I-TASSER results

I-TASSER results for job id Rv0502

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (358 residues)
MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDPNDRASAEQIAAVVREI
DEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSVDEFGFDPHFNSAIVRPLL
RFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLMLSVAVHDEHPAHRDLRLLAA
DMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFG
RGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLLARLFGLPYFPITPLFPLAGPVGLV
PLPSKWRIAFGEPICTADYASTDADDPMVTFELTDQVRETIQQTLYRLLAGRRNIFFG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDPNDRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSVDEFGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLMLSVAVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLLARLFGLPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELTDQVRETIQQTLYRLLAGRRNIFFG
Prediction	CCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEHCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCHHHHHHHHHCCEHCCHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCEEEEEEHCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
Conf.Score	9999998887556557887766666665545566788766678887776655555666665455556777766667756888999999999999865887666788899999999999999999873445999765789999889997788888875899999998866789975777637787687699999998995557999999999899899958976789988765454556787578888999899889999767566544456765567765777777666677778877788875899998898777767877778889999999999999999999999985889999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDPNDRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSVDEFGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLMLSVAVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLLARLFGLPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELTDQVRETIQQTLYRLLAGRRNIFFG
Prediction	8553566551301213455544445444455464544353355355344454354445425534544544433254333302320430030033215452422210111300100021002220211020303011202672101000000032131000000002232335110000002201522011100430400110163025006532000000000114535244445044351100000024170100000000022001224524302321423322222223332233213220201010031030652456545244104300530251025005502752653247
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEHCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCHHHHHHHHHCCEHCCHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCEEEEEEHCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDPNDRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSVDEFGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLMLSVAVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAVFPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLLARLFGLPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELTDQVRETIQQTLYRLLAGRRNIFFG

1k30A2

0.14

0.09

0.64

1.87

wdPPAS

------------------------------------------------------------------------------------------------SSHHKAIREPFD---YYIFGQNYIRPLIDFG-NSFVGNLEKLQQGHNVVLISNHQTEA--DPAIISLLLEKTNPIAENTIFVAGDRVLADPLCKPFSIGRNLICVSLKEMALLLRGGQLIWIAPSGGRDRPDPSTGEWYPAPFSVDNMRRLIQHSDVPLFPLALLCHDIMPPP----SQVEIEIRVIAF------------------NGAGLSVAPEISFEEIAATHKNPEEVREAYSKALFDSVAMQYNVLKTA-----SG

3zifN

0.09

0.03

0.27

1.28

dPPAS2

LPKWSGSVQDKT--GSNMLGGVVLPPNSQAHRTETVGTEATRDNLHAEGARRPEDQTPYMILVEDSL-GGLKRRMDLLEESNQQLLATLNRLRTGLAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1k30A2

0.14

0.09

0.63

1.48

wPPAS

-------------------------------------------------------------------------------------------------SSHKAIREPFD---YYIFGQNYIRPLIDFG-NSFVGNLEKLQQGHNVVLISNHQTEA--DPAIISLLLEKTNP-AENTIFVAGDRVLADPLCKPFSIGRNLICVSLKEMALLLRGGQLIWIAPSGGRDRPDPSGEWYPAPFDSVDNMRRLIQHSDVPLFPLALLC-HDIMP-----SQVEIEIRVIAF------------------NGAGLSVAPEISFEEIAATHKNPEEVREAYSKALFDSVAMQYNVLKTA-----SG

1k30A

0.12

0.10

0.82

1.82

wdPPAS

-------------------------------SHSRKFLDVRSEEELLSCIKKETEAGKLPPNVAAGNAVIESGNPKADEIVLSNMTVALDRILLDVEDPFVAIREPFD---YYIFGQNYIRPLIDFG-NSFVGNLEKLQQGHNVVLISNHQTEA--DPAIISLLLEKTNPIAENTIFVAGDRVLADPLCKPFSIGRNLICVSLKEMALLLRGGQLIWIAPSGGRDRPDPSTGEWYPAPFSVDNMRRLIQHSDVPLFPLALLCHDIMPPP----SQVEIEIRVIAF------------------NGAGLSVAPEISFEEIAATHKNPEEVREAYSKALFDSVAMQYNVLKTA-----SG

