I-TASSER results

I-TASSER results for job id Rv0412c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (439 residues)
MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLAALGVASAFATSTTIEH
RQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPGGVRLRYEQAITDASVA
VTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRAGNPVGSSYLSEASGLMQSTI
LPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVVFGAFAHRWLARRTRRRINPGLV
VGALGILVMVVWVGTALTISTTASRSAKDTAAESLKTITNLAITAQQARADETLSLIRRG
DEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPDLQGADQLLVRWRQANDRINSDISVGN
YRAATQVALGKGEDDATPAFDKLDEALTKAMGQSRTQLRHDILNAHRGLAGAQVGGVVLS
LGAAIAVALGLWPRLKEYR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLAALGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPGGVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRAGNPVGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVVFGAFAHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLKTITNLAITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPDLQGADQLLVRWRQANDRINSDISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMGQSRTQLRHDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR
Prediction	CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	9888899988888888765445678888758985999999999999999999999999999999999999875999999999999999999999864478999999999999999999999999977999899999999999858999999999987667886799999999999999999999999999999999999885687499999999999999999999999988865789999999999999999999999987667777777899999999999999999996999988588866899999999999999998765667889789999999999999999999999997999999999856899885799999999999999999999999999998876568899999999999999999899989869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLAALGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPGGVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRAGNPVGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVVFGAFAHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLKTITNLAITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPDLQGADQLLVRWRQANDRINSDISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMGQSRTQLRHDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR
Prediction	7546444164544444314310420131031111001000000000021011000110331341144025422221320240131013011300200033242753263035104400420140134354550251044026312301210430332123420000000320152026401420440253345404551452230101100210201110110020001102100000000000000001111110000223314413530241142014001202402030000002123654245403510540352056245445514563054035105404510540352075141530142031536642351044005203501551254035204402300100000000000000200000012105328
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLAALGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPGGVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRAGNPVGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVVFGAFAHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLKTITNLAITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPDLQGADQLLVRWRQANDRINSDISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMGQSRTQLRHDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR

5ic0A

0.10

0.96

1.09

dPPAS

TVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLTANPTAKRQFVQSAKEVANSTANLVKT---IKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPR---DPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAAS------------

4ui9O

0.11

0.96

1.03

wMUSTER

LSQQASLLKNDETKALTPASLQKELNNLLKFNP--FAEAHYLSYLNNLRVQ--VFSSTHSLLHYFDRLILTGAESKSNRSLRYAALNLAALHCRFG-----HYQQAELALQEAIRIAQESNDHVCL----QHCLSWLYVLGQKRSDSYVLLEHSVKKAVFGLLASLGIQSLVQQRAFATANKLMDALKDSDLLHWKHSLSELIDIAQKTAIWRLYSTMALQQAQMLLSMNSLEQQNNTESFAVALCHLAELHAEQGFAAASEVLKHLKERQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEA--HKLLQKLLVHCQKLKNTEMVISVLLSVASPTIALPMLL-RLQYLASETVLNLAFAQLILPEQALSLLHMAIEPILAD-GAILDKGRAMFLVAKCQVASAASKKAEALE

5ic0A

0.10

0.09

0.95

1.52

dPPAS2

LLENPVQPINDMSYFGCLDSVMENSKVLG----EAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLTANPTAKRQFVQSAKEVANSTANLVKT---IKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPR---DPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAAS------------

5ic0A

0.10

0.09

0.95

1.11

PPAS

LLENPVQPINDMSYFGSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAGPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLTANPTAKRQFVQSAKEVANSTANLVKT---IKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARA-EASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGAHTQEALEEAVQMMTEAVEDLTTTLNEAAS------------------

