I-TASSER results

I-TASSER results for job id Rv0372c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (251 residues)
MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGTIEGFVGGHCAQNSVRK
AAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGSLEIFLTPQLPAPLIQIYG
ETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASHGGPEAEIIRTALDNGVGYVG
LVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTPAEIAVSIAAELIATLRGGGPRG
RKALADENGGA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGTIEGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGSLEIFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASHGGPEAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTPAEIAVSIAAELIATLRGGGPRGRKALADENGGA
Prediction	CCHHHHHHHHHHHCCCEEEEEEEEHCCCCCCCCCEEEEEHCCCCEEEHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHCCCCHHHHCCCCCEEEHCCCCCCCCEEEEEEHCCCCCEEEEHCCCHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCC
Conf.Score	85999999999989989999999865898874564788858985886557874799999999998776998799997687545444566556654555688568898865888689999798678999999998699899866888888888799998699679999999997899889997786899999999899998998756889888889998999999999999999889876546654666789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGTIEGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGSLEIFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASHGGPEAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTPAEIAVSIAAELIATLRGGGPRGRKALADENGGA
Prediction	45015303502766230000000204343324100200014523221213332113201420240344440223323233443144243232243213332222202223333210000001330212040044040301222433526411000000023430230032017350200000014421440164171466305303010103042631100000000001102364545534535666558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHCCCEEEEEEEEHCCCCCCCCCEEEEEHCCCCEEEHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHCCCCHHHHCCCCCEEEHCCCCCCCCEEEEEEHCCCCCEEEEHCCCHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCC
MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGTIEGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGSLEIFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASHGGPEAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTPAEIAVSIAAELIATLRGGGPRGRKALADENGGA

2we7A

0.25

0.23

0.92

1.71

MUSTER

RDVLGTLSAVWESGGTAGVGTVVRTFRSAPRPAGASVVA-PDGTVSGSVSGGCVEGAVYDLATEVVATGTPVLQRYGGGIRGLLAAGRSEVLYGPDGQRRGEGEVFVSSYAPRPRL-VFGAIDFAAAVAQQGAFLGYRVTVCDARPVIDARTVVCVLTHDPKFDVPLLEVALRLPDIAYIGAGSRRTHEDRLARL-LTEEELARLSSPIGLDLGGRTPEETAVSIAAEIIAKRW-----------------

2we7A

0.25

0.23

0.92

2.19

dPPAS

RDVLGTLSAVWESGGTAGVGTVVRTFRSAPRPAGAS-VVAPDGTVSGSVSGGCVEGAVYDLATEVVATGTPVLQRYGGGIGLLAAGRSEVLTYGPDGQRRGEGEVFVSSYAPRPRL-VFGAIDFAAAVAQQGAFLGYRVTVCDARPVIDARTVVCVLTHDPKFDVPLLEVALRLPDIAYIGAGSRRTHEDRLARLRLTEEELARLSSPIGLDLGGRTPEETAVSIAAEIIAKRW-----------------

2we7A

0.25

0.23

0.92

3.23

wdPPAS

VDVLGTLSAVWESGGTAGVGTVVRTFRSAPRPAGASVVA-PDGTVSGSVSGGCVEGAVYDLATEVVATGTPVLQRYGGGIGLLAAGRSEVLTYGPDGQRRGEGEVFVSSYAPRP-RLVFGAIDFAAAVAQQGAFLGYRVTVCDARPVFDARTVVCVLTHDPKFDVPLLEVALRLPDIAYIGAGSRRTHEDRLARL-LTEEELARLSSPIGLDLGGRTPEETAVSIAAEIIAKRW-----------------

2we7A

0.25

0.23

0.92

2.07

wMUSTER

VDVLGTLSAVWESGGTAGVGTVVRTFRSAPRPAGASVVA-PDGTVSGSVSGGCVEGAVYDLATEVVATGTPVLQRYGGGIRGLLAAGRSEVLYGPDGQRRGEGEVFVSSYAPRP-RLVFGAIDFAAAVAQQGAFLGYRVTVCDARPVIDARTVVCVLTHDPKFDVPLLEVALRLPDIAYIGAGSRRTHEDRLARL-LTEEELARLSSPIGLDLGGRTPEETAVSIAAEIIAKRW-----------------

