I-TASSER results

I-TASSER results for job id Rv0318c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (264 residues)
MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILGGVVPSVRTPSAAMVSG
VQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLVALRRFDGHGEHQDGDDVG
ELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALTVEVLFLGLAVALRLAGSGMP
RIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVLAFAAGALLWLVVEELLVEAHET
PERPWMAVMFFAGFLILYGLGVME

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILGGVVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLVALRRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALTVEVLFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVLAFAAGALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME
Prediction	CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
Conf.Score	985457787776555554444566589999999999999999999999874478899999999999999999999985999987887999999999999999999998755567876554578999999999876678899998766756899999999987556889999999998998999999999999999999999999997555899999999999999999999998999876887589999999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILGGVVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLVALRRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALTVEVLFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVLAFAAGALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME
Prediction	641033104412541133145140310131333233133223311310112423430130010100110000001201120154331211221322332212011300432454556543221101000001111222000000112233211100000010211100000033234622222001000001320330010000111333322101011321110010001100210253663200000113133213312337
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILGGVVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLVALRRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALTVEVLFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVLAFAAGALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME

3wajA

0.12

0.11

0.98

1.00

wMUSTER

YTHFGPFLVYLGSIAGIIFSATS--GESLRAVLAFIPAIGGVLAILPVYLL--TREVFDKRAAVIAAFLIAIVPGQFLQRSILGFNDHHIWEAFWQVSALGTFLLAYNRWKGHDLTARQMAYPVIAGITIGLYVLSAGFIIAPIILANADRKNLSLVAVVTFAVSALIYLPFAFNYPGFSTIFYSPFQLLVLLGSAVIAAAFYQIEKWNDVGFFERVKGMPLAVIVLTALIMGLFFVLTNAHFGALFFFGMAGILYSAYRFLKR

4w6vA2

0.11

0.09

0.85

1.05

wPPAS

----------------------------GRWVTAIMAVVVVIIALISQGVIPINPVMIASLLVYVIAASVTLYFIYLFASRKDRARLLVCFILLVSAAFFWSAFESFNLFANDYTDRMVNALFIILLAPVFSWASITKFVIGILCA---AAGFAVMMYAAQHVLSSG--------GAGVSPLWLVMSILLLTLGELCLSPIGLATMTLLAQVMGLWFCASSLGNLAAGLIGGHVKADQLDMLPRCSIALVICAAVLILLIVPIR

4ke2A

0.15

0.11

0.72

1.22

dPPAS2

---------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP----------------------------------------------------

4kjsA

0.10

0.09

0.99

1.17

PPAS

GLLNATFGNAVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKSGKTIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKN--KMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEGATLLAAYVIMAIGFFLL

4kjsA

0.10

0.09

0.99

0.98

wMUSTER

GLLNATFGNAVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGLKQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKSGKVIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKN--KMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEGATLLAAYVIMAIGFFLL

2n4xA

0.13

0.08

0.62

0.95

wPPAS

-----------------------------------------------------------QLMAFALGILSVFS---VVP--------------LIFAGS-----------------RGRALDAFLIVAGLTISMLILGYTASLGFFRVVAMLFLLIFALILLSD-EKVSIFASRMTSGLSWKISFFFGMLLAFLWLILPFAGIAISQTLLSENPLVMLSYGLGMAVTIAAVFKMGE-----KANFQLIRKVTGAIVLLYLAYFE

4kjsA

0.09

0.97

1.19

dPPAS2

GLLNATFGNAVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGNASKLNLSIGISIIMILLYVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFVFTLPELVAMVSAVLLMIAISND--------GDSNWFEGATLLAAYVIMAIGFFLL

4w6vA2

0.09

0.08

0.88

1.14

PPAS

----------------------------GRWVTAIMAVVVVIIALISQGVIPINPVMIASLLVYVIAASVTLYFIYLFASRKDRARLLVCFILLVSAAFFWSAFESFNLF-RMVMGFEIPTVWFQSINALFIILLAPVFSWAPSSITKFVIGILCAAAGFAVMMYAAQHVLSS--GAGVSPLWLVMSILLLTLGELCLSPIGLATMTLLAQVMGLWFCASSLGNLAAGLIGGHVKADQLDMLPRCSIALVICAAVLILLIVPIR

