I-TASSER results

I-TASSER results for job id Rv0293c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (400 residues)
MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVESSAIADVALRTAVASV
LSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSFPAPTELPKVTSRPASPLT
EWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQHWRHRDGPRPTLCVIHGFMG
SSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFSPFSGFGYFTSGLSGFAEAMAQA
VYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLASVESRLEAVIPNCPVVMPAKLFDEW
FPANKLVKLGLRLTNISRDELIAGLAYHGPLNYRPLLPKDRRMIITGLGDRMAPPEHAVT
LWKQWDRCALHWFPGSHLLHVSQLDYLRRMTVFLQGLMFD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVESSAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSFPAPTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQHWRHRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFSPFSGFGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLASVESRLEAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYRPLLPKDRRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTVFLQGLMFD
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEHCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCHHHHHHHHHHHHHHCCC
Conf.Score	9988777778888888888887777655777777888766455444556666666666544554577776566665445567778888776666558577657888887545546776544445665777886688766787754334456788789999976899997789998899998557777999999999999989998589998888888888876544457678999999999999999999999799859999987889999999967988768998588889999999975655666777765588888999998875846667775899789999789987799999999999799969998698654456689999999999997689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVESSAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSFPAPTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQHWRHRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFSPFSGFGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLASVESRLEAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYRPLLPKDRRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTVFLQGLMFD
Prediction	8544345431536121262322414354026524152433011311110121022001311320323323452043254444350042025242153045115424423414324243234324423142031422132343414542451442100000002376451100000000010321132003003201722010000000000113453352433211242123103001300200220041057351410000000100000000002243030000000000012001201413411432152452226302520331201312430452200000033021012610230161066241010201000103365015202500551338
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEHCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCHHHHHHHHHHHHHHCCC
MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVESSAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSFPAPTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQHWRHRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFSPFSGFGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLASVESRLEAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYRPLLPKDRRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTVFLQGLMFD

3azoA

0.14

0.13

0.92

1.33

MUSTER

RTGWWNDPATGAATQLCRREEEFAGPLWTPGRWFAPLANGLIAVVHGKGAAVLGILDPESGELVDAAGPWTEWAATLTVSGTR----AVGVAASPRTAYEELDTVTGRARTIGARHTDPVDPAYYPEPQIRTFTA----------------PDGREIHAHIYPPPADELPPYVVAHGGPTSRVPA-VLDLDVAYFTSRGIGVADVNYGG--------STGYGRAYRERLRGRWGVVDVEDCAAVATALAEEGTADRARLAVRGGSAGGWTAASSLVSTDVYACGTVLYPVLDLLGWADGGTHDFES--RYLDFLIGSFEEFPERYRDRAPLTRADRV-RVPFLLLQGLEDPVCPPEQCDRFLEAVAGCAYLSFEGGHGFRRKEVRALEAELSLYAQVFVE

4z8zA

0.17

0.13

0.77

1.77

dPPAS

---------------------------------------------------------------------------NEASSKFVDNIAIEKLLNEKLL-----RVSHRPKNLFYDDEKVFDDLCKCETDSKVKLAENLKRFEFPSFLKTEEYIENNIVYLYYHPAKD-PVCNILLLHGLYDDNLN----YGFLTRLNELKFNVFLE-LPFHFNRKPAESFFSGEYFISADLLRARNAFIQSIYDIEASRNLIGNINTLPCLLVGFS-GGCISFRYHLR-DSFKGTFLINPVTDLLLVWDN--PLLVKVKKDLEDSGVGKEQVDVFRIIDPCENINTRFNTDNIAVVYSIYDQIVGEEKNAIFVEKIKLKKILEYHAGHLNILRVPKLSNDIYEFFSCL---

