I-TASSER results

I-TASSER results for job id Rv0530

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (405 residues)
MLVTEHPRTGVGAPDSGNGGTDHPTVQLPPVPSVGAPPAAAGGETPTRSVAGFRTQRLDP
TAYGAYYSGPDEGPASPAERPPYRLEPVPHTPYPELATTTLLRPVKPPPSEGWRRLLYLL
SGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGGVGKTTITATLGATFADLRG
DRVVAVDANPDRGTLSQKVPLETPATVRHLLRDADGIERYSDVRGYTSKGPSGLEVLASD
SDPASSDAFSADDYTRTLDILERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSID
GARSAAATLDWLQAHGHDDQVRNSIAVVNAVRPRAGKVDVGKVVEHFSRRCRAVRVVPFD
PHLEEGAEIALDRLRRETREALTELAAVVAAGFPGDPRRCKPSFT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLVTEHPRTGVGAPDSGNGGTDHPTVQLPPVPSVGAPPAAAGGETPTRSVAGFRTQRLDPTAYGAYYSGPDEGPASPAERPPYRLEPVPHTPYPELATTTLLRPVKPPPSEGWRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGGVGKTTITATLGATFADLRGDRVVAVDANPDRGTLSQKVPLETPATVRHLLRDADGIERYSDVRGYTSKGPSGLEVLASDSDPASSDAFSADDYTRTLDILERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSIDGARSAAATLDWLQAHGHDDQVRNSIAVVNAVRPRAGKVDVGKVVEHFSRRCRAVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAGFPGDPRRCKPSFT
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCHHHCCCCCCCCHHHHHHCHCCCCCHHHHHHHHHCCCCCEEEEHCCCCHHHHHCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHHHHHHHHCCHHHHHCEEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEHCCCCCHHHCCEEEHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
Conf.Score	998889988889998888888898888999888999988888889988888888888999888888999988888888899888888888887766654545667889888757899987567778888989999999999998668998799998799999878999999999999979959999789998854444599988759999875545457899999863478988998689996787669999999999999975999999599998689999999989969998589889999999999999998987776455899966789988778999999998766759985898556467556645589889999999999999975776667777889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLVTEHPRTGVGAPDSGNGGTDHPTVQLPPVPSVGAPPAAAGGETPTRSVAGFRTQRLDPTAYGAYYSGPDEGPASPAERPPYRLEPVPHTPYPELATTTLLRPVKPPPSEGWRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGGVGKTTITATLGATFADLRGDRVVAVDANPDRGTLSQKVPLETPATVRHLLRDADGIERYSDVRGYTSKGPSGLEVLASDSDPASSDAFSADDYTRTLDILERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSIDGARSAAATLDWLQAHGHDDQVRNSIAVVNAVRPRAGKVDVGKVVEHFSRRCRAVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAGFPGDPRRCKPSFT
Prediction	753353245344425455445542446534444444344354454344344434454342544443333244435444444435444454433441445432454543243101200220022315254355144244225305442741000000003110100000000000004236210000001011000010040434200110032163044122034003623520100002331532440336203400520473020000000010222001000100400000021214003102300410363426531520000000025644423053016204630310000021530250330324314460040024003200640455655545528
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCHHHCCCCCCCCHHHHHHCHCCCCCHHHHHHHHHCCCCCEEEEHCCCCHHHHHCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHHHHHHHHCCHHHHHCEEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEHCCCCCHHHCCEEEHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MLVTEHPRTGVGAPDSGNGGTDHPTVQLPPVPSVGAPPAAAGGETPTRSVAGFRTQRLDPTAYGAYYSGPDEGPASPAERPPYRLEPVPHTPYPELATTTLLRPVKPPPSEGWRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGGVGKTTITATLGATFADLRGDRVVAVDANPDRGTLSQKVPLETPATVRHLLRDADGIERYSDVRGYTSKGPSGLEVLASDSDPASSDAFSADDYTRTLDILERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSIDGARSAAATLDWLQAHGHDDQVRNSIAVVNAVRPRAGKVDVGKVVEHFSRRCRAVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAGFPGDPRRCKPSFT

