I-TASSER results

I-TASSER results for job id Rv0365c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (376 residues)
MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLFGSWHYWWQAHLLDCLV
DAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLALALERADRVAGVRRRRAL
PKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFLARYPDQYGKRLKRAEQMADW
IDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLETELAVRTGPAARARHCARVHRL
VAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALVATTLPGDSADDAAARDTARAIVLA
SAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGEQARSVRGAVHSSAIAERDLSVQLSGW
MLMEAAHSAAAVSSLG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLFGSWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLALALERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFLARYPDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLETELAVRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALVATTLPGDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGEQARSVRGAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG
Prediction	CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCEEHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
Conf.Score	9678899999999999999987688887765445788888888888887646779999999999869989999999999987467888888888765899999999999987985699999999999996689999865678998866544579999999998668878999999999999998986899868578888876776444336899999999999989979999999999999999998568996557899887557789999999999986888755578999999999999999999866889987568888888888887765677899998765565544567889999999999886567889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLFGSWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLALALERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFLARYPDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLETELAVRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALVATTLPGDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGEQARSVRGAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG
Prediction	6530533331343135300320110120100102013144554143200000000000000002204264024202400330324333302120000000000000100322647402300300320142124400000102464511000000000000010154365004103400300261011373010000132553442310000000000001002105475125104302400420242015410032314310100000000000100210233443345115202500340041005204545422100020233152344323212202110323414334100000000000000215356568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCEEHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLFGSWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLALALERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFLARYPDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLETELAVRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALVATTLPGDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGEQARSVRGAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG

3k7xA

0.23

0.20

0.88

2.33

MUSTER

-KWSEYANLAQQSLEKFYLADTKEQFLNNF----YPTENPEEDNKVFNYWWLAHLVEVRLDAYLRTKKQADLEVAEKTYLHNKNRNGGTLIHDFYDD-LWNALAAYRLYKATGKSIYLEDAQLVWQDLVD-WNDIGGGFAWRRPQYYKNTPVNAPFIILSCWLYNELNTKYLEWAKTYEWQTKVLV-REDGFVEDGIDGTIDYEWKFTYNQGVYIGANLELYRITKEAIYLDTANKTAAISLKELT---EDGIFKEGNGGDEGLFKGIFYRYFTDLIEETAN---------KTYRDFVLNSCQILVENAKLDGY--LLGNWKEKPS----------------------GKIPYSAELSGIALEAAKLELEHHHHH-

3k7xA

0.23

0.20

0.89

2.92

dPPAS

-KWSEYANLAQQSLEKFYL----ADTKEQFLNNFYPTENPEEDNKVFNYWWLAHLVEVRLDAYLRTKKQADLEVAEKTYLHNKNRNGGTLIHDFYDD-LWNALAAYRLYKATGKSIYLEDAQLVWQDLVDTWNDIGGGFAWRRPQYYKNTPVNAPFIILSCWLYNENETKYLEWAKTYEWQTKV-LVREDGFVEDGIDGTIDYEWKFTYNQGVYIGANLELYRITKEAIYLDTANKTAAISLKELT--EDGIFKDEGNGGDEGLFKGIFYRYFTDLIEETAN---------KTYRDFVLNSCQILVENAKL--DGYLLGNWKEKPSGK----------------------IPYSAELSGIALEAAKLELEHHHHH-

4bojA

0.20

0.18

0.86

4.24

wdPPAS

----SDGDTAMKAFNDTFWD---PNAKMF--------WKDSKREKHQDAWVEAELWELVMDAYQHTSDPALKAELKTQIDDVYDGGQDWTNNPFNDDIMWWAMGSARAYQITGNPRYLEAARDHFDFVYD-EEFANGGIWWNSDHNTKNACINFPAAQAALYLYDKDEHYLNAATKIFRWGKTMLTDG-NGKVFDRIEEHGAVPDATHYNQGTYIGSAVGLYKATGNAVYLDDAVKAAKFTKNHLV--DSNGVLNYGPNGDLKGGKTILMRNLAHLQKTLDETG-QYPEFSAEFDEWLAFNIEMAWSHR---NSDHIVDGNWAGQLLSGTYESWSSAAAVQALNG-------------------------------

