I-TASSER results

I-TASSER results for job id Rv0433

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (376 residues)
MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVIAEIGENPRVHKELLRN
TVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGTHPFARWSAQKLTDAPRYA
ELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNYYPHLLALSASSPWWGGEDTG
YASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSPHLGTLE
VRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWHVQENKWRAARYGLDAV
IILDADSNERLVTDDLADVLTRLEPVAKSLNCADELAAVSDIYRDGASYQRQLRVAQQHD
GDLRAVVDALVAELVI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVIAEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNYYPHLLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCADELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI
Prediction	CCCCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEHCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHCEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
Conf.Score	9865567778888999874456545665379999877767999998489997787578977999878889999999999999999999999989989985779999975578997599999999987677764446889996689999999999999999999999885787648867775458999998688889985559989999999999987987888866555456788997788758999999999999999999999999977658888878999999999999875877779867998467699999999999999999879867999999999989879999999999899999999999999859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVIAEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNYYPHLLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCADELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI
Prediction	5635434350405624311000000000003612512520340054047644033103410000112115103301410350052025104624010000000002427535124450042016304430310000000000115323200300200011000000000000112134010100013004201100001102214202400331140000223420100000232131000000000120310000000000001101432545440352221002101210022013020022452110001300330052025106614034004202400653330210001036572103300220051027
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEHCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHCEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVIAEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNYYPHLLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCADELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI

1r8gB

0.27

0.24

0.92

2.45

MUSTER

LP--------DFHVSEPFTLGIELE-QVVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATDH-HLEICGGGTHPFQKWQQ----------RTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYQ-GTDTRFASSRPNIFSAFPDNGPPW-VSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRV-DTPLT-LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL-RDFVADGGSLIGLVKKHCEIWA-

1r8gB

0.26

0.24

0.93

3.66

dPPAS

-------PLPDFHVSEPFTLGIELEQ-VVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATDH-HLEICGGGTHPFQKWQQ----------RTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYQ-GTDTRFASSRPNIFSAFPDNGPP-WVSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRVDTPLT--LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL-RDFVADGGSLIGLVKKHCEIWA-

1r8gB

0.26

0.24

0.92

5.09

wdPPAS

-------PLPDFHVSEPFTLGIELEQ-VVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATD--HLEICGGGTHPFQKWQQ----------RTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPY-QGTDTRFASSRPNIFSAFPDNGPP-WVSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRVDTPLT--LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLRDFVADG-GSLIGLVKKHCEIWA-

1r8gB

0.26

0.24

0.92

3.13

wMUSTER

LP--------DFHVSEPFTLGIELEQ-VVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATDH-HLEICGGGTHPFQKWQQ----------RTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPY-QGTDTRFASSRPNIFSAFPDNGPPW-VSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRVDTPLT--LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL-RDFVADGGSLIGLVKKHCEIWA-

1r8gB

0.26

0.24

0.92

5.09

wPPAS

LP--------DFHVSEPFTLGIELEQ-VVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATD--HLEICGGGTHPFQKW----------QQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYQ-GTDTRFASSRPNIFSAFPDNGPPW-VSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRVDTPLT--LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLRDFVADG-GSLIGLVKKHCEIWA-

1r8gB

0.26

0.24

0.93

14.04

dPPAS2

-------PLPDFHVSEPFTLGIELEQ-VVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATDH-HLEICGGGTHPFQKWQQ----------RTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYQ-GTDTRFASSRPNIFSAFPDNGPP-WVSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRVDTPLT--LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQL-RDFVADGGSLIGLVKKHCEIWA-

1r8gB

0.26

0.24

0.92

4.13

PPAS

-------PLPDFHVSEPFTLGIELEQ-VVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATD--HLEICGGGTHPFQKW----------QQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYQ-GTDTRFASSRPNIFSAFPDNGPP-WVSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRVDTPLT--LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLRDFVADG-GSLIGLVKKHCEIWA-

