I-TASSER results

I-TASSER results for job id Rv0574c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (380 residues)
MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPV
DWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHV
CALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVA
AESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGY
ATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESF
RSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRV
VTRPDNLLEVVPAANLTSKE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPVDWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHVCALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVAAESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGYATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESFRSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRVVTRPDNLLEVVPAANLTSKE
Prediction	CCCCCCEEEEEEHCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEHCCCCCCCCCCHHHHHHHHHHHHHHCCCEHCCCCCHHHHCCCEEEEHCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCEEEHCCEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEEEHCCEEHCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCEEEEHCCCCCCCCC
Conf.Score	99999889999984444588745655468887544444345555455655555666678888765899999998758988999676555799988888886667899999999998998998476666677599999999999998997776899988856878999899899999998578888887766788899855467776579999999999999759999999978988888899999999999999989989996899888775998998999868765667788777777777668999999977999689999999999798876689899999999999999988996898489779996788887889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPVDWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHVCALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVAAESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGYATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESFRSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRVVTRPDNLLEVVPAANLTSKE
Prediction	75644310000000000001214421544344423331243032203224324441445342420054025204642000000000000045553253320102023300400350300000000100102026003300510572603110022336324300103156120000000002121123312033432000103223244105302520451475000000000001114431374025003200610000000000002212321441000000000002134333344233300000000234773402302010000341304315572052025104600561414033444110202336644468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCEEEEEEHCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEHCCCCCCCCCCHHHHHHHHHHHHHHCCCEHCCCCCHHHHCCCEEEEHCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCEEEHCCEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEEEHCCEEHCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCEEEEHCCCCCCCCC
MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPVDWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHVCALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVAAESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGYATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESFRSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRVVTRPDNLLEVVPAANLTSKE

3ztvA1

0.15

0.12

0.83

0.97

MUSTER

--HKAVELSILHINDH--------------------------HSYLEPHETRINLNGQQTKVDIGFSAVNAKLNKLYKNPLVLH-------AGDAITGTLYFLFGGSADAAVMNAGNFHYFTLG-NHEFDAGNEGLLKLLEP---LKIPVLSANVIPDKSSILDIFTVDGEKIAIIGLDTVNKTVNSSS-----------PGKDVKFYDEIATAQIMANALKQGINKIILLSHAGS-------EKNIEIAQKV--NDIDVIVTGDSHYLYGNDELRSLKLPV-IYEYPLEFKNPNGEEGWAYSAVVGDLGVKFSPEGIASITRKIPHVLMSGKWAELTGDERKKALDTLKSM----KSISLDDHDAKTKYKSEKDRLAQE

2z1aA1

0.20

0.15

0.76

1.15

dPPAS

-------------------------------FTLTLVHTNDTHAHLEPVELTLSGEKTPVGGVARRVALFDRVWARAKNPLFLD-------AGDVFQGTLYNQYRGLADRYFMHRLRYRAMALGN-HEFDLGPGPLADFLKG---ARFKVVSAASREPRLKGLAVVVVGGERVGIIGLTT------PDTREISNPGPTVAFLD------PYESAQKAVYELLAGVNKIVVLSHLGY-------GEDLKLARRL--VGVQVIVGGHSHTLLGSFPHKELSPAGPYPTVVKNPEGKDVLQAWEWGKVVGLLEVTFDAKGELLAYKGEALLM-TPEAAPEDFFAKEALLAYAQP-----------------------------

4h1sA1

0.17

0.13

0.76

2.02

wdPPAS

-------------------------------WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRA----EPNVLLLDAGDQYQGTIWTVYKGAEVAHFMNALRYDAMALG-NHEFDNGVEGLIEPL--LKEAKFPILSANKGPLASQPYKVLPVGDEVVGIVGYTSKETPFLSNPG------------TNLVFEDEITALQPEVDKLKTNVNKIIALGHSGF-------EMDKLIAQKV--RGVDVVVGGHSNTFLYTGNPPSFIVTSDDGR------KVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSS---IPEDPSIKADINKWRIKLDNY------------------------

