I-TASSER results

I-TASSER results for job id Rv0312

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (620 residues)
MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPSQNPNLIEPGALMSGFV
ERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSEIAIAVPAHWKPGAVHALR
NGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSVVGLLDFGGSATYVTLVETKS
DSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDVDPASTAAVGQLGQLREQC
RAAKERLSTDVATELFAELAGCSSSIEMTREQLEDLIQDPLTGFIYAFDDMLARHNASWA
DLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQPGCAAAMGALLLANRGGERDSRTRTS
IGLATAAAAGTSVIELPAGDVMVIDHEALTDRELAWSQTDFPSEAPARFEGDSYNEGGPC
WSMRLNAVEPPKGPAWRRIRVSQLLIGVSAVVAMTAIGGVALTLTAIERRPSPLPTPIVP
GLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTT
TPRPSPTTTTTTAPPSTTTTTEPPVTTTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVP
IPQNPGAGEPQNPFGSLGSG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPSQNPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSEIAIAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSVVGLLDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDVDPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDLIQDPLTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQPGCAAAMGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDRELAWSQTDFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSAVVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVTTTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG
Prediction	CCCEEEEHCCCCCEEEEEHCCCCEEHCCEEEEHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHCHHHHHHHHHHHCCCCCCCCEEEEEHCCCCCCEEEEEEHCCCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEHCCHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	99589997578645788769987674868999589975556555545456888643455677489976886798558899999999999999997599887489985899989999999999876688556887645644899999999756799898789999799998569999975788888869985688998998568999999999999855658999988689999999999999999987787589875789976558876999999999999999999999999989998886878885875555999999999989999999987899999889885778988788876654565566666666668898876665556655456666789877655568876656788776787788899999974787654333334456765678756888756788888877777777788887777777788999888777777777888888888999987655667888888888988888888899888888889988889988888888877777665677777788888888898888888877678899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPSQNPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSEIAIAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSVVGLLDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDVDPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDLIQDPLTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQPGCAAAMGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDRELAWSQTDFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSAVVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVTTTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG
Prediction	73300000010000000014652200000000056231200310412123315100210011012531102154451203200020042015104654515300000001014100200230154340300404011000000000000011462675200000001111000000001543432000002024213200011002000310052037645131562522200330251025004401444404040504244140301043025004300530150034006417043630110000010000020151037206241444230200000000000243645420000000000112112421624233234544422234423224253234414214144324753423251534511453222314011101000000011312121200232644443444343444453445544454544443455444434455444445443344365443454443445443534435444344465443443344654554444454443413342131421224141412653344434411343268
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCEEEEHCCCCCEEEEEHCCCCEEHCCEEEEHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHCHHHHHHHHHHHCCCCCCCCEEEEEHCCCCCCEEEEEEHCCCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEHCCHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPSQNPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSEIAIAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSVVGLLDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDVDPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDLIQDPLTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQPGCAAAMGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDRELAWSQTDFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSAVVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVTTTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG

2v7yA

0.19

0.14

0.77

3.16

MUSTER

MSKIIGIDLGTTNCVAVLEGGEVRTTPSVVAFK-NGERLVGEVAKRQAITNP-NTIISIKRHMGTDY-KVEIEGKQYTPQEISAIILQYLKSYAED-EPVTRAVITVPAYFNDAQRQATKDAGRI-----AGLEVERIINEPTAAALAYGLDKE--EDQTILVYDLGGGTFDVSILELGD-----GVFEVKATAGDNHLGGDDFDQVIIDYLVNQFKQEHGIDLSKD--KMALQRLKDAAEKAKKELSGVTQTQISLPFGPLHLEMTLTRAKFEELSAHLVERTMGPVRQALQDAGLTPADIDKVILVGGSTRIPAVQEAIKRELGKEPHKGVNPDEVVAIGAAIQGGAGEVKDDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFTT------AADNQTTVDIHVLQGERPMAADNKSLGRFQLTGIPPAPPQIEVTFDIDANGIVHVRAKDLGTNKEQSITIKSSSGLSEEEQRMIKEAEENAEAD-RKRKEAAEL------------------------------------------------------------------------------------------------------------------------

