I-TASSER results

I-TASSER results for job id Rv0394c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (239 residues)
MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETTTREICESVGGADTVLS
RIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDDQKVEPASLIVATLSQLEP
VHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVLAALIQTGVAIATTTVWHGNG
TGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLILPSGGSAPTGDHPTPHPSTSR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETTTREICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDDQKVEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVLAALIQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLILPSGGSAPTGDHPTPHPSTSR
Prediction	CCCCCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCHHEEHCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCC
Conf.Score	99987645788754765578887679999999998778899999999999978868999998679578999999999999985899999999999998756455878899999998679856899999999875788888764688999986678866899999874443434555588877778778865456889999999999999755664788768988888889999998899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETTTREICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDDQKVEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVLAALIQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLILPSGGSAPTGDHPTPHPSTSR
Prediction	85533211100132324314324330330143135444543443044005315424201431463552241014104212444154214100400231145464144130112104515332020012004124346554414344014213734412000101421231333223435452353643433212202400430041045242413000013435244474345446668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCHHEEHCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCC
MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETTTREICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDDQKVEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVLAALIQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLILPSGGSAPTGDHPTPHPSTSR

4knhA

0.16

0.15

0.97

0.67

MUSTER

DAGLQESFGVAAEDKIFGIPPPWERQVKKFIPRCMEAMKGVRSMLQCMADKANARNMLQQASLVRP----LDNQETLDFSRLSLVEQHECLASILHAAVQRHHTIADFQDFIKILRKWDKYLIPVLAAYITEFGSPEGMGDLQARRLNDFICKGGALPVLGAAVRAWWIAEHNGFYLDD---TVQDLRGINLDEEDEQRTKQFLDALKEG-AFDFILSVAADCKAQEWQDPRKIPSLPS

4ke2A

0.15

0.12

0.82

0.59

dPPAS

-------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP------------------------

2w53A

0.16

0.11

0.72

0.57

wdPPAS

----------------------------------EDTQATREGILDAAEACFHTLEMIGARAGYTKNKSEVLAAIVERVHLPFMQELERTS---------TDQRDTPVHDLRAVMIHSEDERLRKTMEIMLRS---TEMQQAGFRDALDRME-----RALRRARDLGQLRE----------GADPKIAARMLHATVLGVLHGAMVLKRDGMLALDMTLVKDGVFVP-GTVPEPLP----

4yxxA

0.20

0.16

0.83

0.75

wMUSTER

---------VSL-----------EQALKILKVAAELTVEEAVKRALKLKTKLGSLEQALKILEVAAELGTTVEEAVKRALKLKTKLLEQALKILEVAAKLGTTVEEAVKRALKLKTKLGVSLEQALKILKVAAELG-----TTVEEAVKRALKLKGVSLEQALKILEVAAEL---------GTTVEEAVKRALKLKTKLGVSLEQALKILEVAAKL-----GTTVEEAVKRALKLKTK-

2w53A

0.16

0.11

0.71

0.68

wPPAS

----------------------------------EDTQATREGILDAAEACFHELEMIGARA---KNKSEVLAAIVERVHLPFMQELERTS---------TDQRDTPVHDLRAVMIHSEDERLRKTMEIMLRS---TEMQQAGFRDALDRME-----RALRRARDLGQLRE----------GADPKIAARMLHATVLGVLHGAMVLKRDGMLALDMTLVKDGVFVP-GTVPEPLP----

4yxxA

0.18

0.15

0.84

0.68

dPPAS2

---------------------VSEQALKILKVAAELTVEEAVKRALKLKTKLGSLEQALKILEVAAELGTTVEEAVKRALKLKTKLLEQALKILEVAAKLGTTVEEAVKRALKLKTKLGVSLEQALKILKVAAELGTTVE--EAVKRALKLKTKLGVSLEQALKILEVAAEL---------GTTVEEAVKRALKLKTKLGVSLEQALKILEVAAKL-----GTTVEEAVKRALKLKTK-

