I-TASSER results

I-TASSER results for job id Rv0406c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (272 residues)
MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLVTDDTGVLLIDAGYPGD
RAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHSTPVYCHAEEVGHAKREYR
ENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQPLTAEAAAGLPGQPMAIFTPG
HTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAVFSHSQQNSIRSLAALALLETNI
LAPGHGELWHGPIRKATDEALERAQKSNHVFR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLVTDDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHSTPVYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQPLTAEAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAVFSHSQQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCEEEEHCCEEEHCCCCEEEEEEEHCCEEEEHCCCCCCCHHHHHHHHHHHCCCHHHCCEEEHCCCCCCCCCHHHHHHHHHCCCEEHCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEHCCCEEEHCCCEEEEEHCCCCCCCCEEEEHCCEEEHCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
Conf.Score	98888888788777776778875899859956766887699999979989998599999699999999998998666658984899955555899999998996998888999886875567556677777654444444567777657777888887787698788669858999888999996899989989995588868876678888889999987799999999999959998998599998788899999999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLVTDDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHSTPVYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQPLTAEAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAVFSHSQQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR
Prediction	64436754335351344145254024014301103131010122435741245242165115302610672715054042110250301000004301742604310154015104432533442243224323442244324215334244651444440546440611430202203321331003124300000000001322243331200122234205302500530471715130557141134304400530264055354428
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCEEEEHCCEEEHCCCCEEEEEEEHCCEEEEHCCCCCCCHHHHHHHHHHHCCCHHHCCEEEHCCCCCCCCCHHHHHHHHHCCCEEHCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEHCCCEEEHCCCEEEEEHCCCCCCCCEEEEHCCEEEHCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLVTDDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHSTPVYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQPLTAEAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAVFSHSQQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR

5k0wA

0.17

0.15

0.92

2.74

MUSTER

---SAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESFPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYVDKADVDVLRTGGKSDY--------------------EMGKYGVTFKPVTPDKTLKDQDKIKLGNTLTLLHHPGHTKGSCSFIFEDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFGVMKKLDFDIWVASHASQFDMDKQSYFQNLNDLEKSYLNKIK

5k0wA

0.17

0.15

0.92

4.80

dPPAS

---SAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESFPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYVDKADVDVLRTGGKSDY--------------------EMGKYGVTFKPVTPDKTLKDQDKIKLGNTLTLLHHPGHTKGSCSFIFEDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFGVMKKLDFDIWVASHASQFDMDKQSYFQNLNDLEKSYLNKIK

5k0wA

0.16

0.15

0.92

4.19

wdPPAS

---SAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESFPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYVDKADVDVLRTGGKSDYEMGKYG--------------------VTFKPVTPDKTLKDQDKIKLGNTLTLLHHPGHTKGSCSFIFEDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFGVMKKLDFDIWVASHASQFDLHEKRKPQLFKQSYFQNLNDLE

2zo4A

0.23

0.21

0.88

2.80

wMUSTER

-------------------------ALLPGLYLLPLKTVNLYLLQGAGEVALVDTALRAARGALELHLAELGLCFQDVKTILLTHHHPDHYGLSGFFEGL--ARVFLHEEEFARGHRFWREPEAFAEASWRLFLDHGTPE--ETVEKTRERVHPPQNPLPLRDGEALEVAGRLRVLWTPGHADGHAAFYLEGVLLAGDALLEKVSPNVGL----WAYTRENPLKDFLRSLDRLADLGARVAYAGHFGPIADRAEELKAHHQARLEALLALLD

5k0wA

0.17

0.15

0.90

3.57

wPPAS

---SAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESFPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYVDKADVDVLRTGGKSDYE--------------------MGKYGVTFKPVTPDKTLKDQDKIKLGNTLTLLHHPGHTKGSCSFIFEDEKRKYRVLIANMPSVIKFSEVTAYPN---IQSDYAYTFGVMKKLDFDIWVASHASQFDLHEKRKPQLFKQSYFQNLNDLE

5k0wA

0.18

0.16

0.90

5.50

dPPAS2

---SAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESFPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYVDKADVDVLRTGGKSDY--------------------EMGKYGVTFKPVTPDKTLKDQDKIKLGNTLTLLHHPGHTKGSCSFIFEDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFGVMKKLDFDIWVASHASQFDLNLNDLEKSYLNKIKKD-----

5k0wA

0.17

0.15

0.92

3.51

PPAS

---SAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESFPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYVDKADVDVLRTGGKSDYE--------------------MGKYGVTFKPVTPDKTLKDQDKIKLGNTLTLLHHPGHTKGSCSFIFEDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFGVMKKLDFDIWVASHASQFDLHEKRKPQLFMDKQSYFQNLND

5k0wA

0.16

0.15

0.92

4.03

Env-PPAS

---SAQVVKEPENMPKEWNQAYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESFPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDFKTETAAKFYVDKADVDVLRTGGKSDYEMGKYG--------------------VTFKPVTPDKTLKDQDKIKLGNTLTLLHHPGHTKGSCSFIFEDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFGVMKKLDFDIWVASHASQFDLDKQSYFQNLNDLEKSYLNKIK