2v7yA

0.18

0.14

0.77

4.28

dPPAS

MSKIIGIDLGTTNCVAVLEGGEVRTTPSVVAFK-NGERLVGEVAKRQAITNP-NTIISIKRHMGTDY-KVEIEGKQYTPQEISAIILQYLKSYAEDYEPVTRAVITVPAYFNDAQRQATKDAGRI-----AGLEVERIINEPTAAALAYGLDKE--EDQTILVYDLGGGTFDVSILELGD-----GVFEVKATAGDNHLGGDDFDQVIIDYLVNQFKQEHGIDLSKD--KMALQRLKDAAEKAKKELSGVTQTQISLPFGPLHLEMTLTRAKFEELSAHLVERTMGPVRQALQDAGLTPADIDKVILVGGSTRIPAVQEAIKRELGKEPHKGVNPDEVVAIGAAIQGGAGEVKDDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFTT------AADNQTTVDIHVLQGERPMAADNKSLGRFQLTGIPPAPPQIEVTFDIDANGIVHVRAKDLGTNKEQSITIKSSSGLSEEEIQRMIKEAEENAEADRKRKEAAEL------------------------------------------------------------------------------------------------------------------------

2khoA

0.17

0.15

0.89

6.14

wdPPAS

---IIGIDLGTTNCVAIMDGTTPRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRGDAWVEVKGQKMAPPQISAEVLKKMKKTAED-EPVTEAVITVPAYFNDAQRQATKDAGRI-----AGLEVKRIINEPTAAALAYGLDKG-TGNRTIAVYDLGGGTFDISIIEIDEVDGE-KTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRND--PLAMQRLKEAAEKAKIELSSAQQTDVNLPYGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGTGDVKDDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFST------AEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAEADRKFDELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQ----------------------------------------------------

2v7yA

0.18

0.14

0.77

4.17

wMUSTER

-SKIIGIDLGTTNCVAVLEGGEVRTTPSVVAFK-NGERLVGEVAKRQAITNP-NTIISIKRHMGTDY-KVEIEGKQYTPQEISAIILQYLKSYAED-EPVTRAVITVPAYFNDAQRQATKDAGRI-----AGLEVERIINEPTAAALAYGLDKE--EDQTILVYDLGGGTFDVSILELGD-----GVFEVKATAGDNHLGGDDFDQVIIDYLVNQFKQEHGIDLSKD--KMALQRLKDAAEKAKKELSGVTQTQISLPFGPLHLEMTLTRAKFEELSAHLVERTMGPVRQALQDAGLTPADIDKVILVGGSTRIPAVQEAIKRELGKEPHKGVNPDEVVAIGAAIQGGAGEVKDDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFTT------AADNQTTVDIHVLQGERPMAADNKSLGRFQLTGIPPAPPQIEVTFDIDANGIVHVRAKDLGTNKEQSITIKSSSGLSEEEIQRMIKEAEENAEADRKRKEAAEL------------------------------------------------------------------------------------------------------------------------

2v7yA

0.18

0.14

0.77

4.24

wPPAS

MSKIIGIDLGTTNCVAVLEGGEVRTTPSVVAFK-NGERLVGEVAKRQAITNP-NTIISIKRHMGTDY-KVEIEGKQYTPQEISAIILQYLKSYAED-EPVTRAVITVPAYFNDAQRQATKDAGRI-----AGLEVERIINEPTAAALAYGLDKE--EDQTILVYDLGGGTFDVSILELGD-----GVFEVKATAGDNHLGGDDFDQVIIDYLVNQFKQEHGIDLSKD--KMALQRLKDAAEKAKKELSGVTQTQISLPFGPLHLEMTLTRAKFEELSAHLVERTMGPVRQALQDAGLTPADIDKVILVGGSTRIPAVQEAIKRELGKEPHKGVNPDEVVAIGAAIQGGAGEVKDDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFTT------AADNQTTVDIHVLQGERPMAADNKSLGRFQLTGIPPAPPQIEVTFDIDANGIVHVRAKDLGTNKEQSITIKSSSGLSEEEIQRMIKEAEENAEADRKRKEAAEL------------------------------------------------------------------------------------------------------------------------

