I-TASSER results

I-TASSER results for job id Rv0342

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (640 residues)
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLT
RARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARL
VLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVG
GLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSR
ATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTAL
WQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVG
DNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEA
KANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAE
TERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA
Prediction	CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHCCCCCEEEEEHCCCCCEEEEEHCCHHHHHHHHHHHHCCCCCCEEEEEEHCCHHHCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHCCEEEEEHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHCCHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
Conf.Score	9887645678888888765565555776578999999999999999998697899999999999998799599999679998799999998998788888887765799996789868999866888656666657888888888765678876689999857676568889998899998757899999998766989999867898889999999999998799599999766679857999999999999989998689875655655554577556777688999999999999999999999999999999999999999999998578999999999999999999999999999999999999999999999999999999999999997675668999999999999999999999999999999999999999987876555555566777888887765555555546778888887778899999999999876678899999999999999988888999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999987546777777779
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA
Prediction	6101223304413444445525424455465104301500440251054362540152045025305643010000022601000000000124003303420000000000124220100101234342232212122024203423444234022010100121043100000001113444402300340012000000000022221420130032027324200000010021441540154025204636151100000022134134263240233110230151025202542343114300430340054025304511541545512540352055025304502640440153035104401530253025203500530352046242462064025202510251035004301510340044015303531254134362346225531540351342434424102100000211211111202111113222120211210110000012432442044015402530350044015302530351054015203510450055025403530540354155435414511550453054045025304603651424345358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHCCCCCEEEEEHCCCCCEEEEEHCCHHHHHHHHHHHHCCCCCCEEEEEEHCCHHHCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHCCEEEEEHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHCCHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA

2j69A

0.12

0.98

2.19

MUSTER

VATDRFIQDLERVAQVRSE---------MSVCLNKLAETINKAELAGDSSSLERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDFYTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVRELQASENRLRQVFNANLAEYRVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQPLNLFDFLSSGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRASQYGASYNQITDQITEKLTGKDVEEDNSPGWAKWAMGLLWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLGADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH--

2j69A

0.12

0.99

2.20

dPPAS

----QVATDRFIQDLERVAQVRSEMSVCLNKLAETINKAELAGDSSSGKLSLERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDKYTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVREENRLRQVFNANLAEYCTVERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQPDFLSSGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQYGASYNQITDQITEKLTGKDVEEDNSPGWAKWAMGLLSAGWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLGADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH--

2j69A

0.12

0.95

3.43

wdPPAS

---------------QVATDRFIQDLERVAQVRSEMSVCLNKLAETINKAELERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDFQTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVREENRLRQVFNANLAEYCTVERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQDV--NELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQ-SGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQYGASYNQITDQITEKLTGKD---VEEDNSPGWAKWAMGLLSAGFDWKNILLNYFTVIGIGIITAVTGILLGPIGFALLGLGADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLL-------A

2j69A

0.12

0.97

2.80

wMUSTER

VATDRFIQDLERVAQVRSE---------MSVCLNKLAETINKAELAGDSSSLERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDFYTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVREENRLRQVFNANLAEYIYDERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQSSGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQYGASYNQITDQITEKLTG----KDVEEDNSPGWAKWAMGLLGFDWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLGADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH--

2j69A

0.13

0.12

0.95

4.12

wPPAS

VATDRFIQDLERVAQVRSE---------MSVCLNKLAETINKAELAGDSSSLERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDYKYTIDPAEAKKLEQEKKQAPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIKRGLTVFFLVNAWDQVREENRLRQVFNANLAEYCTDERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQ-SGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQYGASYNQITDQITEKLTG-KDVEEDNSPGWAKWAMWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLGVG-------ADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNL--------A

2j69A

0.13

0.12

0.98

4.02

dPPAS2

VATDRFIQDLERVAQVRSE---------MSVCLNKLAETINKAELAGDSSSGERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDKYTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVREENRLRQVFNANLAEYCTVERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQPDFLSSGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQGASYNQITDQITEKLTGKDVEEDNSPGWAKWAMGLLSAGFDWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH--

