I-TASSER results

I-TASSER results for job id Rv0495c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (296 residues)
MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPGQEVELDFAREWVEFYD
PDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCSHGAFLSDDDDRTRLADAV
HKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGACIFLNRPGFAGGAGCALHSK
ALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILKTTLTEYDRRGWGSGGADLHWYC
TGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAMCKRRSQLGLIAVHPATRAAQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPGQEVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCSHGAFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGACIFLNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILKTTLTEYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAMCKRRSQLGLIAVHPATRAAQ
Prediction	CCCCCCCCCCCCCHHHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCEEEEEEEEHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEHCCCCCCCCCCCCEEHCCEEEEHCCCCCCCCCCCHHHHHHHHHCCCCCHCCCCCEEHCCCCCCCEEEHCCCCCEEEEEEEEEHCCCCCCCCCCCCCEEHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHCCCCCCCCC
Conf.Score	99877777655654544678555557887778877778888888778999986467748999964478876545445477775889888877889998877888888999999999999998998775555555788887555667888777766776868886689998887448999999989998555886646657867754687799989999997554567889998887657589977788998477778999999985999999999999999679855688886679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPGQEVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCSHGAFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGACIFLNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILKTTLTEYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAMCKRRSQLGLIAVHPATRAAQ
Prediction	72433641402010004224231313234245345545561543542516102211103217355210100000000301020026103223664162000220111336522630351056035631522652354631143343576454313415110000023616412000000201547251353204000110134346226235634103030211224212621310001012336014334200311352024002560053015105515724200202134648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCHHHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCEEEEEEEEHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEHCCCCCCCCCCCCEEHCCEEEEHCCCCCCCCCCCHHHHHHHHHCCCCCHCCCCCEEHCCCCCCCEEEHCCCCCEEEEEEEEEHCCCCCCCCCCCCCEEHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHCCCCCCCCC
MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPGQEVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCSHGAFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGACIFLNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILKTTLTEYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAMCKRRSQLGLIAVHPATRAAQ

2r2dA

0.16

0.14

0.85

0.66

MUSTER

M-----GNKLFV---LDLGEIRVDENFIIANSTFVTPQKPTVSSRLIDIPV---SAYLIQ--CTDATVLYD-T----------GCHPECMGTNGRWPAQSQLNAPYIGASEC--NLPERLRQLSPDD-----------STVVLSHLHNDHAGCVEYFGKSRLIAHEDEFAT----AVRYFATGDHSSPY-IVKDIEAWLATPRNWDLVGRDERERELAVNLLNFG-TGHASGLEKQPGFLLVSDACYTAGPPARRAGVLHDTIGY-DRTVSHIRQYAESRS-LTVLFGHREQFASL

3gobA

0.17

0.15

0.87

0.86

dPPAS

LYRQPDGVCPHRFAPLSDGNGHLQCPYGGGQCVHNPHGNGARPASLNVRSFPVVWIWPGDPALAD--------------------PGAIPDFGCRVDPAYRTVGGYGHVDCNYKLLVDNLMDLGHAQYVHRANAQTDAF--------DRLEREVIVGDGEIQALMK--IPGGTPSVLMAKFLRGANTPVDAWNDIRWNKVSAMLNFIAVAPEGTRGTHILTPETEAS--------CHYFFGSSRNFGIDDPEMDGVLRSWQAQALVKEDKVVVEAIERRRAYVEANGIRPAMLSCD

4lzhA

0.16

0.12

0.75

0.62

wdPPAS

-----NAVTYPLPTDGSR-GQNQVITIPDDNKQPLQGLSNLEANPGVDTYLPKG--QLILPDTVHEGIIINSA-YYTNTVIVLPI----GI--GPIN---------------TTKVERKKATPTAKHAEYAAAGNPLPAVVPAGP--DNPGLYALYIGGT----NANGLRVSHGCFLFENV-PVGTRVQFID-------PV----KATTEPDGSRYIEV--------------NPL----STTEAQFQGGEIVPITLTQPVQAVTSQSDQNVVEQAIQNRS--GPVRLN-------

3gobA

0.19

0.16

0.84

0.60

wMUSTER

LYRQPDG-VVAAPAPLSDGNGHLQCPYGGGQCVHNPHGNGARP-ASLNVRFPVEWIWPGDPADPGAI---DFGCRVDAYRTVGGY-DC-----------------------NYKLLVDNLMDLGHAQYVHRAN-AQTDAF-------DRLEREVIVGDGEIQALMK--IPGGTPSVLMAKFLRGANTPVDAWNDIRWNKVSAMLNFIAVAPEGTSRGTHILTPETEA-------SCHYFFGSSRNFGIDDPEMDGVLRSWQAQALVKEDKVVVEAIERRRAYVEANGIRPAMLSCD

