I-TASSER results

I-TASSER results for job id Rv0496

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (328 residues)
MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTIDEFAKIAISSGCAELM
AFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAVRRWYGWSAGRILNLDI
GGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRVAMLRDWLDAELAEPSVT
VLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTANGLRQLIAFISRMTAVDRA
ELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALREGLILRKLDSEADGTALIES
SSVHTSVRAVGGQPADRNAANRSRGSKP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTIDEFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAVRRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRVAMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTANGLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALREGLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP
Prediction	CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEHCCHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHCCCCCCCCCEEEEHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCHHHHHHHHHHCCCCCCCCCCCEEEHCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9888899999999875678999998598899999999999999999999999989856776767776547869999999999989957876858888899998888754555546788679863443579999976467656896776555689999999999999999999988999999986999855664466889999988877788997567658689999999998599889886899996555456668999999999989995676876778878888876688998877788888777777888777888888888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTIDEFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAVRRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRVAMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTANGLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALREGLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP
Prediction	7000231010110322323020021027735036600530150044016105734043000100100120620640152037514040421436400200000011021000120000001100000022321301002002010010024207733154730540152035302620440262242410000031010001101001125213031304263034003202604363117054126610311100000000003217074010000001010001101413545433544544444554444435554545545658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEHCCHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHCCCCCCCCCEEEEHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCHHHHHHHHHHCCCCCCCCCCCEEEHCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTIDEFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFLAVRRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGRRRVAMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRTLTANGLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICPWALREGLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP

3mdqA

0.24

0.20

0.86

2.10

MUSTER

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQAV--PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR----PTQLIGCSGTFDTLAENIQHHREKIALEKSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLD--VKVGS---------------------------------

3mdqA

0.23

0.20

0.87

5.89

dPPAS

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQAV--PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR----PTQLIGCSGTFDTLAENIQHHREKIALQTSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLDGVKVGS----------------------------------

3mdqA

0.24

0.20

0.86

5.29

wdPPAS

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQA---PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTW-----PTQLIGCSGTFDTLAENIQHHREKIALEKSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLD--VKVGS---------------------------------

3mdqA

0.24

0.20

0.86

2.18

wMUSTER

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQAV--PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTW-----PTQLIGCSGTFDTLAENIQHHREKIALEKSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLD--VKVGS---------------------------------

3mdqA

0.24

0.20

0.86

2.52

wPPAS

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQA---PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTW-----PTQLIGCSGTFDTLAENIQHHREKIALEKSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLDG-VKVGS---------------------------------

3mdqA

0.24

0.20

0.87

7.30

dPPAS2

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQAV--PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR----PTQLIGCSGTFDTLAENIQHHREKIALEKSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLDG-VKVGS---------------------------------

3mdqA

0.24

0.20

0.86

2.61

PPAS

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQA---PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR----PTQLIGCSGTFDTLAENIQHHREKIALEKSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLDG-VKVGS---------------------------------

3mdqA

0.24

0.20

0.87

5.47

Env-PPAS

ITDIVND-RPHTLVNEKSAVGLGKGGITKGFITEE-ADRALDTLKKFRVILDEHAVVHVIATGTSAVRSGSNKQVLIDRIKKEVNIDVEVIDGAREAELIFRGVQQAV--PEDHISLADIGGGSVEFIIGNKNEILWKQSFEIGGQRLIDRFHVHDPREDDRVHNYFDEVLVPLEKAINTWR----PTQLIGCSGTFDTLAENIQHHREKIALEKSYLLSLPDFNRLRKQLVASTRRERLAIAGI--ELRADVVVAICLIEHVLKLVSTNAITVSTYSLKEGVLYTLDG-VKVGS---------------------------------

1t6cA

0.24

0.21

0.86

2.03

MUSTER

IAQIKDG-KLSIILERGRITSLGTKVKETGRLQEDRIEETIQVLKEYKKLIDEFKVERVKAVATEAIRRAKNAEEFLERVKREVGLVVEVITPEQEGRYAYLAVAYSL-KPEGEVCVVDQGGGSTEYVFGKGYKVREVISLPIGIVNLTETFFKQDPPTEEEVKRFFEFLEKELSKV------KKPVDTIVGLGGTITTLAALEYNVYPYDPQKVHKVLTYGQIKKWFDTFKEIPSEERSK-RQVEDRRAKVILAGIGIFLKTLEIFEKDCLIVSDWGLREGVLVSEVLKES------------------------------------

