I-TASSER results

I-TASSER results for job id Rv0368c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (403 residues)
MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQLVPRTPAALYWGARLT
LVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRTPVAGVGHRAKRRSCAAQA
QNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPFDQFDPDDLRLLGAWLEATMA
RWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLLARIRPRRRPRRVLLLCDVSRSM
QPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSHRSAEMALHRANARVTDRYG
GTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVWLNPR
AAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQLVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPFDQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSHRSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR
Prediction	CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEHCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
Conf.Score	9987778887678999999999999899789999999999999969999999999999997899999999999999997555556655444555555554556665555555677877776557654444444555545455555544445555455557779999999999999999999887665555567778888999999999998995677777568888886899995998858999999999999999677886899998883456778987799999999999985678998649999999999888766788599998687677885789999999999899699968999988877645899999999998646789999999999997579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQLVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPFDQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSHRSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR
Prediction	8544543364401300020031026240301050012002004404263162012000000022471152024003302532422444223333443433443355432534443443435524444344434444444442434522443344244220440346215303510430144045243343344532540204300230053011003023344454312000000000002300300110010013344143010000001012004204643143004302440362111120030023006402541244000000011124442520140032017104100000010535422210100310141033002022062024006303768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEHCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQLVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRTPVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPFDQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLLARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLTSVLSHRSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDSDPPDVLVHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGLHQLLLALAGAR

2nvoA

0.14

0.12

0.86

0.97

wPPAS

KTAPNAAD-PEVGTMLLHFLAFADAGGWG-GVANVYETVDKLALWAVKYKASQADALRKA--DDAARNAVLKFMVD----------VLPKVDSPALRVIEGHLKATEAQTDAAAAALMQEYRLPLEAVPTHVRGAEVYRAAMQTLTWLLRNLGNLGRVGV--LTPNDSATVQAVIERLTDPAALKRGRARLVYAQGQGVRVVDALEEAFTL--------FGNVQPANTRHLLALDVSGSM---PNMAAAAMSLIALRTE-PDALTMGFAEQFRPL----PRDTLESAMQKAQSVS---FGGTDCAQPILWAAQE-----LDVDTFVVYTDNETWAGQVHPTVALDQYAQKMGKLIVVGATEFSI--DPQRRDM-------------LDVAAAPNVMTAFARGE

5cwiA

0.07

0.04

0.58

1.06

dPPAS2

---------------------------------------------------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKL------CIKAASEAAEAASKAAELAQRHPDSQAARDAIKL------ASQAAEAVKLACELAQEHPNADIAK-------KCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER----------------------------------------------------------------------------------

5a8jA1

0.15

0.06

0.39

1.18

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGIHYVVMIDNSPSMKKINLALSSASRLVQDIIPGNFISIYLFSNDIETLYEGESGKQ--IEL-----KSIKMGYTTNLHKAITKVLEKFKS-SEIPVKIILLSDGKP-TDKRYSRDYESLQVPKNVQLITI--------EDYNEAIMKILADKGSVFYHIND---PSQLPTTLVEQK

4rckA

0.11

0.05

0.43

1.16

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRDLVVDLSGSAEDRLTAVKQVVSDFIDQRKGDRLGLVLFGDHAYLQTPL--TFDRNTVREQLDRVLNLVGQRTAIGEGLGLATKTFIESNAPQRTIILLSDGANTAGVLEPLEAAQLAKDNHAKIYTVGFFGKQTVNTARDLDEDTLTKIATQYFRARNADELAEIYQTID--A

4fx5A1

0.13

0.06

0.42

1.14

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SENVEVIIIDCSGSDYPRTKAAKEATKVAIDTTDGAFFAVVAGTEGARVVYPTGGQLLRYQSRAAAKEAVLHANGGTA-GRWLAQAGRIFDTAPSAIKHAILLTDGKDESETPADLARAIQSSIGNFTADCRG-----IGEDWEPKELRKIADALLTVGIIRDPATLAEDFRETAKS-

4cn8A1

0.16

0.07

0.42

1.12

Env-PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAEEDVQADIIVLFDDSSSIQMMKDFVKELVDSFTTVGVGSQFGVVQFSQGVKTAFPLNKFKTKEDIKKGIQDMVPRNGGQTEIGTGLKHVRENSFSGAEGGKIVILMTDGKSNAGA-PPQHEAHKLKAEGVTVIAI-----GIGQGFVKTELEQIATMKNYVLTTNSFSELSTL--------