2v7yA

0.18

0.14

0.77

5.70

dPPAS2

MSKIIGIDLGTTNCVAVLEGGEVRTTPSVVAFK-NGERLVGEVAKRQAITNP-NTIISIKRHMGTDY-KVEIEGKQYTPQEISAIILQYLKSYAEDYEPVTRAVITVPAYFNDAQRQATKDAGRI-----AGLEVERIINEPTAAALAYGLDKE--EDQTILVYDLGGGTFDVSILELGD-----GVFEVKATAGDNHLGGDDFDQVIIDYLVNQFKQEHGIDLSKD--KMALQRLKDAAEKAKKELSGVTQTQISLPFGPLHLEMTLTRAKFEELSAHLVERTMGPVRQALQDAGLTPADIDKVILVGGSTRIPAVQEAIKRELGKEPHKGVNPDEVVAIGAAIQGGAGEVKDDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFTT------AADNQTTVDIHVLQGERPMAADNKSLGRFQLTGIPPAPPQIEVTFDIDANGIVHVRAKDLGTNKEQSITIKSSSGLSEEEIQRMIKEAEENAEADRKRKEAAEL------------------------------------------------------------------------------------------------------------------------

2v7yA

0.18

0.14

0.77

4.36

PPAS

MSKIIGIDLGTTNCVAVLEGGEVRTTPSVVAFK-NGERLVGEVAKRQAITNP-NTIISIKRHMGT-DYKVEIEGKQYTPQEISAIILQYLKSYAED-EPVTRAVITVPAYFNDAQRQATKDAGRI-----AGLEVERIINEPTAAALAYGLDKE--EDQTILVYDLGGGTFDVSILELGD-----GVFEVKATAGDNHLGGDDFDQVIIDYLVNQFKQEHGIDLSKD--KMALQRLKDAAEKAKKELSGVTQTQISLPFGPLHLEMTLTRAKFEELSAHLVERTMGPVRQALQDAGLTPADIDKVILVGGSTRIPAVQEAIKRELGKEPHKGVNPDEVVAIGAAIQGGAGEVKDDVTPLSLGIETMGGVFTKLIERNTTIPTSKSQVFTT------AADNQTTVDIHVLQGERPMAADNKSLGRFQLTGIPPAPPQIEVTFDIDANGIVHVRAKDLGTNKEQSITIKSSSGLSEEEIQRMIKEAEENAEADRKRKEAAEL------------------------------------------------------------------------------------------------------------------------

5tkyA

0.18

0.15

0.86

7.50

Env-PPAS

YDGAIGIDLGTTYCVAVYEGTNVFTTPSFVSFT-ENCRLIGEAAKNQAAMNPANTIFDVKRLIGRGNPKVEVQTHTFSPQEISAMVLTKMKEIAETKKKVEKAVITVPAYFNDNQRQATKDAGAI-----AGLNVLRIINEPTAAAIAYGLGSGSDKERNVLIYDLGGGAFDVSLLNIQG-----GVFTVKATAGDTHLGGQDFDTNLLEYCKKEFTRKTKKDLSGD--ARALRRLRTACERAKRTLSSGAQTTIEIDFDGEDFNIQITRARFEDLNAKAFAGTLEPVAQVLKDAGIEKHQVDEIVLVGGSTRIPRIQKLLSEFFGKKLEKSINPDEAVAYGAAVQAGSGKATSDVVPLSLGVAMEGNIFAPVVPRGQTVPTIKKRTFTT------VADNQQTVQFPVYQGERVNCEDNTLLGEFTLAPIPPMKPVLEVVFEVDVNGILKVTATEKTSGRSANITIANSVGLSTDEIAEKFKSKCEAFSKRFEAKQQLESYISRVEEIISDKDKIEQALS---------EAMAQLEIEDSTADELKKKELALKRLVT------KAMAS----------------------------------------------------

2khoA

0.18

0.16

0.88

3.09

MUSTER

---IIGIDLGTTNCVAIMDGTTPRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRGDAWVEVKGQKMAPPQISAEVLKKMKKTAED-EPVTEAVITVPAYFNDAQRQATKDAGRI-----AGLEVKRIINEPTAAALAYGLDKG-TGNRTIAVYDLGGGTFDISIIEIDEVDGE-KTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRND--PLAMQRLKEAAEKAKIELSSAQQTDVNLPYGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGTGDVKDDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFST------AEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEQKMVRDAEANAEADRKQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQ----------------------------------------------------------

2khoA

0.18

0.16

0.88

4.16

dPPAS

---IIGIDLGTTNCVAIMDGTTPRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRGDAWVEVKGQKMAPPQISAEVLKKMKKTAEDYEPVTEAVITVPAYFNDAQRQATKDAGRI-----AGLEVKRIINEPTAAALAYGLDKG-TGNRTIAVYDLGGGTFDISIIEIDEVDGE-KTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRND--PLAMQRLKEAAEKAKIELSSAQQTDVNLPYGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGTGDVKDDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFST------AEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIAEANAEADRKFDELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQ----------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.05