1t6cA

0.24

0.21

0.87

5.59

dPPAS

IAQIKDG-KLSIILERGRITSLGTKVKETGRLQEDRIEETIQVLKEYKKLIDEFKVERVKAVATEAIRRAKNAEEFLERVKREVGLVVEVITPEQEGRYAYLAVAYSLK-PEGEVCVVDQGGGSTEYVFGKGYKVREVISLPIGIVNLTETFFKQDPPTEEEVKRFFEFLEKELSKV------KKPVDTIVGLGGTITTLAALEYNVYPYDPQKVHKVLTYGQIKKWFDTFKEIPSEERSKRRQVEDRRAKVILAGIGIFLKTLEIFEKDCLIVSDWGLREGVLVSEVLKENHS----------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.23

Estimated TM-score = 0.68±0.12

Estimated RMSD = 6.9±4.1Å

Download Model 2

C-score=-1.62

Download Model 3

C-score=-2.50

Download Model 4

C-score=-2.94

Download Model 5

C-score=-0.92

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3mdqA	0.829	1.50	0.246	0.866
2	1u6zB	0.786	3.32	0.178	0.908
3	3cerC	0.782	2.75	0.206	0.872
4	3hi0A	0.727	2.75	0.186	0.817
5	1t6cA	0.701	3.65	0.235	0.866
6	3cj9A	0.656	4.14	0.137	0.829
7	3zx0A	0.648	3.74	0.115	0.799
8	3agrA	0.622	4.74	0.106	0.838
9	3aapA	0.619	4.32	0.121	0.805
10	4a5bA	0.616	4.85	0.106	0.838

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.31	9	1hpmA	K	Rep, Mult	119,120,121,124,125,126
2	0.08	3	1u6zA	SO4	Rep, Mult	17,19,245
3	0.08	3	3cj9A	PO4	Rep, Mult	64,65,121,122,123,124
4	0.07	3	4a59C	AMP	Rep, Mult	122,195,196,199
5	0.05	2	1u6zA	SO4	Rep, Mult	187,269,270,271
6	0.02	1	3en9B	TBR	Rep, Mult	128,130,137,139
7	0.02	1	3zx2D	NA	Rep, Mult	64,96,121
8	0.02	1	4a59D	AMP	Rep, Mult	106,282,289,291
9	0.02	1	2j4rA	G4P	Rep, Mult	19,64,195,248,249
10	0.02	1	1u6zA	SO4	Rep, Mult	141,142,173
11	0.02	1	1u6zB	SO4	Rep, Mult	304
12	0.02	1	1u6zB	SO4	Rep, Mult	24,25,33,35,39