1r8gB

0.26

0.24

0.92

7.31

Env-PPAS

LP--------DFHVSEPFTLGIELEQ-VVNPPGYDLSQDSSLIDAVKNKITAGEVKHITESLELATDVCRDINQAAGQFSAQKVVLQAATDH-HLEICGGGTHPFQKW----------QQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYQ-GTDTRFASSRPNIFSAFPDNGPPW-VSNWQQFEALFRCLSY-TTIDSIKDLHWDIRPSPHFGTVEVRVDTPLT--LSHAVNAGLIQATAHWLLTER--PFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLRDFVADG-GSLIGLVKKHCEIWA-

2gwcF

0.20

0.18

0.94

1.57

MUSTER

LTREDLIAYLA-KSKEKWRIGTEHEKFGFEVNTLRPYDQIAELLNSIAGKQSISLE-PGGQFELSGAPLETLHQTCAEVNSHLYQVKAVAEE-GIGFLG-GFQPKWRREDIP-TPKGRYDIRNPKVGSLGLDLRTCTVQVNLDFSSEAD-IRKFRAGLALQPIATALFANSPFTEGKPNGFLS-RSHIWTDTDRTGLPFVFDDSFGFEQYVDYALDVPYFNHLTTIFPEVRLKR-----YERGADGGP-WRRLCALPAFWVGLLYDEDVLQSVLDLTADWT-PAERELRNKVPVTGLKTPFRD------GLLKHVAEDVLKLAKDGLERRGEVGFLNAVTEVVRTGTPAENLLEYNGEWGQSVDPVFQELLY----

2gwcF

0.19

0.18

0.93

1.88

dPPAS

LASGCKSK-------EKWRIGTEHEKFGFEVNTLRPKYDIAELLNSIAGKQSISLE-PGGQFELSGAPLETLHQTCAEVNSHLYQVKAVAEE--GIGFLGGFQPKWRREDI-PTPKGRYDIRNPKVGSLGLDLRTCTVQVNLDFSSEAD-IRKFRAGLALQPIATALFANSPFTEGKPNGFLS-RSHIWTDTDRTGLPFVFDDSFGFEQYVDYALDVPYFAGKLPCLPGELPTEVRLKRYERGADGGP-WRRLCALPAFWVGLLYDEDVLQSVLDLTADWT-PAERELRNKVPVTGLKTPFRD------GLLKHVAEDVLKLAKDGLERRGEVGFLNAVTEVVRTGTPAENLLEYNGEWGQSVDPVFQELLY----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.54

Estimated TM-score = 0.93±0.06

Estimated RMSD = 3.5±2.4Å

Download Model 2

C-score=-3.92

Download Model 3

C-score=-5.00

Download Model 4

C-score=-0.93

Download Model 5

C-score=-1.17

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1r8gB	0.909	0.96	0.264	0.925
2	3ig5A	0.882	2.82	0.110	0.995
3	2gwcF	0.826	3.05	0.184	0.939
4	2d33A	0.782	3.35	0.123	0.925
5	3nztA	0.781	3.37	0.118	0.925
6	3ln6A	0.749	3.60	0.142	0.896
7	3ln7A	0.748	3.37	0.123	0.880
8	4b0rA1	0.667	3.53	0.120	0.798
9	4b0tA	0.598	3.72	0.095	0.729
10	3o6xA	0.576	4.42	0.099	0.731

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.66	42	1lgrA	MN	Rep, Mult	23,139,231,240,242
2	0.14	17	2d32A	GLU	Rep, Mult	25,135,136,137,139,185,242
3	0.05	8	2d32A	ANP	Rep, Mult	19,21,22,23,63,65,66,67,68,139,141,142,143,233,237,238,240
4	0.04	5	2gwcD	BSC	Rep, Mult	25,59,122,135,136,137,185,189,227,242
5	0.04	5	2d33B	AF3	Rep, Mult	23,63,139,242
6	0.02	2	3o6xB	MG	Rep, Mult	25,56,57,63

