I-TASSER results

I-TASSER results for job id Rv0272c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (377 residues)
MTGRAATPGVIREFVGLPSRTAGRAAAGGHPCQGLYHHSVGRKPKVALIAAHYQIDFSEH
YLAEYMAIRGIGFLGWNTRFRGFESSFLLDHALVDIGVGVRWLREVQGVETVVLLGNSGG
GSLMAAYQSQAVDPNVTPLDGMRPAAGVTELPAADAYVAAAAHPGRPDVLTAWMDAAVID
ENDPVATDPELDLFDERNGPPYSPEFISRYRSAQVKRNHTITDWAESELKRVRAAGFSDR
PFSVMRTWADPRMVDPSIEPTKRRPNQCYAGTPVKANRSAHGIAAACTLRGWLGMWSLRV
AQTRAAPHLARITCPALVLNAEADTGIFPSDAQQIYDGLASSDKTQVSIDTDHYFTTPGA
RSEQADTIAKWIAKRWR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGRAATPGVIREFVGLPSRTAGRAAAGGHPCQGLYHHSVGRKPKVALIAAHYQIDFSEHYLAEYMAIRGIGFLGWNTRFRGFESSFLLDHALVDIGVGVRWLREVQGVETVVLLGNSGGGSLMAAYQSQAVDPNVTPLDGMRPAAGVTELPAADAYVAAAAHPGRPDVLTAWMDAAVIDENDPVATDPELDLFDERNGPPYSPEFISRYRSAQVKRNHTITDWAESELKRVRAAGFSDRPFSVMRTWADPRMVDPSIEPTKRRPNQCYAGTPVKANRSAHGIAAACTLRGWLGMWSLRVAQTRAAPHLARITCPALVLNAEADTGIFPSDAQQIYDGLASSDKTQVSIDTDHYFTTPGARSEQADTIAKWIAKRWR
Prediction	CCCCCCCCCCEEEEEHCCCCCCCCCCCCCEEEEEEEEHCCCCCCCEEEEEHCCCCCCCCCHHHHHHHHHCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
Conf.Score	98878898746677756677655567887578899995899999779999958888644669999999899799976777888877666789999999999999868998899997586799999999997678865567777777766787765578875788866888887555554567876667767887888889999999999999999999999999999999999868888875665557887666666688888887545678754467654434444477888877676655545665455678789997578865687999999998588996799986765678886589999999999999859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGRAATPGVIREFVGLPSRTAGRAAAGGHPCQGLYHHSVGRKPKVALIAAHYQIDFSEHYLAEYMAIRGIGFLGWNTRFRGFESSFLLDHALVDIGVGVRWLREVQGVETVVLLGNSGGGSLMAAYQSQAVDPNVTPLDGMRPAAGVTELPAADAYVAAAAHPGRPDVLTAWMDAAVIDENDPVATDPELDLFDERNGPPYSPEFISRYRSAQVKRNHTITDWAESELKRVRAAGFSDRPFSVMRTWADPRMVDPSIEPTKRRPNQCYAGTPVKANRSAHGIAAACTLRGWLGMWSLRVAQTRAAPHLARITCPALVLNAEADTGIFPSDAQQIYDGLASSDKTQVSIDTDHYFTTPGARSEQADTIAKWIAKRWR
Prediction	45446342333333130423334344433230100013153451300000001211110010022014100000000112333522230440040022004103734504100000000000000001211543514414434223444504201000000022321410220022012335424422340221346442513450053036303511520152046305514744444310101001020310111120572423201133133222111110210113110120022203230352044030000000011121031620340063052642322213021102437313400520150046348
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCEEEEEHCCCCCCCCCCCCCEEEEEEEEHCCCCCCCEEEEEHCCCCCCCCCHHHHHHHHHCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
MTGRAATPGVIREFVGLPSRTAGRAAAGGHPCQGLYHHSVGRKPKVALIAAHYQIDFSEHYLAEYMAIRGIGFLGWNTRFRGFESSFLLDHALVDIGVGVRWLREVQGVETVVLLGNSGGGSLMAAYQSQAVDPNVTPLDGMRPAAGVTELPAADAYVAAAAHPGRPDVLTAWMDAAVIDENDPVATDPELDLFDERNGPPYSPEFISRYRSAQVKRNHTITDWAESELKRVRAAGFSDRPFSVMRTWADPRMVDPSIEPTKRRPNQCYAGTPVKANRSAHGIAAACTLRGWLGMWSLRVAQTRAAPHLARITCPALVLNAEADTGIFPSDAQQIYDGLASSDKTQVSIDTDHYFTTPGARSEQADTIAKWIAKRWR