1k30A2

0.14

0.09

0.66

1.11

Env-PPAS

-----------------------------------------------------------------------------------------SSHHKAIREPFDY------YIFGQNYIRPLIDFGNSFVGNLSFKDIEEKLQQGNVVLISNH--QTEADPAIISLLLEKTNPYAENTIFVAGDRVLADPLCKPFSIGRNLICVSLKEMALLLRGGQLIWIAPSGGRDRPDPSTGEWYPAPFDASNMRRLIQHSDVPLFPLALL-CHDIMPPP---SQVEIEIRVIAF------------------NGAGLSVAPEISFEEIAATHKNPEEVREAYSKALFDSVAMQYNVLKTA----ISG

2n73B

0.12

0.03

0.22

1.23

dPPAS2

----------------------GAMVEARSLAVAMGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1k30A

0.14

0.12

0.85

1.05

Env-PPAS

-------------------------SHSRKFLDVRSEEELLSCIKKETEAGKLPPNVAAGMEELYQNAVIESGNPKADEIVLSNMTVALDRILLDVEDPFVAIREPFDYIFGQNYIRPLIDFGNSFVGNLSFKDIEEKLQQGNVVLISNH--QTEADPAIISLLLEKTNPYAENTIFVAGDRVLADPLCKPFSIGRNLICVSLKEMALLLRGGQLIWIAPSGGRDRPDPSTGEWYPAPFDASNMRRLIQHSDVPLFPLALL-CHDIMPPP---SQVEIEIRVIAF------------------NGAGLSVAPEISFEEIAATHKNPEEVREAYSKALFDSVAMQYNVLKTA----ISG

4cwuT

0.08

0.02

0.20

1.10

dPPAS2

----APGLGVQTVDVQETQTSPVASAVADAAVQAVAAAASKTSTEVQTDPWMFRVSAPRRPRGSRKYGAASALLPE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1k30A

0.13

0.10

0.76

1.28

wPPAS

--------------------------------------------------SHSRKFLDVRSEIKKETEAGESGNPKADEIVLSNMTVALDRILLDVEDPFVAIREPFD---YYIFGQNYIRPLID---NSFVGNLEKLQQGHNVVLISNHQTEA--DPAIISLLLEKTNP-AENTIFVAGDRVLADPLCKPFSIGRNLICVSLKEMALLLRGGQLIWIAPSGGRDRPDPSGEWYPAPFDASSNMRRLIQHSDVPLFPLALLC-HDIMP-----SQVEIEIRVIAF------------------NGAGLSVAPEISFEEIAATHKNPEEVREAYSKALFDSVAMQYNVLKTA----ISG

1k30A

0.14

0.11

0.83

0.69

MUSTER

-------------------------SHSRKFLDVRSEEELLSCIKKETEAGKLPPNVAAGMEELYQNAVIESGNPKADEIVLSNMTVALDRILLDVEDPFVAIREPFD---YYIFGQNYIRPLIDFG-NSFVGNLSLF-QQGNVVLISNHQT--EADPAIISLLLEKTNPY-ENTIFVAGDRVLADPLCKPFSIGRNLICVSLKEMALLLRGGQLIWIAPSGGRDRPDPSTGEWYPAPFD-DNMRRLIQHSDVPLFPLALL-CHDIMPPPSQVEIEIRV--IAFNGA-------------------GLSVAPEISFEEIAATHKNPEEVREAYSKALFDSVAMQYNVLKTA----ISG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.38

