I-TASSER results

I-TASSER results for job id Rv0493c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (329 residues)
MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPLTRTGLWVHCETVAPTT
GGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGVRMAPAELTGRTRSLAWEL
SWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLAVGETTHRVDSWRGSVAHIYG
HGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPLAFVRFRIDGKDWPASPLPSLRM
RTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGYTDPDGAKAVCTNTEQADIHIELGG
RHWSVLGTGHAEVGLRGTAAPAIKEGTPA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPLTRTGLWVHCETVAPTTGGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGVRMAPAELTGRTRSLAWELSWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLAVGETTHRVDSWRGSVAHIYGHGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPLAFVRFRIDGKDWPASPLPSLRMRTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGYTDPDGAKAVCTNTEQADIHIELGGRHWSVLGTGHAEVGLRGTAAPAIKEGTPA
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCEEEEEEEEEHCCCCCCCCCCEEEEEHCCCCCCCEEHCCCCCCCCCCCCEEEEHCCEEHCCCEEEEHCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCEEEEEEEEHCCEEEEHCCCHCCCCCCCCCCCHHHHEEEEHCCCCCCEEEEEEEHCCCCCCCCCCCEEEEEEEHCCEEEEHCCCCCCEEEEEHCCCEEEEEEEHCCEEEEEEEEHCCCCEEEEEHCCCCCCCEEEHCCCEEEEEEEEHCCCCEEEEEEEEHCCCCCCCCCCCCCCCCC
Conf.Score	99888888887656666667778887888996579999998799987999998876799998766579999879998645654777665578875899746687586687557868999998688886444676555677777657875787689999999999999879654445678999856636677568999757899875566787656756899999899888865566544567756765799998676899999997888646766479999744443366479999998567667754566545544568776678899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPLTRTGLWVHCETVAPTTGGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGVRMAPAELTGRTRSLAWELSWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLAVGETTHRVDSWRGSVAHIYGHGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPLAFVRFRIDGKDWPASPLPSLRMRTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGYTDPDGAKAVCTNTEQADIHIELGGRHWSVLGTGHAEVGLRGTAAPAIKEGTPA
Prediction	85554444533442444454242441646541000000001027431000000002334734430100000003743533452434614145442314224141344314042440201020444340022025212435034022103023130302030454414054141222111134303300001034255220101102334322321310000001142441423414323333424023030314354120202030447300000022172133102204304030203636343234132413324252343366358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCEEEEEEEEEHCCCCCCCCCCEEEEEHCCCCCCCEEHCCCCCCCCCCCCEEEEHCCEEHCCCEEEEHCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCEEEEEEEEHCCEEEEHCCCHCCCCCCCCCCCHHHHEEEEHCCCCCCEEEEEEEHCCCCCCCCCCCEEEEEEEHCCEEEEHCCCCCCEEEEEHCCCEEEEEEEHCCEEEEEEEEHCCCCEEEEEHCCCCCCCEEEHCCCEEEEEEEEHCCCCEEEEEEEEHCCCCCCCCCCCCCCCCC
MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPLTRTGLWVHCETVAPTTGGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGVRMAPAELTGRTRSLAWELSWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLAVGETTHRVDSWRGSVAHIYGHGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPLAFVRFRIDGKDWPASPLPSLRMRTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGYTDPDGAKAVCTNTEQADIHIELGGRHWSVLGTGHAEVGLRGTAAPAIKEGTPA

2ichB

0.16

0.14

0.88

1.17

MUSTER

-----------LAPVVPGKALEFPQDFGAHNRIEWWYVTGWLTPTGKPLGFQITFFRTANPSHFAIAHVALSDPAIGKLQHD-GFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPASYYYSEPHLQVSGIINRQGEDIPVTG-TAWLDREWSSEYAAGWDWISANLDDGSALAFQIRGKDDSKIWAY--AALRTRLFTPDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPLDD------QELDSRASAGAVYWEGA-----VTFT-RDGQPAGRGYELTGYVR------------

