I-TASSER results

I-TASSER results for job id Rv0336

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (503 residues)
MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSR
CGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLM
FATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKE
YQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGA
LAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAEL
VAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTI
PYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFP
SLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVL
TQTAAATDTHGPPPDPNDDPPPF

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDPNDDPPPF
Prediction	CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEHCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCHHHCCCCCCCCCEHCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHCHHHHCCCCCCCCEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98689999999999875788876558999999999999999999999999999999765556677654454678999999999999999999999999999886999999998999999999999998668998899999999999988757777789999999999984877777656765578699975899779999996899999999999999875688899877666677888887654456666567777766566666557776556455467788886556888877599999999868767775788877777888999999999985887799999999644557645556789999977755554555545567885798789986999889996787589998778888888888898888898888777777888654456777888888778888887766556677777888888888888999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDPNDDPPPF
Prediction	65345213302410443224344312200310330330101010100100010032124434534322242031000000111401242022003203300520220010020010013001000310440244410220021003102411211243134104300431234225446623430200002210000101020103001001200230043115524223210110000101221121200121121212212210111021213221022213100120112100001000000110100001233422233221014102200202110001000110032010100221434120003001100220031234220212222401000001311212031421111131321435333343423544356243532534433454443335442533554455554356543564454343447741117
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEHCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCHHHCCCCCCCCCEHCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHCHHHHCCCCCCCCEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDPNDDPPPF

4ogcA3

0.12

0.04

0.29

0.95

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGFTSRDKANRRRYNDNQEAKKIQRDYGKEGYISR--GDIVRLDALELQGCCLY--CGTGYHTCQLDHIVPQAGPGSNNRGNLVAVCERCNRSKSN---------------TPFVWAQKCGIPHVGV-------------KEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLRRE-------------------------------------

5cwmA

0.10

0.04

0.45

1.05

dPPAS2

-DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEK--QGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRA----------------------VELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.17

0.11

0.64

1.07

PPAS

---------------------------------------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTK

5cwqA

0.11

0.05

0.46

1.04

dPPAS2

-----------------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGN-SEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4ke2A

0.18

0.07

0.39

1.01

dPPAS2

------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAAT---------AADDAAASIATIN--AASAAAKSIAAAAAMAAKDTAAAAASAA----AAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSD---------------AAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3jd8A

0.10

0.94

0.88

MUSTER

YDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVQAYQRDERLQGETLDQQLGRVLGEVAPS-------------MFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFAEDGTSVQASESCLFRFFKNSYS----------PLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHA--GPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDN--YTRIGFAPSSWIDDYFDWVKPQSSCCRVPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFY-----VF

5gaoE

0.14

0.10

0.67

0.68

dPPAS

--------------------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------

4cgkA

0.10

0.07

0.64

wdPPAS

LTAQEAQKQVDQIQEQVSAIQA-EQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQRSAQTNGAVTSYINTIVNSKSIT-SRVAAMSEIVSANNKMLEQQKADKKA----SEKQVANNDAINTV--IANQQKLADDAQALTTK-----QAELKAAELSLAAEKATAEGEKASLLEQKAAA-----------------EAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAPW-------AGDYWGNGAQWATSAAAAGF---RTGSTPQVGA-----------IACWNDGG----G-----------HVA---AGNRT-IGN--------HR-----GWFNPTTTSGFVTYIYAD--------------------------------------------------------------------------------------------------

5l4kN

0.10

0.94

0.85

wMUSTER

LSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGQFLRDNLEWLARATNWTSPGSAYQEGGGLYALGLGGDIIDYLLNQLKNASNDIVRHGGSLGLGLARQDVYDLLKTNLYQ-DDAVTGEAAGLALGLVML--GSKNAQAIEDMVGYAQETQHEKVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYC-NKAIRRLLH-VAVSDVNDDVRRAAVESLGFILFRTPEQCPSVV-SLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVIN-DDVMAKFGAILA-AGGHNV--ISLQSRTGHTHMPSVVGVLVFTQFWFWFP-LSLAYTPTCVIGLNK------------DLKMPKVQYKSNCKPSTFAYPAPLEVPKEK----EKEKVSTAVLSITAKAKKKEKEKEKKEEEKPEPNFQLLDNMPAQLKPETCR-PF

