I-TASSER results

I-TASSER results for job id Rv0497

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (310 residues)
MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDAITVAELTGEIPIIRDD
HHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEPTRTVYWSQPEPRWPKSPP
QDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDPVEHYPDLWVDVLDTEVGEAE
AETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVARRALDVVPTLWRGALVVLQSILA
VAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVSVRAVRKTEDIASTLIAVAVGALIT
LGPLALLQSG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDAITVAELTGEIPIIRDDHHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEPTRTVYWSQPEPRWPKSPPQDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDPVEHYPDLWVDVLDTEVGEAEAETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVARRALDVVPTLWRGALVVLQSILAVAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVSVRAVRKTEDIASTLIAVAVGALITLGPLALLQSG
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	9999999999888999876678889988889888888788889988777888888889999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999998999999888899989999999999888999998888888888888888888998864555789999999999999999999999998657999999999999999999999855766899999999999999999998659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDAITVAELTGEIPIIRDDHHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEPTRTVYWSQPEPRWPKSPPQDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDPVEHYPDLWVDVLDTEVGEAEAETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVARRALDVVPTLWRGALVVLQSILAVAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVSVRAVRKTEDIASTLIAVAVGALITLGPLALLQSG
Prediction	7634546666566432415512155264656656543454677514345144634434576556645565556546656564554456546657555546546654556635465476455565665565565454466466665556565556544364366456445544646456554556566565565565656555656456555555544664664365323001211111122312211120022006311100020122111121110000233522100000131122003202112238
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDAITVAELTGEIPIIRDDHHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEPTRTVYWSQPEPRWPKSPPQDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDPVEHYPDLWVDVLDTEVGEAEAETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVARRALDVVPTLWRGALVVLQSILAVAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVSVRAVRKTEDIASTLIAVAVGALITLGPLALLQSG

5gaoE

0.14

0.13

0.89

1.22

MUSTER

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAA---------AAAAAAAAATTKEAYKKLSQKFHGTKSNKK-------------------------

5gaoE

0.15

0.14

0.93

1.28

dPPAS

-----------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAA

1mv3A

0.13

0.08

0.63

1.36

wdPPAS

----------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDEPFQNPEEQDE-----------------G----------W----------------GVK-------ESDWNQHKKLEKCRGVFENF-P-------

1mv3A

0.13

0.08

0.65

1.60

wMUSTER

-----------------------------------------------------------GSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDKAGDPFQNPEEQDE--------------G----------W--------------LMG-------VKESDWNQHKKLEKCRGVF----PENFTVP-

1mv3A

0.13

0.08

0.63

2.27

wPPAS

----------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDEPFQNPEEQDE-----------------G----------W-L--------------GVK--------ESDNQHKKLEKCRGVFENF-P-------

1mv3A

0.12

0.08

0.62

2.10

dPPAS2

----------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDPFQNPEEQDEGWLMGVKESDWNQHKKLEKCGVFENF-----------------------------------------------------------

5gaoE

0.14

0.97

2.36

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------

5d92D

0.12

0.10

0.87

0.79

Env-PPAS

----------------------------------MRLAYVKNHEIYGEKLLGLTLRERIEKTLQRAGFDVRFFDELSLEEAEDYLIILEPVLILERDLLLEGRKILVSDGFTVGYFFGGDFRTVFDGNLQSSIEKYLSLNNLESY-------EIWAIKLSNDNLKTAEKLLLSSLIGSGSLNKYARGLFAAIFLPIARLLADWGVSPIFYPMGQLFWGTLLFREGPWGAFLDSYLDRVGDSSVFTGIVIWFFLGGANPTIAILALICLVLSSLVSYSKARAEGLGRSERLVVVLVATGLVGLPSWVLLVV

5fmwA

0.08

0.98

1.19

MUSTER

RSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCECGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETY------THYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFS

1mv3A

0.11

0.07

0.68

1.27

dPPAS

--------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKKLEKCRGVFENFTERVP------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.03