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.102	2d33A	0.782	3.35	0.123	0.925	6.3.2.2	25
2	0.060	3b9jC	0.323	7.13	0.033	0.553	1.17.3.2,1.17.1.4	NA
3	0.060	1kyaA	0.378	6.59	0.061	0.612	1.10.3.2	NA
4	0.060	2gwdA	0.852	2.92	0.180	0.960	6.3.2.2	21,23,66
5	0.060	2epoA	0.381	6.49	0.050	0.620	3.2.1.52	NA
6	0.060	3cuzA	0.375	7.03	0.033	0.636	2.3.3.9	NA
7	0.060	2hrgA	0.375	6.55	0.045	0.612	1.10.3.2	NA
8	0.060	2ow6A	0.377	6.87	0.036	0.638	3.2.1.114	NA
9	0.060	2h5uA	0.375	6.47	0.084	0.604	1.10.3.2	NA
10	0.060	1jqnA	0.382	6.66	0.053	0.625	4.1.1.31	NA
11	0.060	3ig5A	0.882	2.82	0.110	0.995	6.3.2.2	289
12	0.060	1lrwC	0.371	6.78	0.033	0.617	1.1.99.8	NA
13	0.060	3nztA	0.781	3.37	0.118	0.925	6.3.2.2	NA
14	0.060	1a65A	0.374	6.70	0.056	0.617	1.10.3.2	NA
15	0.060	1v10A	0.370	6.52	0.069	0.604	1.10.3.2	NA
16	0.060	1gycA	0.375	6.49	0.072	0.604	1.10.3.2	NA
17	0.060	3ebgA	0.377	6.48	0.041	0.601	3.4.11.-	343
18	0.060	2uu7A	0.460	3.70	0.118	0.545	6.3.1.2	NA
19	0.060	3fkyC	0.460	2.91	0.136	0.524	6.3.1.2	NA
20	0.060	1lrwA	0.372	6.80	0.041	0.617	1.1.99.8	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.59	0.899	1.39	0.26	0.93	1tt4A	GO:0000166 GO:0004357 GO:0005524 GO:0016874 GO:0016879 GO:0042398
1	0.47	0.923	1.11	0.26	0.94	1r8gB	GO:0000166 GO:0004357 GO:0005524 GO:0016874 GO:0016879 GO:0042398
2	0.38	0.782	3.36	0.12	0.93	2d32A	GO:0000166 GO:0004357 GO:0005524 GO:0005829 GO:0006750 GO:0006972 GO:0016874 GO:0046872 GO:0071243 GO:0071288
3	0.32	0.758	3.43	0.11	0.90	3ln7A	GO:0000166 GO:0000287 GO:0003824 GO:0004357 GO:0004363 GO:0005524 GO:0006750 GO:0008152 GO:0016874 GO:0030145 GO:0046872
4	0.30	0.883	2.80	0.11	0.99	3ig8A	GO:0000166 GO:0004357 GO:0005524 GO:0005622 GO:0005737 GO:0006750 GO:0016874 GO:0017109 GO:0042542 GO:0046686
5	0.30	0.826	3.05	0.18	0.94	2gwcF	GO:0000166 GO:0004357 GO:0005524 GO:0006750 GO:0009507 GO:0009536 GO:0016874 GO:0042398
6	0.24	0.781	3.37	0.12	0.93	3nztA	GO:0000166 GO:0004357 GO:0005524 GO:0006750 GO:0016874
7	0.19	0.559	4.12	0.12	0.69	4hppA	GO:0003824 GO:0004356 GO:0006542 GO:0006807 GO:0046872
8	0.13	0.749	3.60	0.14	0.90	3ln6A	GO:0000166 GO:0000287 GO:0003824 GO:0004357 GO:0004363 GO:0005524 GO:0006750 GO:0008152 GO:0016874 GO:0030145 GO:0046872
9	0.06	0.324	6.72	0.06	0.53	3pukA	GO:0005737 GO:0005829 GO:0005886 GO:0006810 GO:0006887 GO:0006904 GO:0007420 GO:0015031 GO:0015758 GO:0016020 GO:0016192 GO:0016323 GO:0016324 GO:0017075 GO:0019905 GO:0022615 GO:0030073 GO:0031091 GO:0032868 GO:0042581 GO:0043312 GO:0045955 GO:0051291 GO:0061024 GO:0070062 GO:0070527 GO:0070820