2ichB

0.15

0.13

0.88

1.13

dPPAS

----LAPVVPGKALEFPQDFGAHNDFR-----IEWWYVTGWLTPTGKPLGFQITFFRTANPSHFAPAHVALSDPAIGKLQHDQGFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYYSPHLQVSGIINRQGEDIPVTG-TAWLDREWSSEYAAGWDWISANLDDGSALAFQIRGKD----DSKIWAYAALRDASGHTRLFTPFHPIRTWRSARTQPVATRVLTGETEWQITPLDDQELDSRASAGAVEGAVTFTRDGQPAGRGYELTGYVR--------------------------

2ichB

0.15

0.13

0.87

2.66

wdPPAS

----LAPVVPGKALEFPQDFGAHNDFR-----IEWWYVTGWLTPTGKPLGFQITFFRTANPSHFAPAHVALSDPAIGKLQHD-GFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPQSYYYSEPHLQVSGIINRQGEDIPVTG-TAWLDREWSSEYLDPWDWISANLDDGSALAFQIRGKDDSK----IWAYAALRDASGHTRLFTPWRSARTQAVY-PVATRVLTGETEWQITPLDDQELDSRASAGAVYWEGAVTFTRDGQPAGRGYELTGYVR--------------------------

2ichB

0.15

0.13

0.87

1.53

wMUSTER

-----APVVPGKALEFPQDFGAHNDFR-----IEWWYVTGWLTPTGKPLGFQITFFRTANPSHFAIAHVALSDPAIGKHDQKIGFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPASYYYSEPHLQVSGIINRQGEDIPVTG-TAWLDREWSSEYAAGWDWISANLDDGSALAFQIRGKDDSKI----WAYAALRDASGHTRLFTPWRSARTQAVYPV-ATRVLTG--ETEWQITPLDD----QELDSRASAG-AVYWEGA------VTFT-RDGQPAGRGYELTGYVR------------

2ichB

0.16

0.13

0.85

2.43

wPPAS

----LAPVVPGKALEFPQDFGAHNDFR-----IEWWYVTGW-TPTGKPLGFQITFFRTANPSHFAPAHVALSDPAIGKLQHD-GFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPQSYYYSEPHLQVSGIINRQGEDIPVTG-TAWLDREWSSEYAAGWDWISANLDDGSALAFQIRGKDDSK----IWAYAALRDASGHTRLFTPWRSARTQAVYPV-ATRVLTG--ETEWQITPLDDQEL-AGAVY---EGA-------------VTFTR-DGQPAGRGYELTGYVR------------

2ichB

0.14

0.13

0.88

2.38

dPPAS2

----LAPVVPGKALEFPQDFGAHNDFR-----IEWWYVTGWLTPTGKPLGFQITFFRTANPSHFAPAHVALSDPAIGKLQHDQGFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYYSPHLQVSGIINRQGEDIPVTG-TAWLDREWSSEYAAGWDWISANLDDGSALAFQIRGKD----DSKIWAYAALRDASGHTRLFTPFHPIRTWRSARTQPVATRVLTGETEWQITPLDDQELDSRAS-----AGAVYWE----GAVTFTRDG---QPAGRGYELTGYVR------------

2ichB

0.14

0.12

0.88

1.46

PPAS

----LAPVVPGKALEFPQDFGAHNDFR-----IEWWYVTGW-TPTGKPLGFQITFFRTANPSHFAPAHVALSDPAIGKLQHD-GFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYYSPHLQVSGIINRQGEDIPVTG-TAWLDREWSSEYAAGWDWISANLDDGSALAFQIRGKDDS----KIWAYAALRDASGHTRLFTP------VSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPLDDQE---LDSRASA-GAVTFTRD---GQPAGRGYELTGYVR------------

