I-TASSER results

I-TASSER results for job id Rv0519c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (300 residues)
MLRRGCAGNTDRRGIMTPMADLTRRALLRWGAGAGAGAAGVWAFGALVDPLEPQAAPAPF
EPPTAGSSLPTRISGSFISAARGGIKTNWVISMPPGQSGQLRPVIALHGKDGNAGMMLDL
GVEQGLARLVKEGKPAFAVVGVDGGNTYWHRRSSGGDSGAMVLDELLPMLTSMGMDTSRV
GFLGWSMGGYGALLLGARLGPARTAGICAISPALFTSFTGSTPGAFDSYDDYVQHSVLGL
PALNSIPLRVDCGTSDRFYFATRQFVNQLHQPPAGSFSPGGHDASYWREQLPGELAWMAS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLRRGCAGNTDRRGIMTPMADLTRRALLRWGAGAGAGAAGVWAFGALVDPLEPQAAPAPFEPPTAGSSLPTRISGSFISAARGGIKTNWVISMPPGQSGQLRPVIALHGKDGNAGMMLDLGVEQGLARLVKEGKPAFAVVGVDGGNTYWHRRSSGGDSGAMVLDELLPMLTSMGMDTSRVGFLGWSMGGYGALLLGARLGPARTAGICAISPALFTSFTGSTPGAFDSYDDYVQHSVLGLPALNSIPLRVDCGTSDRFYFATRQFVNQLHQPPAGSFSPGGHDASYWREQLPGELAWMAS
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCEEEEHCCCCCHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHC
Conf.Score	988888888777654456777664556666666777788877654556777777888888888777788858999998566799668999986999999987899968999998999998799999999998999879999599988766888887589999999999999979988885799877757899999999798854367653787778888766777789888887786666656799899996799857899999999989995999859988678999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLRRGCAGNTDRRGIMTPMADLTRRALLRWGAGAGAGAAGVWAFGALVDPLEPQAAPAPFEPPTAGSSLPTRISGSFISAARGGIKTNWVISMPPGQSGQLRPVIALHGKDGNAGMMLDLGVEQGLARLVKEGKPAFAVVGVDGGNTYWHRRSSGGDSGAMVLDELLPMLTSMGMDTSRVGFLGWSMGGYGALLLGARLGPARTAGICAISPALFTSFTGSTPGAFDSYDDYVQHSVLGLPALNSIPLRVDCGTSDRFYFATRQFVNQLHQPPAGSFSPGGHDASYWREQLPGELAWMAS
Prediction	743432464442321233133121210121121100100011011011333434443343434444453443233312133246251300101042266621100000010111410142202410230155452200000000320101232532200200052014103722444531000000100200000002222410000000000011434444452143363044131232363560200000044340152035006407541202022422524203510450366258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCEEEEHCCCCCHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHC
MLRRGCAGNTDRRGIMTPMADLTRRALLRWGAGAGAGAAGVWAFGALVDPLEPQAAPAPFEPPTAGSSLPTRISGSFISAARGGIKTNWVISMPPGQSGQLRPVIALHGKDGNAGMMLDLGVEQGLARLVKEGKPAFAVVGVDGGNTYWHRRSSGGDSGAMVLDELLPMLTSMGMDTSRVGFLGWSMGGYGALLLGARLGPARTAGICAISPALFTSFTGSTPGAFDSYDDYVQHSVLGLPALNSIPLRVDCGTSDRFYFATRQFVNQLHQPPAGSFSPGGHDASYWREQLPGELAWMAS

4rgyA

0.25

0.18

0.73

2.02

MUSTER

---------------------------------------------------------------------HMALFQCDFFSDVLGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRT---SIERYVA--EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAALSDHDLFALAERPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWL--

4rgyA

0.23

0.17

0.74

2.86

dPPAS

--------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQE---EHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQLPGSDHDLFALAERMAQSDGPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWLPL

4rgyA

0.25

0.18

0.73

3.43

wdPPAS

--------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRIFGDLAAGSDHDLFALAERPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWL--

4rgyA

0.25

0.18

0.73

2.58

wMUSTER

----------------------------------------------------------------------MALFQCDFFSDVLGLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRT---SIERYVA--EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRIFGDLAAGSDHDLFALAERPVPKLYQCCGTEDFLYEDNVRFRDHV-LDFMYEESPGEHEWGYWDAQIQRVLAWL--

4rgyA

0.25

0.18

0.73

3.65

wPPAS

--------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRIFGDLAAGSDHDLFALAERPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWL--

4rgyA

0.25

0.18

0.73

4.85

dPPAS2

--------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQE---EHPTLFLLHGLSDDHTIWLRRTSIERYVA-----EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAERPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAW---

4rgyA

0.25

0.19

0.74

3.07

PPAS

--------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRT---SIERYVA--EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAERPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWLPL

4rgyA

0.25

0.19

0.74

4.20

Env-PPAS

--------------------------------------------------------------------HMALFQCDFFSDVL-GLSTSMTVILPQ---EEHPTLFLLHGLSDDHTIWLRRT---SIERYVA--EMGLAVVMPAVHRSFYTDMAHGLQYWTFISEELPALARSFFPAREDTFVAGLSMGGYGALKLGMRH-PERFAAAASLSGALDITVWVAEQRNFGDLAAGSDHDLFALAERPVPKLYQCCGTEDFLYEDNVRFRDHVRLDFMYEESPGEHEWGYWDAQIQRVLAWLPL

1jjfA

0.21

0.17

0.79

1.95

MUSTER

--------------------------------------------------SLPTMPPSGYDQVRNGVPRGQVVNISYFSTAT-NSTRPARVYLPPGYSKKYSVLYLLHGIGGSENDWFEGGANVIADNLIAEGKKPLIIVTPNTNAAGPGIADGYENFTKDLLNSLIPYIESNYSDREHRAIAGLSMGGGQSFNIGLTN-LDKFAYIGPISAAPNT---------YPNERLFPDGGKAAREKLK--LLFIACGTNDSLIGFGQRVHEYCVINHVYWLIQGGHDFNVWKPGLWNFLQMADE

1jjfA

0.20

0.16

0.79

2.81

dPPAS

--------------------------------------------------SLPTMPPSGYDQVRNGVPRGQVVNISYFSTAT-NSTRPARVYLPPGYDKKYSVLYLLHGIGGSENDWFEGGANVIADNLIAEGKKPLIIVTPNTNAAGPGIADGYENFTKDLLNSLIPYIESNYSDREHRAIAGLSMGGGQSFNIGLTN-LDKFAYIGPISAAPNTYPNERLFPDGG-----------KAAREKLKLLFIACGTNDSLIGFGQRVHEYCVINHVYWLIQGGHDFNVWKPGLWNFLQMADE

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.55

Estimated TM-score = 0.52±0.15

Estimated RMSD = 9.7±4.6Å

Download Model 2

C-score=-1.82

Download Model 3

C-score=-2.46

Download Model 4

C-score=-3.15

Download Model 5

C-score=-2.88

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ls2A	0.700	1.91	0.154	0.753
2	4rotA	0.699	2.04	0.204	0.760
3	4rgyA	0.695	1.79	0.261	0.740
4	5l8sA	0.695	3.91	0.123	0.853
5	4b6gA	0.694	2.09	0.169	0.757
6	1jjfA	0.689	2.60	0.203	0.767
7	3i6yA	0.687	1.99	0.181	0.743
8	2ecfA2	0.687	4.05	0.156	0.860
9	3fcxB	0.687	2.05	0.138	0.747
10	3azoA	0.686	3.90	0.142	0.853

