I-TASSER results

I-TASSER results for job id Rv0515

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (503 residues)
MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSR
CGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLM
FATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKE
YQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGA
LAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAEL
VAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTI
PYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFP
SLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVL
TQTAAATDTHGPPPDHNDDPPPF

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDHNDDPPPF
Prediction	CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEHCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCEHCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHCHHHHCCCCCCCCEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98689999999998765778876558999999999999999999999999999999765456677655455578999999999999999999999999999886999999998999999999999998668999899999999999988757777789999999999985877777646665468599985899779999997899999999999999874688899877666677889987655555665667787776666666567876567555468788875555787888999999999768778875789877767888999999999985987899999998644556656556789999977745455555555567885788789986999889996787589998778888888888898888998888877776788754456788889998888888888876655666677888889988889999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDHNDDPPPF
Prediction	65355213302510543324444402300300330330101010100100010032123434535322242031000000111400242022003203300520220010020010013002000310440244410220021003102411211243144104300221224125446622430200002110000101020113001001200340053115424223210110000101210121000021111212222222211021122211020102000120101201102001200120100001234422233232014102200202110001010210032021200321434120003001100220031234220212222401000001211312031321111131321445332443423434356232431534333455234325432533563354453465444365454452537742217
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEHCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCEHCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHCHHHHCCCCCCCCEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDHNDDPPPF

4ogcA3

0.14

0.04

0.27

0.96

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGFTSRDKANRRRYNDNQEAKKIQRDYGKEGYISR--GDIVRLDALELQGCCLY--CGTGYHTCQLDHIVPQAGPGSNNRGNLVAVCERCNRSKSN---------------TPFA--------------------------------------QKCGIPHVGVKEAIGRVRG--SSEDLTRLKKEVIAR---------------RTQEDPE--

5cwmA

0.10

0.04

0.45

1.05

dPPAS2

-DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEK--QGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRA----------------------VELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.19

0.13

0.67

1.13

PPAS

----------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------AAAARAAAAAAAAAA--------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK------------------------------------

4cgkA

0.13

0.09

0.69

1.04

Env-PPAS

------------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKK---------LEGEITELSKNIVSRNQSLEKQARSAQTNGAVTSYINTIVNSKSITISRVAAMSEIVSA--NNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEA-----AYKEKRASQQQSVLASANTNL-----------------TAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLA------------PWAGDYWGNGAQWATSAAAAGFRT------GSTPQVGAIACWNDGGY---GHVAVV---TAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVTAD----------------------------------------------------------------------------------

4b2nA

0.09

0.99

1.00

PPAS

LQFNAYFVDLHNPPPPFVNRLPPRPTTCGQFRASATRGRVNLEERQFPMALATSYHFIFLQWGYLIRPPDFEEQVSKRYRNPYPLPGEDPNQTNGGSGQLTGLIGASCSACHDSRLGTASEASFKWGLPNSANDAGLLASDMFRTTPITALGNLLPLPWIGLISLLPALFDMETLTLAPSLLEYVADAPHAGMDGSLSANIFRDANARRGLEDEFEDINN-SPATYPKTINTALAEQGAVIYHERDLWASGANGAIPKPAGNGSVYSPRHAADPNYLPDPRLKGVAAVVTPMRLMADERQRRAWNSGWWAYNNLSPSWTGYPSDNIVASELRRVPRAIYNNGGPIY-LGPNIWEEPTGYIAPPLYGNGSVPNLWGVLKPSDRPKLWKRPYTAAGIGGKNAGYDYSFASYDWQKLG-----KYTAVACNNSIFTSPFLPCTHNMATIDILYSMWDNVAAQYLNLAYQSPPPITDQQIKSRMVYNSYLYGNDNGGHDFTQSLTDS

5cwqA

0.11

0.05

0.46

1.03

dPPAS2

-----------------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGN-SEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4ke2A

0.18

0.07

0.39

1.01

dPPAS2

------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATA---------ADDAAASIATIN--AASAAAKSIAAAAAMAAKDTAAAAASAA----AAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSD---------------AAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3we0A