4zwnA

0.13

0.10

0.77

1.34

MUSTER

---SAPYPYKVQ----TTVPELQYENFDGAKFGYMFWPVQNNEVRGRVLLIHGFGEYTKIRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSEKGI-PLFMWGHSMGGGICLNYACQGKHKN-----------------EISGYIGSGPLIILH--------------------------------------------------PHTMYNKPTQIIAPLLAKFSPRV---RIDTGLDLKGI-----TSDKAYRAFLGSDPMSVPLYGSFRQIHDFMQRGAKLYKNENN---YIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGARHLETDKVFNTVFNDMKQWLDKHTT

4zwnA

0.12

0.09

0.77

1.51

dPPAS

---SAPYPYKV----QTTVPELQYENFDGAKFGYMFWPVQNGEVRGRVLLIHGFGEYTKFRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSECKAIPLFMWGHSMGGGICLNYACQGKHK-----------------NEISGYIGSGPLIIHPHTMYNKPTQIIAPLLAKFSPRVRIDTGLDLKGITSDKAYRAFLGSD-----------------------------------------------------------PMSVPLYGSFRQIHDFMQRGAKLYKNENN---YIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGARHLETDKVFNTVFNDMKQWLDKHTT

4zwnA

0.12

0.09

0.76

1.96

wdPPAS

---SAPYPYKVQ----TTVPELQYENFDGAKFGYMFWPVQNGEVRGRVLLIHGFGEYTKIRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSEKGI-PLFMWGHSMGGGICLNYACQGKHK-----------------NEISGYIGSGPLII--------LHPHTM--------------------YNKPTQIIAPLLA-----------------------KFSPRVRIDTGLDLK---------TSDKAYRAFLGSDPMSVPL----YGSFRQIHDFMQRGAKLYKNENYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGARHLETDKVFNTVFNDMKQWLDKHTT

4zwnA

0.12

0.10

0.77

1.52

wMUSTER

---APYPYKV-----QTTVPELQYENFDGAKFGYMFWPVQNNEVRGRVLLIHGFGEYTKIRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSEKGI-PLFMWGHSMGGGICLNYACQGKHK-----------------NEISGYIGSGPLIILHPHTMYNKPTQIIAPL--------LAKFSPRV---------------------------------------------RIDTGLDLKGI-----TSDKAYRAFLGSDPMSVP----LYGSFRQIHDFMQRGAKLYKNENYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGARHLETDKVFNTVFNDMKQWLDKHTT

4zwnA

0.12

0.09

0.77

2.23

wPPAS

--SAPYPYKV-----QTTVPELQYENFDGAKFGYMFWPVQNGEVRGRVLLIHGFGEYTKIRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSECKAKPLFMWGHSMGGGICLNYACQGKHK-----------------NEISGYIGSGPLII--------LHPHTM--------------------YNKPTQIIAPLLA-----------------------KFSPRVRIDTGL--DLKGI-----TSDKAYRAFLGSDPMSVPL----YGSFRQIHDFMQRGAKLYKNENYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGARHLETDKVFNTVFNDMKQWLDKHTT

4zwnA

0.11

0.09

0.77

2.47

dPPAS2

---SAPYPYKV----QTTVPELQYENFDGAKFGYMFWPVQNGEVRGRVLLIHGFGEYTKFRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSEKGIP-LFMWGHSMGGGICLNYACQGKHK-----------------NEISGYIGSGPLIILHPHTMYNK--------------------------------------------------PTQIIAPLLAKFSPRVRIDT--------GLDLKGITSDKAYRAFLGSDPMSVPLYGSFRQIHDFMQRGAKLYKNENN---YIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGARHLETDKVFNTVFNDMKQWLDKHTT

4zwnA

0.12

0.09

0.77

1.93

PPAS

--SAPYPYKV-----QTTVPELQYENFDGAKFGYMFWPVQNGEVRGRVLLIHGFGEYTKFRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSECKAIPLFMWGHSMGGGICLNYACQGKHK-----------------NEISGYIGSGPLII--------------------------------------------------LHPHTMYNKPTQIIAPLLAKFSPRV---RIDTGLDLKGI-----TSDKAYRAFLGSDPMSVPLYGSFRQIHDFMQRGAKLYKNENN---YIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGAFSLETDKVFNTVFNDMKQWLDKHTT