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.31	10	1dqyA	DEP	Rep, Mult	109,110,185,186,187,213,287
2	0.10	5	2ripA	UUU	Rep, Mult	90,91,92,140,141,142
3	0.04	2	2buaC	UUU	Rep, Mult	194,231,234,235,240
4	0.04	2	3hrhB	GOL	Rep, Mult	148,149,150,159,194,195,226,235
5	0.02	1	3muoA	ZPR	Rep, Mult	106,139,183,185,186,211,282,291,295
6	0.02	1	3hrhB	GOL	Rep, Mult	85,87,88,89,142
7	0.02	1	1f0nA	MPD	Rep, Mult	186,187,218,219,259
8	0.02	1	3i6yB	CL	Rep, Mult	110,186,187,221
9	0.02	1	3hrhB	GOL	Rep, Mult	148,187,190,191,213,216,226,235
10	0.02	1	3hrhA	GOL	Rep, Mult	192,196,206
11	0.02	1	3fcxA	CA	Rep, Mult	255,256,257,281,282

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.234	1i6wB	0.461	2.97	0.160	0.543	3.1.1.3	186,187,282
2	0.231	2h1iA	0.500	3.32	0.158	0.603	3.1.1.1	112,118,120,142,144,186,212
3	0.231	3c6bA	0.682	2.22	0.146	0.750	3.1.2.12	187,282
4	0.224	3cn7A	0.517	2.89	0.179	0.597	3.1.1.1	186,256,282
5	0.205	2ocgA	0.570	3.30	0.163	0.683	3.1.-.-	107,186,188,192,256,282
6	0.205	3fcxB	0.687	2.05	0.138	0.747	3.1.2.12	186
7	0.203	1auoA	0.531	2.94	0.205	0.617	3.1.1.1	186,282
8	0.192	1vkhA	0.594	3.29	0.098	0.710	3.5.1.9	NA
9	0.107	1fj2A	0.540	3.06	0.137	0.633	3.1.4.39	111
10	0.076	1jjiA	0.657	3.79	0.139	0.813	3.1.1.1	NA
11	0.071	1dinA	0.540	3.03	0.152	0.637	3.1.1.45	NA
12	0.070	2o7rA	0.633	3.75	0.143	0.787	3.1.1.1	186
13	0.067	1j1iA	0.561	3.43	0.132	0.670	3.7.1.8	186
14	0.060	3fakA	0.633	3.76	0.121	0.783	3.1.1.-	186,282
15	0.060	1qz3A	0.649	3.90	0.124	0.813	3.1.1.1	186
16	0.060	3ga7A	0.642	3.44	0.136	0.777	3.1.1.-	288
17	0.060	1jjfA	0.689	2.60	0.203	0.767	3.2.1.8	112,148,187,283
18	0.060	2qr5A	0.677	3.99	0.105	0.850	3.4.19.1	186
19	0.060	1hlgA	0.615	3.63	0.114	0.750	3.1.1.3	NA
20	0.060	1orvA	0.675	4.07	0.125	0.843	3.4.14.5	186
21	0.060	1z68A	0.675	4.12	0.153	0.850	3.4.21.-	186,256,282
22	0.060	1wb4B	0.663	2.65	0.144	0.747	3.2.1.8	187,288
23	0.060	2pm8A	0.624	3.60	0.090	0.763	3.1.1.8	NA
24	0.060	1gz7C	0.628	3.45	0.111	0.753	3.1.1.3	NA
25	0.060	2o7vA	0.632	3.77	0.159	0.783	3.4.23.16	109,143,186
26	0.060	1maaD	0.628	3.58	0.089	0.763	3.1.1.7	NA
27	0.060	1qo9A	0.621	3.72	0.085	0.763	3.1.1.7	NA
28	0.060	1gz7A	0.629	3.60	0.115	0.760	3.1.1.3	NA
29	0.060	1k8qA	0.625	3.46	0.118	0.753	3.1.1.3	NA
30	0.060	1mx9D	0.623	3.55	0.126	0.757	3.1.1.1	NA
31	0.060	2fj0A	0.625	3.74	0.112	0.773	3.1.1.1	NA
32	0.060	1yr2A	0.645	3.71	0.101	0.797	3.4.21.26	186

