I-TASSER results

I-TASSER results for job id Rv0383c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (284 residues)
MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFDYERESTEILKRWTRGV
MSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGTNVVVDLRLKGLKEPRESD
IWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAEIMWNEQNWTLVSMPIASTRA
QWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAAPGRPVAPGGPAELPPRRAQPDP
ATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNGQQATNYQH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFDYERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGTNVVVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAEIMWNEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAAPGRPVAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNGQQATNYQH
Prediction	CCHHHHHHHHHHHHHHHHHHHHHCHCCCCCHHHHHHHHHHHCCEEEHCCHHHHHHCCCCCCCCCCCCCCEEEEEEEHCCEEEEEEEHCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCEEEEHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	97699999999999999998753444676558999999998996775666776655555445678876457888677667999998478768999994899885899984888887667854545667768996668999998569999999997678887753598799998799999999999999999855555899999988888999999999998999989999999889988878888898888888889998888888999999999999998899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFDYERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGTNVVVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAEIMWNEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAAPGRPVAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNGQQATNYQH
Prediction	51100120012012100000001133565555414400663615236425503740441214336424022002122302200001035110000011635140100021641435545214203423322011222510330025303400540352020002233000020246353730350052034004004122245564545554546545454446664546556655545565545556564464455466545654645556656464444468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHCHCCCCCHHHHHHHHHHHCCEEEHCCHHHHHHCCCCCCCCCCCCCCEEEEEEEHCCEEEEEEEHCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCEEEEHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFDYERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGTNVVVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAEIMWNEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAAPGRPVAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNGQQATNYQH

1mv3A

0.05

0.01

0.31

1.31

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGG

2mxxA

0.08

0.05

0.60

1.30

dPPAS2

-------------------------------------------------------------------------------------------------------------MADEATDAARNNDGAYYLQTQFTNADKVNEYLAQHDGEIRAEAAADPAVVAAKAAL------DAVEGGSHNYGEVKAAYEAAFNNAFNAVATYNNATEQEGKTYIQGETPEQANARYLKRVGAANNQNPAAEDKGATTPASKEEAKKSEAAAKNAGKAAGKALPKTSAVKHHHHH

4yt2A

0.12

0.98

0.64

MUSTER

EPPYGGSRMAIEFAEAGHDVVLAEPNKNIMSDDLWKKVEDAGVKVVSDDVEAAKHGEIHVLFTPFGKATFRIAKTIIEHVPAVICNTCTVSGISSMHTPQHGHYVIGGKTTDGKELATEEVELAKSAGK-EAYVVPADVSSVVADMGSLVTAVALSGVLDYYTVGRK--IINAPKKMIEQQVIMTLQTMASLVEMVKALNPE---LLIRSASSMKLLDRQKDLDAALEILQNLDETLKAEVEKAEIKPTTLVAAQSLVKEIKTLIGGAAAEGAIKRSARKLFEH

2mxxA

0.08

0.05

0.60

0.85

dPPAS

-------------------------------------------------------------------------------------------------------------MADEATDAARNNDGAYYLQTQFTNADKVNEYLAQHDGEIRAEAAADPAVVAAKAALDA------VEGGSHNYGEVKAAYEAAFNNAFNAVATYNNATEQEGKTYIQGETPEQANARYLKRVGAANNQNPAAEDKGATTPASKEEAKKSEAAAKNAGKAAGKALPKTSAVKHHHHH

2krgA

0.13

0.08

0.65

0.67

wdPPAS

----------------------------------------------------------G-IDPFTMLRPRLCTMK---G-----FNLHSD--------KSKPGQFIRSVDPDSPAEASG----L-RAQDRIVEVNGVCM-EGKQHGDVVSAIRAGGDETKLL-----------------RETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPKERAHQKRSSKRAPQMDW

2bydA

0.13

0.11

0.79

0.63

wMUSTER

MEGVWFSCGTWLPSRAEWLLAVRS-----QPEEKERIGQ---FVFARD-AAMAGRL-RKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPAVLAAEPEL--QVGIDIMK--TSFPGRGSIP------------EFFHIMKRKFTNKEWETIRSFKDEWTQLDM---WAL--------KESFIKAIFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEKIDEH----RKQRQFT-SSAVPMTPEDPSFWDC-FTEEIPIRNGTK-----------------

4i6eA1

0.11

0.08

0.75

0.63

wPPAS

SSVHWF-LH-PALLAAVCVYILD-AASSSVGINRWRFLLQS--------EDLDTSLRKS--------------------------RL-------FVVRGQPADVFPRL---------------FKEWGTRLTFEYDSEPFGKERDAAIMKMAKEAG--VEVVTENSHDRIIELNGQKPPLTYKRFQALISRM-----ELPKKPAVAVSSQQMESCRAEIQEDTYGVPSLEELGFPTEGLGPAVWQGGETEA-ERKANANSLLASPTG--P-SCR-KKVKSTPPL