4h1sA

0.18

0.14

0.81

1.23

wMUSTER

------ELTILHTNDV--------------------------HSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIEPNVLLLD-------AGDQYQGTIWTVYKGAEVAHFMNALRYDAMALG-NHEFDNGVEGLIEPL--LKEAKFPILSAGPLASQISGLKVLPVGDEVVGIVGYTSKETPFL------------SNPGTNLVFEDEITALQPEVDKLKTNVNKIIALGHSGF-------EMDKLIAQKV---GVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRK-QAYAFGKYLGYLKIEFDERGNVISSHGNPILLNS---SIPEDPSIKADINKWRIKLDNY--QELGKTIVYLDG-SSQSCRFRE

3ivdA1

0.14

0.10

0.75

1.88

wPPAS

LA---KDVTIIYTNDL--------------------------HAHVEPYK--VPWIADGKRDIGGWANITTLVKQEKAK----NKATWFFDAGDYFTGPYISLTKGKAIIDINT--PFDAVTIG-NHEFDHGWDNTLLQLSQ---AKFPIVQGNIFYQNSSKSTIIEKDGVKIGVIGLHGVFA---FNDTVSAATRVGIE------ARDEIKWLQRYIDELKGKVDLTVALIHEGVPARQSSGDKDIQTASQV---GLDILITGHAHVGTP-IKVGNTLILDSGGID----------------VGKLVLDYKEKPHNTVKNFELKTIYADEW----KPDQQTKQVIDGWNKKLDEVVQQ---------------------

4h1sA1

0.17

0.13

0.75

2.88

dPPAS2

-------------------------------WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIEPNVLLLD-------AGDQYQGTIWTVYKGAEVAHFMNALRYDAMALGN-HEFDNGVEGLIEPL--LKEAKFPILSAKGPLASQISGKVLPVGDEVVGIVGYTSKETPFL------SNPGTNLVFED------EITALQPEVDKLKTNVNKIIALGHSGF-------EMDKLIAQKV--RGVDVVVGGHSNTFLYTGNPPS-------KEVPAGKYPFIVTSDDGFGKYLGYLKIEFDERGNVISSHGNPILLNSS---IPEDPSIKADINKWRIKLDNY------------------------

3ivdA1

0.13

0.10

0.74

1.31

PPAS

LA---KDVTIIYTNDL--AH-------EPYKVPWIADGKRDIGG---------------------WANITTLVKQEKAK----NKATWFFDAGDYFTGPYISLTKGKAIIDIN---PFDAVTIG-NHEFDHGWDNTLLQLSQA---KFPIVQGNSSKSFWDKPTIIEKDGVKIGVIGLHGVF---AFNDTVSAATRVGIEARD------EIKWLQRYIDELKGKVDLTVALIHEGVPARQSSGDKDIQTASQV---GLDILITGHAHVGTP-IKVGNTLILDSGGIDV---------------GKLVLDYKEKPHNFTVKNFELKTIYADEW---KPDQQTKQVIDGWNKKLDEVVQQ----------------------

3ivdA1

0.12

0.09

0.76

2.16

Env-PPAS

LA---KDVTIIYTNDL--------------------------HAHVEPYK--VPWIADGKRDIGGWANITTLVKQEKAK----NKATWFFDAGDYFTGPYISLTKGKAIIDIN--TPFDAVTIG-NHEFDHGWDNTLLQLSQAK---FPIVQGNSSKSFWDKPTIIEKDGVKIGVIGLHGVF---AFNDTVSAATRVGIEARD------EIKWLQRYIDELKGKVDLTVALIHEGVPARQSSGGTDLDKDIQTASQGLDILITGHAHVGTPPIKVGNTLILDSGGIDV---------------GKLVLDYKEKPHNFTVKNFELKTIYADEW---KPDQQTKQVIDGWNKKLDEVVQQ----------------------

3ivdA1

0.13

0.10

0.75

0.95

MUSTER

LA---KDVTIIYTNDL--------------------------HAHVEPYK--VPWIADGKRDIGGWANITTLVKQENKATWFFD-------AGDYFTGPYISLTKGKAIIDINT--PFDAVTIG-NHEFDHGWDNTLLQLSQ---AKFPIVQGNIFYQNSSKSTIIEKDGVKIGVIGLHGVF---AFNDTVSAATRVGIEAR------DEIKWLQRYIDELKGKVDLTVALIHEGVPARRRALDKDIQTASQV---GLDILITGHAHVGTPPIKVGNTLILDSGGIDV---------------GKLVLDYKEKPHNFTVKNFELKTIYADEW---KPDQQTKQVIDGWNKKLDEVVQQ----------------------