2ichB

0.14

0.13

0.90

2.48

Env-PPAS

----LAPVVPGKALEFPQDFGAHNDFR-----IEWWYVTGWLTPTGKPLGFQITFFRTANPSHFAPAHVALSDPAIGKLQHDQGFDLAYARTGNTDVKLDDWIFVRERTRIEAEDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYYSPHLQVSGIINRQGEDIPVT-GTAWLDREWSSEYAAGWDWISANLDDGSALAFQIRGKDDS----KIWAYAALRDASGHTRLFT----PDQVSFHPIRTWRSARTQAVYPVATRVLTGETEWQITPLDDQE---LDSRASAGAVYWVTFT-RDGQPAGRGYELTGYVR------------

4kh9A

0.10

0.09

0.98

0.84

MUSTER

-GFTLPQPTKAYECENLSRENLHDKWEITNNRSYGYKERISLEQRGVIISTLAAVVRITPLQNKSIPELLIKTPKNQLLPLKEASSLYNQDDEVGNNPLAITKHQALQIKPELGYGKFILKSKDITNKYADAY-ISVLDKFSITYLEVETDSLKATISLHNDITEYDVNDVDARLVGPKGQVIS---LNLTKL--KSNVFEGTATLDSELNDRGENWYLETDVQTEYGQEIIRRSGHTAFSYSIPSASLNVKKLSSKLTFVVTVDVATASRYALQSVFQKGEARPIQTSQKHVLQFTFDNLSDDNLYLGYLRLIDYGQLKTVYQYNQPV

5fzpA

0.10

0.93

0.99

dPPAS

DGATLAPTTGTLQSVSYTHGLVALDTPNT------LLATHNDTDAGCTWTKVATLGSGSTLTAATGGRAFAWEKNGGYLARVDGRTKLSSPSADIVGVGTDKARRDHVRLAGSDG---QLYDSTDAGATWKPLGKLAFGPGASVYTVSFDPADLDHAVAGGMTTGGAVTTDGGATGLSATAGGKSNLFAASVSPADRNVVYALGIDLVEAAPNSGAEGRHLYRSTGGRTYTRIVDDTPDTELTNSTLLAPSPVDPNVLYFEYGTYFQAYGTDLYRYDARTGKVGKTHNAHDGISAIAFNPARPSVMYLGLEEVQ---------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.27

Estimated TM-score = 0.56±0.15

Estimated RMSD = 9.3±4.6Å

Download Model 2

C-score=-2.95

Download Model 3

C-score=-3.73

Download Model 4

C-score=-3.45

Download Model 5

C-score=-1.65

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ichB	0.769	2.98	0.134	0.884
2	4y23A	0.405	6.19	0.055	0.653
3	4clfA	0.404	6.36	0.045	0.660
4	1qgc4	0.398	5.70	0.056	0.602
5	2yfrA	0.397	6.74	0.043	0.678
6	4jxoA	0.395	6.67	0.045	0.672
7	1t3qB	0.395	6.35	0.067	0.644
8	4uhwA	0.393	6.02	0.066	0.620
9	2sliA	0.390	6.73	0.051	0.663
10	3gvjA	0.389	6.18	0.056	0.620