0.09

0.08

0.95

0.81

MUSTER

IFGPDFPFAFDDWLEHPAGLGSIPAARHGEEVA----IAGLVAAYELMKLGRLRSQAFNGTDGLGGMRFPVSSTAFYHYVDKLGLTPASRSTVIDLAADLPALFQEVTDAWADALESGARFGDIQQAIRDRDVPRLKELWNTLVPLWDDRTTSKAFAKLSFQHREVFGQVGFGTGGWDSDFPNSMLEIFRVVMTNCDDHQHLVVG----GVEQVPQGIWRHVPERCAHWPEGTSLSSLHGGAPRTGVKRIARASDGRLAVTDNWGDCRHYAAVLTTCQSWLLTTQIDCEESLFSQKMWMALDRTRYMQSSKTFVMVDRPFWKDKDPETGRDLMSMTLTDRLTRGTYLFDNGDDKPGVICLSYAWH---PVEKRVQLALDALKKIYPKTDIAGHIIGDPITIS-FLGAFKGALPGHYRYNQRMYAHFMQAQMPVEQRGIFIAGDDVSWTPA-------VEGAVQTSLNAVWGIMNHFG------GKTHADNPGPGDVFDEIGQI

5hzdA

0.08

0.07

0.91

0.69

dPPAS

---------VRLYSCDACPHAVFTTHAALLAHAEEHHADLLPDHARLRRIAQKLNPVWNRALNARRNTITSWGKKIFHVAAQRDAGESKMQEAHRARAQLECVVRRWH------DKARVFIFGSSVAMGVWDGTADIDFAVVDVDAMERGSWPPLEKNAVRSITELLRRVGFSFVNLEPISHARVPIIKHHASSPRFILNGPATREDRLLLEGSVRDAVGPTGNRTSDMMSATLESTTAAVRAAMCSPALASASLRTKAHDECRPELYNIDFDLSFRAFGIRNSTLLRKYLLSHPCARPGAIVLKDWSKTSGVNNSVNGYFTSYAINIMWIYYLVQKGYVPYVDPPESLVNYTDFDPRYTPMIDPEITNTEREELYKAAGDMLVGFFYFYSFEFDWGHNVISLNRPGITTKRMLGWHVEDVRHPTRYELCIEDPYEENLNLGRHIG----------VTKSLRVRTELYRGLLSLLKECVFAA---------------------

4fcyA

0.10

0.07

0.74

0.67

wdPPAS

-----------------------DREALWSKWDNASDSQRRLAEKWLPAVQAADEMLNQGIS---------TKTAFATVAGHYQVSASTLRDKYYQVQKF----KPDWAAALVSEFDEDAWQFLIADYLRPEKPAFRKCYERLELAAREHWSIPSRATAFRRIQQLDEAM--VACREGEHALMEHNVFVRWFNGDVIKTWFWQDVKTRKILGWRCD----------VSENIDSIRLSFMDVVTR-IDNTTGGAPNRYRFKVKEDDPKGLAKMHWLEEYVDKHPALAGAYTGPNPQAKELFLKTLAEGVAFNARTGRETEMCGGKLSFDDVFEREYART----RKPT--LPAEAVNVS-----RKGGSLKGAKNV----YNLALMLAGV-VVRFDPQSTVYCYTLDGRFICE----------------------------------AECLREYRRRQKQLKSATKAAIKAQKQ-------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 4 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.44

Estimated TM-score = 0.43±0.14

Estimated RMSD = 13.3±4.1Å

Download Model 2

C-score=-3.50

Download Model 3

C-score=-4.58

Download Model 4

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4b2nA	0.949	1.92	0.084	0.992
2	1t3tA	0.358	7.52	0.046	0.592
3	3dx4A	0.358	7.40	0.030	0.587
4	4f91B	0.352	7.53	0.049	0.581
5	1l5jA	0.348	7.51	0.058	0.577
6	4zhjA	0.343	7.89	0.042	0.589
7	5eanA	0.341	7.57	0.043	0.567
8	2wyhA	0.340	7.58	0.051	0.573
9	2j5wA	0.339	7.75	0.030	0.577
10	4av3A	0.338	7.86	0.062	0.591