4h1sA1

0.17

0.13

0.77

1.15

dPPAS

-------------------------------WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIEPNVLLLD-------AGDQYQGTIWTVYKGAEVAHFMNALRYDAMALGN-HEFDNGVEGLIEPL--LKEAKFPILSAKGPLASQISGKVLPVGDEVVGIVGYTSKETPFL------SNPGTNLVFED------EITALQPEVDKLKTNVNKIIALGHSGF-------EMDKLIAQKV--RGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSS---IPEDPSIKADINKWRIKLDNY------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.27

Estimated TM-score = 0.56±0.15

Estimated RMSD = 9.6±4.6Å

Download Model 2

C-score=-2.89

Download Model 3

C-score=-3.67

Download Model 4

C-score=-3.43

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4h1sA	0.744	2.71	0.146	0.826
2	2z1aA	0.714	3.22	0.167	0.818
3	3ivdA	0.711	3.12	0.094	0.813
4	1oidA	0.707	3.62	0.111	0.834
5	3ztvA	0.703	3.62	0.139	0.832
6	2wdeA	0.690	3.30	0.102	0.803
7	3c9fB	0.674	3.74	0.105	0.810
8	3qfkA	0.648	3.78	0.133	0.782
9	3gveA	0.644	3.32	0.110	0.753
10	3jyfA	0.637	3.40	0.121	0.750

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.42	51	2wdcA	MN	Rep, Mult	41,94,126,127,233,265
2	0.11	14	3ivdA	MN	Rep, Mult	41,43,94,267
3	0.01	1	1ii7A	MN	Rep, Mult	15,86,126,233,265
4	0.01	1	3ib7A	MN	Rep, Mult	125,232,264
5	0.01	2	1ho5B	PO4	Rep, Mult	94,126,127,186,265
6	0.01	1	2z06A	CO	Rep, Mult	251,255

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	1warA	0.512	4.22	0.107	0.647	3.1.3.2	179,244,267
2	0.060	3bg3A	0.472	5.23	0.086	0.663	6.4.1.1	NA
3	0.060	2fhcA	0.440	6.10	0.054	0.695	3.2.1.41	NA
4	0.060	2fhbA	0.440	6.19	0.054	0.700	3.2.1.41	233
5	0.060	3ecqB	0.440	6.18	0.067	0.687	3.2.1.97	93
6	0.060	1oidA	0.707	3.62	0.111	0.834	3.6.1.45,3.1.3.5	126
7	0.060	2z1aA	0.714	3.22	0.167	0.818	3.1.3.5	NA
8	0.060	1rqeA	0.456	5.51	0.093	0.650	2.1.3.1	153
9	0.060	1jqoA	0.472	5.81	0.072	0.695	4.1.1.31	NA
10	0.060	1hp4A	0.439	5.93	0.077	0.663	3.2.1.52	92
11	0.060	1m7jA	0.435	6.00	0.065	0.655	3.5.1.81	NA
12	0.060	1tiwA	0.435	6.04	0.098	0.666	1.5.1.12,1.5.99.8	96,137,198
13	0.060	1xzwB	0.473	4.47	0.086	0.613	3.1.3.2	NA
14	0.060	2vvnA	0.453	5.96	0.052	0.684	3.2.1.52	NA
15	0.060	3dlaD	0.445	5.40	0.069	0.626	6.3.5.1	NA
16	0.060	2vkzG	0.442	5.28	0.076	0.621	2.3.1.38,3.1.2.14	153
17	0.060	1k87A	0.435	6.04	0.098	0.666	1.5.99.8	137,198
18	0.060	2uv8G	0.441	5.28	0.083	0.621	2.3.1.86	NA
19	0.060	2nxfA	0.509	4.37	0.108	0.655	3.6.1.16,3.6.1.53,3.6.1.13	127,285
20	0.060	1djnA	0.448	6.06	0.071	0.687	1.5.8.2,1.5.99.7	246