4cwuT

0.11

0.03

0.25

1.06

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APGLGVQTVDVQET-QTSPVASAVADAAVQAVAAAASKTSTEVQTDPWMFRVSAPRRPRGSRKYGAASALLPE--------

5gaoE

0.09

0.98

0.93

PPAS

-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

4bb7A

0.13

0.10

0.81

0.71

Env-PPAS

MDEVIVSYH----VGDWALLRNQNDPQKPIGQIFRLWKTPDGKQWLNACWYYRPEQTVHRVDRLFYK--NEVMKTGQY-RDHLVSNLVGKCYVIHFTR------YQRGN----PDMKEGPLFVC-----EFRYNESDKIFNKI---------RTWKACLPEEIRDLDEATIPVNG----------RKFFKYPSPIRHLLPANATPHDRVP--EPTMGSPDAPPLVGAVYMRPKMQRDDLGEYATSDDCPRYIIRPNDSPEEGQVDIETGTITT-----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.11

Estimated TM-score = 0.36±0.12

Estimated RMSD = 13.5±4.0Å

Download Model 2

C-score=-4.79

Download Model 3

C-score=-4.78

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4yt2A	0.927	1.75	0.114	0.989
2	3h65A	0.596	3.99	0.078	0.796
3	4jjfA	0.566	4.48	0.083	0.796
4	3g79A	0.511	4.82	0.042	0.697
5	1zcjA	0.507	4.33	0.059	0.651
6	1muuA	0.492	4.31	0.034	0.634
7	2x58A	0.492	4.19	0.052	0.630
8	2o3jA	0.491	4.46	0.058	0.637
9	2w90B	0.490	4.46	0.055	0.648
10	2p4qA	0.490	4.57	0.036	0.651

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	4	4yt5B	H4M	Rep, Mult	64,65,67,88,144,145,146,148
2	0.07	4	2iypC	A2P	Rep, Mult	24,25,26,28,63,64,68,72
3	0.06	3	2iz0A	NAP	Rep, Mult	4,5,24,25,26,62,63,64,65,68,88,89,97,144
4	0.06	3	1lm1A	F3S	Rep, Mult	67,68,69,72,73,86,91,92
5	0.04	2	3zukA	211	Rep, Mult	141,142,145
6	0.04	2	3twbA	GCO	Rep, Mult	45,56
7	0.04	2	5da5C	GOA	Rep, Mult	153,157
8	0.02	1	3gifA	CA	Rep, Mult	160,164,220
9	0.02	1	1w8qB	CO	Rep, Mult	86,284
10	0.02	1	3fyuC	XYP	Rep, Mult	119,120
11	0.02	1	1uwcA	FER	Rep, Mult	270,275
12	0.02	1	1xs2D	MG	Rep, Mult	23,46
13	0.02	1	3attA	MG	Rep, Mult	86,88
14	0.02	1	1sqpE	PLX	Rep, Mult	151,154

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	3dagA	0.591	4.08	0.083	0.796	1.12.98.2	65,100,144
2	0.060	3gg2A	0.476	4.42	0.074	0.616	1.1.1.22	NA
3	0.060	1zcjA	0.507	4.33	0.059	0.651	1.1.1.35	97
4	0.060	3c7aA	0.488	5.41	0.064	0.715	1.5.1.11	NA
5	0.060	1llwA	0.487	5.81	0.053	0.778	1.4.7.1	NA
6	0.060	1txgB	0.485	4.37	0.089	0.644	1.1.1.94	NA
7	0.060	1mfzA	0.500	4.65	0.047	0.658	1.1.1.132	NA
8	0.060	3mogA	0.481	4.46	0.028	0.616	1.1.1.157	NA
9	0.060	3fr8B	0.475	5.10	0.048	0.687	1.1.1.86	NA
10	0.060	1wdlA	0.490	4.63	0.055	0.655	5.3.3.8,5.1.2.3,4.2.1.17,1.1.1.35	118
11	0.060	1yrlC	0.483	4.77	0.063	0.651	1.1.1.86	NA
12	0.060	1pgjA	0.479	4.53	0.040	0.648	1.1.1.44	NA
13	0.060	2plaA	0.487	4.67	0.065	0.658	1.1.1.8	NA
14	0.060	1x0xA	0.475	4.66	0.049	0.648	1.1.1.8	NA
15	0.060	1dliA	0.483	4.31	0.039	0.609	1.1.1.22	NA
16	0.060	2x58A	0.492	4.19	0.052	0.630	5.3.3.8,4.2.1.17,1.1.1.35	127
17	0.060	2f1kA	0.476	4.15	0.070	0.606	1.3.1.43	NA
18	0.060	3itkC	0.490	4.54	0.050	0.637	1.1.1.22	NA
19	0.060	1bg6A	0.488	4.69	0.045	0.655	1.5.1.28	NA
20	0.060	1mv8B	0.498	4.30	0.038	0.641	1.1.1.132	63,149