Estimated TM-score = 0.28±0.09

Estimated RMSD = 16.3±3.0Å

Download Model 2

C-score=-2.66

Download Model 3

C-score=-4.86

Download Model 4

C-score=-4.96

Download Model 5

C-score=-4.09

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5d92D	0.732	3.29	0.111	0.842
2	4o6mA	0.692	3.57	0.066	0.813
3	4mndA	0.548	4.90	0.071	0.784
4	3ogzA	0.488	4.81	0.036	0.664
5	1jv3A	0.481	4.67	0.050	0.642
6	4bmaA2	0.469	4.58	0.057	0.616
7	2yqjA	0.465	4.47	0.053	0.607
8	3oc9A	0.463	4.47	0.038	0.613
9	3d8vA	0.446	3.84	0.045	0.558
10	1hm8A	0.445	3.51	0.019	0.539

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	3	1fxoH	TMP	Rep, Mult	38,40,41,72,75,76,77,78,115
2	0.05	3	3arcm	CLA	Rep, Mult	235,243,247
3	0.04	2	1hv9A	COA	Rep, Mult	42,88,89
4	0.04	2	1gwgA	IOD	Rep, Mult	251,252,256,258
5	0.04	2	2onkE	MG	Rep, Mult	49,55,59
6	0.04	2	4o6nB	MPG	Rep, Mult	232,291,295
7	0.02	1	2q8zA	NUP	Rep, Mult	285,286,289
8	0.02	1	2civA	MAN	Rep, Mult	17,19
9	0.02	1	1v51A	ZN	Rep, Mult	141,175
10	0.02	1	3pyoY	MG	Rep, Mult	265,300
11	0.02	1	3zvwC	MG	Rep, Mult	160,161
12	0.02	1	2axtM	CLA	Rep, Mult	243,247
13	0.02	1	2oi7A	DCA	Rep, Mult	107,108,147,149,151
14	0.02	1	3twdB	GOB	Rep, Mult	105,106,107,108,144,145
15	0.02	1	2q6qA	CO	Rep, Mult	284,285
16	0.02	1	2vd4A	P21	Rep, Mult	112,156,157,158,163,166,167
17	0.02	1	5d56E	78M	Rep, Mult	267,270,274
18	0.02	1	3a0bZ	CLA	Rep, Mult	274,277
19	0.02	1	2rh1A	CLR	Rep, Mult	248,268
20	0.02	1	1xmeC	HAS	Rep, Mult	261,265

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1kblA	0.332	7.04	0.042	0.616	2.7.9.1	NA
2	0.060	1lvwA	0.440	3.94	0.052	0.552	2.7.7.24	35
3	0.060	1lrwA	0.380	6.30	0.039	0.645	1.1.99.8	NA
4	0.060	1kb0A	0.382	6.40	0.035	0.652	1.1.99.-	NA
5	0.060	2i5kB	0.406	4.36	0.027	0.529	2.7.7.9	47
6	0.060	1mc3A	0.427	4.12	0.064	0.545	2.7.7.24	NA
7	0.060	3cf4A	0.386	6.87	0.057	0.694	1.2.99.2	NA
8	0.060	3hl3A	0.384	3.54	0.055	0.465	2.7.7.24	278
9	0.060	3cmmC	0.393	6.89	0.044	0.703	6.3.2.19	64
10	0.060	2d0vA	0.384	6.13	0.039	0.639	1.1.99.8	NA
11	0.060	1lrwC	0.380	6.17	0.027	0.635	1.1.99.8	87
12	0.060	3dk5A	0.440	3.68	0.041	0.542	2.3.1.157	NA
13	0.060	2o6yA	0.330	5.25	0.093	0.484	4.3.1.-	NA
14	0.060	2icyB	0.416	4.68	0.036	0.552	2.7.7.9	69
15	0.060	2qr5A	0.384	6.52	0.051	0.652	3.4.19.1	67
16	0.060	2vd4A	0.440	3.85	0.034	0.542	2.3.1.157,2.7.7.23	63,65,159
17	0.060	2ggoA	0.418	3.40	0.026	0.506	2.7.7.24	NA
18	0.060	2yqjA	0.465	4.47	0.053	0.607	2.7.7.23	66
19	0.060	1e1cA	0.391	6.62	0.074	0.677	5.4.99.2	155