3wajA1

0.12

0.11

0.97

wMUSTER

THFG-PFLVYLGSIAGIIFSATS--GESLRAVLAFIPAIGGVLAILPVYLL--TREVFDKRAAVIAAFLIAIVPGQFLQRSILGFNDHHIWEAFWQVSALGTFLLAYNRWKGHDLTARQMAYPVIAGITIGLYVLSAGFIIAPIILANADRKNLSLVAVVTFAVSALIYLPFAFNYPGFSTIFYSPFQLLVLLGSAVIAAAFYQIEKWNDVGFFERVKGMPLAVIVLTALIMGLFFVLTNA---ALFFFGMAGILYSAYRFLKR

4ikvA2

0.14

0.10

0.76

0.95

wPPAS

-------------------------TVETFISLVGILGIIIPIIYFVVMYRSPKSRVIAYIPLFVASAMFWAIQEQG---ILAN-PAWFQSLNPLFIIILAPVFAWMWVKLGKRQ------------------TIPQKFALGLLFA---GLSFIVILVPGHLS------------GGLVHPIWLVLSYFIVVLGELCLSPVGLSATTKLAQTMSLWFLSNAAAQAINAQLVRFYTPENETA--TIGGAALVLGLILLAIAPRIG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.58

Estimated TM-score = 0.52±0.15

Estimated RMSD = 9.5±4.6Å

Download Model 2

C-score=-4.68

Download Model 3

C-score=-3.88

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4kjsA	0.918	1.97	0.095	0.989
2	4k1cA	0.865	2.65	0.130	0.989
3	4kppA	0.792	3.09	0.095	0.951
4	3v5sA	0.707	3.68	0.092	0.886
5	5j65A	0.506	5.07	0.068	0.750
6	2ibzC	0.468	5.10	0.058	0.708
7	4lz6A1	0.461	5.46	0.084	0.720
8	4k1pA	0.458	5.36	0.050	0.686
9	3h1jC	0.450	5.09	0.070	0.693
10	3g61A	0.449	5.79	0.070	0.758

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	3	3cwbC	CDL	Rep, Mult	40,254,257,258
2	0.06	2	1sqpC	CDL	Rep, Mult	2,5,6,190,193,194,197
3	0.06	2	3o32B	MYY	Rep, Mult	213,216,220
4	0.03	1	1swiC	BNZ	Rep, Mult	233,237
5	0.03	1	3dugA	ZN	Rep, Mult	238,264
6	0.03	1	1pprM	PID	Rep, Mult	218,222
7	0.03	1	2pnqA	MG	Rep, Mult	137,138
8	0.03	1	3v5uA	MYS	Rep, Mult	245,248,249
9	0.03	1	1xmeC	HAS	Rep, Mult	155,159
10	0.03	1	5hxcA	MYC	Rep, Mult	156,157,160,262
11	0.03	1	1yq9H	H2S	Rep, Mult	10,204,213
12	0.03	1	3h1jC	CDL	Rep, Mult	35,39,159,163,166,167
13	0.03	1	3iprA	CA	Rep, Mult	137,156