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.689	2.60	0.20	0.77	1jjfA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0031176 GO:0033905 GO:0045493
1	0.27	0.664	2.17	0.23	0.73	2uz0A
2	0.26	0.676	2.48	0.16	0.75	1dqyA	GO:0004144 GO:0005576 GO:0005618 GO:0006869 GO:0009247 GO:0016740 GO:0016746 GO:0016747 GO:0046677 GO:0050348 GO:0071769
3	0.25	0.579	3.00	0.17	0.67	4cg3A	GO:0003847 GO:0015996 GO:0016042 GO:0016787 GO:0047746 GO:0050525
4	0.25	0.542	3.02	0.18	0.63	3u0vA	GO:0002084 GO:0004622 GO:0005737 GO:0005829 GO:0008474 GO:0016787 GO:0052689 GO:0070062
5	0.24	0.693	2.86	0.16	0.79	5cxxB	GO:0016787 GO:0030600
6	0.24	0.575	2.92	0.17	0.66	4eb0A	GO:0003847 GO:0016042 GO:0016787 GO:0050525
7	0.23	0.541	3.00	0.14	0.63	3trdA	GO:0016787
8	0.22	0.582	3.31	0.14	0.69	1ufoA	GO:0016020 GO:0016021
9	0.22	0.577	3.13	0.15	0.67	3visA	GO:0003847 GO:0015996 GO:0016042 GO:0046872 GO:0047746
10	0.21	0.663	2.64	0.14	0.75	1gklA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0043263 GO:0045493
11	0.20	0.694	2.09	0.17	0.76	4b6gA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
12	0.19	0.700	1.91	0.18	0.75	3i6yA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
13	0.18	0.493	3.83	0.15	0.62	4h0cA	GO:0016787
14	0.18	0.671	2.18	0.15	0.74	1sfrA	GO:0004144 GO:0005576 GO:0005618 GO:0005737 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0044119 GO:0044121 GO:0050348
15	0.17	0.687	2.05	0.14	0.75	3fcxB	GO:0005737 GO:0005788 GO:0016023 GO:0016787 GO:0016788 GO:0018738 GO:0031410 GO:0046294 GO:0047374 GO:0052689 GO:0070062 GO:1901687
16	0.17	0.494	3.56	0.15	0.61	2r8bA	GO:0016787
17	0.16	0.538	3.28	0.15	0.64	4ke6E	GO:0016787 GO:0047372 GO:0052689
18	0.15	0.544	2.97	0.15	0.64	2i3dB	GO:0016787
19	0.14	0.624	4.03	0.08	0.79	4e15B	GO:0004061 GO:0006569 GO:0008152 GO:0016272 GO:0016787 GO:0019441
20	0.14	0.597	3.15	0.15	0.70	3pf8A	GO:0016787
21	0.14	0.684	3.70	0.18	0.84	3mgaA	GO:0005506 GO:0005737 GO:0006826 GO:0008849
22	0.13	0.564	3.26	0.17	0.67	4wfiA	GO:0003847 GO:0016042 GO:0046872
23	0.12	0.585	3.55	0.15	0.71	3hjuA	GO:0004622 GO:0005654 GO:0005737 GO:0005789 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0006954 GO:0009966 GO:0016020 GO:0016042 GO:0016787 GO:0019369 GO:0019433 GO:0019898 GO:0036155 GO:0042803 GO:0046464 GO:0047372 GO:0050727 GO:0051930 GO:0052689 GO:2000124
24	0.11	0.700	1.91	0.15	0.75	3ls2A	GO:0016787 GO:0018738 GO:0046294 GO:0052689
25	0.11	0.517	2.89	0.18	0.60	3cn7A	GO:0002084 GO:0005737 GO:0008474 GO:0016787 GO:0052689
26	0.10	0.684	2.24	0.15	0.75	1pv1A	GO:0005737 GO:0005829 GO:0016787 GO:0018738 GO:0046294 GO:0052689