5dlqB

0.10

0.97

0.98

wMUSTER

APDGTRNLTANGVASREEEEISELQEDDRDQFSDQLASVGMLGRIAAEHCMPLLTSLLEERVTRLHGQLQRHQQDNKMLDDLYEDIHWLILVTGYLLADDTQPPEIMEYSIKHINTTLQILGSPGEKASSIPGYSRTDSVIRLLSAVLRVSEVESRAIRADL------THLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPLSTAFEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAKQFASRSPPLNFLS-SPVQRTLMKALVLGGFADTETKQQYWTEVLQPLQQRFLRVINQENFQQMDFLNNCIGLMEVYKNTPETVNLIIEV--FVEVAHKQICYGESKAMHLYEACLTLLQVYSKNN-TAEEEQYQDLLLIMELLTNLLSK-AADVVLYGVNLILPLLLKFP

4ke2A

0.11

0.05

0.45

1.42

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAA--AAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------

5ic0A

0.11

0.10

0.94

0.98

wMUSTER

MA-----PGQKE---DNALRQLETVRELLEVQPSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSGQQGLVEPTQFARANQAIQMACQSLGE--PGCTQAQVLSAATIVAKHTSALCNSCRLASARTA--NPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRA-ATAPLLEAVDNLSAFASN---ISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLEC---ETAIAALNSCLRDLDQASLAAVSREGISQEALHTQMLTAVQEISHLIEPLASAARA-EASQLGHKVS-----QMAQYFEPLTLAAVGAASKTHPQQMALLDQTKTLAESALQLLYTAKEAGG--QAAHTQEALEEAV

5cwmA

0.13

0.07

0.51

1.31

dPPAS2

-----------------------------------------------------------------------------------------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGD-----------------PEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQG------------DPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARES--GSEEAKERAERVREEARELQERVKELRER---------------------------------------------------------------------------------

4xriA

0.11

0.10

0.98

wMUSTER

ARKEEPNNENNFKHEGERNYIMQVVCEATQADSRIQQGAFGCLNRIMALYYEHMRYYMEKALFGLTILGMKSEDVAKLAVEFWSTVCEEEIAIEDDNAQVESSEQMRNFARVATNEVVPVLLQLLTKQDERAAYQCLQLYAQAVTIIPPVIQFVEHNLRHADHFRDAAVSAFGAIMEKVLEPIVKTGMQPLIAMMEDESIQVRDSTAYALGRITEACSEAIDPNTHLEPLIRSLFSPKMAASCCWALMNIAERFA---AAQNPLTPHFNQSVTNLLTVTA---STVRTAAYEVLSVFVQNAANDSLSAVASLSTVILQRLEETLPLQQVVSVEDKLILEDMQTSLCTVLQATVQRLDK--MQVLLQILSTCGGKSPEGVFAAISALANAMEEEFAKYMEAFAPFLYNALG--EPSLCSMAIGLVSDVTRSLGERSQPYC

4akkA

0.08

0.06

0.74

1.27

dPPAS2

--------------------------------------------PEVVDWFARARRLQKQQLHQLAQQGTLAGQISALVHMLQCERGASNIWLCSG---GRLYAAECRAGAALVDEQLTRFYAALEPAASSALCWRIACAVWYLP---------------------------------------------QLAALRKRVRDREIAAEEATGQFSRIIRHLLNIVPQLNDSIDD----PQIAGRMVALYSFMQGKELAGQERALGALGFARGQ--FSDELRQQLVDRIDGQQPCFDSFQALAQPPQTALFAEQCLEIEQLRRVACTRQPPADEG--ETALRWFCAQTQRLEQLRGVEEL-LIVDLLNAADALLEGSIALRLDKQLLPLVRQQAHELQQLSGQLASLKDALEERKLIEKAKSVLMTYQ------------G

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.40

Estimated TM-score = 0.54±0.15

Estimated RMSD = 10.3±4.6Å

Download Model 2

C-score=-2.97

Download Model 3

C-score=-2.17

Download Model 4

C-score=-4.25

Download Model 5

C-score=-4.19

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5ic0A	0.912	1.63	0.101	0.950
2	3dyjA	0.394	3.92	0.058	0.478
3	5anbK	0.385	7.38	0.054	0.654
4	3iydC	0.384	7.27	0.052	0.635
5	4fhmB	0.382	7.02	0.056	0.620
6	5fj8B	0.377	6.99	0.044	0.613
7	1st6A	0.376	5.81	0.058	0.519
8	1zyrM	0.375	7.61	0.067	0.651
9	3h0gB	0.375	7.07	0.052	0.611
10	2x0cA	0.374	3.48	0.093	0.426