4cgkA

0.11

0.07

0.63

0.79

wPPAS

LTAQEAQKQVDQIQEQVSAIQA-EQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEK-RSAQTNGAVTSYINTIVNSKSIT-----SRVAAMSEIVSANNKMLEQQKA-AI-SEKQVANNDAINTV--IANQQKLADDAQALTTK-----QAELKAAELSLAAEKATAEGEKASLLEQKAAA-----------------EAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAPW-------AGDYWGNGAQWATSAAAAGF---RTGSTPQVGA-----------IACWNDGG----G-----------HVA---AGNRT-IGN--------HR-----GWFNPTTTSGFVTYIYAD--------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.82

Estimated TM-score = 0.39±0.13

Estimated RMSD = 14.3±3.8Å

Download Model 2

C-score=-3.69

Download Model 3

C-score=-4.84

Download Model 4

C-score=-3.18

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3jd8A	0.904	1.96	0.101	0.946
2	2j8sA	0.589	5.64	0.083	0.789
3	4mt1A	0.572	5.73	0.053	0.779
4	3k07A	0.552	5.95	0.078	0.765
5	4k0eA	0.527	6.18	0.068	0.744
6	3aqpA	0.438	4.56	0.074	0.539
7	2cse1	0.350	7.61	0.052	0.585
8	1st6A	0.344	7.59	0.064	0.561
9	1zyrM3	0.342	6.87	0.030	0.529
10	3hmjA	0.341	7.58	0.018	0.567

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	7	1x62A	ZN	Rep, Mult	342,347,377,380
2	0.06	3	2ceiA	ZN	Rep, Mult	78,129
3	0.06	3	4iqdA	PYR	Rep, Mult	232,233,236
4	0.04	2	3knvA	ZN	Rep, Mult	342,347,358,377
5	0.02	1	3wmm7	CRT	Rep, Mult	94,104
6	0.02	1	2a6hC	STD	Rep, Mult	99,103,106
7	0.02	1	2iceD	CA	Rep, Mult	345,355,357
8	0.02	1	3ae3C	NBI	Rep, Mult	110,120,123,124,127
9	0.02	1	2ppbC	STD	Rep, Mult	331,335,338,365
10	0.02	1	1n38A	CH1	Rep, Mult	372,377,378,379,380
11	0.02	1	3t7dB	MG	Rep, Mult	230,233
12	0.02	1	1sw1A	ZN	Rep, Mult	133,135
13	0.02	1	1zyrM	STD	Rep, Mult	188,189,190,191,194,199
14	0.02	1	3gl6A	ZN	Rep, Mult	342,347