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.703	3.71	0.12	0.83	1ho5A	GO:0000166 GO:0008253 GO:0008768 GO:0009166 GO:0016311 GO:0016787 GO:0016788 GO:0030288 GO:0042597 GO:0046872
1	0.28	0.716	3.11	0.09	0.82	3ivdA	GO:0000166 GO:0009166 GO:0016787 GO:0016788 GO:0046872
2	0.28	0.656	3.24	0.12	0.76	3gveA	GO:0000166 GO:0003824 GO:0005576 GO:0005618 GO:0008152 GO:0008253 GO:0008254 GO:0008663 GO:0009166 GO:0016311 GO:0016787 GO:0016788 GO:0046872
3	0.26	0.674	3.74	0.10	0.81	3c9fB	GO:0009166 GO:0016787 GO:0046872
4	0.23	0.706	3.61	0.14	0.83	3zu0B	GO:0000166 GO:0008253 GO:0009166 GO:0016311 GO:0016787 GO:0016788 GO:0042597 GO:0046872
5	0.16	0.691	3.38	0.11	0.81	4uwqA	GO:0000166 GO:0009166 GO:0016787 GO:0046872
6	0.13	0.746	2.93	0.15	0.84	4h1yP	GO:0000166 GO:0005737 GO:0005886 GO:0006164 GO:0006195 GO:0006196 GO:0006259 GO:0007159 GO:0007420 GO:0008198 GO:0008253 GO:0009166 GO:0009986 GO:0010044 GO:0016020 GO:0016311 GO:0016787 GO:0016788 GO:0031225 GO:0046085 GO:0046086 GO:0046135 GO:0046872 GO:0046889 GO:0050728 GO:0070062 GO:0097060
7	0.11	0.703	3.62	0.14	0.83	3ztvA	GO:0000166 GO:0008253 GO:0009166 GO:0016311 GO:0016787 GO:0016788 GO:0042597 GO:0046872
8	0.11	0.714	3.22	0.17	0.82	2z1aA	GO:0000166 GO:0009166 GO:0016787 GO:0016788 GO:0046872
9	0.09	0.660	3.37	0.12	0.77	5eqvA	GO:0000166 GO:0008663 GO:0009117 GO:0009166 GO:0016787 GO:0016788 GO:0046872
10	0.09	0.658	3.78	0.14	0.79	4q7fA	GO:0000166 GO:0009166 GO:0016787 GO:0016788 GO:0046872
11	0.08	0.658	3.34	0.12	0.77	3jyfA	GO:0000166 GO:0008663 GO:0009117 GO:0009166 GO:0016787 GO:0016788 GO:0046872
12	0.07	0.484	3.50	0.10	0.57	1uf3A	GO:0046872
13	0.06	0.304	5.34	0.07	0.44	1vqtA	GO:0003824 GO:0004590 GO:0005829 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
14	0.06	0.292	6.68	0.08	0.49	2vvtA	GO:0006807 GO:0008152 GO:0008360 GO:0008881 GO:0009252 GO:0016853 GO:0016855 GO:0036361 GO:0071555
15	0.06	0.273	5.43	0.06	0.39	3e9cA	GO:0003824 GO:0004083 GO:0004331 GO:0005634 GO:0005737 GO:0005739 GO:0005741 GO:0005829 GO:0006003 GO:0006914 GO:0006915 GO:0008152 GO:0016311 GO:0016787 GO:0030388
16	0.06	0.322	5.76	0.07	0.48	1y7iB	GO:0002376 GO:0006952 GO:0008152 GO:0009862 GO:0016298 GO:0016787 GO:0045087 GO:0080031
17	0.06	0.269	7.03	0.06	0.46	4l0eA	GO:0004497 GO:0005506 GO:0016491 GO:0016705 GO:0020037 GO:0046872 GO:0055114
18	0.06	0.241	6.48	0.02	0.39	4efjA	GO:0004519 GO:0005739 GO:0090305
19	0.06	0.241	6.25	0.04	0.38	1a0iA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0016874 GO:0046872 GO:0051103

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0000166	GO:0008253	GO:0016462	GO:0004112
GO-Score	0.79	0.72	0.61	0.58	0.56
Biological Processes	GO:0009166	GO:0016311
GO-Score	0.79	0.61
Cellular Component	GO:0030313	GO:0030312	GO:0042597
GO-Score	0.58	0.56	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.