4zwnA

0.13

0.10

0.77

2.44

Env-PPAS

---SAPYPYKVQ----TTVPELQYENFDGAKFGYMFWPVQNNEVRGRVLLIHGFGEYTKFRLMDHLSLNGYESFTFDQRGAGVTSPTDEYHVFNDLEHFVEKNLSECKAIPLFMWGHSMGGGICLNYACQGKHK-----------------NEISGYIGSG---------------------------PLIILH-----------------------PHTMYNKPTQIIAPLLAKFSPRV---RIDTGLDLKGI-----TSDKAYRAFLGSDPMSVPL----YGSFRQIHDFMQRGAKLYKNENYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIRDCPSADKELKLYPGAFSLETDKVFNTVFNDMKQWLDKHTT

2zjfA

0.13

0.11

0.88

1.28

MUSTER

--------------------VHRILNCRGTRIHAVADSPPDQQ-GPLVVLLHGFPESWYRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPD-------------------RCAGVVGISVPF--AGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYQDGIITEIEEDLRGWLLGLTYTVGEGMMAATKAAVSMDPIDVIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQKPLTPPALFIGGQYDVGTIAQAIERAHEVMP-NYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGL-R

2wtnB

0.14

0.09

0.64

1.40

dPPAS

--------------------GAMYIDCDGIKLNAYLDMPKNNPEKPLCIIIHGFTGHSEEAVQETLNEIGVATLRADMYGHGKSDGHTLFKWLTNILAVVDYAKKLDFVTDIYMAGHSQGGLSVMLAAAMERD-------------------IIKALIPLSPAA---------------------------------------------------------------MIPEIARTGELLGL---------------KFDPENIPDELDAWDGRKLK-----------------GNYVRVAQTIRVEDFVDKYTKPVLIVHGDQDEAVPYEASVAFSKQY--KNCKLVTIPGDTHCYDHH-LELVTEAVKEFMLEQIA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.40

Estimated TM-score = 0.54±0.15

Estimated RMSD = 9.9±4.6Å

Download Model 2

C-score=-1.46

Download Model 3

C-score=-3.61

Download Model 4

C-score=-2.24

Download Model 5

C-score=-4.69

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4zwnA	0.733	1.75	0.113	0.772
2	1k8qA	0.641	3.83	0.100	0.769
3	1ivyA	0.633	4.33	0.071	0.788
4	4qlaA	0.633	4.47	0.091	0.798
5	1wpxA	0.632	4.50	0.078	0.790
6	2hdwA	0.627	3.86	0.107	0.756
7	4meaA	0.625	3.97	0.048	0.756
8	1azwA	0.622	4.03	0.103	0.764
9	1qtrA	0.622	4.07	0.137	0.769
10	3kdaA	0.619	3.67	0.071	0.740

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.16	9	1a8uA	BEZ	Rep, Mult	53,54,117,118,119,163,293,326
2	0.05	3	3pe6A	ZYH	Rep, Mult	53,54,56,117,118,119,166,249,251,254,255,265,266,269,289,290,326,354
3	0.05	3	1k8qA	C11	Rep, Mult	53,54,118,119,221,253,326,354
4	0.05	3	1q0rA	AKT	Rep, Mult	118,119,122,161,162,163,174,175,206,295,296,298,300,326
5	0.04	2	3muoA	ZPR	Rep, Mult	50,73,115,117,118,161,365,369
6	0.02	1	2rauA	CA	Rep, Mult	108,110
7	0.02	1	5esrA	MG	Rep, Mult	71,369
8	0.02	1	3jweB	F4P	Rep, Mult	234,244,283,286,287,290
9	0.02	1	4fhvA	MG	Rep, Mult	116,118,155
10	0.02	1	1xrmA	III	Rep, Mult	229,232
11	0.02	1	3fyuC	XYP	Rep, Mult	249,250
12	0.02	1	1tk3B	NAG	Rep, Mult	28,79,95
13	0.02	1	4zxfC	4S7	Rep, Mult	53,54,55,118,119,163,166,223,227,228,249,278,292,293