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	3pyoH	MG	Rep, Mult	437,438
2	0.04	2	5ezmA	MPG	Rep, Mult	282,285
3	0.04	2	3hd7A	GGG	Rep, Mult	433,434
4	0.04	2	3wmn2	BCL	Rep, Mult	427,431
5	0.02	1	2gdcA	III	Rep, Mult	338,341,342,345,346,349,352,369,404,411,415,418,419,422
6	0.02	1	3k7tA	GP7	Rep, Mult	33,34
7	0.02	1	5l89U	CA	Rep, Mult	305,360
8	0.02	1	4h13A	8K6	Rep, Mult	323,412
9	0.02	1	2ppbC	STD	Rep, Mult	155,167,170
10	0.02	1	3gi7A	UNL	Rep, Mult	107,110
11	0.02	1	1gkiA	ADP	Rep, Mult	159,439
12	0.02	1	1zyrM	STD	Rep, Mult	92,93,114,115,118
13	0.02	1	1ibvA	UUU	Rep, Mult	172,173
14	0.02	1	2yu91	III	Rep, Mult	102,108,109,112,113,116,117,118
15	0.02	1	4wxlA	BB2	Rep, Mult	61,247
16	0.02	1	1hnz2	III	Rep, Mult	338,339,343,382,383,387
17	0.02	1	4ecgA	CA	Rep, Mult	196,198
18	0.02	1	1m18G	UUU	Rep, Mult	231,232
19	0.02	1	2gwwA	III	Rep, Mult	337,338,341,344,345,348,352,405,408,416,419
20	0.02	1	3u3cA	III	Rep, Mult	313,316,317,320,419