3azoA2

0.17

0.12

0.69

2.18

wdPPAS

--------------------------------------------------------------------------------------------------------------VSTAPYGAWQSPIDAALVASRSGTDPVDPAYPEPQIRTFTAPDGREIHAHIYPPPADELPPYVVAHGGPTSRV-PAVLDLDVAYFTSRGIGVADVNYGG--------STGYGRAYRERLRGRWGVVDVEDCAAVATALAEEGTADRARLAVRGGSAGGWTAASSLVSTDVYACGTVLYPVLDLLGWADGGTHDFES--RYLDFLIGSFEEFPERYRDRAPLTRADRV-RVPFLLLQGLEDPVCPPEQCDRFLEAVAGCAYLSFEGGHGFRRKEVRALEAELSLYAQVFGV

3azoA

0.15

0.14

0.91

1.83

wMUSTER

RTGWWN-DPATGAAQLCRREEEFAGP-------LWTPGRWFAPLANGLIAVVHGKGAAVLGIL----DPESGELVDAAGPWTEWAATLTVSGTRA-----VAASPRTAYEVVEL-------DTVTGRARTIGARHTDPVDPPEPQIRTFTAPDGREIHAHIYPPPADELPPYVVAHGGPTSRVPA-VLDLDVAYFTSRGIGVADVNYGG--------STGYGRAYRERLRGRWGVVDVEDCAAVATALAEEGTADRARLAVRGGSAGGWTAASSLVSTDVYACGTVLYPVLDLLGWADGGTHDFES--RYLDFLIGSFEEFPERYRDRAPLTRADRV-RVPFLLLQGLEDPVCPPEQCDRFLEAVAGCGYLSFEGGHGFRRKEVRALEAELSLYAQVFVE

3fvrA

0.15

0.11

0.76

2.53

wPPAS

-------------MQLFDLS---------------------------------LEELKKYKPKKTARP------------------DFSDFWKKSLEELRQVE-----AEPTLESYD---YPVKGVKVYRLTYQS----------------FGHSKIEGFYAVPDQGPHPALVRFHGYNASY---DGGIHDIVNWALHGYATFGMLVRGQGGSEDTSPGGHALGWMTKGILSYYRGVYLDAVRALEVIQSFPEVDEHRIGVIGGSQGGALAIAAAALSDIPKVVVADYPLSNFERAVDVALEQYLEINSYFRRNSDVEEKAFETLSYFDLINLAGWV-KQPTLMAIGLIDKITPPSTVFAAYNHLETDDLKVYRYGHEFI---PAFQTEKLSFLQKHLLL

4z8zA

0.17

0.13

0.77

2.73

dPPAS2

---------------------------------------------------------------------NEASSKFVDNIAIEKLLNEKLLRVSHRPKNLFYDDEKVFDDL--CKCETDSKVKLAENLKRFEFPSFLK---------TEEYIENNIVYLYYHPAKD-PVCNILLLHGLYDDNLN----YGFLTRLNELKFNVFLE-LPFHFNRKPAESFFSGEYFISADLLRARNAFIQSIYDIEASRNLIGNINTLPCLLVGFS-GGCISFRYHLR-DSFKGTFLINPVTDLLLVWDN--PLLVKVKKDLEDSGVGKEQVDVFRIIDPCENINTRFNTDNIAVVYSIYDQIVGEEKNAIFVEKIKKKKILEYHAGHLNILRVPKLSNDIYEFFSCL---

4z8zA

0.18

0.14

0.76

2.34

PPAS

---------------------------------------------------------------------------NEASSKFVDNIAIEKLLNESHRPKNLFYDDEKVFDD-LCKCETDSKVKLAENLKRFEFPSFL---------KTEEYIENNIVYLYYHPAKD-PVCNILLLHGLYDDNLN----YGFLTRLNELKFNVFLE-LPFHFNRKPAESFFSGEYFISADLLRARNAFIQSIYDIEASRNLIGNINTLPCLLVGFS-GGCISFRYHL-RDSFKGTFLINPVTDLLLVWDN--PLLVKVKKDLEDSGVGKEQVDVFRIIDPCENINTRFNTDNIAVVYSIYDQIVGEEKNAIFVEKIKLKKILEYHAGHLNILRVPKLSNDIYEFFSCL---