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.239	2ocgA	0.536	3.63	0.124	0.642	3.1.-.-	114,118,120,125,162,317,324,332
2	0.111	3hjuA	0.624	2.98	0.152	0.708	3.1.1.23	64,118
3	0.108	2r11D	0.576	3.63	0.082	0.682	3.1.1.1	162
4	0.104	1a88B	0.596	3.12	0.135	0.682	1.11.1.10	161
5	0.104	1a8qA	0.599	3.16	0.105	0.684	1.11.1.10	118,324,353
6	0.104	1va4A	0.597	3.09	0.136	0.679	3.1.1.2	118
7	0.098	1j1iA	0.562	2.81	0.138	0.634	3.7.1.8	118
8	0.096	3a2lA	0.589	3.75	0.088	0.716	3.8.1.5	NA
9	0.094	1mt3A	0.603	3.91	0.132	0.722	3.4.11.5	NA
10	0.093	1a7uA	0.590	3.17	0.147	0.676	1.11.1.10	118,324,353
11	0.088	1ehyA	0.576	3.76	0.096	0.687	3.3.2.10	NA
12	0.083	1iunB	0.578	3.31	0.099	0.668	3.7.1.9	NA
13	0.081	2pu5A	0.593	3.11	0.070	0.679	3.7.1.8	368
14	0.067	1auoA	0.451	2.64	0.138	0.496	3.1.1.1	74
15	0.060	3e3aB	0.586	3.03	0.119	0.668	1.11.1.-	NA
16	0.060	2pl5A	0.590	3.77	0.099	0.708	2.3.1.31	NA
17	0.060	1y37A	0.604	3.82	0.123	0.729	3.8.1.3	85
18	0.060	1c4xA	0.589	3.37	0.093	0.687	3.7.1.8	118
19	0.060	1ac5A	0.617	4.95	0.076	0.801	3.4.16.6	118
20	0.060	2og1A	0.594	3.06	0.070	0.679	3.7.1.8	NA
21	0.060	1a8sA	0.592	3.22	0.125	0.679	1.11.1.10	118,324
22	0.060	1ivyA	0.633	4.33	0.071	0.788	3.4.16.5	NA
23	0.060	1vj5A	0.606	3.92	0.116	0.729	3.3.2.10,3.3.2.3	NA
24	0.060	1b6gA	0.589	4.47	0.095	0.753	3.8.1.5	NA
25	0.060	3g0iA	0.615	4.29	0.099	0.761	3.3.2.3	363
26	0.060	3nwoA	0.589	3.85	0.126	0.706	3.4.11.5	118
27	0.060	2qvbB	0.588	3.80	0.107	0.716	3.8.1.5	NA
28	0.060	1azwA	0.622	4.03	0.103	0.764	3.4.11.5	NA
29	0.060	1a88A	0.597	3.09	0.135	0.682	1.11.1.10	118,324
30	0.060	1u2eA	0.597	3.16	0.096	0.684	3.7.1.-	60
31	0.060	2vf2A	0.591	3.44	0.134	0.692	3.7.1.8	82
32	0.060	1zoiA	0.594	3.22	0.128	0.682	3.1.1.-	118,161,324
33	0.060	2cjpA	0.599	4.09	0.126	0.729	3.3.2.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.556	3.06	0.12	0.63	3pf8A	GO:0016787
1	0.21	0.731	1.78	0.11	0.77	4zwnB	GO:0005737 GO:0005739 GO:0005741 GO:0005783 GO:0005811 GO:0006641 GO:0009966 GO:0016020 GO:0016787 GO:0019433 GO:0047372
2	0.18	0.566	3.93	0.10	0.68	4pw0A	GO:0016787
3	0.18	0.600	3.22	0.12	0.69	4dgqA	GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
4	0.17	0.501	2.95	0.13	0.57	1ufoA	GO:0016020 GO:0016021
5	0.16	0.582	3.34	0.12	0.68	4ns4A	GO:0016787 GO:0016788
6	0.16	0.453	3.50	0.13	0.53	3ksrA	GO:0004252 GO:0006508 GO:0008236 GO:0016787
7	0.16	0.565	3.54	0.12	0.67	3qitB	GO:0003824 GO:0008152 GO:0016740 GO:0031177
8	0.15	0.595	3.28	0.15	0.69	1hkhA	GO:0003824 GO:0004601 GO:0098869
9	0.15	0.603	3.91	0.13	0.72	1mt3A	GO:0004177 GO:0006508 GO:0008233 GO:0016787
10	0.12	0.624	2.98	0.15	0.71	3hjuA	GO:0004622 GO:0005654 GO:0005737 GO:0005789 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0006954 GO:0009966 GO:0016020 GO:0016042 GO:0016787 GO:0019369 GO:0019433 GO:0019898 GO:0036155 GO:0042803 GO:0046464 GO:0047372 GO:0050727 GO:0051930 GO:0052689 GO:2000124