Estimated TM-score = 0.44±0.14

Estimated RMSD = 12.2±4.4Å

Download Model 2

C-score=-3.00

Download Model 3

C-score=-2.67

Download Model 4

C-score=-4.08

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1k30A	0.785	2.63	0.113	0.863
2	4g9iA	0.429	6.27	0.055	0.668
3	4ksrA	0.427	5.88	0.049	0.645
4	3vthA	0.422	6.51	0.063	0.690
5	1p9wA	0.417	6.14	0.059	0.642
6	2gszA	0.414	5.69	0.078	0.615
7	5hm8A	0.410	5.01	0.087	0.575
8	3uekA	0.409	6.08	0.061	0.637
9	3zu2A	0.408	5.87	0.076	0.609
10	5fl3A	0.407	5.87	0.059	0.626

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	2y7fD	MG	Rep, Mult	335,339
2	0.04	2	1p9wA	ANP	Rep, Mult	207,211,215,241,242,244,245,246,247
3	0.04	2	3wmnA	MQ8	Rep, Mult	341,345
4	0.04	2	5d56B	78M	Rep, Mult	334,337,341
5	0.04	2	3iibA	ZN	Rep, Mult	150,157,221
6	0.02	1	3bjeA	R1P	Rep, Mult	150,173
7	0.02	1	3psoA	ZN	Rep, Mult	150,202
8	0.02	1	1iuqA	GOL	Rep, Mult	94,95,98,100,194
9	0.02	1	3jvvA	ACP	Rep, Mult	152,157,158,159,262
10	0.02	1	3iilA	MG	Rep, Mult	220,221
11	0.02	1	3h9uA	NAD	Rep, Mult	206,210,256
12	0.02	1	1iuqA	GOL	Rep, Mult	244,245,248,337
13	0.02	1	3nteA	FE	Rep, Mult	257,265
14	0.02	1	1t5bA	FMN	Rep, Mult	178,183
15	0.02	1	3jvvC	ACP	Rep, Mult	158,161,162,164,260
16	0.02	1	1xmeC	HAS	Rep, Mult	329,333
17	0.02	1	1iuqA	GOL	Rep, Mult	238,239,241,331,334,335,338
18	0.02	1	3a0bK	CLA	Rep, Mult	254,255,257
19	0.02	1	1sqpE	PLX	Rep, Mult	331,334
20	0.02	1	3uieB	ADX	Rep, Mult	137,138