4n4jA1

0.18

0.15

0.86

0.49

wPPAS

------GPTFQVAQVFGQPVGPDNDGTLYIFGLTAKYTEPEYDGRGPYKSFSIRWYDWTNGSQTEGVFK----------ECV----LCPTIVNVEDLVGCC-HGNN--HQKLEMPTYKLCND-PKETAEHRAGGLGSHAYTVNVLEFSWHVGKPAEEVTGCAHCHAIAENRCSGCH-HKFDPAEAR-----KPTACRVCHMGIDAMYNTSIHGA-LYEAESARMDWGKKLKKG-NYR--CA---YCHMGDHNP-QRFGGEYLDLL--PGWKRKPGDVDVEWFKRTDIPHRANADAG

2n5xA

0.13

0.02

0.13

0.92

dPPAS2

LWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2r2dA

0.16

0.13

0.82

0.66

PPAS

M-----GNKLFV---LDLGEIRVDENFIIANSTFVTPQKP---------TVSSRLIDIP--QCTDATVLYD-T---------CHPECMGTNGRWPAQSQLNAPYIGASECNLPERLRQL---LSPDD-----------STVVLSHLHNDHAGCVEYFGKSRLIAHEDEFAT----AVRYFATGDHSSPY-IVKDIEAWLATPRNWDLVGRDERERELAVNLLNF--TGHASGLEKQPGFLLVSDACYT-GPPARRAGVLHDTIGY-DRTVSHIRQYAESRSLT-VLFGHREQFASL

2p6pA2

0.16

0.11

0.67

0.70

Env-PPAS

--DI-------CPPSL---------RPANAAPARMMRHVATSRQCPLE-----PWMY-TRDTRQ----RVLVTS---------GS-----RVAKES---------YDRNFDFLRGLAKDLVRWDVEPDTVAEALRAEVPQARVGWTPLDVVAPTC----DLLVHH------A-GGVSTLTGLSAGV------PQLLI--PK-----GSVLEAPARRVA-------DYGA---AIALL-----------PGEDSTEAIADSCQELQAKDTYARRAQDLSREISG---MPLPATVVTA

4bqnA

0.15

0.14

0.91

0.59

MUSTER

M---AQRKKYSVPALAKMARDWELVEMEPCFVASEEQIDPVSEGYR-GEKYSSVFLRNSMPPGGNALSVQYMHWYHPTVNSPYGLPPHPEGYVDALIAGAVVMD--VDKETYLRHLEEIGASLRIDIDEIESWCVDELKTREVGENDGGKQIDISVTQKRLFYTNHPTAALMRE-IAARCMLALGYTYSDISFDQ---LDPLDVTKMSLYPIYRDCF-------DFSELNRMNE----YQV------LYKKKAYEPYLLEQFEWFERSPKADVSAFFDRVAANRRWVRTALRRAFE

4iv9A1

0.12

0.11

0.98

0.81

dPPAS

IGSYSAGTPTPRVAIVG-AGISLRAGVKDVVYESRDRIGGRVWSQVFDQTRPRYIAEMGAMRPPSATGLFHYLKKFGISTSTTFPGFTEILRMVINGYQSDQRLIPDGISSLAARLADQSFDGKALRDRVCFSRVGRISREAEKIIIQTEAGEQRVFDRVIVMIHCLTDSESFLSRDVARAVRETHLTGSSK--LFILTRTKNKLPTTIQSDGLVRGVYCLD-YQPDEPEGHGVVLLSYTWEDDAQKMLAMPDKKTRCQVLVDDL-AAIHPTFASYLLPVDGDYERYVWLTDPHSA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.85

Estimated TM-score = 0.30±0.10

Estimated RMSD = 15.7±3.3Å

Download Model 2

C-score=-4.09

Download Model 3

C-score=-4.03

Download Model 4

C-score=-4.08

Download Model 5

C-score=-4.75

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3gobA	0.726	3.35	0.127	0.851
2	3gcfO	0.595	4.65	0.069	0.801
3	1z01A	0.588	4.85	0.068	0.818
4	1wqlA	0.580	5.16	0.070	0.851
5	1uuvA	0.576	4.85	0.069	0.828
6	2ckfA	0.575	5.07	0.074	0.841
7	4qdcA	0.573	4.40	0.079	0.780
8	3gkqA	0.572	4.76	0.069	0.794
9	2de6B	0.572	4.75	0.077	0.790
10	1uliC	0.570	5.23	0.063	0.835