2nvoA2

0.15

0.08

0.53

1.10

Env-PPAS

------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDESRLTRFLVLGVDTFYASAQKHTVQATDF-VRELVQRDAALARVTLDVVRGQRAPANTRHLLALDVSGSMVAGPNMAAAAMSLIALRTE-PDALTMGFAEQFRPL-GITPRDTLESAMQKAQ---SVSFGGTDCAQPILWAAQER----LDVDTFVVYTDNETWAGQVHPTVALDQYAQKMGIVVGLTATEFSI-ADPQRRDM--------LDVVGFD-AAAPNVMTAFARGE

4c0oA

0.10

0.98

0.86

MUSTER

CVEKAGTDEKMLMKVFRCLGSWFNLGVLDANNKLLALLFEVLQQ--DKTSSNLHEAASDCVCSALYAVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRLLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDVSDLVKDLIFLIGECFAQLYSTLKEGNPPLFIMAAIAKSVDPNNPTLVEVLEGVVRLPETVHTAVYTSIELVGEMSEVVDRNFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQNGLLEIARSLDSFLLSPEAAVGLLKGTALV-----LARLPLDKITECLSELCSVQVMALKKLLPTVFLDRLAVIFRHTNPIV

5cwiA

0.07

0.04

0.58

0.59

dPPAS

---------------------------------------------------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKL------CIKAASEAAEAASKAAELAQRHPDSQAARDAIKL------ASQAAEAVKLACELAQEHPNADIAK-------KCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER----------------------------------------------------------------------------------

1yvpB

0.11

0.10

0.91

0.81

wdPPAS

RAVPEVCRIPTHLFTFIQFKKDLKEG--MWGRALRKAVSDWYNTKDALN--SHKDLLRLS--ANEGLTMVAKYVSKGWKEVQEAYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLVREHLL---TIHLKSKEIWKSLLQDMPLTALLRNLGKMTADSVSEVSSVCERLTNEKLLKKARIHKGHGNKLRWIPDTSIVEALDN----FYKSFKLVEPTGKRFLLAIDVSASMNILNASVVAAAMCMLVARTEKDSHMVAFSDEMLPCP---VNMLLHEVVEKMSDIT---MGSTDCALPMLWAQKT-----TAADIFIVFTDCETNVEDVHPATALKQYREKMGKLIVCA-MTSNG-ADPDDRGMLDI-------FDSGALDVIRNFTLDL----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.44

Estimated TM-score = 0.43±0.14

Estimated RMSD = 12.7±4.3Å

Download Model 2

C-score=-3.02

Download Model 3

C-score=-2.11

Download Model 4

C-score=-3.30

Download Model 5

C-score=-3.35

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1yvpB	0.818	3.17	0.087	0.943
2	2nvoA	0.703	4.32	0.104	0.906
3	1djnA	0.482	6.48	0.083	0.754
4	1vsy4	0.480	6.50	0.040	0.752
5	3k30A	0.478	6.43	0.066	0.742
6	5cskA	0.466	6.35	0.043	0.717
7	1ps9A	0.461	6.73	0.082	0.730
8	1dfjI	0.458	6.97	0.070	0.772
9	5lqwQ	0.449	6.64	0.045	0.715
10	4k17A	0.448	6.91	0.085	0.752

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.45	21	1mhpA	MN	Rep, Mult	235,237,239,302,330
2	0.04	2	1djnA	SF4	Rep, Mult	305,308,338,339,340,344,345,346
3	0.02	1	1ps9A	SF4	Rep, Mult	267,275,276,278,279,288,290
4	0.02	1	2bptA	III	Rep, Mult	308,311,312,315,316,347,351
5	0.02	1	2z7xB	UUU	Rep, Mult	234,326,329,355