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2pflA	0.379	6.24	0.024	0.595	2.3.1.54	336,340
2	0.060	2e28A	0.382	5.70	0.065	0.578	2.7.1.40	NA
3	0.060	2vz9B	0.299	6.23	0.032	0.483	2.3.1.85	NA
4	0.060	1v8bA	0.394	5.17	0.074	0.561	3.3.1.1	150
5	0.060	1pg3B	0.405	5.61	0.060	0.589	6.2.1.1	265,345
6	0.060	3h9uC	0.400	5.08	0.098	0.567	3.3.1.1	NA
7	0.060	1e7pA	0.386	6.80	0.046	0.659	1.3.99.1	NA
8	0.060	1kf6A	0.380	6.57	0.079	0.637	1.3.99.1	222
9	0.060	3etcB	0.388	5.86	0.061	0.592	6.2.1.-	NA
10	0.060	1k30A	0.785	2.63	0.113	0.863	2.3.1.15	150,157
11	0.060	3ce6A	0.401	5.15	0.062	0.570	3.3.1.1	183
12	0.060	3n58A	0.387	5.15	0.096	0.550	3.3.1.1	181,222
13	0.060	1ry2A	0.401	5.68	0.065	0.587	6.2.1.1	NA
14	0.060	2pffA	0.382	6.53	0.039	0.617	2.3.1.41,2.3.1.86	NA
15	0.060	3d64A	0.389	5.25	0.060	0.556	3.3.1.1	NA
16	0.060	3ifgA	0.358	6.48	0.050	0.584	1.2.1.16	NA
17	0.060	3ifh6	0.361	6.37	0.054	0.584	1.2.1.16	179
18	0.060	1z8lA	0.385	6.86	0.060	0.659	3.4.17.21	NA
19	0.060	3fedA	0.385	6.79	0.054	0.659	3.4.17.21	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.15	0.785	2.63	0.11	0.86	1k30A	GO:0004366 GO:0006629 GO:0006650 GO:0008152 GO:0008654 GO:0009507 GO:0009536 GO:0009570 GO:0016024 GO:0016740 GO:0016746
1	0.06	0.422	6.51	0.06	0.69	3vthA	GO:0003725 GO:0008270 GO:0016743 GO:0046872 GO:0046944
2	0.06	0.293	6.60	0.03	0.48	5a2aA	GO:0003824 GO:0004556 GO:0005975 GO:0008152 GO:0016020 GO:0016021 GO:0016787 GO:0016798
3	0.06	0.315	6.84	0.05	0.54	4e2xA	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
4	0.06	0.379	6.68	0.09	0.63	3tsqA	GO:0003725 GO:0008270 GO:0016743 GO:0046872 GO:0046944
5	0.06	0.304	7.26	0.04	0.54	4uirA	GO:0005504 GO:0006629 GO:0006631 GO:0009636 GO:0016491 GO:0016829 GO:0050151 GO:0055114 GO:0070542 GO:0071949
6	0.06	0.440	6.12	0.04	0.68	4g9iA	GO:0003725 GO:0008270 GO:0016743 GO:0046872 GO:0046944
7	0.06	0.333	6.99	0.06	0.58	3en9A	GO:0000166 GO:0000408 GO:0002949 GO:0003824 GO:0004222 GO:0004672 GO:0004674 GO:0004712 GO:0005506 GO:0005524 GO:0005737 GO:0006468 GO:0006508 GO:0008033 GO:0008152 GO:0008270 GO:0016301 GO:0016310 GO:0016740 GO:0016746 GO:0016747 GO:0046872 GO:0061711
8	0.06	0.291	7.09	0.07	0.51	1ox0A	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817 GO:0046872
9	0.06	0.267	7.06	0.01	0.47	4p8mB	GO:0003824 GO:0003885 GO:0016020 GO:0016491 GO:0016614 GO:0045227 GO:0050660 GO:0055114 GO:0071555
10	0.06	0.268	7.42	0.05	0.48	4ncrA	GO:0003824 GO:0003885 GO:0005737 GO:0005886 GO:0016020 GO:0016491 GO:0016614 GO:0035884 GO:0040007 GO:0045227 GO:0050660 GO:0055114 GO:0070592 GO:0071555
11	0.06	0.265	6.91	0.04	0.46	1o4yA	GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0033916
12	0.06	0.268	6.70	0.05	0.45	4p8lA	GO:0003824 GO:0003885 GO:0016020 GO:0016491 GO:0016614 GO:0045227 GO:0050660 GO:0055114 GO:0071555
13	0.06	0.271	7.27	0.05	0.50	1sb8A	GO:0000166 GO:0003824 GO:0005975 GO:0016857 GO:0050662
14	0.06	0.248	6.72	0.05	0.42	2zbwB	GO:0004324 GO:0016491 GO:0050660 GO:0050661 GO:0055114
15	0.06	0.261	6.39	0.06	0.42	4v8pBB	GO:0003735 GO:0005622 GO:0005737 GO:0005840 GO:0006412 GO:0030529
16	0.06	0.249	6.34	0.10	0.40	2qnkA	GO:0000334 GO:0005506 GO:0005737 GO:0005829 GO:0006569 GO:0008198 GO:0009055 GO:0009435 GO:0010043 GO:0016491 GO:0019363 GO:0019805 GO:0034354 GO:0043420 GO:0046686 GO:0046872 GO:0046874 GO:0051213 GO:0055114 GO:0070050 GO:0070062
17	0.06	0.233	5.35	0.03	0.34	1q80A	GO:0005509 GO:0046872
18	0.06	0.203	5.81	0.02	0.31	4e0rA	GO:0002474 GO:0006955 GO:0009986 GO:0016020 GO:0016021 GO:0042605 GO:0042612

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0008374
GO-Score	0.36	0.30
Biological Processes	GO:0046474	GO:0046341
GO-Score	0.30	0.30
Cellular Component	GO:0044434	GO:0009532
GO-Score	0.30	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.