5cmlA

0.17

0.10

0.57

2.45

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------MQIKTVTFEN----------------NRGERLAARLDLPVDTPVAYALFAHCFTCSKN-LKAVTTISRALTTQGYAVLRFDFTGLGATN--------------------------FEDLRAACRFLSAQYEPPALLIGHSLGGAAVLAVAGEFPEVKAVATIGAPCDPAHVRHLLRPALDTTVGEAVVDLGGRKQFLEELERVNLEDQVRTM-RRPLLLFHSPTDQIVGIENAACLFQAARHPSFVSLDADHLLSNSAAFVGEVLGAWARRYVG-

3fvrA

0.15

0.11

0.76

1.33

MUSTER

---------------------------------------------------------------MQLFDLSLEELKKYKPKKTAPDFSDFWKKSLE-ELRQV------EAEPTLESYD---YPVKGVKVYRLTYQSF----------------GHSKIEGFYAVPDQGPHPALVRFHGYNASY---DGGIHDIVNWALHGYATFGMLVRGQGGSEDTSVTPGGHGWMTKGILSKDTYYRGVYLDAVRALEVIQSVDEHRIGVIGGSQGGALAIAAAALSDIPKVVVADYPYLSNFERAVDVALPYLEINSYFRRNSDVEEKAFETLSYFDLINLAGWV-KQPTLMAIGLIDKITPPSTVFAAYNHLETDDLKVYRFGHEFI---PAFQTEKLSFLQKHLLL

3fvrA

0.14

0.11

0.77

1.62

dPPAS

---------------------------------------------------------------MQLFDLSLEELKKYKPKKTARP-DFSDFWKKSLEELRQVEAEP--------TLESYDYPVKGVKVYRLTYQS----------------FGHSKIEGFYAVPDQGPHPALVRFHGYNASY---DGGIHDIVNWALHGYATFGMLVRGQGGSEDTSVTPGGHALILSKDTYYYRGVYLDAVRALEVIQSFPEVDEHRIGVIGGSQGGALAIAAAALSDIPKVVVADYPYLSNFERAVDVALEQPYLEINSYFRRNSEEKAFETLSYFDLINLAGWV-KQPTLMAIGLIDKITPPSTVFAAYNHLETDDLKVYRY--FGHEFIPAFQTEKLSFLQKHLLL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.15

Estimated TM-score = 0.57±0.15

Estimated RMSD = 9.5±4.6Å

Download Model 2

C-score=-3.37

Download Model 3

C-score=-3.28

Download Model 4

C-score=-3.91

Download Model 5

C-score=-4.13

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3fvrA	0.655	3.21	0.141	0.757
2	3azoA	0.652	3.47	0.145	0.765
3	5l8sA	0.638	3.61	0.126	0.752
4	2xe4A	0.637	3.80	0.097	0.762
5	1h2xA	0.634	3.65	0.121	0.750
6	3fcyA	0.634	3.45	0.173	0.745
7	1vlqL	0.633	3.37	0.097	0.740
8	4hxeB	0.629	3.73	0.116	0.745
9	2bklB	0.627	3.75	0.124	0.748
10	4hvtA	0.627	3.79	0.095	0.752

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.24	17	1orwC	P2Y	Rep, Mult	176,265,266,290,301,306,377
2	0.09	6	2hu5A	UUU	Rep, Mult	177,265,266,293,296,305,351,377
3	0.06	4	2bucC	UUU	Rep, Mult	232,234,235,239,273,324,327,328,334
4	0.04	3	3i6yA	CL	Rep, Mult	177,179,265,266
5	0.03	2	3ivmA	ZPR	Rep, Mult	174,191,202,262,264,288,377,387,391
6	0.01	1	3fytC	XYP	Rep, Mult	174,180,181,182,188
7	0.01	1	3azqA	III	Rep, Mult	61,265,266,290,296,351

