I-TASSER results

I-TASSER results for job id Rv0449c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (439 residues)
MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHAHTHYLDNGGGPRGTDV
VGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADDIGLEYAGALGARGLFACR
QSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLEAFLSRHHFSQYFVDYFITPL
VAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTWRTVTGGSANYVQAIAAQLDEVS
TRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQALLLLDEPTPAERAVLGAIAYS
TNSAQLHTDESVLPRHHRARASWNYLVTPGQHQVVVSYDISRLMRLDGGRRYLVTLGGHD
RVDPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVFAGAYHGWGFHEDGAASGLRAA
RRLGADWPAAIPQEAMVAC

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHAHTHYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADDIGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLEAFLSRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTWRTVTGGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQALLLLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQVVVSYDISRLMRLDGGRRYLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVFAGAYHGWGFHEDGAASGLRAARRLGADWPAAIPQEAMVAC
Prediction	CCCCCCCEEEEHCCCHHHHHHHHHHHHCCCEEEEHCCCCCCCEEEEEEHCCCCCCCCCCCEEEHCCEEEHCCCHHHHHHHHHHHHCCCCEEHCCCEEEEHCCCEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCCCHHHHHHHHHHHCCEEHCCCCEEEEEEHCCEEEEEHCCCCEEEHCEEEEHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEHCCCCCCCCCCCCCCCCHCCCCCCCCEEEEEHCCCCCCCCCCCCEEEHCCCCCCCCHHHEEEEEEEHCCCCCHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
Conf.Score	9988898699988989999999999978959999589988865689998688655688756874675776565678999999998999477566467997897565688888776556545478477889999999999999987655567666789999999998999999999999999997579999999868999999999877777788886688589869999999998885876886799999799899998999699968999958979999986999999999997887656669998578778876556666664467888976898746655678889868997899988894446899999757789999999999999699989997667898777799999999999989989988886555689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHAHTHYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADDIGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLEAFLSRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTWRTVTGGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQALLLLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQVVVSYDISRLMRLDGGRRYLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVFAGAYHGWGFHEDGAASGLRAARRLGADWPAAIPQEAMVAC
Prediction	6776442100000011000000110276130100122530313020130323202222201000000000121113201410440505333142000021464312122322130011223102020010011002024102400454453461341001100353421420020001000000100312100200000001002201003135212111033002200420173054020304444344422001010362331203312000104101400450254024003204113210000012103253441200001023445422111021220141446310000012454044520122120100111250130042045045300000000000000000020013004404151116246634468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEEEHCCCHHHHHHHHHHHHCCCEEEEHCCCCCCCEEEEEEHCCCCCCCCCCCEEEHCCEEEHCCCHHHHHHHHHHHHCCCCEEHCCCEEEEHCCCEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCCCHHHHHHHHHHHCCEEHCCCCEEEEEEHCCEEEEEHCCCCEEEHCEEEEHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEHCCCCCCCCCCCCCCCCHCCCCCCCCEEEEEHCCCCCCCCCCCCEEEHCCCCCCCCHHHEEEEEEEHCCCCCHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHAHTHYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADDIGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLEAFLSRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTWRTVTGGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHPDQALLLLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQVVVSYDISRLMRLDGGRRYLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTLGDNRVVFAGAYHGWGFHEDGAASGLRAARRLGADWPAAIPQEAMVAC

3lovA

0.17

0.15

0.91

1.95

MUSTER

---GSSKRLVIVGGGITGLAAAYYAERAFNITLLEAGERLGGKVATYREDG---------FTIERGPDSYVAR-KHILTDLIEAIGLKLVRNNTSQAFILDTGGLHPIPKGAVGIPTDLDLFRQTTLLT-----EEEKQEVADLLLHPSDSLRIQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSLRLRPTGQFLSLETGLESLIERLEEVLSEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHST--ATVTIFDQQQSLPIEGTG---FVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAFVGGRTLEPKQVIISRLDGLPAYTADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTIESIELEQ-------------

3lovA

0.16

0.15

0.91

2.58

dPPAS

---GSSKRLVIVGGGITGLAAAYYAERAFPITLLEAGERLGGKVATYREDGFT---------IERGPDSYVAR-KHILTDLIEAIGLGEVRNNTSQAFILDTGGLHPIPKGAVGIPTDQTTLLTEEEKQEVADLLLHPS--------DSLRIPEQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSGRLRPTGQFLSLETGLESLIERLEEVLEEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHST--ATVTIFDQQQSLPIEGTG---FVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAFVGGRTLEPKQVIISRLDGLPAYTADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTIESIELEQ-------------