10	0.06	0.281	7.11	0.05	0.48	3lmmD	GO:0005524
11	0.06	0.244	6.74	0.05	0.41	4recA	GO:0000287 GO:0000724 GO:0003677 GO:0004518 GO:0004519 GO:0004527 GO:0004528 GO:0005634 GO:0005654 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008409 GO:0016787 GO:0016788 GO:0017108 GO:0033683 GO:0036297 GO:0043130 GO:0045171 GO:0046872 GO:0070336
12	0.06	0.276	7.41	0.03	0.49	3uowB	GO:0003921 GO:0003922 GO:0005524 GO:0005829 GO:0006164 GO:0006177 GO:0016462 GO:0016874
13	0.06	0.307	6.64	0.05	0.50	4xviA	GO:0000724 GO:0003676 GO:0003677 GO:0003887 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0006260 GO:0006261 GO:0006281 GO:0006974 GO:0008409 GO:0016740 GO:0016779 GO:0019985 GO:0030332 GO:0036297 GO:0090305
14	0.06	0.264	6.70	0.06	0.43	4p7aA	GO:0000289 GO:0000712 GO:0000793 GO:0000794 GO:0000795 GO:0001673 GO:0002204 GO:0003682 GO:0003697 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0005712 GO:0006281 GO:0006298 GO:0006303 GO:0006974 GO:0007049 GO:0007060 GO:0007126 GO:0007129 GO:0007131 GO:0007140 GO:0007283 GO:0008630 GO:0016020 GO:0016321 GO:0016446 GO:0016447 GO:0016887 GO:0030983 GO:0032137 GO:0032389 GO:0032407 GO:0043060 GO:0045132 GO:0045141 GO:0045143 GO:0045190 GO:0045950 GO:0048477 GO:0051257
15	0.06	0.282	6.98	0.03	0.48	4uoxC	GO:0003824 GO:0003992 GO:0005829 GO:0006526 GO:0008483 GO:0009447 GO:0016740 GO:0030170 GO:0033094 GO:0042802
16	0.06	0.267	7.04	0.04	0.46	4rebA	GO:0000287 GO:0000724 GO:0003677 GO:0004518 GO:0004519 GO:0004527 GO:0004528 GO:0005634 GO:0005654 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008409 GO:0016787 GO:0016788 GO:0017108 GO:0033683 GO:0036297 GO:0043130 GO:0045171 GO:0046872 GO:0070336
17	0.06	0.260	5.46	0.05	0.38	3iccA	GO:0000166 GO:0016491 GO:0055114
18	0.06	0.273	7.31	0.07	0.48	4ribB	GO:0000287 GO:0000724 GO:0003677 GO:0004518 GO:0004519 GO:0004527 GO:0004528 GO:0005634 GO:0005654 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008409 GO:0016787 GO:0016788 GO:0017108 GO:0033683 GO:0036297 GO:0043130 GO:0045171 GO:0046872 GO:0070336
19	0.06	0.235	5.32	0.05	0.34	3g7rB	GO:0003677 GO:0003700 GO:0006351 GO:0006355

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0004357	GO:0030145	GO:0000287	GO:0004363
GO-Score	0.94	0.94	0.32	0.32	0.32
Biological Processes	GO:0006750	GO:0071288	GO:0071243	GO:0006972	GO:0046686	GO:0042542
GO-Score	0.70	0.38	0.38	0.38	0.30	0.30
Cellular Component	GO:0005829	GO:0017109
GO-Score	0.38	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.