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.429	3fcyA	0.634	3.45	0.173	0.745	3.1.1.41	265,350,377
2	0.250	2ocgA	0.489	3.28	0.154	0.560	3.1.-.-	261,265,267,350,358,370,377
3	0.149	3hjuA	0.513	3.60	0.138	0.595	3.1.1.23	211
4	0.126	1l7aA	0.658	3.16	0.131	0.757	3.1.1.72,3.1.1.41	350
5	0.074	3fcxB	0.535	3.61	0.099	0.632	3.1.2.12	135
6	0.067	1dinA	0.454	3.02	0.141	0.520	3.1.1.45	173,249
7	0.067	3c6bA	0.524	3.80	0.135	0.627	3.1.2.12	NA
8	0.067	2vf2A	0.502	3.46	0.176	0.583	3.7.1.8	211,216,266
9	0.066	1u2eA	0.504	3.59	0.160	0.588	3.7.1.-	265
10	0.066	1vkhA	0.477	3.03	0.083	0.545	3.5.1.9	177
11	0.066	1jjfA	0.459	3.14	0.140	0.530	3.2.1.8	180,187
12	0.066	1j1iA	0.463	3.34	0.147	0.532	3.7.1.8	265
13	0.060	1jjiA	0.533	3.81	0.108	0.630	3.1.1.1	385
14	0.060	1k4yA	0.526	4.59	0.097	0.665	3.1.1.1	NA
15	0.060	1f6wA	0.541	4.14	0.123	0.662	3.1.1.13,3.1.1.3	NA
16	0.060	1thgA	0.531	4.14	0.080	0.655	3.1.1.3	272
17	0.060	2gbcA	0.607	3.87	0.094	0.728	3.4.14.5,3.4.15.5	265,377
18	0.060	2ecfA	0.607	3.79	0.119	0.728	3.4.14.5	350,377
19	0.060	1yr2A	0.589	3.82	0.112	0.700	3.4.21.26	265
20	0.060	1hlgB	0.539	3.92	0.139	0.642	3.1.1.3	281
21	0.060	1gz7A	0.531	4.33	0.084	0.662	3.1.1.3	NA
22	0.060	1b41A	0.531	4.31	0.078	0.665	3.1.1.7	NA
23	0.060	1crlA	0.530	4.32	0.073	0.660	3.1.1.3	NA
24	0.060	2fj0A	0.533	4.23	0.126	0.657	3.1.1.1	NA
25	0.060	1aknA	0.541	4.44	0.107	0.677	3.1.1.13,3.1.1.3	NA
26	0.060	3i6yA	0.529	3.68	0.119	0.630	3.1.1.2	NA
27	0.060	1maaD	0.533	4.20	0.092	0.655	3.1.1.7	NA
28	0.060	3g0bB	0.609	4.02	0.093	0.735	3.4.14.5	342
29	0.060	2c7bA	0.540	3.40	0.128	0.625	3.1.1.1	NA
30	0.060	1vlqA	0.642	3.36	0.102	0.750	3.1.1.41	350,377
31	0.060	3fvrA	0.655	3.21	0.141	0.757	3.1.1.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.25	0.655	3.21	0.14	0.76	3fvrA	GO:0008126 GO:0016787
1	0.22	0.658	3.16	0.13	0.76	1l7aA	GO:0000272 GO:0005737 GO:0005975 GO:0016787 GO:0030245 GO:0046555 GO:0047739 GO:0052689
2	0.21	0.500	3.82	0.10	0.59	2r11D	GO:0016787 GO:0052689
3	0.20	0.620	3.80	0.12	0.74	3o4jC	GO:0005737 GO:0006508 GO:0008236 GO:0016787
4	0.20	0.473	2.65	0.14	0.53	2o2gA	GO:0016787
5	0.17	0.462	2.91	0.16	0.52	4q3kB	GO:0006508 GO:0008152 GO:0008236 GO:0016787
6	0.16	0.484	3.75	0.11	0.57	4ns4A	GO:0016787 GO:0016788
7	0.15	0.478	3.58	0.11	0.57	4g8bA	GO:0003824 GO:0016787 GO:0016788
8	0.15	0.475	3.48	0.13	0.56	3e3aB	GO:0003824 GO:0004601 GO:0009062 GO:0016298 GO:0016491 GO:0055114 GO:0098869