2j69A

0.13

0.12

0.98

3.51

PPAS

VATDRFIQDLERVAQVRSE---------MSVCLNKLAETINKAELAGGKLSLERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDKYTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVREENRLRQVFNANLAEYCTVERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQPDFLSSGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQGASYNQITDQITEKLTGKDVEEDNSPGWAKWAMGLLSAGFDWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH--

2j69A

0.13

0.12

0.98

3.94

Env-PPAS

VATDRFIQDLERVAQVRSE---------MSVCLNKLAETINKAELAGGKLSLERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSDVNPCTAVLTVLRYGPEKKVTIHFNDGKSPQQLDFQTIDPAEAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIKRGLTVFFLVNAWDQVRESVEELQASENRLRQVFYDERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQ--DVNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYQPDFLSSGKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQGASYNQITDQITEKLTGKDVEEDNSPGWAKWAMGLLSAGFDWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTREINRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH--

2w6dA

0.14

0.13

0.96

2.00

MUSTER

VNQVATDRFIQDLERVAQV------RSEMSVCLNKLAETINKAELAGDSSSGERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPS-----TAVLTVLRYGPEKKVTIHFNDGKSPQQLDFQNFKYKYAKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVREENRLRQVFNANLAEYCYDERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQYGASYNQITDQITEKLTGWAKWAMGLLSLSFALAGAGFDWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLGVGFLQADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTNRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH---------

2w6dA

0.13

0.96

2.02

dPPAS

VNQVATDRFIQDLERVAQVRS------EMSVCLNKLAETINKAELAGDSSSGERDIEDITIASKNLQQGVFRLLVLGDMKRGKSTFLNALIGENLLPSTAVL-----TVLRYGPEKKVTIHFNDGKSPQQLDFQNFKYKYTKKLEQEKKQAFPDVDYAVVEYPLTLLQKGIEIVDSPGLNDT-EARNELSLGYVNNCHAILFVMRASQPCTLGERRYLENYIGRGLTVFFLVNAWDQVREENRLRQVFNANLAEYCTVERVFELSSIQALRRRLKNPQADLDGTGFPKFMDSLNTFLTRERAIAELRQVRTLARLACNHTREAVARRIPLLEQD--VNELKKRIDSVEPEFNKLTGIRDEFQKEIINTRDTQARTISESFRSYVLNLGNTFENDFLRYKREAFNAALQKAFEQYITDKSAAWTLTAEKDINAAFKELSRSASQYGASYNQITDQITEKLTGWAKWAMGLLSLSFALAGAGFDWKNILLNYFTVIGIGGIITAVTGILLGPIGFALLGLGVGFLQADQARRELVKTAKKELVKHLPQVAHEQSQVVYNAVKECFDSYEREVSKRINDDIVSRKSELDNLVKQKQTNRESEFNRLKNLQEDVIAQLQKIEAAYSNLLAYYSHH---------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.28

Estimated TM-score = 0.75±0.10

Estimated RMSD = 7.2±4.2Å

Download Model 2

C-score=-1.98

Download Model 3

C-score=-2.21

Download Model 4

C-score=-2.25

Download Model 5

C-score=-2.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2j69A	0.940	1.83	0.120	0.975
2	3t34A	0.383	3.82	0.148	0.441
3	2qptA	0.368	5.66	0.121	0.478
4	1llwA	0.366	7.65	0.067	0.577
5	4aurA	0.358	5.53	0.078	0.464
6	4f4cA	0.348	6.42	0.053	0.481
7	3jbrA	0.345	7.89	0.032	0.550
8	3vuoA	0.343	8.01	0.031	0.547
9	3v0aB	0.342	7.80	0.044	0.530
10	3jd8A	0.336	7.52	0.059	0.519