2w53A

0.17

0.13

0.76

PPAS

DTQAT--------------------REGILDAAEACFHEHARTTLEMIGARAGYTRGAVYW----KNKSEVLAAIVERVHLPFMQELERTS---------TDQRDTPVHDLRAVMIHSEDERLRKTMEIMLRS---TEMQQAGFRDALDRME-----RALRRARDLGQL-----------EGADPKIAARMLHATVLGVLHGAMVLKRDGMLALDMTLVKDGVFVPGTV-PEPLP----

2vsgA1

0.17

0.15

0.92

0.69

Env-PPAS

-------THFGVKYEL-WQPE--CELTAELRKTAGVAKMKVNSDLNSFKTLELTKMKLLTFAAKFPEKEALTLRALEAALNTDLRALRDNIANGIDRAVRATA---YASEAAGALFS----GIQTLHDLSASGQGSNGNAAMASQPLALPELLTEDSYNTDVISDKGF-PKISPLTNAQGQGKSQAASGAQATNTGVQFSRINLGLGAIVASAAQQPTRPSDFSGTARNQADTLYGKAH

5a9q1

0.12

0.11

0.95

0.64

MUSTER

HLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETDIRDVICLIKCLRLIEESV--TVDMSVIMEMSCYNLQSPE-----KAAEQILEDMITIDVE-NVMEDICSKLQEIRN-PIHAIGLLIREMDYETTQLYGSNTAGYIVCRGVHKIASTRFLICRDLLILQQLLMRLGDA--VIWGTGQLLLHRTAPLLLSYYLIKWGSECLAT--DVPLANSPQTVARKHILSQTGL

4yxxA

0.17

0.15

0.85

0.57

dPPAS

--------------------VSLEQALKILKVAAELTVEEAVKRALKLKTKLGSLEQALKILEVAAELGTTVEEAVKRALKLKTKLLEQALKILEVAAKLGTTVEEAVKRALKLKTKLGVSLEQALKILKVAAELGTTVE--EAVKRALKLKTKLGVSLEQALKILEVAAEL---------GTTVEEAVKRALKLKTKLGVSLEQALKILEVAAKL-----GTTVEEAVKRALKLKTK-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.29

Estimated TM-score = 0.35±0.12

Estimated RMSD = 13.6±4.0Å

Download Model 2

C-score=-3.83

Download Model 3

C-score=-3.87

Download Model 4

C-score=-4.34

Download Model 5

C-score=-4.35

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4yxxA	0.803	1.51	0.168	0.845
2	1a12A	0.515	5.41	0.077	0.841
3	5fkqA	0.507	5.28	0.067	0.816
4	5e6rA2	0.506	5.01	0.083	0.787
5	4lg9A	0.505	4.86	0.079	0.770
6	4lgnA	0.505	5.34	0.053	0.816
7	4gbfA	0.503	5.49	0.039	0.816
8	1pevA	0.500	5.29	0.048	0.799
9	4tqjA	0.499	5.54	0.049	0.837
10	5teeA2	0.499	4.67	0.045	0.745

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1iw7F	MG	Rep, Mult	164,204
2	0.06	3	3k6sC	CA	Rep, Mult	63,64,65,68,69,71
3	0.04	2	2yx4A	GLN	Rep, Mult	97,104,105
4	0.04	2	1tyeA	UUU	Rep, Mult	27,42,59
5	0.02	1	2qfnB	OXY	Rep, Mult	122,126
6	0.02	1	3psqB	ZN	Rep, Mult	186,190
7	0.02	1	3hycA	MG	Rep, Mult	22,236
8	0.02	1	1f61A	MG	Rep, Mult	56,119
9	0.02	1	3h7vA	MG	Rep, Mult	102,119,138
10	0.02	1	1o5qA	MG	Rep, Mult	102,144
11	0.02	1	2pjtA	CA	Rep, Mult	121,122
12	0.02	1	2ie7A	CA	Rep, Mult	180,181
13	0.02	1	4b92A	ZN	Rep, Mult	194,198
14	0.02	1	1bpyA	MG	Rep, Mult	138,140
15	0.02	1	2akaA	III	Rep, Mult	115,116,117,118
16	0.02	1	3v94F	MG	Rep, Mult	101,122
17	0.02	1	1aiiA	ETA	Rep, Mult	182,183
18	0.02	1	2c25A	SIA	Rep, Mult	11,25,57,58
19	0.02	1	3t1gA	ZN	Rep, Mult	102,106