9	0.14	0.504	3.52	0.10	0.59	4ccyB	GO:0005737 GO:0016787 GO:0052689
10	0.14	0.468	3.43	0.14	0.55	1q0rA	GO:0016787 GO:0017000 GO:0052689
11	0.13	0.463	3.34	0.15	0.53	1j1iA	GO:0016787
12	0.11	0.464	3.55	0.15	0.54	3qitB	GO:0003824 GO:0008152 GO:0016740 GO:0031177
13	0.09	0.657	3.60	0.14	0.77	3azoA	GO:0004177 GO:0006508 GO:0008236
14	0.09	0.589	3.52	0.10	0.69	5hfnD	GO:0000272 GO:0005509 GO:0005737 GO:0005975 GO:0005976 GO:0008152 GO:0016787 GO:0030245 GO:0046555 GO:0046872 GO:0047739 GO:0052689
15	0.08	0.480	3.64	0.14	0.56	4lxhA	GO:0016787
16	0.08	0.463	3.10	0.15	0.53	2xuaH	GO:0016787 GO:0042952 GO:0047570
17	0.07	0.604	3.85	0.13	0.72	1xfdA	GO:0005886 GO:0006508 GO:0008076 GO:0008236 GO:0008239 GO:0009986 GO:0015459 GO:0016020 GO:0016021 GO:0043025 GO:0043268 GO:0070062 GO:0072659 GO:1901379
18	0.07	0.641	3.42	0.10	0.75	3m83A	GO:0000272 GO:0005509 GO:0005737 GO:0005975 GO:0005976 GO:0008152 GO:0016787 GO:0030245 GO:0046555 GO:0046872 GO:0047739 GO:0052689
19	0.07	0.634	3.65	0.12	0.75	4amyA	GO:0004252 GO:0005737 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0070008
20	0.07	0.487	2.97	0.18	0.56	1mt3A	GO:0004177 GO:0006508 GO:0008233 GO:0016787
21	0.07	0.630	3.70	0.11	0.74	4hxgF	GO:0006508 GO:0008236 GO:0046872
22	0.07	0.627	3.75	0.12	0.75	2bklB	GO:0004252 GO:0006508 GO:0008236 GO:0070008
23	0.07	0.537	3.64	0.10	0.64	3e4dA	GO:0016787 GO:0018738 GO:0046294 GO:0046872 GO:0052689
24	0.07	0.634	3.45	0.17	0.74	3fcyA
25	0.07	0.616	3.56	0.11	0.72	2d5lA	GO:0004177 GO:0006508 GO:0008233 GO:0008236 GO:0016787
26	0.07	0.631	3.65	0.11	0.74	3munA	GO:0004252 GO:0006508 GO:0008236 GO:0070008
27	0.07	0.607	3.79	0.12	0.73	2ecfA	GO:0006508 GO:0008236
28	0.07	0.608	4.15	0.11	0.74	1z68A	GO:0001525 GO:0002020 GO:0004175 GO:0004222 GO:0004252 GO:0005178 GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0005925 GO:0006508 GO:0006915 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0009986 GO:0010710 GO:0010716 GO:0016020 GO:0016021 GO:0016787 GO:0030027 GO:0030054 GO:0031258 GO:0032587 GO:0042803 GO:0042995 GO:0043542 GO:0045177 GO:0045178 GO:0046983 GO:0051603 GO:0051917 GO:0060244 GO:0071158 GO:0071438 GO:0071850 GO:0097325 GO:1900119 GO:1902362 GO:1903054
29	0.07	0.609	4.05	0.10	0.73	2aj8A	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
30	0.07	0.607	3.87	0.09	0.73	2gbcA	GO:0002020 GO:0002709 GO:0004177 GO:0004252 GO:0005102 GO:0005518 GO:0005576 GO:0005783 GO:0005794 GO:0005886 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0042277 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0051234 GO:0071438