27	0.10	0.677	2.30	0.16	0.75	1f0nA	GO:0004144 GO:0005576 GO:0005618 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0040007 GO:0044119 GO:0046677 GO:0050348 GO:0052572
28	0.09	0.693	2.09	0.16	0.76	3e4dA	GO:0016787 GO:0018738 GO:0046294 GO:0046872 GO:0052689
29	0.08	0.588	2.74	0.16	0.68	3f67A	GO:0016787
30	0.08	0.596	3.04	0.16	0.70	2wtmA
31	0.08	0.649	3.90	0.12	0.81	1qz3A	GO:0008152 GO:0016787
32	0.07	0.531	2.94	0.20	0.62	1auoA	GO:0016787 GO:0052689
33	0.07	0.684	3.88	0.18	0.84	2b20A	GO:0005506 GO:0005737 GO:0006826 GO:0008849 GO:0016787
34	0.07	0.569	3.63	0.13	0.71	1u2eA	GO:0003824 GO:0005737 GO:0016787 GO:0018771 GO:0019380 GO:0019439 GO:0019622 GO:0042803 GO:0052823
35	0.07	0.574	3.77	0.15	0.71	3p2mA	GO:0052689
36	0.07	0.594	3.49	0.12	0.71	4opmA	GO:0004806 GO:0016787
37	0.07	0.611	3.71	0.12	0.74	3dohA	GO:0002084 GO:0005737 GO:0008474 GO:0016787 GO:0052689
38	0.07	0.560	3.23	0.15	0.66	4dgqA	GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
39	0.07	0.565	3.47	0.13	0.69	4i3fA	GO:0016787
40	0.07	0.539	3.23	0.15	0.64	4lheA	GO:0016787 GO:0047372 GO:0052689
41	0.07	0.553	3.26	0.17	0.65	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
42	0.07	0.555	3.46	0.15	0.67	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
43	0.07	0.551	3.12	0.16	0.65	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
44	0.07	0.551	3.02	0.16	0.64	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
45	0.07	0.564	3.73	0.12	0.71	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
46	0.07	0.634	3.47	0.10	0.78	4eziA	GO:0004806 GO:0016042
47	0.07	0.569	3.86	0.16	0.71	4ns4A	GO:0016787 GO:0016788
48	0.07	0.569	3.48	0.12	0.70	3b12A	GO:0003824 GO:0016787 GO:0018785
49	0.07	0.580	2.92	0.12	0.67	4ufoA	GO:0003824 GO:0016787
50	0.07	0.570	3.16	0.12	0.67	4x00A	GO:0016787
51	0.07	0.576	3.49	0.14	0.70	3wlaA	GO:0016787 GO:0042597 GO:0047699
52	0.07	0.514	3.29	0.15	0.61	4nmwA	GO:0005737 GO:0009102 GO:0016787 GO:0052689
53	0.07	0.514	3.49	0.15	0.62	1m33A	GO:0005737 GO:0009102 GO:0016787 GO:0052689 GO:0090499

Consensus prediction of GO terms

Molecular Function	GO:0097599	GO:0016411	GO:0052689	GO:0098599	GO:0016790	GO:0004620	GO:0005488
GO-Score	0.55	0.53	0.50	0.50	0.50	0.50	0.43
Biological Processes	GO:0000272	GO:0045491	GO:0044765	GO:1901137	GO:0042221	GO:0006664	GO:0071702	GO:0071766	GO:0022607	GO:0010876	GO:0046467	GO:0044712	GO:0046149	GO:0015994	GO:0006787	GO:0042159	GO:0098734	GO:0035601
GO-Score	0.55	0.55	0.53	0.53	0.53	0.53	0.53	0.53	0.53	0.53	0.53	0.50	0.50	0.50	0.50	0.50	0.50	0.50
Cellular Component	GO:0030312	GO:1903561	GO:0031988	GO:0044444
GO-Score	0.53	0.50	0.50	0.50

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.