3k7xA

0.23

0.20

0.88

2.78

wMUSTER

--WSEYANLAQQSLEKFYLADTKEQFLNNF----YPTENPEEDNKVFNYWWLAHLVEVRLDAYLRTKKQADLEVAEKTYLHNKNRNGGTLIHDFYDD-LWNALAAYRLYKATGKSIYLEDAQLVWQDLVD-WNDIGGGFAWRRPQYYKNTPVNAPFIILSCWLYNELNTKYLEWAKTYEWQTKVLV-REDGFVEDGIDGTIDYEWKFTYNQGVYIGANLELYRITKEAIYLDTANKTAAISLKELT---EDGIFKEGNGGDEGLFKGIFYRYFTDLIEETAN---------KTYRDFVLNSCQILVENAKLDGY--LLGNWKEKPS----------------------GKIPYSAELSGIALEAAKLELEHHHHH-

3k7xA

0.23

0.20

0.88

4.60

wPPAS

-KWSEYANLAQQSLEKFYLADTKEQFLNNF----YPTENPEEDNKVFNYWWLAHLVEVRLDAYLRTKKQADLEVAEKTYLHNKNRNGGTLIHDFYDD-LWNALAAYRLYKATGKSIYLEDAQLVWQDLVD-WNDIGGGFAWRRPQYYKNTPVNAPFIILSCWLYN-NETKYLEWAKTYEWQTKVLVR-EDGFVEDGIDGTIDYEWKFTYNQGVYIGANLELYRITKEAIYLDTANKTAAISLKELT---EDGIFKDENGGDEGLFKGIFYRYFTDLIEETAN---------KTYRDFVLNSCQILVENAKLDGY--LLGNWKEKPS----------------------GKIPYSAELSGIALEAAKLELEHHHHH-

3k7xA

0.23

0.20

0.88

7.67

dPPAS2

-KWSEYANLAQQSLEKFYLADTKEQFLNNF----YPTENPEEDNKVFNYWWLAHLVEVRLDAYLRTKKQADLEVAEKTYLHNKNRNGGTLIHDFYDD-LWNALAAYRLYKATGKSIYLEDAQLVWQDLVDTWNDIGGGFAWRRPQYYKNTPVNAPFIILSCWLYNENETKYLEWAKTYEWQTKV-LVREDGFVEDGIDGTIDYEWKFTYNQGVYIGANLELYRITKE---AIYLDTANKTAAISLKELTEDGFKDEGNGGDEGLFKGIFYRYFTDLIEETAN---------KTYRDFVLNSCQILVENAKL--DGYLLGNWKEKPSGK----------------------IPYSAELSGIALEAAKLELEHHHHH-

3k7xA

0.23

0.20

0.88

3.71

PPAS

-KWSEYANLAQQSLEKFYLADTKEQFLNNF----YPTENPEEDNKVFNYWWLAHLVEVRLDAYLRTKKQADLEVAEKTYLHNKNRNGGTLIHDFYDD-LWNALAAYRLYKATGKSIYLEDAQLVWQDLVD-WNDIGGGFAWRRPQYYKNTPVNAPFIILSCWLYNENETKYLEWAKTYEWQTKV-LVREDGFVEDGIDGTIDYEWKFTYNQGVYIGANLELYRITKE---AIYLDTANKTAAISLKELTEDGIFKDGNGGDEGLFKGIFYRYFTDLIEETAN---------KTYRDFVLNSCQILVENAKLDGY--LLGNWKEKPS----------------------GKIPYSAELSGIALEAAKLELEHHHHH-

3k7xA

0.23

0.21

0.88

6.91

Env-PPAS

-KWSEYANLAQQSLEKFYLADTKEQFLNNF----YPTENPEEDNKVFNYWWLAHLVEVRLDAYLRTKKQADLEVAEKTYLHNKNRNGGTLIHDFYDD-LWNALAAYRLYKATGKSIYLEDAQLVWQDLVDTWNDIGGGFAWRRPQYYKNTPVNAPFIILSCWLYNENETKYLEWAKTYEWQTKVLV-REDGFVEDGIDGTIDYEWKFTYNQGVYIGANLELYRITKE---AIYLDTANKTAAISLKELTEDGIFKDENGGDEGLFKGIFYRYFTDLIEETA---------NKTYRDFVLNSCQILVENAKLDGY--LLGNWKEKPSGK----------------------IPYSAELSGIALEAAKLELEHHHHH-