3lovA

0.17

0.15

0.91

3.39

wdPPAS

---GSSKRLVIVGGGITGLAAAYYAERALNITLLEAGERLGGKVATYREDGFT---------IERGPDSYVAR-KHILTDLIEAIGLGLVRNNTSQAFILDTGGLHPIPKG-AVGIPTDLDLFRQTTLLTEEEKQEVADLLLH---SDSLRIPEQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSLRLRPTGQFLSLETGLESLIERLEEVLEEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHST--ATVTIFDQQQSLPIEGT---GFVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAF--GRTLEPKQVIISRLDGLPAYTADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTIESIELEQ-------------

3lovA

0.17

0.15

0.91

2.58

wMUSTER

----SSKRLVIVGGGITGLAAAYYAERALNITLLEAGERLGGKVATYREDG---------FTIERGPDSYVAR-KHILTDLIEAIGLGLVRNNTSQAFILDTGGLHPIPKGA-VGIPTDLDLFRQTTLLTEEEKQEVADLLLHP--SDSLRIPEQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSLRLRPTGQFLSLETGLESLIERLEEVLSEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHSTA--TVTIFDQQQSLPIEG---TGFVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAFVGGRTLEPKQVIISRLDGLPAYTVGHADRIQRVREE-YPGIYLAGLAYGVGL-PDCVASAKTIESIELEQ-------------

3lovA

0.16

0.15

0.91

3.72

wPPAS

---GSSKRLVIVGGGITGLAAAYYAERALNITLLEAGERLGGKVATYREDG---------FTIERGPDSYVA-RKHILTDLIEAIGLGLVRNNTSQAFILDTGGLHPIPKGAV-GIPTDLDLFRQTTLLTEEEKQEVADLLLH---SDSLRIPEQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSLRLRPTGQFLSLETGLESLIERLEEVLSEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHST--ATVTIFDQQQSLPIEG---TGFVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAF--GRTLEPKQVIISRLDGLPAYTADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTIESIELEQ-------------

3lovA

0.17

0.15

0.91

4.58

dPPAS2

---GSSKRLVIVGGGITGLAAAYYAERAFPITLLEAGERLGGKVATYREDGFT---------IERGPDSYVAR-KHILTDLIEAIGLGEVRNNTSQAFILDTGGLHPIPKGAVGIPTDQTTLLTEEEKQEVADLLLHPS--------DSLRIPEQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSLRLRPTGQFLSLETGLESLIERLEEVLEEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHST--ATVTIFDQQQSLPIEGTG---FVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAFVGGRTLEPKQVIISRLDGLPAYTADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTIESIELEQ-------------

3lovA

0.17

0.15

0.91

3.43

PPAS

---GSSKRLVIVGGGITGLAAAYYAERAFNITLLEAGERLGGKVATYREDGFT---------IERGPDSYVAR-KHILTDLIEAIGLGEVRNNTSQAFILDTGGLHPIPKGAVGIPTDQTTLLTEEEKQEVADLLLHPS--------DSLRIPEQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSLRLRPTGQFLSLETGLESLIERLEEVLSEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHST--ATVTIFDQQQSLPIEG---TGFVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAFVGGRTLEPKQVIISRLDGLPAYTADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTIESIELEQ-------------

3lovA

0.17

0.15

0.91

3.80

Env-PPAS

---GSSKRLVIVGGGITGLAAAYYAERAFNITLLEAGERLGGKVATYREDG---------FTIERGPDSYVAR-KHILTDLIEAIGLGLVRNNTSQAFILDTGGLHPIPKGAVGDLFRQTTLLTEEEKQEVADLLLHPS--------DSLRIPEQDIPLGEYLRPR-LGDALVEKLIEPLLSGIYAGNIDQSTFATYPQFVANEQKAGSLRLRPTGQFLSLETGLESLIERLEEVLSEIRLETPLLAISREDGRYRLKTDHG-PEYADYVLLTIPHPQVVQLLPDAHLPELEQLTTHST--ATVTIFDQQQSLPIEGTG---FVVNRRAPYSITACTAIDQKWNHSAPDHTVLRAFVGGRTLEPKQVIISRLDGLPAYTADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTIESIELEQ-------------