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.17	0.704	3.48	0.11	0.84	5d92B	GO:0000166 GO:0008654 GO:0016020 GO:0016021 GO:0016740 GO:0016780 GO:0046872
1	0.10	0.684	3.81	0.07	0.82	4o6mB	GO:0000166 GO:0008654 GO:0016020 GO:0016021 GO:0016740 GO:0016780 GO:0046872
2	0.07	0.548	4.90	0.07	0.78	4mndA	GO:0003824 GO:0008152 GO:0008654 GO:0016020 GO:0016021 GO:0016740 GO:0016779 GO:0016780 GO:0046872
3	0.06	0.415	4.63	0.05	0.55	4j18A	GO:0003983 GO:0005829 GO:0006011 GO:0008152 GO:0016740 GO:0016779 GO:0070569
4	0.06	0.416	4.73	0.02	0.55	3r2wC	GO:0003983 GO:0005536 GO:0005634 GO:0005737 GO:0005829 GO:0005978 GO:0006011 GO:0006065 GO:0008152 GO:0016740 GO:0016779 GO:0019255 GO:0032557 GO:0042802 GO:0046872 GO:0070062 GO:0070569
5	0.06	0.393	4.62	0.04	0.52	3gueA	GO:0003983 GO:0006011 GO:0008152 GO:0016740 GO:0016779 GO:0020015 GO:0046872 GO:0070569
6	0.06	0.413	4.47	0.03	0.55	4r7pA	GO:0003983 GO:0005536 GO:0005634 GO:0005737 GO:0005829 GO:0005978 GO:0006011 GO:0006065 GO:0008152 GO:0016740 GO:0016779 GO:0019255 GO:0032557 GO:0042802 GO:0046872 GO:0070062 GO:0070569
7	0.06	0.416	4.68	0.04	0.55	2icyB	GO:0003983 GO:0005737 GO:0005829 GO:0005886 GO:0005985 GO:0006011 GO:0008152 GO:0009555 GO:0009651 GO:0016036 GO:0016740 GO:0016779 GO:0052543 GO:0070569 GO:0090406
8	0.06	0.379	3.31	0.05	0.45	1wvcA	GO:0000166 GO:0009058 GO:0009103 GO:0009243 GO:0016740 GO:0016779 GO:0046872 GO:0047343
9	0.06	0.376	4.01	0.03	0.48	4jd0A	GO:0009058 GO:0016740 GO:0016779
10	0.06	0.312	6.91	0.03	0.56	2ct8A	GO:0000166 GO:0004812 GO:0004825 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006431 GO:0016874 GO:0046872
11	0.06	0.248	6.67	0.07	0.43	4bmaA	GO:0003977 GO:0008152 GO:0016740 GO:0016779 GO:0070569
12	0.06	0.486	4.61	0.04	0.65	3oh0A	GO:0008152 GO:0070569
13	0.06	0.476	4.31	0.04	0.62	1vm8A	GO:0003977 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006048 GO:0008152 GO:0016740 GO:0016779 GO:0042802 GO:0070569
14	0.06	0.316	6.44	0.05	0.53	4bqhA	GO:0003977 GO:0005829 GO:0006011 GO:0006048 GO:0008152 GO:0016740 GO:0016779 GO:0070569
15	0.06	0.465	4.48	0.05	0.61	2yqcA	GO:0003977 GO:0005737 GO:0006048 GO:0008152 GO:0016740 GO:0016779 GO:0070569
16	0.06	0.237	6.60	0.04	0.42	3kjeA	GO:0000166 GO:0019415
17	0.06	0.230	6.80	0.02	0.41	3rgbA	GO:0004497 GO:0016020 GO:0016021 GO:0016491 GO:0046872 GO:0055114
18	0.06	0.271	7.42	0.04	0.53	4wj3M	GO:0000166 GO:0003676 GO:0004812 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0016874 GO:0050560

Consensus prediction of GO terms

Molecular Function	GO:0016772	GO:1901265	GO:0036094	GO:0046872
GO-Score	0.60	0.50	0.50	0.34
Biological Processes	GO:0090407	GO:0044249	GO:0006644	GO:0008610
GO-Score	0.60	0.60	0.60	0.60
Cellular Component	GO:0031224
GO-Score	0.48

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.