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b8eC	0.350	6.51	0.045	0.538	3.6.3.9	NA
2	0.060	3b8cA	0.326	6.93	0.046	0.510	3.6.3.6	NA
3	0.060	3g61A	0.315	7.22	0.046	0.519	3.6.3.44	109
4	0.060	1rqgA	0.333	6.10	0.044	0.476	6.1.1.10	NA
5	0.060	3gtgB	0.373	7.29	0.043	0.617	2.7.7.6	NA
6	0.060	2vz9B	0.342	6.94	0.053	0.556	2.3.1.85	NA
7	0.060	1qxpB	0.313	7.14	0.059	0.512	3.4.22.53,3.4.22.52	NA
8	0.060	2vz8A	0.356	6.74	0.064	0.560	2.3.1.85	NA
9	0.060	1mhsA	0.340	7.24	0.045	0.563	3.6.3.6	NA
10	0.060	3ixzA	0.348	6.64	0.047	0.540	3.6.3.10	NA
11	0.060	1mo7A	0.136	5.76	0.070	0.194	3.6.3.9	117
12	0.060	1fohC	0.331	7.07	0.038	0.531	1.14.13.7	NA
13	0.060	1pn0C	0.327	7.18	0.041	0.533	1.14.13.7	NA
14	0.060	3dy5A	0.337	7.68	0.041	0.601	1.13.11.40,4.2.1.92	353
15	0.060	1gaxA	0.318	6.38	0.039	0.465	6.1.1.9	NA
16	0.060	1wz2A	0.330	7.13	0.039	0.549	6.1.1.4	NA
17	0.060	1k1xA	0.322	6.43	0.050	0.483	2.4.1.25	169
18	0.060	1pj6A	0.314	7.23	0.051	0.533	1.5.3.10	NA
19	0.060	2jfdA	0.221	6.02	0.050	0.319	2.3.1.85	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.912	1.63	0.10	0.95	5ic0A	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
1	0.06	0.404	3.50	0.05	0.48	3dyjA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
2	0.06	0.353	2.06	0.12	0.38	2l7nA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
3	0.06	0.347	2.01	0.10	0.37	3fyqA	GO:0001726 GO:0003779 GO:0005158 GO:0005178 GO:0005200 GO:0005856 GO:0005925 GO:0006909 GO:0007016 GO:0007155 GO:0007298 GO:0007390 GO:0007430 GO:0007475 GO:0007526 GO:0008360 GO:0016203 GO:0033627 GO:0035160 GO:0045214 GO:0045892 GO:0051015 GO:0060439 GO:0086042
4	0.06	0.331	2.64	0.07	0.36	2kvpA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
5	0.06	0.385	7.38	0.05	0.65	5anbK	GO:0000166 GO:0003924 GO:0005525 GO:0005622 GO:0006412 GO:0042254 GO:0042256 GO:0043022
6	0.06	0.289	7.53	0.04	0.51	4v6wAz	GO:0000022 GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005737 GO:0005811 GO:0005829 GO:0005875 GO:0006412 GO:0006414 GO:0007052
7	0.06	0.304	6.54	0.03	0.46	3izyP	GO:0000166 GO:0003743 GO:0003924 GO:0005525 GO:0005622 GO:0005654 GO:0005739 GO:0005759 GO:0006412 GO:0006413 GO:0008135 GO:0032790 GO:0043024 GO:0044822 GO:0070124
8	0.06	0.286	7.44	0.04	0.49	3wbkA	GO:0000166 GO:0000462 GO:0001732 GO:0003743 GO:0003924 GO:0005525 GO:0005737 GO:0006412 GO:0006413 GO:0006446 GO:0016787 GO:0022627 GO:0031369 GO:0033290 GO:0042255 GO:0043022 GO:0046872
9	0.06	0.268	7.75	0.06	0.48	2dy1A	GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0006414
10	0.06	0.290	7.94	0.03	0.52	3jb9B	GO:0000166 GO:0000244 GO:0000974 GO:0003924 GO:0005525 GO:0005634 GO:0005681 GO:0005682 GO:0005737 GO:0005829 GO:0006397 GO:0006412 GO:0008380 GO:0045292 GO:0046540 GO:1902802
11	0.06	0.265	7.94	0.06	0.49	4v9hAY	GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0006412 GO:0006414
12	0.06	0.282	7.26	0.05	0.48	2xexB	GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0006412 GO:0006414
13	0.06	0.286	6.99	0.05	0.46	1g7sA	GO:0000166 GO:0003743 GO:0003924 GO:0005525 GO:0005622 GO:0006412 GO:0006413
14	0.06	0.293	7.36	0.04	0.49	5gamC	GO:0000166 GO:0000244 GO:0000349 GO:0000388 GO:0000398 GO:0003924 GO:0005525 GO:0005634 GO:0005682 GO:0006397 GO:0006412 GO:0008380 GO:0030623 GO:0042256 GO:0046540
15	0.06	0.271	6.90	0.03	0.43	4v8zCV	GO:0000166 GO:0000462 GO:0001732 GO:0003743 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0006412 GO:0006413 GO:0006446 GO:0016787 GO:0022627 GO:0031369 GO:0033290 GO:0042255 GO:0043022 GO:0046872
16	0.06	0.266	7.26	0.06	0.44	4ujcAB	GO:0000166 GO:0003924 GO:0005525
17	0.06	0.272	7.48	0.03	0.47	4v6vA1	GO:0000166 GO:0003924 GO:0005525 GO:0006412 GO:0046677
18	0.06	0.266	7.09	0.03	0.44	4n3nA	GO:0000166 GO:0003743 GO:0003924 GO:0005525 GO:0005737 GO:0006412 GO:0006413 GO:0016787 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0005178	GO:0005200	GO:0051015	GO:0017166	GO:0030274
GO-Score	0.47	0.47	0.47	0.43	0.43
Biological Processes	GO:0007016	GO:0070527	GO:0030866	GO:0007044
GO-Score	0.47	0.43	0.43	0.43
Cellular Component	GO:0005925	GO:0070062	GO:0005737	GO:0009986	GO:0032587	GO:0005815
GO-Score	0.47	0.43	0.43	0.43	0.43	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.