2b9xA

0.16

0.15

0.91

1.81

MUSTER

ISKD--SRIAIIGAGPAGLAAGMYLEQAGDYTILERTDHVGGKCHSPNYHG---------RRYEMGAIMGVPS-YDTIQEIMDRTGDKVDGPKLRREFLHEDGEIYVPEKDPVRGPQVM------AAVQKLGQLLATKYQGYDANGHYNKVHEDLMLPFDEFLALNGC-EAARDLWINPFTAFGYGH----FDNVPAAYVLKYLDFVTMMSFAKG-DLWTWADGTQAMFEHLNATLEPAERNVDITRITREDGKVHIHTTDW-DRESDVLVLTVPLEKFLDYSD-ADDDEREYFSKIIHQQYMVDACLVKNMRPERLGHVMVYYHRWADDPHQIITTYLLRNHPDYADKTQVLDDMETFGHPVEKIIEEQTWYYFPHVSDYKAGWYEKVEGMGRRNTFYAGEIMSFGNFDEVCHYSKDLVTRFFV--------------

3i6dB

0.15

0.13

0.86

2.31

dPPAS

-----KKHVVIIGGGITGLAAAFYMEKELELTLVEASPRVGGKIQTVKKDG---------YIIERGPDSFLER-KKSAPQLVKDLGLEHLLVNNA-----TGQSYVLVNRTLHPMPKGSG------------------KARAAMDFILPASKTKDDQSLGEFFRRR-VGDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFY----------QTQGQFQTLSTGLQTLVEEIEKQLKKVYKGTKVTKLSHSGSCYSLELDNGVTLDADSVIVTAPHKAAAGMLSELP--AISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVISRNSDFAITACTWTNKKWPHAAPEGKTLLRAMNINGEPEMTCVTRWHESMPQYHKQRIKELREALASAYPGVYMTGASFEGVGIPDCIDQGKAAVSDALTYLFS----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.11

Estimated TM-score = 0.70±0.12

Estimated RMSD = 7.3±4.2Å

Download Model 2

C-score=-0.43

Download Model 3

C-score=-2.66

Download Model 4

C-score=-2.74

Download Model 5

C-score=-2.62

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3lovA	0.855	2.09	0.140	0.911
2	2iveA	0.815	2.64	0.188	0.895
3	3nksA	0.813	2.79	0.183	0.897
4	3i6dB	0.795	2.57	0.154	0.854
5	1sezA	0.790	2.83	0.181	0.877
6	4dsgA	0.767	3.67	0.146	0.904
7	3x0vA	0.762	3.87	0.123	0.895
8	3uteA	0.760	3.71	0.129	0.902
9	2yr4A	0.760	3.94	0.126	0.909
10	4iv9A	0.758	4.00	0.120	0.904

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.63	156	4gdpC	FAD	Rep, Mult	12,13,15,16,17,34,35,36,37,41,42,43,44,66,67,68,69,71,243,245,273,274,275,371,374,401,402,407,408,409,412
2	0.00	1	3i6dA	PO4	Rep, Mult	271,398,399,422,423
3	0.00	1	3i6dB	ACJ	Rep, Mult	75,184,375,407
4	0.00	1	5g3tA	MG	Rep, Mult	13,15,17,18,273
5	0.00	1	3ngcX	GP7	Rep, Mult	110,117,131,176,177,197,209,210,213
6	0.00	1	3nrnA	AMP	Rep, Mult	13,15,34,35,36,42,43,243,245,273,274