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	4	1kn4L	PDE	Rep, Mult	123,154,156,168,170,172
2	0.05	4	3kdjB	MN	Rep, Mult	41,193,307
3	0.04	3	1q72H	COC	Rep, Mult	116,118,159,160,161,165
4	0.04	3	1yt3A	ZN	Rep, Mult	52,54,293
5	0.04	3	1mjjL	HAL	Rep, Mult	39,50,52,53,68,70
6	0.03	2	3ck0H	III	Rep, Mult	220,222,224,232,300
7	0.03	2	3ig8A	MG	Rep, Mult	34,177
8	0.01	1	1c9uB	CA	Rep, Mult	179
9	0.01	1	3n12A	ZN	Rep, Mult	3,34
10	0.01	1	1indH	EOT	Rep, Mult	39,50,52
11	0.01	1	3cfbL	SPB	Rep, Mult	190,204,218,220
12	0.01	1	1qygH	BCG	Rep, Mult	196,198,223,225,226,227
13	0.01	1	2epfA	ZN	Rep, Mult	191,248
14	0.01	1	2x27X	C8E	Rep, Mult	33,180
15	0.01	1	3q2vA	MN	Rep, Mult	286,290
16	0.01	1	1froA	ZN	Rep, Mult	248,297
17	0.01	1	3i8hK	MG	Rep, Mult	27,36
18	0.01	1	1iw7E	MG	Rep, Mult	34,37
19	0.01	1	2bq8X	ZN	Rep, Mult	34,42
20	0.01	1	2o011	CLA	Rep, Mult	195,196