2we7A

0.25

0.23

0.92

3.32

wPPAS

VDVLGTLSAVWESGGTAGVGTVVRTFRSAPRPAGASVVA-PDGTVSGSVSGGCVEGAVYDLATEVVATGTPVLQRYGGGHPDAQWIGSEVLTYGPDGQRRGEGEVFVSSYAPRP-RLVFGAIDFAAAVAQQGAFLGYRVTVCDARPVIDARTVVCVLTHDPKFDVPLLEVALRLPDIAYIGAGSRRTHEDRLARL-LTEEELARLSSPIGLDLGGRTPEETAVSIAAEIIAKRW-----------------

2we7A

0.25

0.23

0.92

5.74

dPPAS2

RDVLGTLSAVWESGGTAGVGTVVRTFRSAPRPAGAS-VVAPDGTVSGSVSGGCVEGAVYDLATEVVATGTPVLQRYGGGIGLLAAGRSEVLTYGPDGQRRGEGEVFVSSYAPRPRL-VFGAIDFAAAVAQQGAFLGYRVTVCDARPVIDARTVVCVLTHDPKFDVPLLEVALRLPDIAYIGAGSRRTHEDRLARLRLTEEELARLSSPIGLDLGGRTPEETAVSIAAEIIAKRW-----------------

2we7A

0.25

0.23

0.92

2.67

PPAS

RDVLGTLSAVWESGGTAGVGTVVRTFRSAPRPAGASVVA-PDGTVSGSVSGGCVEGAVYDLATEVVATGTPVLQRYGGGHPDAQWIGSEVLTYGPDGQRRGEGEVFVSSYAPRPRL-VFGAIDFAAAVAQQGAFLGYRVTVCDARPVIDARTVVCVLTHDPKFDVPLLEVALRLPDIAYIGAGSRRTHEDRLARL-LTEEELARLSSPIGLDLGGRTPEETAVSIAAEIIAKRW-----------------

3on5A

0.21

0.20

0.95

3.16

Env-PPAS

--SDIELLETLAGTDQPRVATIIHVEGSSYRKEG--ALFQEDGTQVGLLSGGCLETDLTIKAQKVWQEQLPRTVVYDLSSEHLKRVHSGHPVEWIRKIDENEEPLFTHIYSPKERLIIFGAGPDVPPLVTFASNVGFYTVVTDWRPNLIRPDDFVLITHHFQKDQEILHFLLEKELRYIGILGSKERTRRLLQNR----KPPDHLYSPVGLSIDAQGPEEIAISIVAQLIQLIRSRKQASSPFSYLF----

3on5A

0.21

0.20

0.94

1.66

MUSTER

IELLETLAG----TDQPRVATIIHVEGSSYRKEG--ALFQEDGTQVGLLSGGCLETDLTIKAQKVWQEQLPRTVVYDLSSEYFGEWHSGHPVEWIRKIDENEEPLFTHIYSPKERLIIFGAGPDVPPLVTFASNVGFYTVVTDWRPNLIRPDDFVLITHHFQKDQEILHFLLEKELRYIGILGSKERTRRLLQ----NRKPPDHLYSPVGLSIDAQGPEEIAISIVAQLIQLIRSRKQSPFSYLF------

3on5A

0.21

0.20

0.95

1.98

dPPAS

--SDIELLETLAGTDQPRVATIIHVEGSSYRKEG--ALFQEDGTQVGLLSGGCLETDLTIKAQKVWQEQLPRTVVYDLSSEYFGEWHSGHPVEWIRKIDENEEPLFTHIYSPKERLIIFGAGPDVPPLVTFASNVGFYTVVTDWRKFLIRPDDFVLITHHFQKDQEILHFLLEKELRYIGILGSKERTRRLLQ----NRKPPDHLYSPVGLSIDAQGPEEIAISIVAQLIQLIRSRKQASSPFSYLF----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.24