3ea0B

0.15

0.09

0.58

1.41

MUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDHVGVWVLEHL-DELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIGRPIS--KRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------

3ea0B

0.16

0.09

0.58

2.38

dPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDH-VGVWVLEHLDELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIG--RPISKRIPQDESLLSGQSVLKVAPKSQLSKTIVDWALHLN---------------

3ea0B

0.15

0.09

0.58

2.42

wdPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDHVGVWVLEHL-DELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIGRPI--SKRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------

3ea0B

0.16

0.09

0.58

1.82

wMUSTER

---------------------------------------------------------------------------------------------------------------------------------------------------NAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDHVGVWVLEHL-DELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILN--RADTSRITSDEIEKVIGRPI--SKRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------

3ea0B

0.15

0.09

0.58

2.48

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDHVGVWVLEHL-DELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIGRPI--SKRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------

3ea0B

0.16

0.09

0.58

5.51

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDH-VGVWVLEHLDELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIG--RPISKRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------

3ea0B

0.16

0.09

0.58

2.31

PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDH-VGVWVLEHLDELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIG--RPISKRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------

3ea0B

0.16

0.09

0.58

3.36

Env-PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNTHSQDLADISNASDRLD--KSLLDTVQHISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDH-VGVWVLEHLDELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIG--RPISKRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------

4v02A

0.25

0.14

0.57

1.28

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------AEVIVITSGKGGVGKTTLTANIGTALAKL--KKVLLIDAAIGLRNLDMILGLENRYDILDVLEG---RVPYEKA--VKDKRGLSLWLLPAD-------VIDIEKWNKTVEEIKNSYDYILVDSPAGIEKGFQIAVSP-ADKALIVVNPEVSSIRDADRVIGLLESMD----KRNYKVIVNRIKWRGAMLSVEDIVDILK--AEIIGIIPEEPKLVDGEPIVLDE-KFPASQAIIDTARRLMGESIPLKRYGE----

1hyqA

0.24

0.14

0.56

2.10

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------VRTITVASGKGGTGKTTITANLGVALAQLG-HDVTIVDADITMANLELILGMEGLVTLQNVLAGEAR------IDEAIYVGPGGVKVVPAGVSLEGLRKANPEKLEDVLTQIMESTDILLLDAPAGLERSAVIAIAAA-QELLLVVNPEISSITDGLKTKIVAERLG----TKVLGVVVNRITTLGIEMAKNEIEAILE--AKVIGLIPEDPEVRRGKPVVLRSPNSPAARAIVELANYIA---------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.83

Estimated TM-score = 0.39±0.13

Estimated RMSD = 13.7±4.0Å

Download Model 2

C-score=-2.94

Download Model 3

C-score=-2.09

Download Model 4

C-score=-2.15

Download Model 5

C-score=-3.05

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ez2B	0.582	3.64	0.120	0.689
2	3ea0B	0.567	1.27	0.144	0.583
3	3q9lA	0.533	2.68	0.179	0.593
4	2ozeA	0.531	3.73	0.110	0.635
5	3ez9B	0.523	4.26	0.128	0.647
6	4v02A	0.517	2.50	0.222	0.568
7	2bejA	0.515	2.63	0.232	0.573
8	4ru8A	0.509	3.16	0.168	0.585
9	3fwyA	0.502	3.14	0.174	0.575
10	4rz2A	0.501	3.02	0.165	0.568

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.54	72	2c8vA	ATP	Rep, Mult	159,160,161,162,163,164,165,166,192,329,357,358,359,360,363,365,378,382
2	0.07	9	4ru8A	ANP	Rep, Mult	159,160,298,300
3	0.04	5	3ea0B	MG	Rep, Mult	165,189,273
4	0.02	3	1n2cE	ALF	Rep, Mult	160,161,164,165,189,193,274
5	0.01	1	2afkH	SF4	Rep, Mult	168,169,170,198