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	4	3gb4B	D3M	Rep, Mult	123,193,205,207,257,260
2	0.10	4	1z01A	FES	Rep, Mult	175,178,208,215,216,217
3	0.07	3	2f9yB	ZN	Rep, Mult	81,88,100,101
4	0.05	2	1n4pB	ZN	Rep, Mult	194,196,247
5	0.03	1	3gtsA	FE	Rep, Mult	119,125,130,265,269
6	0.02	1	3iaqA	MG	Rep, Mult	96,97
7	0.02	1	3o72C	OXY	Rep, Mult	109,202
8	0.02	1	2wl3A	CA	Rep, Mult	61,109
9	0.02	1	3qy6A	MG	Rep, Mult	103,247
10	0.02	1	2xsoW	FES	Rep, Mult	196,198,202,204,221,222
11	0.02	1	1l8tA	MG	Rep, Mult	28,225

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2c10B	0.375	5.87	0.027	0.605	1.4.3.21,1.4.3.6	NA
2	0.060	1gz3A	0.376	6.17	0.040	0.622	1.1.1.38	NA
3	0.060	2vz9B	0.331	7.05	0.044	0.622	2.3.1.85	NA
4	0.060	2zy2A	0.381	6.32	0.039	0.632	4.1.1.12	NA
5	0.060	1g8kE	0.380	6.51	0.041	0.659	1.20.98.1	128,148
6	0.060	1aorB	0.402	6.59	0.048	0.696	1.2.7.5	156,160
7	0.060	2vz8A	0.376	6.65	0.054	0.662	2.3.1.85	NA
8	0.060	1eg9A	0.576	4.91	0.069	0.831	1.14.12.12	NA
9	0.060	2wgqB	0.373	5.95	0.029	0.608	1.4.3.21	NA
10	0.060	2zy4F	0.375	6.23	0.029	0.628	4.1.1.12	NA
11	0.060	1llwA	0.407	6.65	0.037	0.723	1.4.7.1	NA
12	0.060	2b1xA	0.568	5.13	0.067	0.835	1.14.12.12	NA
13	0.060	1ea0A	0.405	6.80	0.041	0.737	1.4.1.13	NA
14	0.060	1tgoA	0.343	6.11	0.058	0.571	2.7.7.7	155
15	0.060	3ikmD	0.395	6.41	0.044	0.676	2.7.7.7	72
16	0.060	1n2lA	0.388	6.38	0.080	0.662	3.1.6.8	197
17	0.060	1wqlA	0.580	5.16	0.070	0.851	1.14.12.-	NA
18	0.060	1z01A	0.588	4.85	0.068	0.818	1.14.13.61	NA
19	0.060	1g8kA	0.377	6.53	0.045	0.655	1.20.98.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.726	3.35	0.13	0.85	3gobA	GO:0005506 GO:0016491 GO:0016708 GO:0019439 GO:0046872 GO:0051536 GO:0051537 GO:0055114
1	0.09	0.588	4.85	0.07	0.82	1z01A	GO:0004497 GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114
2	0.09	0.570	5.23	0.06	0.83	1uliC	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0018687 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
3	0.08	0.575	5.08	0.07	0.84	3gzxA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0018687 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
4	0.08	0.580	5.04	0.06	0.84	3en1A	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0018619 GO:0018624 GO:0019439 GO:0042184 GO:0042203 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
5	0.08	0.635	3.60	0.13	0.77	3gl0C	GO:0005506 GO:0016491 GO:0016708 GO:0019439 GO:0046872 GO:0051536 GO:0051537 GO:0055114
6	0.08	0.592	4.75	0.07	0.80	3gcfA	GO:0016491 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
7	0.07	0.583	4.96	0.08	0.84	2gbwA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
8	0.07	0.568	5.13	0.07	0.83	2b1xA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
9	0.07	0.576	4.91	0.07	0.83	1eg9A	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0018625 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
10	0.07	0.572	4.76	0.07	0.79	3gkqA	GO:0016491 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
11	0.07	0.580	5.16	0.07	0.85	1wqlA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
12	0.07	0.581	4.95	0.07	0.84	2bmoA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0019439 GO:0046872 GO:0051536 GO:0051537 GO:0055114
13	0.07	0.561	5.22	0.05	0.83	3n0qA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0019439 GO:0046872 GO:0051536 GO:0051537 GO:0055114
14	0.07	0.572	4.75	0.08	0.79	2de6B	GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114
15	0.07	0.573	4.40	0.08	0.78	4qdcA	GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114
16	0.07	0.549	5.31	0.04	0.83	4qurA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
17	0.07	0.573	5.14	0.07	0.84	5aeuA	GO:0005506 GO:0006725 GO:0016491 GO:0016705 GO:0016708 GO:0018687 GO:0019439 GO:0046872 GO:0051213 GO:0051536 GO:0051537 GO:0055114
18	0.07	0.542	4.73	0.09	0.77	4qdfB	GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0051537	GO:0005506	GO:0016708
GO-Score	0.49	0.44	0.44
Biological Processes	GO:0055114	GO:0019439
GO-Score	0.49	0.44
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.