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.36	19	1fzqA	GDP	Rep, Mult	79,80,81,82,83,84,85,233,234,236,237,265,266,267
2	0.03	2	3t34A	MG	Rep, Mult	84,104
3	0.03	2	2vdcA	F3S	Rep, Mult	261,262,263,264,265,266,286,290
4	0.03	2	1f5nA	GNP	Rep, Mult	79,80,81,82,83,84,85,98,99,100,178,233,234
5	0.03	2	2w6dA	CPL	Rep, Mult	512,514,515,516,517,518
6	0.03	2	2w6dA	CPL	Rep, Mult	517,519,532,533
7	0.02	1	2w6dB	CPL	Rep, Mult	412,415,493,494,496,497,498,500,501,504,505,508,520,527,528,537,540
8	0.02	1	1jb0B	CL1	Rep, Mult	165,166,167,171
9	0.02	1	1tq2B	MG	Rep, Mult	84,175
10	0.02	1	1lm1A	F3S	Rep, Mult	75,76,77,78,79,82,98,99

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1skqA	0.322	6.33	0.095	0.447	3.6.5.3	NA
2	0.060	3dnyT	0.292	6.36	0.097	0.389	3.6.5.3	NA
3	0.060	1ob2A	0.304	5.55	0.113	0.384	3.6.1.48	NA
4	0.060	3hmjA	0.314	7.98	0.047	0.509	2.3.1.86	NA
5	0.060	1z8lA	0.317	7.56	0.049	0.481	3.4.17.21	NA
6	0.060	3iayA	0.305	7.88	0.058	0.494	2.7.7.7	74,86
7	0.060	2cseW	0.316	7.75	0.039	0.495	3.6.4.13	NA
8	0.060	2vuaA	0.189	7.63	0.020	0.297	3.4.24.69	282
9	0.060	1kwgA	0.308	7.66	0.058	0.481	3.2.1.23	NA
10	0.060	1llwA	0.366	7.65	0.067	0.577	1.4.7.1	NA
11	0.060	2vycA	0.311	6.79	0.052	0.447	4.1.1.19	NA
12	0.060	1a47A	0.307	7.82	0.048	0.484	2.4.1.19	NA
13	0.060	2vdcA	0.331	8.66	0.043	0.575	1.4.1.13	NA
14	0.060	2e1rA	0.324	6.31	0.109	0.434	3.6.5.3	NA
15	0.060	1d7fA	0.305	7.30	0.023	0.452	2.4.1.19	NA
16	0.060	1fo4A	0.309	7.79	0.049	0.491	1.17.1.4	NA
17	0.060	1w6jA	0.322	7.83	0.053	0.514	5.4.99.7	NA
18	0.060	2vdcF	0.336	8.58	0.047	0.578	1.4.1.13	99
19	0.060	3ffzA	0.309	7.92	0.046	0.478	3.4.24.69	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.45	0.866	3.53	0.12	0.96	2j68A	GO:0000166 GO:0003924 GO:0005525 GO:0005886 GO:0008289 GO:0016020 GO:0016021 GO:0016787
1	0.12	0.376	5.96	0.09	0.50	4cidA	GO:0000166 GO:0005509 GO:0005524 GO:0005525 GO:0005737 GO:0005768 GO:0005829 GO:0005886 GO:0005901 GO:0006897 GO:0010008 GO:0016020 GO:0016787 GO:0019898 GO:0019904 GO:0030036 GO:0030866 GO:0032456 GO:0046872 GO:0048471 GO:0055038 GO:0070062 GO:0072659 GO:0097320 GO:1901741 GO:2001137
2	0.08	0.380	4.34	0.13	0.45	3w6nB	GO:0000166 GO:0000266 GO:0001836 GO:0003374 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005741 GO:0005777 GO:0005794 GO:0005829 GO:0005874 GO:0005903 GO:0005905 GO:0006897 GO:0006921 GO:0008289 GO:0010821 GO:0012501 GO:0012505 GO:0015630 GO:0016020 GO:0016559 GO:0016787 GO:0030054 GO:0030672 GO:0031410 GO:0031625 GO:0032459 GO:0042802 GO:0042803 GO:0043065 GO:0043231 GO:0043234 GO:0043653 GO:0045202 GO:0048471 GO:0050714 GO:0051289 GO:0060047 GO:0061025 GO:0070266 GO:0070584 GO:0070585 GO:0090141 GO:0090149 GO:0090200 GO:1900063 GO:1903146 GO:1903578 GO:2001244