4bojA

0.21

0.18

0.86

2.22

MUSTER

----SDGDTAMKAFNDTFWD---PNAKMF--------WKDSKREKHQDAWVEAELWELVMDAYQHTSDPALKAELKTQIDDVYDYGQDWTNNPFNDDIMWWAMGSARAYQITGNPRYLEAARDHFDFVYDTEEFANGGIWWNSDHNTKNACINFPAAQAALYLYDKDEHYLNAATKIFRWGKTMLTD-GNGKVFDRIEIEHAVPDATHYNQGTYIGSAVGLYKATGNAVYLDDAVKAAKFTKNHLV--DSNGVLNYEGNGDLKGGKTILMRNLAHLQKTLDETGQ-YPEFSAEFDEWLAFNIEMAWSHRNSD---HIVDGNWAGQLLSGTYESWSSAAAVQALNG-------------------------------

4bojA

0.20

0.18

0.86

2.89

dPPAS

--------SDGDTAMKAFNDTFWDPNAKMF-------WKDSKREKHQDAWVEAELWELVMDAYQHTSDPALKAELKTQIDDVYDGGQDWTNNPFNDDIMWWAMGSARAYQITGNPRYLEAARDHFDFVYDTEEFANGGIWWNSDHNTKNACINFPAAQAALYLYDKDEHYLNAATKIFRWGKTMLTDG-NGKVFDRIEIEHAVPDATHYNQGTYIGSAVGLYKATGNAVYLDDAVKAAKFTKNHLV--DSNGVLNYGPNGDLKGGKTILMRNLAHLQKTLDETG-QYPEFSAEFDEWLAFNIEMAWSHR---NSDHIVDGNWAGQLLSGTYESWSSAAAVQALNG-------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.37

Estimated TM-score = 0.76±0.10

Estimated RMSD = 5.9±3.7Å

Download Model 2

C-score=-0.42

Download Model 3

C-score=-0.95

Download Model 4

C-score=-4.58

Download Model 5

C-score=0.25

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3k7xA	0.834	1.78	0.238	0.883
2	4bojA	0.801	2.07	0.191	0.862
3	4c1sA	0.785	2.89	0.159	0.888
4	4mu9A	0.755	2.81	0.169	0.851
5	4v1rA	0.742	3.23	0.135	0.862
6	3wkfA	0.741	3.68	0.111	0.896
7	3h7lA	0.735	4.13	0.095	0.928
8	5dgqA	0.731	4.28	0.069	0.925
9	3vw5A	0.727	3.65	0.089	0.880
10	4z4jA	0.726	3.63	0.069	0.878

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	3	2hodB	CA	Rep, Mult	96,97,100,101
2	0.06	2	1js4A	CA	Rep, Mult	215,216,219,220,272
3	0.06	2	2cqtA	PO4	Rep, Mult	151,195,208,209
4	0.06	2	4d4bA	MSX	Rep, Mult	141,149,151,195,209,262
5	0.04	1	4d4dA	IFM	Rep, Mult	50,96,97,100,141,209,262
6	0.03	1	1vd5A	DTT	Rep, Mult	141,149
7	0.03	1	2zhcA	MG	Rep, Mult	195,196
8	0.03	1	3rj8A	ZN	Rep, Mult	175,179
9	0.03	1	1js4A	CA	Rep, Mult	57,105,108,109
10	0.03	1	3ungC	CA	Rep, Mult	195,196,261
11	0.03	1	1dogA	MAN	Rep, Mult	213,268,269,270,271,272
12	0.03	1	3l22A	ZN	Rep, Mult	187,189
13	0.03	1	1rq5A	CA	Rep, Mult	82,89,90,92,94,95,96,97