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.13	7	3kdeC	ZN	Rep, Mult	342,347,377,380
2	0.04	2	3t7aA	MG	Rep, Mult	355,357
3	0.04	2	1llwA	F3S	Rep, Mult	370,371,372,373,374,375,377,382
4	0.04	2	3ez2A	ADP	Rep, Mult	27,29,30
5	0.04	2	1jb0M	CLA	Rep, Mult	328,332
6	0.02	1	3bvvA	MPD	Rep, Mult	55,104,142,147
7	0.02	1	4q8rA	ZN	Rep, Mult	232,236
8	0.02	1	1ofdB	F3S	Rep, Mult	75,81,82,83,84,104
9	0.02	1	1e7fA	DAO	Rep, Mult	31,35
10	0.02	1	2xquB	CVM	Rep, Mult	38,42
11	0.02	1	4b2nA	HEM	Rep, Mult	290,359,360,361,362,364,367,373,376,377,494,496
12	0.02	1	3e3jB	QNA	Rep, Mult	69,70,74,75,137,141
13	0.02	1	3gl6A	ZN	Rep, Mult	342,347
14	0.02	1	1s0vC	APC	Rep, Mult	302,337,338,341,342
15	0.02	1	1fsiC	SO4	Rep, Mult	41,214
16	0.02	1	3mhhE	ZN	Rep, Mult	342,347,358