3	0.06	0.388	4.03	0.15	0.45	3t34B	GO:0000166 GO:0000911 GO:0003924 GO:0005525 GO:0005737 GO:0005773 GO:0005774 GO:0005829 GO:0005856 GO:0005874 GO:0005886 GO:0007049 GO:0009504 GO:0009506 GO:0009524 GO:0009535 GO:0009793 GO:0009920 GO:0010051 GO:0010091 GO:0016787 GO:0030276 GO:0043424 GO:0051301 GO:0072583
4	0.06	0.370	5.93	0.09	0.50	4aurA	GO:0005525
5	0.06	0.326	6.92	0.04	0.48	5a3fB	GO:0000166 GO:0001917 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005794 GO:0005856 GO:0005874 GO:0006897 GO:0007416 GO:0014069 GO:0016787 GO:0030424 GO:0031798 GO:0031802 GO:0043083 GO:0043197 GO:0044327 GO:0045202 GO:0046847 GO:0048471 GO:0050998 GO:0051491 GO:0061001 GO:0061002 GO:0070062
6	0.06	0.315	6.98	0.07	0.46	4whjA	GO:0000166 GO:0002376 GO:0003924 GO:0005525 GO:0005634 GO:0005643 GO:0005737 GO:0005829 GO:0006810 GO:0006952 GO:0009615 GO:0015031 GO:0035455 GO:0045087 GO:0046822 GO:0051028 GO:0051607 GO:0051726 GO:0060337
7	0.06	0.303	7.04	0.05	0.45	3szrA	GO:0000166 GO:0002376 GO:0003924 GO:0005525 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0005829 GO:0006915 GO:0006952 GO:0007165 GO:0009615 GO:0016020 GO:0031965 GO:0034340 GO:0045071 GO:0045087 GO:0048471 GO:0051607 GO:0060337
8	0.06	0.308	6.89	0.05	0.44	5a3fC	GO:0000166 GO:0001917 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005794 GO:0005856 GO:0005874 GO:0006897 GO:0007416 GO:0014069 GO:0016787 GO:0030424 GO:0031798 GO:0031802 GO:0043083 GO:0043197 GO:0044327 GO:0045202 GO:0046847 GO:0048471 GO:0050998 GO:0051491 GO:0061001 GO:0061002 GO:0070062
9	0.06	0.299	7.15	0.05	0.44	3snhA	GO:0000166 GO:0001917 GO:0002031 GO:0003924 GO:0005525 GO:0005737 GO:0005794 GO:0005856 GO:0005874 GO:0005886 GO:0006897 GO:0006898 GO:0007032 GO:0007605 GO:0008021 GO:0008022 GO:0008344 GO:0016787 GO:0019901 GO:0030117 GO:0031623 GO:0031749 GO:0032403 GO:0042802 GO:0043196 GO:0043209 GO:0043234 GO:0044822 GO:0045202 GO:0046983 GO:0048013 GO:0050998 GO:0051262 GO:0051932 GO:0070062 GO:0072583 GO:1901998 GO:1903423
10	0.06	0.310	7.21	0.06	0.46	3zvrA	GO:0000166 GO:0001917 GO:0002031 GO:0003924 GO:0005525 GO:0005737 GO:0005794 GO:0005856 GO:0005874 GO:0005886 GO:0006897 GO:0006898 GO:0007032 GO:0007605 GO:0008021 GO:0008022 GO:0008344 GO:0016787 GO:0019901 GO:0030117 GO:0031623 GO:0031749 GO:0032403 GO:0042802 GO:0043196 GO:0043209 GO:0043234 GO:0044822 GO:0045202 GO:0046983 GO:0050998 GO:0051262 GO:0051932 GO:0070062 GO:0072583 GO:1901998 GO:1903423
11	0.06	0.300	5.01	0.10	0.37	4p4uA	GO:0000166 GO:0002376 GO:0003924 GO:0005525 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0005829 GO:0006915 GO:0006952 GO:0007165 GO:0009615 GO:0016020 GO:0031965 GO:0034340 GO:0045071 GO:0045087 GO:0048471 GO:0051607 GO:0060337