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1bglA	0.427	6.87	0.072	0.701	3.2.1.23	NA
2	0.060	1cp2A	0.492	3.60	0.154	0.585	1.18.6.1	159,164
3	0.060	2pffA	0.417	5.82	0.060	0.603	2.3.1.41,2.3.1.86	300
4	0.060	1bxrA	0.415	6.48	0.090	0.657	6.3.5.5	NA
5	0.060	1bhgA	0.441	6.53	0.064	0.704	3.2.1.31	NA
6	0.060	1yq2A	0.425	6.81	0.060	0.696	3.2.1.23	NA
7	0.060	3k1dA	0.399	6.16	0.054	0.603	2.4.1.18	300,380
8	0.060	2prmA	0.402	6.23	0.074	0.603	1.3.5.2	NA
9	0.060	1vcoA	0.411	4.70	0.138	0.523	6.3.4.2	193
10	0.060	2vz9B	0.412	6.69	0.090	0.664	2.3.1.85	NA
11	0.060	2je8B	0.403	7.16	0.032	0.699	3.2.1.25	NA
12	0.060	1cp2B	0.491	3.55	0.154	0.583	1.18.6.1	160,190,281
13	0.060	1cwyA	0.406	6.52	0.063	0.637	2.4.1.25	235,271
14	0.060	3i68A	0.401	6.16	0.056	0.595	1.3.5.2	NA
15	0.060	1eg7A	0.489	5.08	0.121	0.659	6.3.4.3	164
16	0.060	1de0A	0.496	3.50	0.137	0.588	1.18.6.1	159,164
17	0.060	1a82A	0.408	3.61	0.134	0.484	6.3.3.3	164
18	0.060	3gm8A	0.432	6.49	0.047	0.686	3.2.1.-	NA
19	0.060	1uuoA	0.396	6.19	0.077	0.590	1.3.3.1,1.3.99.11	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.533	2.68	0.18	0.59	3q9lA	GO:0000166 GO:0005524 GO:0005829 GO:0005886 GO:0007049 GO:0007059 GO:0009898 GO:0016020 GO:0016887 GO:0031226 GO:0042802 GO:0051301 GO:0051782 GO:0060187
1	0.34	0.457	3.77	0.17	0.55	3kb1A	GO:0000166 GO:0005524 GO:0016787 GO:0016887 GO:0046872 GO:0051536
2	0.27	0.482	3.32	0.16	0.56	3kjeA	GO:0000166 GO:0019415
3	0.26	0.582	3.64	0.12	0.69	3ez2B	GO:0030541 GO:0042802
4	0.26	0.513	2.60	0.20	0.57	1g3qA	GO:0000166 GO:0005524 GO:0051301
5	0.25	0.502	3.14	0.17	0.58	3fwyA	GO:0000166 GO:0005524 GO:0015979 GO:0015995 GO:0016491 GO:0016636 GO:0016730 GO:0019685 GO:0030494 GO:0036070 GO:0046148 GO:0046872 GO:0051536 GO:0051539 GO:0055114
6	0.25	0.515	2.63	0.23	0.57	2bejA	GO:0000166 GO:0003677 GO:0005524 GO:0007059 GO:0016787
7	0.22	0.427	3.99	0.12	0.51	3la6B	GO:0000166 GO:0000271 GO:0004713 GO:0005524 GO:0005886 GO:0005887 GO:0009103 GO:0009242 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016887 GO:0018108 GO:0038083 GO:0045226
8	0.19	0.517	2.50	0.22	0.57	4v02A	GO:0000166 GO:0005524 GO:0016887
9	0.18	0.488	2.88	0.25	0.55	1hyqA	GO:0000166 GO:0005524 GO:0051301
10	0.18	0.501	3.02	0.17	0.57	4rz2A	GO:0000166 GO:0005524
11	0.15	0.496	3.50	0.14	0.59	2afhE	GO:0000166 GO:0005524 GO:0009399 GO:0016163 GO:0016491 GO:0016612 GO:0018697 GO:0046872 GO:0051536 GO:0051539 GO:0055114