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3gtgB	0.310	7.18	0.044	0.501	2.7.7.6	126
2	0.060	1llwA	0.302	7.85	0.048	0.519	1.4.7.1	NA
3	0.060	3hmjA	0.341	7.58	0.018	0.567	2.3.1.86	NA
4	0.060	2gtqA	0.316	6.93	0.047	0.487	3.4.11.2	NA
5	0.060	1vbgA	0.299	7.85	0.038	0.505	2.7.9.1	NA
6	0.060	3g61A	0.323	7.59	0.056	0.533	3.6.3.44	NA
7	0.060	3hkzJ	0.323	6.66	0.053	0.495	2.7.7.6	330
8	0.060	3cmmC	0.319	7.87	0.022	0.553	6.3.2.19	332
9	0.060	1w27A	0.301	7.13	0.056	0.473	4.3.1.24	NA
10	0.060	2r7oA	0.301	7.80	0.043	0.515	2.7.7.48	165,170,179,203,208
11	0.060	3b9jJ	0.202	6.06	0.071	0.290	1.17.1.4,1.17.3.2	370,371
12	0.060	2vkzG	0.321	8.20	0.034	0.579	2.3.1.38,3.1.2.14	NA
13	0.060	2ckjA	0.326	7.55	0.020	0.541	1.17.1.4,1.17.3.2	NA
14	0.060	1ofdA	0.292	7.74	0.041	0.491	1.4.7.1	NA
15	0.060	2e1qA	0.338	7.61	0.026	0.563	1.17.3.2,1.17.1.4	NA
16	0.060	1z68A	0.301	7.59	0.043	0.505	3.4.21.-	NA
17	0.060	2pffB	0.318	8.13	0.044	0.569	2.3.1.86	317,324
18	0.060	1n1hA	0.351	7.65	0.045	0.592	2.7.7.48	NA
19	0.060	1q16A	0.316	7.56	0.044	0.529	1.7.99.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.904	1.96	0.10	0.95	3jd8A	GO:0001618 GO:0004872 GO:0004888 GO:0005319 GO:0005576 GO:0005635 GO:0005764 GO:0005765 GO:0005768 GO:0005783 GO:0005794 GO:0005886 GO:0005887 GO:0006486 GO:0006629 GO:0006897 GO:0006914 GO:0007041 GO:0007165 GO:0007628 GO:0008202 GO:0008203 GO:0008206 GO:0015248 GO:0015485 GO:0016020 GO:0016021 GO:0016032 GO:0016242 GO:0030301 GO:0031579 GO:0031902 GO:0031982 GO:0033344 GO:0042493 GO:0042632 GO:0045121 GO:0046686 GO:0046718 GO:0048471 GO:0060548 GO:0070062 GO:0071383 GO:0071404 GO:0090150 GO:2000189
1	0.07	0.588	5.67	0.08	0.79	3d9bA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
2	0.07	0.574	5.49	0.08	0.77	3nogA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
3	0.07	0.572	5.73	0.05	0.78	4mt1A	GO:0005215 GO:0006810 GO:0016020 GO:0016021
4	0.07	0.542	6.35	0.06	0.77	4dnrA	GO:0005215 GO:0005375 GO:0005507 GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0006825 GO:0006878 GO:0008324 GO:0010272 GO:0010273 GO:0015080 GO:0015673 GO:0015679 GO:0016020 GO:0016021 GO:0046688 GO:0060003 GO:1902601
5	0.07	0.568	5.83	0.07	0.79	2v50D	GO:0005215 GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0016020 GO:0016021 GO:0046677
6	0.07	0.555	5.95	0.08	0.77	3w9iF	GO:0005215 GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0016020 GO:0016021 GO:0046677
7	0.07	0.527	6.18	0.07	0.74	4k0eA	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
8	0.07	0.526	6.23	0.08	0.74	4k0eC	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
9	0.07	0.504	6.15	0.07	0.72	4k0eB	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
10	0.06	0.251	6.65	0.08	0.38	5en5C	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
11	0.06	0.258	5.09	0.05	0.34	4r86B	GO:0005215 GO:0006810 GO:0016020 GO:0016021
12	0.06	0.214	6.42	0.02	0.32	3wxvA	GO:0004872 GO:0005886 GO:0006629 GO:0006631 GO:0007186 GO:0009755 GO:0010633 GO:0010719 GO:0010906 GO:0016020 GO:0016021 GO:0019216 GO:0019395 GO:0019901 GO:0030308 GO:0031226 GO:0033210 GO:0033211 GO:0042593 GO:0042802 GO:0046426 GO:0046427 GO:0046628 GO:0046872 GO:0046982 GO:0055100 GO:0097003 GO:1901223
13	0.06	0.212	7.53	0.04	0.35	4i0wD	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787
14	0.06	0.199	6.06	0.04	0.29	3f7jA	GO:0016491 GO:0043892 GO:0055114
15	0.06	0.185	5.96	0.03	0.27	1vknA	GO:0003942 GO:0005737 GO:0006526 GO:0008652 GO:0016491 GO:0016620 GO:0046983 GO:0051287 GO:0055114
16	0.06	0.177	6.38	0.05	0.26	3qntA	GO:0005886 GO:0006629 GO:0006695 GO:0008144 GO:0008202 GO:0008203 GO:0015918 GO:0016020 GO:0016021 GO:0016324 GO:0017137 GO:0030299 GO:0030301 GO:0030659 GO:0031410 GO:0031489 GO:0031526 GO:0042157 GO:0042493
17	0.06	0.153	5.65	0.05	0.21	1texD	GO:0016740
18	0.06	0.157	5.60	0.03	0.21	2fi7A	GO:0009297 GO:0043683 GO:0046903

Consensus prediction of GO terms

Molecular Function	GO:0032934	GO:0038023	GO:0043178	GO:0099600	GO:0005319
GO-Score	0.42	0.42	0.42	0.42	0.42
Biological Processes	GO:0072657	GO:0016125	GO:0032846	GO:0071407	GO:0016192	GO:0032787	GO:0043413	GO:1902652	GO:0090659	GO:0009101	GO:0016241	GO:0048545	GO:0030260	GO:0010941	GO:0007034	GO:0008344	GO:0006464	GO:2000188	GO:0032870	GO:0019058	GO:0010507	GO:0071396	GO:0007154	GO:0010038	GO:0030301	GO:0071402	GO:0044700	GO:0055098	GO:0045184	GO:0042493
GO-Score	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.31
Cellular Component	GO:0044428	GO:0005764	GO:0031967	GO:0098852	GO:0031988	GO:0010008	GO:0098857	GO:0005770	GO:1903561	GO:0005887
GO-Score	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.