Estimated TM-score = 0.58±0.14

Estimated RMSD = 10.3±4.6Å

Download Model 2

C-score=-1.73

Download Model 3

C-score=-1.90

Download Model 4

C-score=-2.75

Download Model 5

C-score=-3.59

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2khoA	0.831	2.13	0.175	0.877
2	1yuwA	0.545	2.53	0.138	0.581
3	3c7nA	0.544	4.47	0.178	0.635
4	4j8fA	0.543	2.69	0.160	0.579
5	2v7yA	0.530	2.42	0.166	0.561
6	3iucC	0.525	1.74	0.204	0.543
7	4kboA	0.518	1.86	0.233	0.540
8	4rtfD	0.514	1.86	0.217	0.535
9	5tkyA	0.513	3.70	0.182	0.581
10	5e84A	0.511	3.53	0.173	0.577

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.55	88	4czmA	ANP	Rep, Mult	10,11,12,13,167,168,169,170,241,244,245,309,310,311,313,314,336
2	0.10	19	3l4iA	PO4	Rep, Mult	10,11,60,141,170
3	0.04	11	2nztA	BG6	Rep, Mult	8,11,12,106,108,141,165,167,169,308,309,310,338,339
4	0.04	7	1s3xA	NA	Rep, Mult	165,167,170,171,172
5	0.02	4	4bqlB	MG	Rep, Mult	8,14,339
6	0.01	2	3l6qB	MG	Rep, Mult	12,13,168
7	0.01	3	1s3xA	CA	Rep, Mult	198,202,203
8	0.01	2	4k42B	CA	Rep, Mult	8,141,165,339
9	0.01	2	4eahG	ATP	Rep, Mult	8,10,11,12,14,141,165,167,168,241,244,245,309,310,313,314,335
10	0.01	3	1hpmA	K	Rep, Mult	8,10,13,336
11	0.00	1	3qmlA	MG	Rep, Mult	19,20
12	0.00	1	3atuA	PG0	Rep, Mult	46,50,231
13	0.00	1	3d2fB	MG	Rep, Mult	154,155,156,157
14	0.00	1	2e88A	ZN	Rep, Mult	196,198
15	0.00	1	3d2fA	MG	Rep, Mult	348,349
16	0.00	1	5ey4A	DTP	Rep, Mult	24,244,245,248,310,311,313,314,334

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2vz8B	0.333	7.99	0.086	0.539	2.3.1.85	NA
2	0.060	1ig8A	0.361	5.61	0.105	0.479	2.7.1.1	88
3	0.060	2uytA	0.340	4.61	0.100	0.411	2.7.1.5	141,309
4	0.060	1x3mA	0.333	5.20	0.113	0.429	2.7.2.15,2.7.2.-	NA
5	0.060	3hz6A	0.339	4.80	0.104	0.418	2.7.1.17	10,142
6	0.060	3flcX	0.351	4.63	0.096	0.426	2.7.1.30	12,141,200
7	0.060	3b8aX	0.390	4.76	0.111	0.482	2.7.1.1	NA
8	0.060	2d4wA	0.342	5.05	0.092	0.431	2.7.1.30	202,310
9	0.060	1u6zB	0.357	5.72	0.071	0.471	3.6.1.11	10,167,195
10	0.060	3en9A	0.333	5.15	0.053	0.423	3.4.24.57	141
11	0.060	1qhaA	0.464	6.31	0.081	0.635	2.7.1.1	141
12	0.060	2zf5Y	0.351	4.67	0.110	0.426	2.7.1.30	10,12,141
13	0.060	2vz9B	0.334	7.95	0.079	0.535	2.3.1.85	NA
14	0.060	3jvpD	0.348	5.19	0.132	0.442	2.7.1.16	89
15	0.060	3gbtA	0.334	4.92	0.102	0.413	2.7.1.12	140
16	0.060	1zc6B	0.329	4.44	0.139	0.398	2.7.1.59	198
17	0.060	2e2oA	0.351	4.08	0.117	0.413	2.7.1.1	141
18	0.060	2vz8A	0.293	8.26	0.041	0.493	2.3.1.85	NA
19	0.060	1hkgA	0.387	4.92	0.095	0.485	2.7.1.1	15,141,166,169,311

