I-TASSER results

I-TASSER results for job id Rv0498

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (280 residues)
MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVSQDIDAVRKLSRRYRVP
VLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVHPPFRWQRRYAEGFSDQVA
ALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGPGPAISAFAPSYDPLDGNHAH
YTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLPADEHLVPGRGTQPTAEVCQMLA
GSGFVGHVVLEVSTSSARSANERESMLAESLQFARTHLLR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVSQDIDAVRKLSRRYRVPVLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVHPPFRWQRRYAEGFSDQVAALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGPGPAISAFAPSYDPLDGNHAHYTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLPADEHLVPGRGTQPTAEVCQMLAGSGFVGHVVLEVSTSSARSANERESMLAESLQFARTHLLR
Prediction	CCCCCCEEEEHCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCHHHHHHHHCCCEEEEEHCCCCCCCCCEHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
Conf.Score	9998857987545799999999999999899889997689987768999999999989969999777667888677589999999999999998999899868988765789999999999999989989997677455555555556666654667876679999999999859998899985788888799999999998574789998589999876455788888999999999999899977999976998777645699999999999999969
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVSQDIDAVRKLSRRYRVPVLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVHPPFRWQRRYAEGFSDQVAALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGPGPAISAFAPSYDPLDGNHAHYTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLPADEHLVPGRGTQPTAEVCQMLAGSGFVGHVVLEVSTSSARSANERESMLAESLQFARTHLLR
Prediction	8447120000000035230330042037133402000032422362063025006727030000000001224542255005203400400460404000000222244411540252035007624010000002223344223142124204424322042043015105404252000000000012054201300440252021014122533442201000316031640151047260500000002346164265125003400510261068
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCEEEEHCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCHHHHHHHHCCCEEEEEHCCCCCCCCCEHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVSQDIDAVRKLSRRYRVPVLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVHPPFRWQRRYAEGFSDQVAALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGPGPAISAFAPSYDPLDGNHAHYTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLPADEHLVPGRGTQPTAEVCQMLAGSGFVGHVVLEVSTSSARSANERESMLAESLQFARTHLLR

3wqoA

0.22

0.20

0.91

2.21

MUSTER

---DMKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGYLSPKNIKYLMELRDRYEVEIVVHAPLNPASMNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNGYD-DEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3wqoA

0.22

0.20

0.91

2.56

dPPAS

---DMKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGYLSPKNIKYLMELRDRYEVEIVVHSDLNPASMNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNGYD-DEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3wqoA

0.22

0.20

0.91

2.99

wdPPAS

---DMKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGTHYPKNIKYLMELRDRYEVEIVVHSDLNPASMNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNGYD-DEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3wqoA

0.22

0.20

0.91

2.80

wMUSTER

----MKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGTHYPKNIKYLMELRDRYEVEIVVHAPLNPASMNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNG-YDDEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3wqoA

0.22

0.20

0.90

3.44

wPPAS

---DMKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGTHYPKNIKYLMELRDRYEVEIVVH--PFSDLNNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNGYD-DEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3wqoA

0.22

0.20

0.91

4.89

dPPAS2

---DMKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGYLSPKNIKYLMELRDRYEVEIVVHSDLNPASMNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNGYD-DEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3wqoA

0.22

0.20

0.91

3.21

PPAS

---DMKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGYLSPKNIKYLMELRDRYEVEIVVHSDLNPASMNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNGYD-DEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3wqoA

0.22

0.20

0.91

4.25

Env-PPAS

---DMKFGVSSLVFLPESLTSSMEKIAEHNFDAWEIVCEGTHYPKNIKYLMELRDRYEVEIVVHSDLNPASMNERVRKLTVECIRDAIEGAFELDSEVVVVHPGYIPELDNNFSTLSEIVEIAEDYGIKIGLENMP------------------NFRGVLGITPESLLEIVKDIDSKNLGITFDIGHANTAGNEFVEKLQNIGIGIIHVHAHDNNGY-DDEHLKIGEGNINFIEVLEKLKEIGYDGVISIENKN--IRDAVKSKEILKEYLEIVNEKVA-

3cqiA

0.16

0.14

0.90

2.02

MUSTER

--KQIPLGIYEKALPGECWLERLQLAKTLGFDFVEMSVDETWSREQRLALVNAIVETGVRVPSMCLSPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYRRRFRDGLKESVEMASRAQVTLAMEIM---------------------DYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKP-GVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETA---EDPAAEVAKARDWVKARMAK

3cqiA

0.16

0.14

0.90

2.35

dPPAS

--KQIPLGIYEKALPGECWLERLQLAKTLGFDFVEMSVDETWSREQRLALVNAIVETGVRVPSMCLSPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYRRRFRDGLKESVEMASRAQVTLAMEIM---------------------DYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFK-NVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAED---PAAEVAKARDWVKARMAK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.53