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3hm8A	0.481	4.81	0.114	0.683	2.7.1.1	NA
2	0.060	1u6zB	0.786	3.32	0.178	0.908	3.6.1.11	23,121,194,279
3	0.060	2i7nA	0.418	4.46	0.111	0.579	2.7.1.33	NA
4	0.060	2e2oA	0.448	4.66	0.070	0.625	2.7.1.1	NA
5	0.060	2vwbA	0.486	5.11	0.069	0.707	3.4.24.57	119
6	0.060	2nztA	0.472	4.85	0.086	0.668	2.7.1.1	124
7	0.060	3en9A	0.511	5.34	0.069	0.753	3.4.24.57	123,141,148
8	0.060	3enhA	0.476	5.16	0.087	0.701	3.4.24.57	119
9	0.060	1tuuA	0.496	4.95	0.071	0.686	2.7.2.1	123
10	0.060	2h3gX	0.450	4.19	0.081	0.582	2.7.1.33	NA
11	0.060	3cqyA	0.531	4.42	0.097	0.717	2.7.1.-	92,122
12	0.060	3mdqA	0.829	1.50	0.246	0.866	3.6.1.11	67,119,121,147,194,197
13	0.060	2ivpA	0.485	5.01	0.057	0.701	3.4.24.57	123
14	0.060	2ch5A	0.458	5.07	0.067	0.671	2.7.1.59	120
15	0.060	2hoeA	0.469	4.88	0.054	0.655	2.7.1.59	NA
16	0.060	1hkgA	0.488	5.00	0.090	0.704	2.7.1.1	70
17	0.060	1woqA	0.455	4.68	0.087	0.634	2.7.1.63	NA
18	0.060	1x9jB	0.492	5.41	0.092	0.735	2.7.2.7	123
19	0.060	1qhaA	0.488	5.31	0.096	0.720	2.7.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.44	0.701	3.65	0.23	0.87	1t6cA	GO:0046872
1	0.35	0.852	1.33	0.24	0.88	3mdqA	GO:0004309 GO:0016787
2	0.32	0.746	2.81	0.17	0.84	3hi0A	GO:0004309 GO:0006793
3	0.15	0.786	3.32	0.18	0.91	1u6zB	GO:0004309 GO:0005886 GO:0006793 GO:0006798 GO:0016020 GO:0016787
4	0.06	0.334	6.03	0.06	0.53	1lfwA	GO:0005737 GO:0006508 GO:0008152 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0016805 GO:0046872
5	0.06	0.322	6.52	0.04	0.55	4dibA	GO:0004365 GO:0006006 GO:0006096 GO:0016491 GO:0016620 GO:0050661 GO:0051287 GO:0055114
6	0.06	0.310	6.31	0.07	0.51	4pvfA	GO:0003682 GO:0003824 GO:0004372 GO:0005634 GO:0005737 GO:0005739 GO:0005743 GO:0005758 GO:0005759 GO:0006544 GO:0006545 GO:0006563 GO:0006564 GO:0006730 GO:0008284 GO:0008732 GO:0015630 GO:0016020 GO:0016597 GO:0016740 GO:0019264 GO:0030170 GO:0034340 GO:0035999 GO:0042645 GO:0042802 GO:0046653 GO:0046655 GO:0051262 GO:0051289 GO:0070062 GO:0070536 GO:0070552
7	0.06	0.306	5.82	0.04	0.47	3pdiB	GO:0006461 GO:0009399 GO:0016163 GO:0016491 GO:0046872 GO:0051536 GO:0051539 GO:0055114
8	0.06	0.327	5.34	0.06	0.48	3uveA	GO:0016491 GO:0033702 GO:0055114
9	0.06	0.302	7.19	0.07	0.55	3p3oA	GO:0004497 GO:0005506 GO:0016491 GO:0016705 GO:0020037 GO:0046872 GO:0055114
10	0.06	0.261	6.62	0.02	0.44	1rwiA	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0005576 GO:0005618 GO:0005829 GO:0005886 GO:0005887 GO:0006468 GO:0009405 GO:0016020 GO:0016021 GO:0016036 GO:0016301 GO:0016310 GO:0016740 GO:0030145 GO:0032091 GO:0043085 GO:0043086 GO:0045717
11	0.06	0.284	6.24	0.03	0.46	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
12	0.06	0.277	6.26	0.08	0.46	5amvA	GO:0005576 GO:0016829 GO:0030570 GO:0045490 GO:0046872
13	0.06	0.280	6.50	0.05	0.47	3bt7A	GO:0000049 GO:0005829 GO:0006396 GO:0008033 GO:0008168 GO:0008173 GO:0016740 GO:0019843 GO:0030488 GO:0030697 GO:0032259
14	0.06	0.285	6.14	0.03	0.46	2r5vA	GO:0003868 GO:0005506 GO:0009072 GO:0016491 GO:0016701 GO:0017000 GO:0033072 GO:0046872 GO:0050585 GO:0055114
15	0.06	0.279	6.27	0.05	0.45	3a3uA	GO:0009234 GO:0016829 GO:0016830
16	0.06	0.264	6.37	0.07	0.44	3bm3A	GO:0003677 GO:0004519 GO:0009036 GO:0009307 GO:0090305
17	0.06	0.248	6.41	0.04	0.42	3a25A	GO:0005737 GO:0006400 GO:0008033 GO:0016740 GO:0016765
18	0.06	0.259	6.95	0.05	0.46	1v5vA	GO:0004047 GO:0006546 GO:0008483 GO:0016740 GO:0019464 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0004309	GO:0046872
GO-Score	0.63	0.47
Biological Processes	GO:0044248	GO:0044712	GO:0006797
GO-Score	0.31	0.31	0.31
Cellular Component	GO:0071944
GO-Score	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.