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.25	0.526	1.76	0.21	0.55	3qfuA	GO:0000166 GO:0000742 GO:0005524 GO:0005783 GO:0005788 GO:0006616 GO:0006986 GO:0016887 GO:0030433 GO:0031204 GO:0034099 GO:0051082 GO:0070880
1	0.25	0.545	2.53	0.14	0.58	1yuwA	GO:0000151 GO:0000166 GO:0000974 GO:0001664 GO:0001786 GO:0005524 GO:0005615 GO:0005622 GO:0005634 GO:0005681 GO:0005730 GO:0005737 GO:0005770 GO:0005829 GO:0005886 GO:0005925 GO:0006351 GO:0006355 GO:0006397 GO:0006457 GO:0008380 GO:0016020 GO:0016887 GO:0019899 GO:0023026 GO:0030529 GO:0031072 GO:0031625 GO:0031647 GO:0042026 GO:0042470 GO:0042623 GO:0043209 GO:0044822 GO:0045892 GO:0046034 GO:0048026 GO:0051082 GO:0051085 GO:0051726 GO:0055131 GO:0061738 GO:0070062 GO:0072318 GO:0072562 GO:1902904
2	0.24	0.515	2.33	0.20	0.55	3a8yA	GO:0000151 GO:0000166 GO:0001618 GO:0001664 GO:0005102 GO:0005524 GO:0005654 GO:0005737 GO:0005814 GO:0005829 GO:0005925 GO:0010628 GO:0010941 GO:0016234 GO:0016887 GO:0019899 GO:0031072 GO:0031396 GO:0031397 GO:0031625 GO:0032757 GO:0034599 GO:0034605 GO:0042026 GO:0042623 GO:0042826 GO:0044183 GO:0046034 GO:0046718 GO:0048471 GO:0050821 GO:0051082 GO:0051092 GO:0055131 GO:0060548 GO:0070370 GO:0070434 GO:0072562 GO:0090084 GO:1900034 GO:1903265 GO:2001240
3	0.24	0.524	2.09	0.20	0.55	3kvgB	GO:0000166 GO:0005524
4	0.22	0.544	4.47	0.18	0.64	3c7nA	GO:0000166 GO:0000774 GO:0005516 GO:0005524 GO:0005737 GO:0005844 GO:0006457 GO:0042026 GO:0042277 GO:0050790
5	0.22	0.525	2.01	0.21	0.55	3fe1B	GO:0000166 GO:0005524 GO:0005737 GO:0005814 GO:0005829 GO:0006986 GO:0008180 GO:0019899 GO:0031072 GO:0034605 GO:0042026 GO:0042623 GO:0051082 GO:0070062 GO:0070370 GO:0072562
6	0.19	0.514	1.86	0.22	0.54	4rtfD	GO:0000166 GO:0005524 GO:0006457 GO:0051082
7	0.17	0.510	2.25	0.19	0.54	4gniA	GO:0000166 GO:0005524
8	0.16	0.497	2.82	0.13	0.54	4aniC	GO:0000166 GO:0005524 GO:0006457 GO:0051082
9	0.16	0.543	2.69	0.16	0.58	4j8fA	GO:0000151 GO:0000166 GO:0001618 GO:0001664 GO:0005102 GO:0005524 GO:0005654 GO:0005737 GO:0005814 GO:0005829 GO:0005925 GO:0006457 GO:0010628 GO:0010941 GO:0016234 GO:0016887 GO:0019899 GO:0019904 GO:0030544 GO:0031072 GO:0031396 GO:0031397 GO:0031625 GO:0032403 GO:0032564 GO:0032757 GO:0034599 GO:0034605 GO:0042026 GO:0042623 GO:0042802 GO:0042826 GO:0043234 GO:0044183 GO:0046034 GO:0046718 GO:0048471 GO:0050821 GO:0051082 GO:0051087 GO:0051092 GO:0051260 GO:0055131 GO:0060548 GO:0061084 GO:0070062 GO:0070370 GO:0070389 GO:0070434 GO:0072562 GO:0090084 GO:1900034 GO:1903265 GO:2001240
10	0.15	0.445	3.52	0.13	0.50	4czmA	GO:0000902
11	0.14	0.442	3.54	0.14	0.50	1jcfA	GO:0000166 GO:0000902
12	0.14	0.522	1.90	0.20	0.55	3i33A	GO:0000166 GO:0000795 GO:0001673 GO:0001934 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005819 GO:0005829 GO:0005856 GO:0006986 GO:0007140 GO:0007141 GO:0007283 GO:0007286 GO:0009408 GO:0009409 GO:0009986 GO:0016020 GO:0019899 GO:0030154 GO:0031662 GO:0032781 GO:0036128 GO:0042026 GO:0043209 GO:0051082 GO:0051861 GO:0070062 GO:0070194 GO:0072562 GO:0072687 GO:0090084 GO:1901896
13	0.14	0.518	1.86	0.23	0.54	4kboA	GO:0000166 GO:0005524 GO:0005634 GO:0005730 GO:0005737 GO:0005739 GO:0005925 GO:0006457 GO:0006611 GO:0009636 GO:0017134 GO:0019899 GO:0031012 GO:0031072 GO:0031625 GO:0042645 GO:0043066 GO:0043209 GO:0044822 GO:0051082 GO:0070062 GO:0071347 GO:1902037 GO:1903707
14	0.14	0.520	2.07	0.21	0.55	3gl1A	GO:0000054 GO:0000166 GO:0002181 GO:0005516 GO:0005524 GO:0005737 GO:0005844 GO:0006364 GO:0006412 GO:0006415 GO:0006450 GO:0006452 GO:0016887 GO:0042149 GO:0051082 GO:0051083
15	0.13	0.511	3.53	0.17	0.58	5e84A	GO:0000166 GO:0001948 GO:0005509 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005793 GO:0005886 GO:0005913 GO:0005925 GO:0006983 GO:0006987 GO:0008180 GO:0009986 GO:0016020 GO:0016887 GO:0019899 GO:0019904 GO:0021589 GO:0021680 GO:0021762 GO:0030176 GO:0030335 GO:0030433 GO:0030496 GO:0030512 GO:0030968 GO:0031012 GO:0031398 GO:0031625 GO:0034663 GO:0034975 GO:0034976 GO:0035437 GO:0036498 GO:0036499 GO:0036500 GO:0042149 GO:0042470 GO:0043022 GO:0043066 GO:0043209 GO:0051082 GO:0051087 GO:0051603 GO:0051787 GO:0060904 GO:0070062 GO:0071236 GO:0071287 GO:0071353 GO:0090074 GO:0098609 GO:0098641 GO:1901998 GO:1903891 GO:1903894 GO:1903897 GO:1990440
16	0.13	0.518	3.54	0.18	0.58	4b9qA	GO:0000166 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0006260 GO:0006457 GO:0006461 GO:0008270 GO:0009408 GO:0016020 GO:0016989 GO:0034620 GO:0043241 GO:0043531 GO:0044183 GO:0051082 GO:0051085 GO:0070389 GO:1903506
17	0.07	0.518	3.51	0.16	0.58	3d2eA	GO:0000166 GO:0000774 GO:0005516 GO:0005524 GO:0005737 GO:0005844 GO:0006457 GO:0042026 GO:0042277 GO:0050790
18	0.06	0.345	3.08	0.13	0.38	3h1qB	GO:0000166 GO:0005524

