006886 GO:0016192 GO:0030117
14	0.06	0.299	8.11	0.05	0.58	4xfvA	GO:0002098 GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0006357 GO:0006810 GO:0008017 GO:0015031 GO:0032447 GO:0033588
15	0.06	0.268	7.31	0.04	0.46	1nr0A	GO:0003779 GO:0005737 GO:0005856 GO:0016528 GO:0030016 GO:0030240 GO:0030836 GO:0030837 GO:0040011 GO:0040012 GO:0042643 GO:0051015 GO:0071689
16	0.06	0.277	7.52	0.05	0.49	2ymuA	GO:0016020 GO:0016021
17	0.06	0.280	6.93	0.04	0.46	3jroA	GO:0000139 GO:0005198 GO:0005634 GO:0005643 GO:0005773 GO:0005774 GO:0005783 GO:0005789 GO:0006810 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0030127 GO:0030433 GO:0031080 GO:0031081 GO:0031410 GO:0035859 GO:0042802 GO:0043547 GO:0045893 GO:0051028 GO:0090114 GO:1904263
18	0.06	0.285	7.18	0.04	0.49	5a1uD	GO:0000139 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0006890 GO:0006891 GO:0015031 GO:0016020 GO:0016192 GO:0030117 GO:0030126 GO:0030663 GO:0031410 GO:1901998

Consensus prediction of GO terms

Molecular Function	GO:0016505	GO:0043028	GO:0005524	GO:0005515
GO-Score	0.54	0.54	0.45	0.44
Biological Processes	GO:0043280	GO:0051259	GO:0006309	GO:0051128	GO:0071495	GO:0036293	GO:0048869	GO:0034976	GO:0071363	GO:0014020	GO:0010658	GO:1903624	GO:0071559	GO:0031667	GO:2001233	GO:0097193	GO:0060606	GO:0070997	GO:0007420	GO:0009967	GO:1900117
GO-Score	0.54	0.54	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.44
Cellular Component	GO:0043234	GO:0044445	GO:1903561	GO:0043231	GO:0031988
GO-Score	0.54	0.54	0.44	0.44	0.44

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.