Estimated TM-score = 0.75±0.11

Estimated RMSD = 5.3±3.4Å

Download Model 2

C-score=-2.27

Download Model 3

C-score=-3.03

Download Model 4

C-score=-3.52

Download Model 5

C-score=-0.63

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2we7A	0.850	1.82	0.241	0.908
2	3on5A	0.670	3.91	0.167	0.865
3	5kcaA	0.551	5.38	0.053	0.829
4	1sy7A	0.514	5.66	0.064	0.829
5	1cf9A	0.499	5.82	0.087	0.817
6	2iufA	0.495	5.96	0.083	0.841
7	1xzpA	0.489	5.25	0.077	0.729
8	3ej6A	0.489	5.90	0.070	0.821
9	4ja0A	0.476	4.50	0.072	0.665
10	3gehA	0.472	4.94	0.074	0.677

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3ze6A	SBY	Rep, Mult	114,116,137,154,181,226,230,233
2	0.04	2	1gzmA	C8E	Rep, Mult	230,233
3	0.04	2	5d51S	KR	Rep, Mult	116,118,128,137,229
4	0.04	2	2a68P	MG	Rep, Mult	224,227
5	0.04	2	1jb0M	CLA	Rep, Mult	222,226
6	0.04	2	1w5cD	CLA	Rep, Mult	218,221,222,229
7	0.04	2	5ezmA	MPG	Rep, Mult	219,222
8	0.04	2	1xzqA	FON	Rep, Mult	3,19,38,46,48
9	0.02	1	1bdiA	QNA	Rep, Mult	37,52,55
10	0.02	1	1ibvA	UUU	Rep, Mult	183,184
11	0.02	1	3p27A	GDP	Rep, Mult	122,123,124,125,127,128,129,130,224
12	0.02	1	2wtfA	CA	Rep, Mult	193,196
13	0.02	1	1vpwA	QNA	Rep, Mult	21,22,47,55,58
14	0.02	1	1k4pA	ZN	Rep, Mult	35,228
15	0.02	1	1c9uA	CA	Rep, Mult	166,178,186
16	0.02	1	3q9cH	Q9C	Rep, Mult	178,201
17	0.02	1	2fkaA	CXS	Rep, Mult	135,223,226