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0051082	GO:0005543	GO:0003723	GO:0072341	GO:0023023	GO:0004872	GO:0033218	GO:0060590	GO:0031072	GO:0042623	GO:0001664	GO:0055131	GO:0031625
GO-Score	0.74	0.57	0.49	0.49	0.49	0.49	0.48	0.43	0.43	0.43	0.43	0.43	0.43	0.43
Biological Processes	GO:0042026	GO:0043161	GO:0070879	GO:0051278	GO:0000741	GO:0035966	GO:0065002	GO:0000747	GO:0051274	GO:0006614	GO:0036503	GO:0006620	GO:0010629	GO:0072319	GO:1902903	GO:1903054	GO:2000113	GO:0065008	GO:0033120	GO:0050685	GO:0006914	GO:0007049	GO:0051084	GO:0048024	GO:1903507	GO:0061077	GO:0006979	GO:0010803	GO:0001961	GO:0019058	GO:1903321	GO:0051091	GO:2001237	GO:2001239	GO:0070426	GO:0032677	GO:0010286	GO:0080135	GO:0070432	GO:0034605	GO:0090083	GO:0001819	GO:0031396	GO:0030260	GO:1901099	GO:0046034
GO-Score	0.55	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.43
Cellular Component	GO:0044432	GO:0071944	GO:0048770	GO:1903561	GO:0031981	GO:0005768	GO:1990904	GO:0005813	GO:0044450	GO:0005829	GO:0000151	GO:0005925	GO:0072562
GO-Score	0.50	0.49	0.49	0.49	0.49	0.49	0.49	0.48	0.48	0.43	0.43	0.43	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.