5aebA

0.16

0.14

0.90

2.60

MUSTER

-------VKEPTVSNADWSKPYRPFRIAGNLYYIGTYDLACYLITTKQGNIIVNTGLAASALQIKNNIKALGFKLTDTKILLTTQAHYDHLGAMAEIKKITGAKLMADEGDATVMADGGSSDYAFGG--------------------HGSMFEPIIADRLLHDKDTIQLGDKLVMLHHPGHTKGSCSFLFDDEQRSYRILIANMPTIVIEKKFSEVSSYPGIAKDYAYTLQAMKNLSFDIWVASHASQFSYNPKSFRKGYDESLDKLQKEYE

5iqkA

0.17

0.15

0.90

4.45

dPPAS

---------PGCEVCATWNADQAPFRLFGNTYYVGMKGLSSVLVTSPQGHVLIDGGLPESAPKIIANIGALGFRIEDVKLILNSHGHIDHAGGLAELQRRSNALVAASPSAALDLASGEVGPD------------DPQYH-------ALPKYPPVKDMRLARDGGQFNVGPYLTAHATPGHTPGGLSWTWQDGPRCLNMVYADSINAVSRPGFKFSASSEYPLADLRHSFETLEKLPCDVLISAHPEASQLWQRLEASATGGSDAFVDPQAC

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.55

Estimated TM-score = 0.79±0.09

Estimated RMSD = 4.8±3.2Å

Download Model 2

C-score=-2.60

Download Model 3

C-score=-1.21

Download Model 4

C-score=-2.49

Download Model 5

C-score=-2.35

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5k0wA	0.871	1.51	0.169	0.915
2	5aebA	0.844	1.67	0.147	0.897
3	1l9yA	0.822	1.77	0.155	0.879
4	5iqkA	0.811	2.21	0.156	0.893
5	2fu9A	0.807	2.14	0.194	0.886
6	2gmnA	0.789	2.23	0.151	0.875
7	4awyB	0.789	2.24	0.212	0.875
8	3vpeA	0.776	2.20	0.175	0.860
9	2zo4A	0.699	3.36	0.204	0.842
10	5i0pA	0.697	3.25	0.142	0.835

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.20	45	1bc2A	ZN	Rep, Mult	85,87,181
2	0.19	48	2gfjB	VI	Rep, Mult	18,85,87,89,125,181,206,208,245
3	0.12	32	1vmeA	FEO	Rep, Mult	85,87,90,181,203,245
4	0.10	23	1smlA	ZN	Rep, Mult	89,90,245
5	0.10	30	2nypA	ZN	Rep, Mult	89,90,198,245
6	0.02	8	2bmiB	NA	Rep, Mult	39,40,54,89,201
7	0.01	3	3r2uA	FE	Rep, Mult	85,181,198
8	0.01	2	5b1uA	HIW	Rep, Mult	18,89,90,125,145,181,204,206,245,247,248,266
9	0.01	2	1x8gA	CO3	Rep, Mult	89,181,198,212,245
10	0.00	1	4awyB	CA	Rep, Mult	199,243,244,245,248,256
11	0.00	1	2fhxA	AZI	Rep, Mult	55,84,85,195,197,198
12	0.00	1	1jt1A	MCO	Rep, Mult	181,204,206,248,259,263,266
13	0.00	1	4awyB	MG	Rep, Mult	58,59,60,61,62,93,96
14	0.00	1	3f9oA	CO3	Rep, Mult	229,230,234,261
15	0.00	1	4awyB	MG	Rep, Mult	248,256
16	0.00	1	4awyB	MG	Rep, Mult	114,117,121
17	0.00	1	2fu9A	MP2	Rep, Mult	10,87,89,126,149,181,207,209
18	0.00	1	2hb9A	L13	Rep, Mult	75,76,98,99,101,102
19	0.00	1	4awyB	MG	Rep, Mult	22,67
20	0.00	1	3m8tA	ZN	Rep, Mult	23,70