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.920	1.87	0.11	0.99	4yt2B	GO:0015948 GO:0016491 GO:0018537 GO:0047068 GO:0055114
1	0.07	0.585	4.15	0.08	0.80	3f46A	GO:0006730 GO:0015948 GO:0016491 GO:0018537 GO:0019386 GO:0047068 GO:0055114
2	0.07	0.566	4.48	0.08	0.80	4jjfA	GO:0006730 GO:0015948 GO:0016491 GO:0018537 GO:0019386 GO:0047068 GO:0055114
3	0.07	0.511	4.82	0.04	0.70	3g79A	GO:0000271 GO:0016020 GO:0016021 GO:0016491 GO:0016616 GO:0016628 GO:0051287 GO:0055114
4	0.07	0.500	4.65	0.05	0.66	1mfzA	GO:0003979 GO:0006065 GO:0016491 GO:0016616 GO:0042121 GO:0047919 GO:0051287 GO:0055114
5	0.07	0.475	4.52	0.06	0.63	4xr9A	GO:0000166 GO:0000271 GO:0016616 GO:0016628 GO:0051287 GO:0055114
6	0.07	0.491	4.46	0.06	0.64	2o3jA	GO:0000003 GO:0002009 GO:0003979 GO:0005634 GO:0005737 GO:0005829 GO:0005975 GO:0006024 GO:0006065 GO:0009792 GO:0016491 GO:0016616 GO:0018991 GO:0040025 GO:0042802 GO:0051287 GO:0055114
7	0.07	0.485	4.30	0.06	0.62	2y0cA	GO:0000271 GO:0003979 GO:0016616 GO:0051287 GO:0055114
8	0.07	0.475	4.48	0.08	0.64	3ojlA	GO:0000166 GO:0000271 GO:0016616 GO:0016628 GO:0051287 GO:0055114
9	0.07	0.475	4.42	0.07	0.62	3vtfA	GO:0000271 GO:0003979 GO:0016491 GO:0016616 GO:0051287 GO:0055114
10	0.07	0.483	4.31	0.04	0.61	1dliA	GO:0000271 GO:0003979 GO:0006065 GO:0016491 GO:0016616 GO:0051287 GO:0055114
11	0.07	0.490	4.54	0.05	0.64	3itkC	GO:0001702 GO:0003824 GO:0003979 GO:0005634 GO:0005654 GO:0005829 GO:0005975 GO:0006011 GO:0006024 GO:0006065 GO:0008152 GO:0009055 GO:0016491 GO:0016616 GO:0051287 GO:0055114 GO:0070062
12	0.07	0.473	4.24	0.07	0.60	4a7pA	GO:0000166 GO:0000271 GO:0003979 GO:0016491 GO:0016616 GO:0051287 GO:0055114
13	0.07	0.468	4.47	0.07	0.61	4r16A	GO:0000271 GO:0016616 GO:0016628 GO:0051287 GO:0055114
14	0.07	0.476	4.42	0.07	0.62	3gg2A	GO:0000271 GO:0003979 GO:0016616 GO:0051287 GO:0055114
15	0.07	0.465	4.22	0.05	0.59	3pjgA	GO:0000271 GO:0003979 GO:0016491 GO:0016616 GO:0051287 GO:0055114
16	0.07	0.458	4.55	0.05	0.60	4edfA	GO:0001702 GO:0003824 GO:0003979 GO:0005634 GO:0005654 GO:0005829 GO:0005975 GO:0006011 GO:0006024 GO:0006065 GO:0008152 GO:0009055 GO:0016491 GO:0016616 GO:0051287 GO:0055114 GO:0070062
17	0.07	0.454	1.58	0.18	0.48	4yteA	GO:0015948 GO:0016491 GO:0018537 GO:0047068 GO:0055114
18	0.06	0.396	6.21	0.06	0.68	3jzdA	GO:0000166 GO:0016491 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0047068	GO:0018537
GO-Score	0.36	0.36
Biological Processes	GO:0015948
GO-Score	0.36
Cellular Component	GO:0016021
GO-Score	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.