Estimated TM-score = 0.78±0.09

Estimated RMSD = 4.9±3.2Å

Download Model 2

C-score=-1.36

Download Model 3

C-score=-2.05

Download Model 4

C-score=-0.33

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wqoA	0.888	1.08	0.216	0.911
2	4xkmA	0.837	2.40	0.111	0.936
3	1a0dA	0.834	2.42	0.115	0.936
4	1a0eA	0.830	2.51	0.107	0.936
5	1bxcA	0.826	2.44	0.141	0.932
6	1qt1A	0.825	2.35	0.175	0.929
7	5xinA	0.824	2.47	0.156	0.932
8	1didA	0.824	2.37	0.163	0.929
9	2i57C	0.812	2.63	0.109	0.921
10	3ktcA	0.805	2.51	0.141	0.907

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.66	246	2ximB	XYL	Rep, Mult	37,102,133,135,184,187,210,251
2	0.06	24	1a0eA	CO	Rep, Mult	184,187,220,222
3	0.01	4	3wqoA	MN	Rep, Mult	64,102,133,210
4	0.00	1	3cqkB	ZN	Rep, Mult	172,205
5	0.00	2	3itxA	MN	Rep, Mult	134,184,187
6	0.00	1	3vnmB	MN	Rep, Mult	237
7	0.00	2	2nq9A	NUC	Rep, Mult	10,17,18,37,40,64,102,133,184,187,210,222,251
8	0.00	1	3cqiA	SO4	Rep, Mult	230,231,232,233,277
9	0.00	1	1gw9A	IOD	Rep, Mult	6,245,246,247
10	0.00	1	3vnkA	MN	Rep, Mult	223,227
11	0.00	1	4yvlA	TGK	Rep, Mult	29,30,268

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.480	1xp3A	0.752	2.86	0.171	0.871	3.1.21.2	251
2	0.241	2v81A	0.550	3.54	0.103	0.693	4.1.2.21	35
3	0.239	3cnyA	0.744	2.90	0.136	0.864	4.2.1.44	251
4	0.231	1vlwB	0.549	3.49	0.093	0.686	4.1.3.16	35
5	0.231	2yw3E	0.528	3.59	0.102	0.664	4.1.2.14	35
6	0.175	3ngfA	0.729	2.74	0.148	0.843	5.3.1.22	NA
7	0.164	3cqiA	0.798	2.44	0.163	0.900	5.1.3.22	NA
8	0.121	1xi3A	0.528	3.47	0.092	0.657	2.5.1.3	NA
9	0.118	1j2wA	0.555	3.52	0.096	0.700	4.1.2.4	NA
10	0.092	3f4wA	0.575	3.33	0.111	0.711	4.1.2.-	NA
11	0.091	1qtwA	0.759	2.86	0.161	0.889	3.1.21.2	251
12	0.089	2cz5A	0.580	3.49	0.108	0.729	4.1.1.23	NA
13	0.088	1dvjA	0.612	3.57	0.096	0.768	4.1.1.23	NA
14	0.087	1xbzB	0.583	3.40	0.128	0.725	4.1.1.85	49,53
15	0.085	2czfA	0.571	3.69	0.123	0.729	4.1.1.23	96,102,135
16	0.081	1eixC	0.594	4.17	0.089	0.786	4.1.1.23	NA
17	0.076	3inpA	0.567	3.40	0.117	0.704	5.1.3.1	NA
18	0.075	3exrA	0.568	3.63	0.079	0.725	4.1.1.85	233
19	0.072	1vqtA	0.530	3.86	0.101	0.675	4.1.1.23	NA
20	0.067	1xi3B	0.527	3.48	0.092	0.657	2.5.1.3	NA
21	0.060	2i56C	0.812	2.63	0.109	0.921	5.3.1.14	NA
22	0.060	1qoxA	0.677	4.18	0.056	0.889	3.2.1.21	NA
23	0.060	1a0dD	0.834	2.42	0.115	0.936	5.3.1.5	NA
24	0.060	1gowA	0.674	4.21	0.078	0.889	3.2.1.23	NA
25	0.060	3cqhA	0.740	2.37	0.159	0.829	5.1.3.22	NA
26	0.060	3bdkB	0.766	3.37	0.107	0.929	4.2.1.8	178
27	0.060	1i60A	0.777	2.56	0.141	0.886	5.3.99.-	NA
28	0.060	1bxbA	0.827	2.43	0.156	0.932	5.3.1.5	133,187
29	0.060	9ximD	0.823	2.47	0.156	0.932	5.3.1.5	9,11
30	0.060	1bhwA	0.824	2.46	0.156	0.932	5.3.1.5	275
31	0.060	1tr1D	0.674	4.22	0.073	0.893	3.2.1.21	97
32	0.060	1bxcD	0.826	2.44	0.141	0.932	5.3.1.5	94
33	0.060	1didA	0.824	2.37	0.163	0.929	5.3.1.5	187,220
34	0.060	1kwgA	0.676	3.71	0.087	0.864	3.2.1.23	NA
35	0.060	1gnxA	0.673	4.03	0.086	0.875	3.2.1.21	NA
36	0.060	2e3zA	0.671	4.13	0.077	0.882	3.2.1.21	NA
37	0.060	2ou4A	0.773	2.29	0.165	0.864	5.3.1.-	251
38	0.060	1de5A	0.793	2.81	0.124	0.921	5.3.1.14	178