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2ac1A	0.449	5.58	0.049	0.741	3.2.1.26	NA
2	0.060	1lrwC	0.469	5.50	0.070	0.757	1.1.99.8	31
3	0.060	1y9mA	0.454	5.23	0.079	0.716	3.2.1.80	NA
4	0.060	1qksB	0.502	5.15	0.030	0.791	1.7.2.1	76
5	0.060	3elqB	0.458	5.85	0.085	0.791	2.8.2.22	125,130
6	0.060	1jofA	0.465	5.48	0.031	0.761	5.5.1.5	NA
7	0.060	1cvmA	0.446	5.65	0.020	0.745	3.1.3.8	NA
8	0.060	1vcuB	0.434	5.99	0.044	0.757	3.2.1.18	NA
9	0.060	2vk6A	0.454	5.16	0.034	0.720	3.2.1.18	24
10	0.060	1z68A	0.479	5.37	0.047	0.761	3.4.21.-	122
11	0.060	2d0vA	0.471	5.58	0.077	0.787	1.1.99.8	NA
12	0.060	2agsA	0.452	5.47	0.039	0.741	3.2.1.18	205
13	0.060	2ecfA	0.453	5.32	0.082	0.728	3.4.14.5	122
14	0.060	2bixA	0.474	5.69	0.060	0.795	1.14.99.-	7,210
15	0.060	2h47H	0.452	5.84	0.044	0.782	1.4.99.4	NA
16	0.060	1kb0A	0.480	5.35	0.056	0.778	1.1.99.-	NA
17	0.060	2bklB	0.457	5.24	0.039	0.724	3.4.21.26	NA
18	0.060	1yniB	0.474	5.91	0.050	0.820	3.5.3.23	2
19	0.060	1y4wA	0.454	5.17	0.074	0.711	3.2.1.80	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.479	5.61	0.05	0.80	3mvdL	GO:0000793 GO:0003682 GO:0005085 GO:0005087 GO:0005634 GO:0005737 GO:0006607 GO:0007049 GO:0007067 GO:0007076 GO:0007346 GO:0007417 GO:0007419 GO:0022008 GO:0043547 GO:0046822 GO:0050767 GO:0051301
1	0.07	0.490	5.49	0.05	0.82	2cn3A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033946 GO:0043263 GO:2000899
2	0.07	0.504	5.62	0.07	0.84	4d9sA	GO:0000785 GO:0003682 GO:0005085 GO:0005634 GO:0005737 GO:0005829 GO:0007165 GO:0009411 GO:0009649 GO:0009881 GO:0010224 GO:0018298 GO:0042803 GO:0043547 GO:0050896
3	0.07	0.451	4.90	0.09	0.69	2cn2A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033946 GO:0043263 GO:2000899
4	0.07	0.483	5.59	0.09	0.82	3b7fA	GO:0016787
5	0.07	0.502	5.25	0.05	0.81	5jwzA	GO:0004553 GO:0005975 GO:0030246 GO:0030247
6	0.07	0.444	4.76	0.07	0.67	2ebsB	GO:0000272 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033945
7	0.07	0.515	5.41	0.08	0.84	1a12A	GO:0000082 GO:0000790 GO:0000794 GO:0003677 GO:0003682 GO:0005085 GO:0005087 GO:0005634 GO:0005654 GO:0005737 GO:0007049 GO:0007052 GO:0007059 GO:0007067 GO:0007088 GO:0016032 GO:0031492 GO:0031965 GO:0042393 GO:0043547 GO:0051225 GO:0051301
8	0.07	0.489	5.54	0.01	0.80	3of7A	GO:0000054 GO:0000790 GO:0004871 GO:0005085 GO:0005087 GO:0005634 GO:0006407 GO:0006810 GO:0007049 GO:0007067 GO:0007165 GO:0019236 GO:0043547 GO:0051301