12	0.06	0.297	4.75	0.10	0.36	5d3qB	GO:0000166 GO:0001917 GO:0002031 GO:0003924 GO:0005525 GO:0005737 GO:0005794 GO:0005856 GO:0005874 GO:0005886 GO:0006897 GO:0006898 GO:0007032 GO:0007605 GO:0008021 GO:0008022 GO:0008344 GO:0016787 GO:0019901 GO:0030117 GO:0031623 GO:0031749 GO:0032403 GO:0042802 GO:0043196 GO:0043209 GO:0043234 GO:0044822 GO:0045202 GO:0046983 GO:0048013 GO:0050998 GO:0051262 GO:0051932 GO:0070062 GO:0072583 GO:1901998 GO:1903423
13	0.06	0.300	5.03	0.12	0.37	4h1uA	GO:0000166 GO:0000266 GO:0001836 GO:0003374 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005741 GO:0005777 GO:0005794 GO:0005829 GO:0005874 GO:0005903 GO:0005905 GO:0006897 GO:0006921 GO:0008289 GO:0010821 GO:0012501 GO:0012505 GO:0015630 GO:0016020 GO:0016559 GO:0016787 GO:0030054 GO:0030672 GO:0031410 GO:0031625 GO:0032459 GO:0042802 GO:0042803 GO:0043065 GO:0043231 GO:0043234 GO:0043653 GO:0045202 GO:0048471 GO:0050714 GO:0051289 GO:0060047 GO:0061025 GO:0070266 GO:0070584 GO:0070585 GO:0090141 GO:0090149 GO:0090200 GO:1900063 GO:1903146 GO:1903578 GO:2001244
14	0.06	0.283	4.55	0.11	0.34	1jwyB	GO:0000166 GO:0000920 GO:0003924 GO:0005522 GO:0005525 GO:0005543 GO:0005737 GO:0006907 GO:0006909 GO:0006997 GO:0007005 GO:0007015 GO:0007032 GO:0007163 GO:0016787 GO:0031288 GO:0032154 GO:0032195 GO:0042802 GO:0044351 GO:0044656 GO:0045335 GO:0048312 GO:0090383 GO:0097204 GO:1900756
15	0.06	0.312	6.83	0.05	0.45	4bejB	GO:0000166 GO:0000266 GO:0001836 GO:0003374 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005741 GO:0005777 GO:0005794 GO:0005829 GO:0005874 GO:0005903 GO:0005905 GO:0006897 GO:0006921 GO:0008289 GO:0010821 GO:0012501 GO:0012505 GO:0015630 GO:0016020 GO:0016559 GO:0016787 GO:0030054 GO:0030672 GO:0031410 GO:0031625 GO:0032459 GO:0042802 GO:0042803 GO:0043065 GO:0043231 GO:0043234 GO:0043653 GO:0045202 GO:0048471 GO:0050714 GO:0051289 GO:0060047 GO:0061025 GO:0070266 GO:0070584 GO:0070585 GO:0090141 GO:0090149 GO:0090200 GO:1900063 GO:1903146 GO:1903578 GO:2001244
16	0.06	0.210	7.51	0.04	0.33	4ujcAB	GO:0000166 GO:0003924 GO:0005525
17	0.06	0.240	3.06	0.16	0.26	1sulB	GO:0000166 GO:0000287 GO:0003924 GO:0005525 GO:0005829 GO:0007049 GO:0046872 GO:0051301
18	0.06	0.227	3.51	0.15	0.26	2wjgA	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0005886 GO:0006810 GO:0006811 GO:0015093 GO:0015684 GO:0016020 GO:0016021 GO:0055072 GO:1903874

Consensus prediction of GO terms

Molecular Function	GO:0005525	GO:0003924	GO:0008289
GO-Score	0.61	0.53	0.50
Biological Processes	GO:0016192
GO-Score	0.37
Cellular Component	GO:0005886	GO:0044444	GO:0016021
GO-Score	0.55	0.48	0.45

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.