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1bglA	0.362	6.89	0.054	0.647	3.2.1.23	201
2	0.060	2dgaA	0.366	7.01	0.061	0.660	3.2.1.21	54,55
3	0.060	3beqB	0.368	6.43	0.036	0.599	3.2.1.18	NA
4	0.060	2vk6A	0.380	6.89	0.042	0.656	3.2.1.18	197,228
5	0.060	2jf6B	0.370	6.96	0.060	0.653	3.2.1.105	NA
6	0.060	1simA	0.368	6.43	0.044	0.611	3.2.1.18	194
7	0.060	1dgjA	0.380	6.45	0.045	0.638	1.2.-.-	119
8	0.060	3eqoA	0.332	6.62	0.059	0.556	3.2.1.58	NA
9	0.060	1ncaN	0.365	6.36	0.028	0.599	3.2.1.18	NA
10	0.060	2e0wB	0.365	6.67	0.049	0.626	2.3.2.2	105
11	0.060	2htrA	0.369	6.47	0.050	0.602	3.2.1.18	68,99
12	0.060	1ingA	0.364	6.39	0.057	0.593	3.2.1.18	NA
13	0.060	1vcuB	0.374	6.69	0.073	0.629	3.2.1.18	201
14	0.060	3fimB	0.368	6.30	0.050	0.593	1.1.3.7	NA
15	0.060	2z8kD	0.239	5.86	0.054	0.374	2.3.2.2	NA
16	0.060	3gvjA	0.389	6.18	0.056	0.620	3.2.1.129	229,232
17	0.060	1sllA	0.389	6.69	0.051	0.656	4.2.2.15	NA
18	0.060	1yifA	0.368	6.27	0.055	0.602	3.2.1.37	190,198,232,255
19	0.060	1yq2A	0.375	6.86	0.045	0.653	3.2.1.23	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.17	0.769	2.98	0.13	0.88	2ichB
1	0.06	0.409	6.23	0.04	0.66	4oyzA	GO:0000166 GO:0000287 GO:0003351 GO:0004016 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0005856 GO:0005886 GO:0005929 GO:0006171 GO:0007283 GO:0009190 GO:0015630 GO:0016020 GO:0016829 GO:0016849 GO:0030145 GO:0030424 GO:0030425 GO:0030426 GO:0031514 GO:0035556 GO:0042995 GO:0043025 GO:0043065 GO:0045177 GO:0045178 GO:0046872 GO:0048471 GO:0051117 GO:0071241 GO:0071890
2	0.06	0.385	6.25	0.03	0.63	2nlzD	GO:0003840 GO:0006749
3	0.06	0.383	6.22	0.06	0.62	2i3oD	GO:0003840 GO:0006749 GO:0016740
4	0.06	0.365	6.67	0.05	0.63	2e0wB	GO:0003840 GO:0006508 GO:0006749 GO:0006750 GO:0008233 GO:0016740 GO:0016746 GO:0016787 GO:0036374 GO:0042597
5	0.06	0.315	6.37	0.03	0.53	3jcmB	GO:0000398 GO:0005634 GO:0005681 GO:0006397 GO:0008380 GO:0017070 GO:0030621 GO:0034247 GO:0046540
6	0.06	0.298	6.98	0.06	0.53	5e7qA	GO:0003824 GO:0008152
7	0.06	0.405	6.19	0.06	0.65	4y23A	GO:0003840 GO:0006749
8	0.06	0.276	6.81	0.04	0.49	3whqA	GO:0003840 GO:0005576 GO:0006508 GO:0006749 GO:0006750 GO:0008233 GO:0016740 GO:0016746 GO:0016787 GO:0036374
9	0.06	0.286	6.59	0.03	0.48	4lv8A	GO:0000166 GO:0004672 GO:0005524 GO:0006468
10	0.06	0.273	6.87	0.06	0.47	2dbuA	GO:0003840 GO:0006508 GO:0006749 GO:0006750 GO:0008233 GO:0016740 GO:0016746 GO:0016787 GO:0036374 GO:0042597
11	0.06	0.266	6.61	0.02	0.45	4z1iB	GO:0000166 GO:0005164 GO:0005524 GO:0005654 GO:0005739 GO:0005743 GO:0005758 GO:0005759 GO:0005811 GO:0006457 GO:0006950 GO:0009386 GO:0016020 GO:0019901 GO:0044822 GO:0051082 GO:0061077 GO:0070062 GO:1901856 GO:1902176 GO:1903427 GO:1903751
12	0.06	0.281	6.19	0.04	0.45	4knsA	GO:0005507 GO:0006807 GO:0046872 GO:0050421 GO:0055114
13	0.06	0.243	6.72	0.03	0.41	4gg2A	GO:0002682 GO:0003840 GO:0005615 GO:0005886 GO:0006508 GO:0006520 GO:0006536 GO:0006691 GO:0006749 GO:0006750 GO:0006751 GO:0006805 GO:0007283 GO:0008233 GO:0016020 GO:0016021 GO:0016740 GO:0016746 GO:0016787 GO:0019344 GO:0019370 GO:0031362 GO:0031638 GO:0036374 GO:0050727 GO:0070062
14	0.06	0.255	7.23	0.06	0.47	3q5zA	GO:0000166 GO:0004672 GO:0005524 GO:0006468
15	0.06	0.250	7.06	0.05	0.44	1qxoA	GO:0004107 GO:0008652 GO:0009073 GO:0009423 GO:0010181 GO:0016829
16	0.06	0.248	6.30	0.04	0.41	2dbuB	GO:0003840 GO:0006508 GO:0006749 GO:0006750 GO:0008233 GO:0016740 GO:0016746 GO:0016787 GO:0036374 GO:0042597
17	0.06	0.247	7.01	0.02	0.44	4yutA	GO:0005622 GO:0009190 GO:0009785 GO:0009882 GO:0016849 GO:0035556 GO:0071949
18	0.06	0.244	6.45	0.03	0.42	5a6cB	GO:0000132 GO:0000166 GO:0000922 GO:0001965 GO:0005092 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005938 GO:0007052 GO:0007155 GO:0007165 GO:0007186 GO:0007267 GO:0008022 GO:0017016 GO:0030054 GO:0030695 GO:0034332 GO:0042802 GO:0043547 GO:0045177 GO:0050790 GO:0051661 GO:0060487 GO:0090557 GO:0097431 GO:0098609 GO:0098641

Consensus prediction of GO terms

Molecular Function	GO:0016755
GO-Score	0.36
Biological Processes	GO:0006790	GO:0006575	GO:0006518
GO-Score	0.36	0.36	0.36
Cellular Component	GO:0030426	GO:0030424	GO:0045177	GO:0015630	GO:0045178	GO:0005829	GO:0005886	GO:0048471	GO:0043025	GO:0030425	GO:0005634	GO:0031514	GO:0005739	GO:0042597
GO-Score	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.