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.53	0.759	2.86	0.16	0.89	1qtwA	GO:0000726 GO:0003677 GO:0003906 GO:0004518 GO:0004519 GO:0006281 GO:0006284 GO:0006974 GO:0008081 GO:0008270 GO:0008833 GO:0016787 GO:0046872 GO:0090305
1	0.48	0.798	2.44	0.16	0.90	3cqiA	GO:0005975 GO:0016853 GO:0016861 GO:0019852 GO:0019854 GO:0034015
2	0.47	0.788	2.69	0.14	0.90	1i60A	GO:0016853 GO:0046872
3	0.47	0.756	2.81	0.14	0.87	3kwsA	GO:0046872
4	0.45	0.888	1.08	0.22	0.91	3wqoA	GO:0003677 GO:0006281 GO:0008270
5	0.41	0.734	2.76	0.15	0.85	3ngfB	GO:0004519 GO:0008903 GO:0016853 GO:0046872 GO:0090305
6	0.40	0.819	2.49	0.14	0.92	3ktcA	GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
7	0.39	0.748	2.66	0.15	0.87	3dx5A	GO:0016829 GO:0046279 GO:0046872
8	0.39	0.752	2.93	0.18	0.88	3aalA	GO:0003677 GO:0004518 GO:0004519 GO:0006281 GO:0006974 GO:0008270 GO:0008833 GO:0016787 GO:0046872 GO:0090305
9	0.37	0.772	2.41	0.20	0.87	3vnlA	GO:0016853 GO:0016857 GO:0030145 GO:0046872 GO:0050897
10	0.36	0.740	2.37	0.16	0.83	3cqhA	GO:0005975 GO:0016853 GO:0016861 GO:0019852 GO:0019854 GO:0034015
11	0.35	0.824	2.37	0.16	0.93	1didA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
12	0.34	0.790	2.48	0.16	0.89	4pfhA	GO:0016853 GO:0046872
13	0.33	0.824	2.46	0.16	0.93	1bhwA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
14	0.33	0.739	2.79	0.12	0.86	1k77A	GO:0008903 GO:0016853
15	0.33	0.766	2.44	0.17	0.86	2hk0A	GO:0016853 GO:0016857 GO:0030145 GO:0046872 GO:0050897
16	0.33	0.830	2.51	0.11	0.94	1a0eA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
17	0.32	0.831	2.50	0.09	0.94	1a0cA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
18	0.32	0.769	3.21	0.20	0.93	3u0hA	GO:0016853
19	0.30	0.834	2.42	0.12	0.94	1a0dA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
20	0.28	0.803	2.25	0.14	0.89	3vylA	GO:0046872
21	0.28	0.827	2.33	0.15	0.93	4duoA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
22	0.26	0.837	2.40	0.11	0.94	4xkmA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0042843 GO:0046872
23	0.24	0.771	2.71	0.13	0.87	3tvaA	GO:0016853 GO:0046872
24	0.17	0.528	3.62	0.14	0.68	3qvqA
25	0.17	0.827	2.43	0.16	0.93	1bxbA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
26	0.16	0.725	2.30	0.20	0.81	3ayvD	GO:0003677 GO:0006281 GO:0008270 GO:0046872
27	0.14	0.601	3.81	0.07	0.77	1d9eD	GO:0003824 GO:0005737 GO:0005829 GO:0008152 GO:0008676 GO:0009058 GO:0009103 GO:0016740 GO:0019294 GO:0051289
28	0.12	0.748	2.73	0.14	0.87	3cnyA	GO:0016829 GO:0019310 GO:0030145 GO:0050114
29	0.10	0.751	3.41	0.11	0.91	1tz9A	GO:0006064 GO:0008927 GO:0016829

Consensus prediction of GO terms

Molecular Function	GO:0003677	GO:0008270	GO:0008081	GO:0003906	GO:0008833	GO:0034015	GO:0016861
GO-Score	0.74	0.74	0.53	0.53	0.53	0.48	0.48
Biological Processes	GO:0000726	GO:0006284	GO:0090305	GO:0019854	GO:0005975
GO-Score	0.53	0.53	0.53	0.48	0.48
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.