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.068	2f6dA	0.686	4.55	0.088	0.902	3.2.1.3	NA
2	0.067	1ayxA	0.684	4.54	0.091	0.899	3.2.1.3	334
3	0.067	1ia7A	0.667	4.42	0.075	0.854	3.2.1.4	NA
4	0.067	1gaiA	0.682	4.40	0.092	0.886	3.2.1.3	NA
5	0.067	1is9A	0.592	3.73	0.095	0.705	3.2.1.4	209,261
6	0.067	2ri9B	0.665	4.65	0.076	0.878	3.2.1.113	195
7	0.067	1tnzL	0.574	4.52	0.075	0.761	2.5.1.59	352
8	0.067	1nxcA	0.664	4.47	0.077	0.859	3.2.1.113	NA
9	0.067	1wzzA	0.528	4.15	0.104	0.662	3.2.1.4	141
10	0.067	1n4pB	0.573	4.51	0.072	0.758	2.5.1.59,2.5.1.-	NA
11	0.060	1hzfA	0.547	4.14	0.100	0.689	3.4.21.43	NA
12	0.060	1h12A	0.608	4.41	0.070	0.785	3.2.1.8	143
13	0.060	1ks8A	0.657	4.46	0.119	0.851	3.2.1.4	NA
14	0.060	1fp3A	0.710	4.16	0.086	0.896	5.1.3.8	NA
15	0.060	2jg0A	0.656	4.11	0.069	0.830	3.2.1.28	NA
16	0.060	1kktA	0.667	4.60	0.078	0.880	3.2.1.113	NA
17	0.060	1ft1B	0.599	4.56	0.071	0.795	2.5.1.58,2.5.1.-	NA
18	0.060	1w6jA	0.563	4.03	0.093	0.707	5.4.99.7	NA
19	0.060	1fo2A	0.653	4.83	0.068	0.883	3.2.1.113	152
20	0.060	2sqcA	0.637	4.13	0.113	0.795	5.4.99.17	97,207,209
21	0.060	1dceB	0.584	4.34	0.069	0.755	2.5.1.60,2.5.1.-	NA
22	0.060	2vn7A	0.682	4.52	0.099	0.899	3.2.1.3	171,173,176
23	0.060	1ksdA	0.658	4.42	0.125	0.848	3.2.1.4	NA
24	0.060	1ojnA	0.573	5.10	0.054	0.803	4.2.2.1	NA
25	0.060	1fmiA	0.652	4.76	0.083	0.878	3.2.1.113	NA
26	0.060	2drsA	0.601	4.53	0.111	0.785	3.2.1.156	141,209
27	0.060	1g87B	0.674	4.49	0.102	0.875	3.2.1.4	NA
28	0.060	1dl2A	0.666	5.06	0.065	0.920	3.2.1.113	NA
29	0.060	1h54B	0.574	4.80	0.089	0.771	2.4.1.8	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.51	0.840	1.92	0.25	0.90	3k7xA	GO:0003824
1	0.43	0.803	2.09	0.19	0.86	5agdB	GO:0003824 GO:0030246
2	0.39	0.769	2.81	0.17	0.87	4mu9A	GO:0003824 GO:0016787
3	0.37	0.785	2.89	0.16	0.89	4c1sA	GO:0003824
4	0.33	0.758	3.15	0.13	0.88	4v1rA	GO:0003824
5	0.22	0.677	4.49	0.11	0.88	2xfgA	GO:0000272 GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030248 GO:0042802
6	0.20	0.695	4.38	0.10	0.89	3wiwA	GO:0003824 GO:0016787
7	0.14	0.735	4.13	0.10	0.93	3h7lA	GO:0003824 GO:0004553 GO:0005975 GO:0008810
8	0.12	0.726	3.63	0.07	0.88	4z4jA	GO:0003824 GO:0016853 GO:0047736
9	0.10	0.688	3.99	0.08	0.85	2d8lA	GO:0003824 GO:0005737 GO:0008152 GO:0016787 GO:0016798 GO:0102211
10	0.09	0.701	4.11	0.08	0.88	2zblB	GO:0003824 GO:0006044 GO:0016853 GO:0050121 GO:0061593 GO:1902777
11	0.08	0.649	4.56	0.10	0.85	3wc3A	GO:0000272 GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0046872