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.212	1ng4B	0.520	4.37	0.120	0.633	1.4.3.19	13,15,35,38,42,66,376
2	0.208	3cn8B	0.699	3.92	0.160	0.834	1.5.3.17	13,36,42,274,413
3	0.165	3i6dB	0.795	2.57	0.154	0.854	1.3.3.4	248
4	0.127	1reoA	0.756	3.54	0.166	0.870	1.4.3.2	NA
5	0.108	1o5wC	0.746	3.58	0.159	0.868	1.4.3.4	NA
6	0.107	3he3A	0.636	4.18	0.119	0.774	5.4.99.9	NA
7	0.105	2z5xA	0.749	3.56	0.148	0.868	1.4.3.4	13
8	0.101	2bi8A	0.632	4.30	0.085	0.786	5.4.99.9	12
9	0.083	3bi2B	0.698	3.93	0.160	0.834	1.5.3.11	NA
10	0.070	2jaeA	0.664	4.19	0.149	0.793	1.4.3.2	NA
11	0.066	1ng3A	0.519	4.30	0.120	0.631	1.4.3.19,1.5.3.-	NA
12	0.066	1aa8B	0.484	4.79	0.105	0.611	1.4.3.3	13,15
13	0.066	1zovA	0.515	4.66	0.129	0.645	1.5.3.1	407
14	0.066	2du8A	0.484	4.83	0.112	0.615	1.4.3.3	NA
15	0.066	2uzzB	0.498	4.74	0.125	0.633	1.5.3.-	NA
16	0.060	2jb2A	0.664	4.21	0.146	0.795	1.4.3.2	13,36,39,42
17	0.060	1rsgA	0.688	4.11	0.154	0.829	1.5.3.11	NA
18	0.060	1qlaD	0.509	5.04	0.102	0.656	1.3.99.1	13,15,17,66,231
19	0.060	1oj9A	0.749	3.62	0.155	0.870	1.4.3.4	NA
20	0.060	1v0jA	0.636	4.48	0.145	0.795	5.4.99.9	NA
21	0.060	1x31B	0.513	4.76	0.107	0.649	1.5.3.1	259
22	0.060	1i8tA	0.626	4.28	0.105	0.774	5.4.99.9	44
23	0.060	1y56B	0.516	4.25	0.103	0.631	1.5.99.8	405
24	0.060	2gmjA	0.550	4.21	0.140	0.667	1.5.5.1	NA
25	0.060	2iveA	0.815	2.64	0.188	0.895	1.3.3.4	NA
26	0.060	2bi7A	0.631	4.23	0.085	0.781	5.4.99.9	NA
27	0.060	3lovA	0.855	2.09	0.140	0.911	1.3.3.4	13,36,40
28	0.060	1b37B	0.702	3.98	0.131	0.841	1.5.3.15,1.5.3.14	NA
29	0.060	1d7lA	0.513	4.48	0.122	0.647	1.14.13.2	NA
30	0.060	2iw5A	0.698	4.32	0.142	0.859	1.-.-.-	NA
31	0.060	1vrqB	0.513	4.78	0.123	0.651	1.5.3.1	NA
32	0.060	2dkiA	0.552	4.14	0.118	0.676	1.14.13.23	NA
33	0.060	1e7pA	0.516	5.10	0.092	0.667	1.3.99.1	387
34	0.060	2vvmA	0.705	3.68	0.125	0.829	1.4.3.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.868	2.10	0.14	0.92	3lovA	GO:0000166 GO:0004729 GO:0006779 GO:0016491 GO:0055114
1	0.34	0.815	2.64	0.19	0.90	2iveA	GO:0004729 GO:0005737 GO:0006779 GO:0006782 GO:0006783 GO:0016020 GO:0016491 GO:0055114
2	0.34	0.813	2.79	0.18	0.90	3nksA	GO:0004729 GO:0005739 GO:0005743 GO:0005758 GO:0006779 GO:0006782 GO:0006783 GO:0016020 GO:0016491 GO:0031304 GO:0031305 GO:0031966 GO:0042493 GO:0046501 GO:0050660 GO:0055114
3	0.32	0.795	2.57	0.15	0.85	3i6dB	GO:0004729 GO:0005737 GO:0006779 GO:0006782 GO:0016491 GO:0055114
4	0.31	0.804	2.80	0.17	0.89	1sezA	GO:0004729 GO:0005739 GO:0006779 GO:0006782 GO:0006783 GO:0016491 GO:0055114
5	0.29	0.749	3.61	0.15	0.87	4a79A	GO:0005739 GO:0005740 GO:0005741 GO:0005743 GO:0008131 GO:0009055 GO:0009636 GO:0010044 GO:0010269 GO:0014063 GO:0016020 GO:0016021 GO:0016491 GO:0021762 GO:0032496 GO:0042420 GO:0042493 GO:0042803 GO:0045471 GO:0045964 GO:0048545 GO:0050660 GO:0050665 GO:0051412 GO:0055114 GO:0070062
6	0.27	0.716	3.90	0.15	0.85	3rhaA	GO:0016491 GO:0050232 GO:0055114
7	0.27	0.757	3.54	0.16	0.87	3kveA	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0044179 GO:0046872 GO:0055114