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1hwxA	0.389	5.75	0.045	0.621	1.4.1.3	NA
2	0.060	3ikmD	0.396	5.86	0.045	0.655	2.7.7.7	40,182
3	0.060	1gowA	0.390	5.98	0.044	0.636	3.2.1.23	NA
4	0.060	2uxwA	0.381	5.37	0.073	0.580	1.3.99.-	138
5	0.060	3a47A	0.393	5.64	0.058	0.621	3.2.1.10	NA
6	0.060	1h2rL	0.393	5.90	0.044	0.655	1.12.2.1	64
7	0.060	1cp9B	0.394	6.07	0.047	0.670	3.5.1.11	NA
8	0.060	2z8kC	0.307	6.47	0.058	0.542	2.3.2.2	69,72,189,224,228
9	0.060	3cxhN	0.439	5.34	0.058	0.705	1.10.2.2	81
10	0.060	2fhcA	0.390	5.86	0.065	0.651	3.2.1.41	191,230
11	0.060	1izjA	0.383	5.96	0.071	0.636	3.2.1.135,3.2.1.1	NA
12	0.060	1qleC	0.445	5.04	0.069	0.659	1.9.3.1	NA
13	0.060	3g61A	0.449	5.79	0.070	0.758	3.6.3.44	NA
14	0.060	1yrqI	0.401	6.18	0.038	0.697	1.12.2.1	NA
15	0.060	3dwcB	0.390	6.06	0.059	0.659	3.4.17.19	44
16	0.060	3etdA	0.386	5.59	0.065	0.614	1.4.1.3	32
17	0.060	1w4xA	0.388	6.10	0.055	0.655	1.14.13.92	NA
18	0.060	1yrlC	0.384	5.91	0.052	0.629	1.1.1.86	25,162
19	0.060	2vr5A	0.383	5.73	0.068	0.614	3.2.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.907	2.13	0.10	0.99	4kjrA	GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006812 GO:0006816 GO:0008324 GO:0015297 GO:0015369 GO:0016020 GO:0016021 GO:0055085 GO:0070588
1	0.20	0.865	2.65	0.13	0.99	4k1cA	GO:0000324 GO:0000329 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0006812 GO:0006816 GO:0006828 GO:0006874 GO:0008324 GO:0015085 GO:0015369 GO:0015386 GO:0016020 GO:0016021 GO:0046872 GO:0055085 GO:0070588 GO:0071805 GO:0098655
2	0.16	0.792	3.09	0.10	0.95	4kppA	GO:0016020 GO:0016021 GO:0046872 GO:0055085
3	0.14	0.711	3.53	0.09	0.88	5hwyA	GO:0005262 GO:0005509 GO:0005886 GO:0005887 GO:0006874 GO:0008273 GO:0016020 GO:0016021 GO:0030955 GO:0031402 GO:0035725 GO:0055085 GO:0070588
4	0.14	0.447	5.08	0.07	0.69	3cwbC	GO:0005739 GO:0005743 GO:0006122 GO:0008121 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0022904 GO:0045275 GO:0046872 GO:0055114 GO:0070469 GO:1902600
5	0.07	0.328	4.64	0.08	0.46	2e74A	GO:0005506 GO:0009055 GO:0009579 GO:0015979 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0042651 GO:0045158 GO:0046872 GO:0055114
6	0.07	0.506	5.07	0.07	0.75	5j65A	GO:0030435
7	0.07	0.423	5.61	0.07	0.69	2yiuA	GO:0005886 GO:0006122 GO:0008121 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0022904 GO:0045275 GO:0046872 GO:0055114 GO:0070469 GO:1902600
8	0.07	0.456	5.58	0.09	0.72	4mlbB	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
9	0.07	0.470	5.44	0.07	0.73	3vvpA	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
10	0.07	0.455	5.40	0.09	0.71	5c6nA	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
11	0.06	0.342	6.18	0.08	0.58	4z3nA	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
12	0.06	0.416	5.75	0.06	0.69	1zrtC	GO:0005886 GO:0006122 GO:0008121 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0022904 GO:0045275 GO:0046872 GO:0055114 GO:0070469 GO:1902600
13	0.06	0.228	6.61	0.05	0.41	3ic1A	GO:0005829 GO:0006508 GO:0008152 GO:0008237 GO:0008270 GO:0008652 GO:0009014 GO:0009085 GO:0009089 GO:0016787 GO:0019877 GO:0043171 GO:0046872 GO:0050897 GO:0070573
14	0.06	0.451	5.27	0.06	0.71	1be3C	GO:0005739 GO:0005743 GO:0006122 GO:0008121 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0022904 GO:0045275 GO:0046872 GO:0055114 GO:0070469 GO:1902600
15	0.06	0.333	4.21	0.04	0.45	1q90B	GO:0005506 GO:0009055 GO:0009507 GO:0009535 GO:0009536 GO:0009579 GO:0015979 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0045158 GO:0046872 GO:0055114
16	0.06	0.439	5.34	0.06	0.70	3cx5C	GO:0005739 GO:0005743 GO:0005750 GO:0006122 GO:0008121 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0022904 GO:0045153 GO:0045275 GO:0046872 GO:0055114 GO:0070469 GO:1902600
17	0.06	0.355	6.32	0.04	0.61	1w07B	GO:0000062 GO:0001676 GO:0003995 GO:0003997 GO:0005777 GO:0005829 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0009506 GO:0009611 GO:0009620 GO:0009695 GO:0016491 GO:0016627 GO:0033539 GO:0046686 GO:0050660 GO:0052890 GO:0055088 GO:0055114
18	0.06	0.420	5.93	0.10	0.70	2fynA	GO:0005886 GO:0006122 GO:0008121 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0022904 GO:0045275 GO:0046872 GO:0055114 GO:0070469 GO:1902600

Consensus prediction of GO terms

Molecular Function	GO:0015369	GO:0046872	GO:0022821	GO:0005451
GO-Score	0.44	0.42	0.40	0.40
Biological Processes	GO:0070588	GO:0000041	GO:0071804	GO:0006874
GO-Score	0.52	0.40	0.40	0.31
Cellular Component	GO:0098852	GO:0000324	GO:0005887
GO-Score	0.40	0.40	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.