12	0.08	0.645	4.67	0.07	0.85	2yikA	GO:0000272 GO:0003824 GO:0004553 GO:0005975 GO:0016787 GO:0046872
13	0.07	0.625	4.82	0.10	0.85	2v8iA	GO:0016829 GO:0016837 GO:0042597 GO:0045490 GO:0046872
14	0.07	0.499	4.68	0.06	0.66	2veqA	GO:0000775 GO:0000778 GO:0000921 GO:0000981 GO:0003677 GO:0005634 GO:0005694 GO:0006355 GO:0006357 GO:0007094 GO:0008270 GO:0008301 GO:0019237 GO:0031518 GO:0046872
15	0.06	0.292	6.47	0.05	0.48	4g68A	GO:0005215 GO:0006810
16	0.06	0.275	6.39	0.06	0.44	2q02A	GO:0046872
17	0.06	0.284	6.80	0.04	0.47	2wkpA	GO:0000139 GO:0000155 GO:0000160 GO:0000166 GO:0001891 GO:0001934 GO:0002093 GO:0002551 GO:0003382 GO:0003924 GO:0004672 GO:0004674 GO:0005524 GO:0005525 GO:0005622 GO:0005634 GO:0005737 GO:0005789 GO:0005802 GO:0005829 GO:0005884 GO:0005886 GO:0005925 GO:0006468 GO:0006897 GO:0006911 GO:0006928 GO:0006935 GO:0006954 GO:0006972 GO:0007010 GO:0007015 GO:0007155 GO:0007160 GO:0007186 GO:0007264 GO:0007411 GO:0007596 GO:0008283 GO:0008361 GO:0009611 GO:0009653 GO:0010310 GO:0010592 GO:0010762 GO:0010811 GO:0014041 GO:0016020 GO:0016023 GO:0016358 GO:0016477 GO:0017137 GO:0019897 GO:0019899 GO:0019901 GO:0021799 GO:0021831 GO:0021894 GO:0022604 GO:0023014 GO:0030027 GO:0030032 GO:0030036 GO:0030041 GO:0030168 GO:0030334 GO:0030742 GO:0030838 GO:0031012 GO:0031295 GO:0031410 GO:0031529 GO:0031901 GO:0031996 GO:0032587 GO:0032707 GO:0034446 GO:0035025 GO:0035556 GO:0035567 GO:0036464 GO:0038095 GO:0038096 GO:0042470 GO:0042826 GO:0042995 GO:0043065 GO:0043552 GO:0043652 GO:0045216 GO:0045453 GO:0045740 GO:0048010 GO:0048013 GO:0048261 GO:0048532 GO:0048812 GO:0048813 GO:0048870 GO:0048873 GO:0050690 GO:0051022 GO:0051056 GO:0051496 GO:0051668 GO:0051894 GO:0051932 GO:0060071 GO:0060263 GO:0070062 GO:0071260 GO:0071526 GO:0071542 GO:0072659 GO:0090023 GO:0090103 GO:0097178 GO:1900026
18	0.06	0.279	6.93	0.06	0.48	1xa0A
19	0.06	0.213	5.66	0.04	0.32	4fglD	GO:0005654 GO:0005737 GO:0007613 GO:0008753 GO:0009055 GO:0016491 GO:0046872 GO:0055114 GO:0070062
20	0.06	0.222	4.98	0.06	0.30	1ek0A	GO:0000011 GO:0000166 GO:0003924 GO:0005525 GO:0005739 GO:0005768 GO:0005769 GO:0005770 GO:0005829 GO:0005886 GO:0006623 GO:0006810 GO:0006895 GO:0006897 GO:0007264 GO:0010008 GO:0015031 GO:0016020 GO:0030139 GO:0031966 GO:0032511 GO:0036010 GO:0036258 GO:0061709

Consensus prediction of GO terms

Molecular Function	GO:0030246	GO:0016787
GO-Score	0.43	0.39
Biological Processes
GO-Score
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.