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3mtjA	0.423	3.43	0.107	0.518	1.1.1.3	139,227
2	0.060	1b8pA	0.420	3.38	0.099	0.518	1.1.1.37	NA
3	0.060	2jfdA	0.311	6.02	0.097	0.526	2.3.1.85	NA
4	0.060	2ldxA	0.422	3.97	0.122	0.542	1.1.1.27	14
5	0.060	1p1jA	0.432	4.32	0.066	0.578	5.5.1.4	NA
6	0.060	2vz8B	0.444	5.61	0.079	0.721	2.3.1.85	NA
7	0.060	2f7kA	0.424	4.04	0.072	0.558	2.7.1.35	NA
8	0.060	5ldhA	0.412	3.84	0.121	0.530	1.1.1.27	NA
9	0.060	5r1rA	0.436	5.49	0.073	0.689	1.17.4.1	NA
10	0.060	1cqzB	0.435	5.38	0.052	0.697	3.3.2.10,3.3.2.3	NA
11	0.060	1sy7A	0.514	5.66	0.064	0.829	1.11.1.6	NA
12	0.060	2h31A	0.462	4.68	0.083	0.669	4.1.1.21,6.3.2.6	66
13	0.060	1ldxA	0.411	4.04	0.115	0.534	1.1.1.27	156,190,221,224
14	0.060	1sy7B	0.491	5.14	0.053	0.725	1.11.1.6	224,230,233
15	0.060	3ej6D	0.490	5.84	0.071	0.809	1.11.1.6	229
16	0.060	2iufA	0.495	5.96	0.083	0.841	1.11.1.6	NA
17	0.060	1cf9A	0.499	5.82	0.087	0.817	1.11.1.6	NA
18	0.060	3ej6A	0.489	5.90	0.070	0.821	1.11.1.6	NA
19	0.060	2ejwA	0.422	2.77	0.145	0.494	1.1.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.514	5.66	0.06	0.83	1sy7A	GO:0004096 GO:0004601 GO:0005576 GO:0005618 GO:0005619 GO:0005829 GO:0006979 GO:0016491 GO:0020037 GO:0042542 GO:0042744 GO:0046872 GO:0048315 GO:0055114 GO:0098869
1	0.07	0.435	6.03	0.07	0.76	4b2yA	GO:0004096 GO:0004601 GO:0006979 GO:0016491 GO:0020037 GO:0042744 GO:0046872 GO:0055114 GO:0098869
2	0.07	0.488	5.83	0.09	0.80	2xf2A	GO:0004096 GO:0004601 GO:0006979 GO:0016491 GO:0020037 GO:0042744 GO:0046872 GO:0055114 GO:0098869
3	0.06	0.369	4.16	0.09	0.49	2vrnA	GO:0006508 GO:0008233 GO:0016798 GO:0019172 GO:0019243 GO:0019249 GO:0046872
4	0.06	0.356	3.65	0.08	0.45	4y0nB	GO:0016798
5	0.06	0.350	3.64	0.09	0.45	1g2iA	GO:0005737 GO:0006508 GO:0008233 GO:0016787 GO:0016798
6	0.06	0.354	3.82	0.07	0.46	3l18A	GO:0006508 GO:0008233 GO:0016798
7	0.06	0.501	5.84	0.09	0.82	5bv2P	GO:0004096 GO:0004601 GO:0005506 GO:0005737 GO:0005829 GO:0006972 GO:0006974 GO:0006979 GO:0016491 GO:0020037 GO:0042542 GO:0042744 GO:0042802 GO:0046872 GO:0055114 GO:0098869
8	0.06	0.295	6.54	0.02	0.53	1si8A	GO:0004096 GO:0004601 GO:0006979 GO:0016491 GO:0020037 GO:0042744 GO:0046872 GO:0055114 GO:0098869
9	0.06	0.354	3.54	0.07	0.45	1ba2A	GO:0005886 GO:0006810 GO:0006935 GO:0008643 GO:0015145 GO:0015749 GO:0016020 GO:0016021 GO:0030288 GO:0042597
10	0.06	0.309	6.71	0.04	0.57	4cabA	GO:0004096 GO:0004601 GO:0005737 GO:0006979 GO:0016491 GO:0020037 GO:0042542 GO:0042744 GO:0046872 GO:0055114 GO:0098869
11	0.06	0.295	5.42	0.03	0.47	3ozcA	GO:0003824 GO:0004645 GO:0005634 GO:0005737 GO:0005829 GO:0006139 GO:0006166 GO:0006738 GO:0009116 GO:0016740 GO:0016757 GO:0016763 GO:0017061 GO:0019509 GO:0032259 GO:0033574 GO:0043101 GO:0070062
12	0.06	0.306	6.65	0.01	0.57	1a4eA	GO:0000302 GO:0001315 GO:0004096 GO:0004601 GO:0005759 GO:0005777 GO:0005782 GO:0006979 GO:0016491 GO:0020037 GO:0042542 GO:0042744 GO:0046872 GO:0055114 GO:0098869
13	0.06	0.270	6.26	0.04	0.48	1h99A	GO:0003723 GO:0006351 GO:0006355 GO:0045893
14	0.06	0.277	6.87	0.06	0.53	5akrA	GO:0005507 GO:0006807 GO:0016491 GO:0019333 GO:0042128 GO:0042597 GO:0046872 GO:0050421 GO:0055114
15	0.06	0.290	5.56	0.03	0.47	1u0bB	GO:0000166 GO:0004812 GO:0004817 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006423 GO:0008270 GO:0016874 GO:0046872
16	0.06	0.281	6.61	0.03	0.52	4qoqA	GO:0004096 GO:0004601 GO:0006979 GO:0016491 GO:0020037 GO:0042744 GO:0046872 GO:0055114 GO:0098869
17	0.06	0.309	6.72	0.04	0.58	1qwlA	GO:0004096 GO:0004601 GO:0005737 GO:0006979 GO:0016491 GO:0020037 GO:0042744 GO:0046872 GO:0055114 GO:0098869
18	0.06	0.309	6.70	0.03	0.57	2isaA	GO:0004096 GO:0004601 GO:0006979 GO:0016491 GO:0020037 GO:0042744 GO:0046872 GO:0055114 GO:0098869

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0016684	GO:0016209	GO:0046906
GO-Score	0.47	0.37	0.37	0.37
Biological Processes	GO:0044248	GO:0006950	GO:0044710	GO:1990748	GO:0042743
GO-Score	0.37	0.37	0.37	0.37	0.37
Cellular Component	GO:0005829	GO:0005619	GO:0005576
GO-Score	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.