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jI	0.153	5.23	0.053	0.208	1.17.1.4,1.17.3.2	260
2	0.060	2eabA	0.403	7.21	0.032	0.690	3.2.1.63	NA
3	0.060	1h54B	0.397	7.56	0.061	0.707	2.4.1.8	NA
4	0.060	1fo4A	0.408	7.19	0.052	0.697	1.17.1.4	NA
5	0.060	2ewbA	0.397	6.47	0.071	0.623	3.4.11.1,3.4.11.5	235,306
6	0.060	3b9jC	0.299	7.10	0.037	0.506	1.17.3.2,1.17.1.4	NA
7	0.060	1kc7A	0.427	6.98	0.058	0.720	2.7.9.1	NA
8	0.060	2vz8B	0.394	6.47	0.065	0.610	2.3.1.85	NA
9	0.060	1j0mA	0.395	7.32	0.052	0.690	4.2.2.12	266
10	0.060	1bf2A	0.405	6.48	0.044	0.645	3.2.1.68	NA
11	0.060	1b0pA	0.435	7.03	0.049	0.722	1.2.7.1	NA
12	0.060	1vbgA	0.405	6.83	0.063	0.667	2.7.9.1	NA
13	0.060	2j5wA	0.437	6.84	0.058	0.732	1.16.3.1	NA
14	0.060	3f93A	0.423	5.61	0.096	0.610	3.2.1.-	297
15	0.060	2ebsB	0.411	7.25	0.045	0.710	3.2.1.150	NA
16	0.060	3c5wA	0.292	5.79	0.081	0.432	3.1.3.16	NA
17	0.060	3ebgA	0.405	7.38	0.047	0.702	3.4.11.-	NA
18	0.060	1ps9A	0.461	6.73	0.082	0.730	1.3.1.34	247,289
19	0.060	2gtqA	0.394	7.13	0.064	0.677	3.4.11.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.54	0.818	3.17	0.09	0.94	1yvpB	GO:0003723 GO:0005737 GO:0030030 GO:0030529 GO:0034336 GO:0046872
1	0.11	0.703	4.32	0.10	0.91	2nvoA	GO:0003723 GO:0005737 GO:0030529 GO:0046872
2	0.07	0.482	6.48	0.08	0.75	1djnA	GO:0003824 GO:0010181 GO:0016491 GO:0046872 GO:0050470 GO:0051536 GO:0051539 GO:0055114
3	0.07	0.478	6.43	0.07	0.74	3k30A	GO:0000166 GO:0003824 GO:0010181 GO:0016491 GO:0046872 GO:0051536 GO:0051539 GO:0055114
4	0.07	0.461	6.73	0.08	0.73	1ps9A	GO:0003824 GO:0003959 GO:0005622 GO:0008670 GO:0010181 GO:0016491 GO:0033543 GO:0046872 GO:0051536 GO:0051539 GO:0055114 GO:0071949
5	0.06	0.352	6.93	0.05	0.58	5d80B	GO:0000166 GO:0000221 GO:0000329 GO:0003677 GO:0004518 GO:0004519 GO:0005524 GO:0005773 GO:0005774 GO:0006314 GO:0006810 GO:0006811 GO:0007035 GO:0012505 GO:0015991 GO:0015992 GO:0016020 GO:0016539 GO:0016787 GO:0016820 GO:0030908 GO:0033178 GO:0044267 GO:0046034 GO:0046961 GO:0090305
6	0.06	0.347	6.28	0.07	0.53	4d7kF	GO:0008168 GO:0008171 GO:0016740 GO:0032259
7	0.06	0.328	7.26	0.06	0.57	1fohC	GO:0004497 GO:0005737 GO:0016491 GO:0018662 GO:0019336 GO:0019439 GO:0055114 GO:0071949
8	0.06	0.327	7.20	0.08	0.55	5er0A	GO:0005623 GO:0016491 GO:0045454 GO:0050660 GO:0055114
9	0.06	0.310	7.27	0.05	0.53	2cduA	GO:0000166 GO:0005623 GO:0016491 GO:0045454 GO:0050660 GO:0055114
10	0.06	0.301	7.31	0.06	0.52	3oc4A	GO:0000166 GO:0005623 GO:0016491 GO:0045454 GO:0050660 GO:0055114
11	0.06	0.296	7.20	0.05	0.50	4rnxA	GO:0003824 GO:0003959 GO:0010181 GO:0016491 GO:0018548 GO:0052690 GO:0055114
12	0.06	0.319	6.26	0.10	0.49	1q1wA	GO:0005623 GO:0016491 GO:0019383 GO:0045454 GO:0050660 GO:0055114
13	0.06	0.306	6.20	0.05	0.47	3atyA	GO:0000166 GO:0003824 GO:0010181 GO:0016491 GO:0055114
14	0.06	0.292	6.27	0.04	0.45	1z41A	GO:0003824 GO:0003959 GO:0005622 GO:0009636 GO:0010181 GO:0016491 GO:0018548 GO:0050661 GO:0052690 GO:0055114
15	0.06	0.275	6.87	0.06	0.45	2q3oB	GO:0003824 GO:0003959 GO:0005777 GO:0006629 GO:0006631 GO:0006633 GO:0009620 GO:0009695 GO:0010181 GO:0010193 GO:0016491 GO:0016629 GO:0031408 GO:0055114
16	0.06	0.269	6.62	0.05	0.43	3l5aA	GO:0003824 GO:0010181 GO:0016491 GO:0055114
17	0.06	0.284	6.39	0.06	0.44	1gwjA	GO:0000166 GO:0003824 GO:0010181 GO:0016491 GO:0055114
18	0.06	0.273	6.52	0.04	0.42	4jicA	GO:0000166 GO:0003824 GO:0010181 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0034336	GO:0051536	GO:0048037	GO:0032553
GO-Score	0.67	0.54	0.37	0.37	0.37
Biological Processes	GO:0030030	GO:0044710
GO-Score	0.54	0.37
Cellular Component	GO:0005737	GO:0030529
GO-Score	0.59	0.59

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.