31	0.07	0.612	3.66	0.10	0.72	4q1vA	GO:0006508 GO:0008236 GO:0016787 GO:0046872
32	0.07	0.605	3.91	0.10	0.73	4n8eB	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
33	0.07	0.502	3.46	0.18	0.58	2vf2A	GO:0005618 GO:0005886 GO:0006629 GO:0006694 GO:0016042 GO:0016787 GO:0018774 GO:0019439 GO:0034820 GO:0044117 GO:0102296
34	0.07	0.598	3.85	0.10	0.72	4wjlB	GO:0005886 GO:0006508 GO:0008236 GO:0008239 GO:0015459 GO:0016020 GO:0016021 GO:0072659 GO:0090004 GO:1901379
35	0.07	0.512	4.00	0.10	0.62	4mj3B	GO:0003824 GO:0016787 GO:0018786
36	0.07	0.464	3.11	0.14	0.53	3kxpA	GO:0016787 GO:0042803 GO:0042820 GO:0047411
37	0.07	0.496	3.36	0.12	0.58	3wi7A	GO:0016787 GO:0018786
38	0.07	0.504	3.59	0.16	0.59	1u2eA	GO:0003824 GO:0005737 GO:0016787 GO:0018771 GO:0019380 GO:0019439 GO:0019622 GO:0042803 GO:0052823
39	0.07	0.474	2.92	0.15	0.54	3om8B	GO:0016787 GO:0042952 GO:0047570
40	0.07	0.496	3.62	0.13	0.58	4i3fA	GO:0016787
41	0.07	0.471	3.39	0.09	0.55	3wzlA	GO:0016787
42	0.07	0.492	3.34	0.12	0.57	1c4xA	GO:0016787 GO:0018774
43	0.07	0.500	3.63	0.17	0.59	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
44	0.07	0.487	3.60	0.13	0.58	4k2aC	GO:0003824 GO:0016787 GO:0018786
45	0.07	0.484	3.26	0.13	0.56	3wmrA	GO:0006508 GO:0008233 GO:0016787
46	0.07	0.493	3.75	0.16	0.58	4b9aA	GO:0003824 GO:0009062 GO:0016298 GO:0016787
47	0.07	0.507	3.65	0.10	0.59	4f0jA	GO:0003824 GO:0016787
48	0.07	0.506	4.33	0.15	0.62	4opmA	GO:0004806 GO:0016787
49	0.07	0.478	3.69	0.14	0.57	4io0A	GO:0003824 GO:0008152 GO:0016787 GO:0016798 GO:0047405
50	0.07	0.483	3.87	0.13	0.59	3sk0A	GO:0003824 GO:0009636 GO:0016787 GO:0018786
51	0.07	0.495	3.33	0.15	0.57	1azwA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0016787
52	0.07	0.475	3.39	0.12	0.55	1hkhA	GO:0003824 GO:0004601 GO:0098869
53	0.07	0.470	3.25	0.14	0.54	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
54	0.07	0.466	3.39	0.12	0.54	4pw0A	GO:0016787
55	0.07	0.454	3.59	0.13	0.53	2xmzA	GO:0009234 GO:0016787 GO:0016829 GO:0070205

Consensus prediction of GO terms

Molecular Function	GO:0034338	GO:0019213	GO:0017171	GO:0070011
GO-Score	0.49	0.44	0.41	0.41
Biological Processes	GO:0030243	GO:0051275	GO:0019538
GO-Score	0.44	0.44	0.41
Cellular Component	GO:0005737
GO-Score	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.