11	0.11	0.597	3.09	0.14	0.68	1a88A	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
12	0.11	0.536	3.63	0.12	0.64	2ocgA	GO:0005739 GO:0005741 GO:0006520 GO:0006805 GO:0009636 GO:0016787 GO:0047658 GO:0070062
13	0.10	0.592	3.22	0.12	0.68	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
14	0.10	0.599	3.10	0.13	0.68	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
15	0.10	0.557	3.07	0.12	0.63	2wtmA
16	0.08	0.576	3.26	0.12	0.66	2xmzA	GO:0009234 GO:0016787 GO:0016829 GO:0070205
17	0.08	0.450	2.92	0.14	0.51	4fhzA	GO:0016787
18	0.08	0.632	4.37	0.07	0.79	1cpyA	GO:0000324 GO:0004180 GO:0004185 GO:0005773 GO:0006508 GO:0007039 GO:0008233 GO:0016787 GO:0046938 GO:0051603
19	0.08	0.561	3.63	0.10	0.67	4htaA	GO:0005634 GO:0005737 GO:0005829 GO:0009640 GO:0009704 GO:0016787 GO:0080167
20	0.07	0.641	3.83	0.10	0.77	1k8qA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787 GO:0016788
21	0.07	0.465	2.42	0.13	0.51	3trdA	GO:0016787
22	0.07	0.622	4.07	0.14	0.77	1qtrA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0016787
23	0.07	0.633	4.14	0.11	0.78	1hlgA	GO:0004806 GO:0005576 GO:0005739 GO:0006108 GO:0006629 GO:0006641 GO:0008289 GO:0016042 GO:0016615 GO:0016787 GO:0016788 GO:0055114
24	0.07	0.609	3.87	0.10	0.75	3sk0A	GO:0003824 GO:0009636 GO:0016787 GO:0018786
25	0.07	0.633	4.33	0.07	0.79	1ivyA	GO:0004180 GO:0004185 GO:0004308 GO:0005654 GO:0005764 GO:0005783 GO:0006508 GO:0006687 GO:0006886 GO:0008047 GO:0008233 GO:0016020 GO:0016787 GO:0031647 GO:0043085 GO:0043202 GO:0043231 GO:0051603 GO:0061684 GO:0070062 GO:0098575 GO:1904714
26	0.07	0.615	4.16	0.10	0.75	4ci9A	GO:0004180 GO:0004185 GO:0004308 GO:0005654 GO:0005764 GO:0005783 GO:0006508 GO:0006687 GO:0006886 GO:0008047 GO:0008233 GO:0016020 GO:0016787 GO:0031647 GO:0043085 GO:0043202 GO:0043231 GO:0051603 GO:0061684 GO:0070062 GO:0098575 GO:1904714
27	0.07	0.610	3.67	0.11	0.72	4opmA	GO:0004806 GO:0016787
28	0.07	0.617	4.95	0.08	0.80	1ac5A	GO:0004180 GO:0004185 GO:0005794 GO:0005802 GO:0006508 GO:0006915 GO:0008233 GO:0016020 GO:0016021 GO:0016787 GO:0051603
29	0.07	0.599	3.16	0.10	0.68	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
30	0.07	0.451	2.64	0.14	0.50	1auoA	GO:0016787 GO:0052689
31	0.07	0.597	3.09	0.14	0.68	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
32	0.07	0.455	3.03	0.12	0.52	1fj2A	GO:0002084 GO:0004622 GO:0005737 GO:0005739 GO:0005829 GO:0006629 GO:0006631 GO:0008474 GO:0016298 GO:0016787 GO:0042997 GO:0050999 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0016298	GO:0052689	GO:0004601
GO-Score	0.42	0.42	0.36
Biological Processes	GO:0048583	GO:0007165	GO:0046464	GO:0023051	GO:0010646	GO:1990748
GO-Score	0.42	0.42	0.42	0.42	0.42	0.36
Cellular Component	GO:0043232	GO:0031968	GO:0012505	GO:0031966
GO-Score	0.42	0.42	0.42	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.