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3gpbA	0.305	7.61	0.025	0.509	2.4.1.1	165
2	0.060	2r7oA	0.312	7.60	0.029	0.517	2.7.7.48	306,325,327
3	0.060	1h16A	0.312	7.48	0.044	0.515	2.3.1.54	NA
4	0.060	2hpiA	0.307	7.24	0.035	0.493	2.7.7.7	356
5	0.060	3gtgB	0.318	8.10	0.042	0.559	2.7.7.6	307,346
6	0.060	1fa9A	0.305	7.70	0.048	0.515	2.4.1.1	NA
7	0.060	2rnpC	0.280	7.74	0.019	0.471	2.7.7.6	NA
8	0.060	2vuaA	0.243	6.84	0.014	0.378	3.4.24.69	203,211,216
9	0.060	2j5wA	0.339	7.75	0.030	0.577	1.16.3.1	NA
10	0.060	2pflA	0.313	7.47	0.041	0.507	2.3.1.54	211
11	0.060	1ygpA	0.314	7.34	0.030	0.517	2.4.1.1	79
12	0.060	2ow6A	0.357	7.39	0.025	0.585	3.2.1.114	133
13	0.060	3lxuX	0.326	7.77	0.036	0.555	3.4.14.10	145
14	0.060	2bf4A	0.324	7.55	0.053	0.545	1.6.2.4	333
15	0.060	1t3tA	0.358	7.52	0.046	0.592	6.3.5.3	NA
16	0.060	1s76D	0.279	8.05	0.055	0.491	2.7.7.6	329
17	0.060	1k32A	0.316	7.95	0.038	0.557	3.4.21.-	NA
18	0.060	2a4zA	0.277	7.71	0.047	0.465	2.7.1.153	NA
19	0.060	3ctzA	0.314	7.48	0.051	0.513	3.4.11.9	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.949	1.92	0.08	0.99	4b2nA	GO:0009055 GO:0020037 GO:0046872
1	0.06	0.289	7.61	0.03	0.48	3ikmD	GO:0002020 GO:0003676 GO:0003677 GO:0003682 GO:0003887 GO:0005739 GO:0005760 GO:0006259 GO:0006260 GO:0006261 GO:0006264 GO:0006287 GO:0007568 GO:0008408 GO:0009416 GO:0010332 GO:0016740 GO:0016779 GO:0042645 GO:0043195 GO:0043234 GO:0055093 GO:0070062 GO:0071333 GO:0071897 GO:0090305
2	0.06	0.357	7.41	0.03	0.59	3bubA	GO:0000139 GO:0003824 GO:0004553 GO:0004559 GO:0004572 GO:0005783 GO:0005794 GO:0005795 GO:0005975 GO:0006013 GO:0006486 GO:0006487 GO:0006491 GO:0006517 GO:0008152 GO:0008270 GO:0015923 GO:0016020 GO:0016021 GO:0016063 GO:0016787 GO:0016798 GO:0030246 GO:0035010 GO:0046872
3	0.06	0.314	7.31	0.05	0.51	4lgyA	GO:0000166 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0006541 GO:0009156 GO:0016874 GO:0046872
4	0.06	0.281	7.60	0.04	0.46	2hruA	GO:0000166 GO:0000287 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0006541 GO:0009156 GO:0016874 GO:0046872
5	0.06	0.259	8.09	0.03	0.46	3viuA	GO:0000166 GO:0000287 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0016874 GO:0046872
6	0.06	0.246	7.72	0.05	0.41	2hs3A	GO:0000166 GO:0000287 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0006541 GO:0009156 GO:0016874 GO:0046872
7	0.06	0.252	6.75	0.05	0.39	1pmiA	GO:0004476 GO:0005737 GO:0005975 GO:0008270 GO:0009298 GO:0016853 GO:0031505 GO:0046872
8	0.06	0.232	7.25	0.04	0.38	3zlfA	GO:0000015 GO:0000287 GO:0004634 GO:0005576 GO:0005737 GO:0006096 GO:0009405 GO:0009986 GO:0016829 GO:0046872
9	0.06	0.270	7.40	0.07	0.44	1opeA	GO:0005739 GO:0008152 GO:0008260 GO:0008410 GO:0016740 GO:0042803 GO:0046950 GO:0046952
10	0.06	0.232	7.07	0.04	0.37	1a12A	GO:0000082 GO:0000790 GO:0000794 GO:0003677 GO:0003682 GO:0005085 GO:0005087 GO:0005634 GO:0005654 GO:0005737 GO:0007049 GO:0007052 GO:0007059 GO:0007067 GO:0007088 GO:0016032 GO:0031492 GO:0031965 GO:0042393 GO:0043547 GO:0051225 GO:0051301
11	0.06	0.223	6.79	0.03	0.34	1a5zA	GO:0003824 GO:0004459 GO:0005737 GO:0005975 GO:0006096 GO:0016491 GO:0016616 GO:0019752 GO:0055114
12	0.06	0.249	6.90	0.06	0.39	4zhtA	GO:0000166 GO:0003824 GO:0004553 GO:0005524 GO:0005737 GO:0005829 GO:0006045 GO:0006047 GO:0006054 GO:0007155 GO:0008152 GO:0008761 GO:0009384 GO:0016301 GO:0016310 GO:0016740 GO:0016787 GO:0046835 GO:0046872
13	0.06	0.201	7.69	0.03	0.34	1oc5A	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016162 GO:0016787 GO:0016798 GO:0030245 GO:0030248
14	0.06	0.233	7.01	0.04	0.37	5bofA	GO:0000015 GO:0000287 GO:0004634 GO:0005576 GO:0005737 GO:0006096 GO:0009405 GO:0009986 GO:0016829 GO:0046872
15	0.06	0.261	7.26	0.04	0.41	1r9jB	GO:0003824 GO:0004802 GO:0008152 GO:0016740 GO:0046872
16	0.06	0.226	7.26	0.04	0.37	3ikwA	GO:0016829 GO:0046872
17	0.06	0.272	7.12	0.03	0.43	5jm0A	GO:0000329 GO:0003824 GO:0004553 GO:0004559 GO:0005773 GO:0005975 GO:0006013 GO:0006517 GO:0008152 GO:0008270 GO:0009313 GO:0015923 GO:0016787 GO:0016798 GO:0030246 GO:0044262 GO:0046872
18	0.06	0.228	6.93	0.03	0.36	4q1tD	GO:0000166 GO:0003723 GO:0004349 GO:0005524 GO:0005737 GO:0006561 GO:0008652 GO:0016301 GO:0016310 GO:0016740 GO:0055129

Consensus prediction of GO terms

Molecular Function	GO:0046906	GO:0046872
GO-Score	0.48	0.38
Biological Processes	GO:0006541	GO:0006189	GO:0071897	GO:0035010	GO:0016063	GO:0055093	GO:0006264	GO:0006491	GO:0071333	GO:0006287	GO:0006013	GO:0009416	GO:0007568	GO:0006517	GO:0010332	GO:0090305
GO-Score	0.12	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0005783	GO:0070062	GO:0005795	GO:0000139	GO:0016021	GO:0042645	GO:0005760	GO:0043195
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.