9	0.07	0.507	5.28	0.07	0.82	5fkqA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0030247 GO:0030248
10	0.07	0.479	5.12	0.08	0.75	3kciA	GO:0004842 GO:0005085 GO:0005634 GO:0005654 GO:0005737 GO:0005743 GO:0005814 GO:0005856 GO:0006281 GO:0006303 GO:0006886 GO:0006974 GO:0007283 GO:0008270 GO:0016020 GO:0016567 GO:0016874 GO:0016925 GO:0031625 GO:0032183 GO:0042787 GO:0043547 GO:0046872
11	0.07	0.505	5.34	0.05	0.82	4lgnA	GO:0004553 GO:0005975 GO:0030246 GO:0030247 GO:0030248
12	0.07	0.479	5.28	0.09	0.76	4o2wA	GO:0004842 GO:0005085 GO:0005086 GO:0005737 GO:0005794 GO:0005829 GO:0006810 GO:0010507 GO:0016020 GO:0016567 GO:0016874 GO:0021702 GO:0031175 GO:0043547 GO:0050885
13	0.07	0.498	5.07	0.05	0.77	4l1mA	GO:0004842 GO:0005085 GO:0005634 GO:0005654 GO:0005737 GO:0005743 GO:0005814 GO:0005856 GO:0006281 GO:0006303 GO:0006886 GO:0006974 GO:0007283 GO:0008270 GO:0016020 GO:0016567 GO:0016874 GO:0016925 GO:0031625 GO:0032183 GO:0042787 GO:0043547 GO:0046872
14	0.07	0.476	5.06	0.06	0.75	4qamA	GO:0001750 GO:0005085 GO:0005737 GO:0005794 GO:0005813 GO:0005815 GO:0005856 GO:0005929 GO:0006886 GO:0007601 GO:0030030 GO:0036064 GO:0036126 GO:0042073 GO:0042384 GO:0042995 GO:0043547 GO:0044822 GO:0050896 GO:0072372
15	0.07	0.452	5.47	0.12	0.74	1jtdB	GO:0046872
16	0.07	0.444	5.88	0.05	0.77	4d4oA	GO:0000226 GO:0002098 GO:0005506 GO:0005634 GO:0005737 GO:0007017 GO:0007117 GO:0008270 GO:0009055 GO:0017183 GO:0046872
17	0.06	0.415	5.81	0.06	0.70	4kc7A	GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031222 GO:0046558 GO:0046872
18	0.06	0.366	6.32	0.07	0.66	2f02A	GO:0000166 GO:0005524 GO:0005975 GO:0005988 GO:0009024 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0019512 GO:2001059

Consensus prediction of GO terms

Molecular Function	GO:0033946	GO:0003682	GO:0005087	GO:0009881	GO:0042803
GO-Score	0.13	0.13	0.07	0.07	0.07
Biological Processes	GO:2000899	GO:0043547	GO:0030245	GO:0010224	GO:0007419	GO:0007076	GO:0050767	GO:0018298	GO:0006607	GO:0007165	GO:0046822	GO:0009649	GO:0051301	GO:0007346
GO-Score	0.13	0.13	0.13	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07
Cellular Component	GO:0043263	GO:0005634	GO:0000785	GO:0005829	GO:0000793
GO-Score	0.13	0.13	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.