8	0.27	0.756	3.54	0.17	0.87	1reoA	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0044179 GO:0055114
9	0.26	0.711	3.84	0.16	0.84	2yg3B	GO:0000166 GO:0016491 GO:0055114
10	0.25	0.749	3.53	0.13	0.86	4e0vB	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0044179 GO:0055114
11	0.25	0.758	4.00	0.12	0.90	4iv9A	GO:0004497 GO:0009851 GO:0016491 GO:0050361 GO:0055114
12	0.25	0.754	3.56	0.15	0.87	1f8rA	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0055114
13	0.23	0.700	4.28	0.15	0.86	2x0lA	GO:0000122 GO:0000784 GO:0000790 GO:0001085 GO:0001701 GO:0002039 GO:0003677 GO:0003682 GO:0003700 GO:0004407 GO:0005634 GO:0005654 GO:0005667 GO:0006351 GO:0006355 GO:0006357 GO:0006482 GO:0007275 GO:0007596 GO:0008134 GO:0008283 GO:0010569 GO:0010725 GO:0016491 GO:0016568 GO:0016575 GO:0019899 GO:0021983 GO:0030374 GO:0030851 GO:0032091 GO:0032451 GO:0032452 GO:0032453 GO:0032454 GO:0033169 GO:0033184 GO:0034644 GO:0034648 GO:0034720 GO:0042162 GO:0043234 GO:0043392 GO:0043426 GO:0043433 GO:0043518 GO:0044212 GO:0045648 GO:0045654 GO:0045892 GO:0045944 GO:0046886 GO:0050660 GO:0050681 GO:0051091 GO:0051572 GO:0051573 GO:0055001 GO:0055114 GO:0061752 GO:0071480 GO:1902166 GO:1903827 GO:1990391 GO:2000179 GO:2000648
14	0.23	0.691	4.39	0.15	0.85	2dw4A	GO:0000122 GO:0000784 GO:0000790 GO:0001085 GO:0001701 GO:0002039 GO:0003677 GO:0003682 GO:0003700 GO:0004407 GO:0005634 GO:0005654 GO:0005667 GO:0006351 GO:0006355 GO:0006357 GO:0006482 GO:0007275 GO:0007596 GO:0008134 GO:0008283 GO:0010569 GO:0010725 GO:0016491 GO:0016568 GO:0016575 GO:0019899 GO:0021983 GO:0030374 GO:0030851 GO:0032091 GO:0032451 GO:0032452 GO:0032453 GO:0032454 GO:0033169 GO:0033184 GO:0034644 GO:0034648 GO:0034720 GO:0042162 GO:0043234 GO:0043392 GO:0043426 GO:0043433 GO:0043518 GO:0044212 GO:0045648 GO:0045654 GO:0045892 GO:0045944 GO:0046886 GO:0050660 GO:0050681 GO:0051091 GO:0051572 GO:0051573 GO:0055001 GO:0055114 GO:0061752 GO:0071480 GO:1902166 GO:1903827 GO:1990391 GO:2000179 GO:2000648
15	0.23	0.725	3.97	0.12	0.87	4uirA	GO:0005504 GO:0006629 GO:0006631 GO:0009636 GO:0016491 GO:0016829 GO:0050151 GO:0055114 GO:0070542 GO:0071949
16	0.23	0.706	4.01	0.13	0.85	3kpfA	GO:0016491 GO:0052893 GO:0052896 GO:0052897 GO:0052898 GO:0052900 GO:0055114
17	0.22	0.690	3.97	0.14	0.82	2b9wA	GO:0000166 GO:0016491 GO:0055114
18	0.16	0.576	3.23	0.14	0.67	3qj4A	GO:0002931 GO:0005576 GO:0005615 GO:0016491 GO:0055114 GO:0071869 GO:0071871 GO:1902074
19	0.14	0.746	3.58	0.16	0.87	1o5wC	GO:0005739 GO:0005741 GO:0006584 GO:0008131 GO:0016020 GO:0016021 GO:0016491 GO:0042135 GO:0042424 GO:0042428 GO:0042443 GO:0050660 GO:0051378 GO:0055114
20	0.11	0.705	3.68	0.12	0.83	2vvmA	GO:0005777 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0004729	GO:0050660
GO-Score	0.87	0.34
Biological Processes	GO:0055114	GO:0006782	GO:0042493
GO-Score	0.87	0.80	0.34
Cellular Component	GO:0031305	GO:0005758
GO-Score	0.34	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.