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.215	1znbB	0.634	2.75	0.111	0.735	3.5.2.6	92,245
2	0.168	1smlA	0.806	2.19	0.198	0.890	3.5.2.6	89
3	0.109	1m2xA	0.634	2.58	0.141	0.728	3.5.2.6	89
4	0.108	1ko2A	0.637	2.88	0.169	0.746	3.5.2.6	NA
5	0.092	1bvtA	0.619	2.63	0.155	0.713	3.5.2.6	232,236
6	0.091	1a8tA	0.633	2.75	0.121	0.735	3.5.2.6	89
7	0.068	1p9eA	0.633	3.72	0.162	0.783	3.1.8.1	213
8	0.067	1xm8A	0.593	2.68	0.178	0.680	3.1.2.6	NA
9	0.067	1qh5A	0.588	2.84	0.166	0.688	3.1.2.6	179,183
10	0.067	1qh3A	0.587	2.85	0.166	0.688	3.1.2.6	89
11	0.067	2qedA	0.572	2.95	0.186	0.673	3.1.2.6	179
12	0.067	3dhaA	0.559	3.15	0.205	0.669	3.1.1.-	NA
13	0.060	1hqdA	0.404	6.01	0.077	0.662	3.1.1.3	33
14	0.060	2gmnA	0.789	2.23	0.151	0.875	3.5.2.6	89
15	0.060	2p18A	0.621	2.92	0.156	0.732	3.1.2.6	89
16	0.060	1x8hA	0.655	3.12	0.139	0.787	3.5.2.6	NA
17	0.060	1tahA	0.423	5.67	0.110	0.673	3.1.1.3	NA
18	0.060	1e5dA	0.645	2.63	0.135	0.735	1.-.-.-	NA
19	0.060	1gnxA	0.426	5.13	0.060	0.629	3.2.1.21	NA
20	0.060	2fk6A	0.495	3.81	0.137	0.621	3.1.26.11	NA
21	0.060	2i7tA	0.522	4.17	0.105	0.684	3.1.27.-	245
22	0.060	2q42A	0.591	2.69	0.178	0.680	3.1.2.6	92,179
23	0.060	1gonA	0.426	5.08	0.060	0.625	3.2.1.21	NA
24	0.060	2zoxA	0.421	5.28	0.027	0.636	3.2.1.21	64,71,100,102
25	0.060	1l9yA	0.822	1.77	0.155	0.879	3.5.2.6	89
26	0.060	1ycfA	0.629	3.08	0.188	0.743	1.7.99.7	NA
27	0.060	2cbnA	0.494	4.16	0.136	0.640	3.1.26.11	87,89
28	0.060	2e9lA	0.334	6.07	0.028	0.559	3.2.1.21	NA
29	0.060	2i7vA	0.529	4.43	0.117	0.710	3.1.27.-	89
30	0.060	2zo4A	0.699	3.36	0.204	0.842	3.-.-.-	NA
31	0.060	3hnnA	0.622	3.31	0.118	0.746	1.-.-.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.46	0.794	2.38	0.15	0.89	3lvzB	GO:0046872
1	0.41	0.699	3.36	0.20	0.84	2zo4A	GO:0046872
2	0.37	0.631	3.22	0.17	0.76	3adrA	GO:0008270 GO:0046872
3	0.37	0.807	2.18	0.20	0.89	5evdA	GO:0008270 GO:0008800 GO:0016787 GO:0017001 GO:0042597 GO:0046677 GO:0046872
4	0.37	0.779	2.14	0.17	0.86	5axoA	GO:0046872
5	0.36	0.789	2.24	0.21	0.88	4awyB	GO:0046872
6	0.31	0.637	3.95	0.15	0.81	4zo2B	GO:0052689
7	0.27	0.822	1.77	0.15	0.88	1l9yA	GO:0008800 GO:0016787 GO:0046872
8	0.24	0.559	3.15	0.20	0.67	3dhaA	GO:0016787 GO:0046872 GO:0102007
9	0.21	0.609	3.34	0.18	0.74	4ad9A	GO:0004521 GO:0005739 GO:0005759 GO:0008270 GO:0016787 GO:0046872 GO:0090502
10	0.15	0.582	2.96	0.13	0.69	4chlB	GO:0005506 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005759 GO:0006749 GO:0016491 GO:0046872 GO:0050313 GO:0051213 GO:0055114 GO:0070221 GO:0070813
11	0.13	0.633	3.72	0.16	0.78	1p9eA	GO:0016787 GO:0046872
12	0.07	0.621	2.92	0.16	0.73	2p18A	GO:0004416 GO:0016787 GO:0046872
13	0.07	0.603	3.06	0.22	0.71	2zwrB	GO:0046872
14	0.07	0.556	3.03	0.19	0.65	1ztcA
15	0.07	0.613	3.47	0.17	0.75	4efzA	GO:0016787 GO:0046872
16	0.07	0.603	3.27	0.19	0.72	2xf4A	GO:0016787
17	0.07	0.605	3.45	0.17	0.74	3tp9A	GO:0046872
18	0.07	0.572	2.95	0.19	0.67	2qedA	GO:0004416 GO:0016787 GO:0019243 GO:0046872
19	0.07	0.595	3.00	0.16	0.70	2gcuA	GO:0005739 GO:0009651 GO:0009793 GO:0009960 GO:0016491 GO:0016788 GO:0046872 GO:0047951 GO:0048316 GO:0050313 GO:0051213 GO:0055114
20	0.07	0.587	2.96	0.22	0.68	3aj3A	GO:0016787 GO:0042820 GO:0046872 GO:0047585
21	0.07	0.591	2.69	0.18	0.68	2q42A	GO:0004416 GO:0005506 GO:0005739 GO:0008270 GO:0016787 GO:0019243 GO:0046872
22	0.07	0.605	3.44	0.14	0.74	3r2uA

Consensus prediction of GO terms

Molecular Function	GO:0008270	GO:0008800
GO-Score	0.60	0.37
Biological Processes	GO:0046677	GO:0017001
GO-Score	0.37	0.37
Cellular Component	GO:0042597
GO-Score	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.