12	0.09	0.472	3.35	0.17	0.55	3pg5C	GO:0005524 GO:0016491 GO:0055114
13	0.08	0.445	2.65	0.14	0.49	4dzzA	GO:0000166
14	0.07	0.492	3.60	0.15	0.59	1cp2A	GO:0000166 GO:0005524 GO:0009399 GO:0016163 GO:0016491 GO:0016612 GO:0018697 GO:0046872 GO:0051536 GO:0051539 GO:0055114
15	0.07	0.569	1.30	0.15	0.59	3ea0B	GO:0000166 GO:0005524
16	0.07	0.511	2.68	0.20	0.57	1ionA	GO:0000166 GO:0005524 GO:0051301
17	0.06	0.397	3.74	0.11	0.47	4jlvA	GO:0000166 GO:0005576 GO:0006859 GO:0009103 GO:0015542 GO:0015992 GO:0016020 GO:0016021 GO:0045226
18	0.06	0.283	7.16	0.07	0.49	3ezyA	GO:0008152 GO:0016491 GO:0050112 GO:0055114
19	0.06	0.302	6.56	0.04	0.48	4cmnA	GO:0001701 GO:0001750 GO:0004439 GO:0005096 GO:0005634 GO:0005737 GO:0005768 GO:0005769 GO:0005794 GO:0005795 GO:0005798 GO:0005802 GO:0005829 GO:0005886 GO:0005905 GO:0005929 GO:0006629 GO:0006661 GO:0007165 GO:0016020 GO:0016023 GO:0016787 GO:0030030 GO:0030136 GO:0030670 GO:0031410 GO:0031901 GO:0042384 GO:0042995 GO:0043087 GO:0043547 GO:0043647 GO:0046856 GO:0048365 GO:0051056 GO:0052658 GO:0052659 GO:0052745 GO:0070062
20	0.06	0.283	6.06	0.05	0.43	4mzyA	GO:0004514 GO:0004516 GO:0009435 GO:0016740 GO:0016757 GO:0016874 GO:0019358 GO:0019363
21	0.06	0.301	5.47	0.09	0.42	4cblA	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0004175 GO:0004197 GO:0004252 GO:0004386 GO:0005216 GO:0005524 GO:0006508 GO:0006810 GO:0006811 GO:0008026 GO:0008233 GO:0008234 GO:0008236 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016817 GO:0017111 GO:0019012 GO:0019062 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0033897 GO:0034220 GO:0039503 GO:0039520 GO:0039548 GO:0039654 GO:0039663 GO:0039694 GO:0039707 GO:0042025 GO:0044228 GO:0044385 GO:0046718 GO:0051259 GO:0055036 GO:0070008 GO:0090502 GO:1903608 GO:1990219
22	0.06	0.244	3.21	0.11	0.28	1mvoA	GO:0000160 GO:0003677 GO:0005737 GO:0006351 GO:0006355 GO:0006810 GO:0006817
23	0.06	0.221	6.77	0.04	0.36	3j79F	GO:0003735 GO:0005840 GO:0006412 GO:0022625

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0016887	GO:0042802	GO:0051536	GO:0046872
GO-Score	0.69	0.58	0.53	0.34	0.34
Biological Processes	GO:0019413	GO:0006276	GO:0007059	GO:0051782	GO:0007049
GO-Score	0.53	0.53	0.36	0.36	0.36
Cellular Component	GO:0031226	GO:0060187	GO:0005829	GO:0009898
GO-Score	0.36	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.