I-TASSER results

I-TASSER results for job id Rv0263c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (300 residues)
MTTLEILRSGPLALVEDLGRAGLAHLGVGRSGAADRRSHTLANRLVANPDDWATVEVTFG
GFSARVRGGDVDIAVTGADTDPTVNGIMVGTNSIHHVRDGQVISLGTPRAGLRTYLAVRG
GVCVEPVLGSRSYDVMSAIGPSPLRAGDVLPVGEHTDDYPELDQAPVAAIEEHLVELRVV
PGPRDDWLVDPDALVHTIWMASNRSDRVGMRLQGRPLQHRWPDRQLPGEGVTRGAIQVPP
NGLPVILGPDHPITGSYPVVGVITDEDIDKVAQIRPGQYVRLHWARPRSRLPGQGVTQAW

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTLEILRSGPLALVEDLGRAGLAHLGVGRSGAADRRSHTLANRLVANPDDWATVEVTFGGFSARVRGGDVDIAVTGADTDPTVNGIMVGTNSIHHVRDGQVISLGTPRAGLRTYLAVRGGVCVEPVLGSRSYDVMSAIGPSPLRAGDVLPVGEHTDDYPELDQAPVAAIEEHLVELRVVPGPRDDWLVDPDALVHTIWMASNRSDRVGMRLQGRPLQHRWPDRQLPGEGVTRGAIQVPPNGLPVILGPDHPITGSYPVVGVITDEDIDKVAQIRPGQYVRLHWARPRSRLPGQGVTQAW
Prediction	CCEEEEHCCCCCHHHHHCCCCCHHHHCCCCCCCHCHHHHHHHHHHHCCCCCCCEEEEHCCCCEEEEHCCCEEEEEHCCCCEEEHCCEEHCCCEEEHCCCCEEEEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCHHHHHHCCEEEHCCCCEEEEEEHCCCCCCCCCCCCCCCCCEHCCEEHCCCCCCEEEHCCCCCCCCCCCEEEEEEEHHHHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHHC
Conf.Score	986999657774455657875546658988885659999999999889999868999858868999759989999599856788999867987998589989998567999589998579988874569855555578898778998799967888877666666677888997589998588876689588876498899588984899986898765678988877765566577689996799879988889997678997366678766899967999986999999999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTLEILRSGPLALVEDLGRAGLAHLGVGRSGAADRRSHTLANRLVANPDDWATVEVTFGGFSARVRGGDVDIAVTGADTDPTVNGIMVGTNSIHHVRDGQVISLGTPRAGLRTYLAVRGGVCVEPVLGSRSYDVMSAIGPSPLRAGDVLPVGEHTDDYPELDQAPVAAIEEHLVELRVVPGPRDDWLVDPDALVHTIWMASNRSDRVGMRLQGRPLQHRWPDRQLPGEGVTRGAIQVPPNGLPVILGPDHPITGSYPVVGVITDEDIDKVAQIRPGQYVRLHWARPRSRLPGQGVTQAW
Prediction	552040341222000002104112430012001003200310010040365100000011303020453301000001403031443302222303044413040330430000000031305024101010112234243230342020202423443452442332224753010000101223202554302434040245011100104154152336735020210010000024622000001201131210100000411032000132534020430326303513543666
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEHCCCCCHHHHHCCCCCHHHHCCCCCCCHCHHHHHHHHHHHCCCCCCCEEEEHCCCCEEEEHCCCEEEEEHCCCCEEEHCCEEHCCCEEEHCCCCEEEEEHCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCHHHHHHCCEEEHCCCCEEEEEEHCCCCCCCCCCCCCCCCCEHCCEEHCCCCCCEEEHCCCCCCCCCCCEEEEEEEHHHHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHHC
MTTLEILRSGPLALVEDLGRAGLAHLGVGRSGAADRRSHTLANRLVANPDDWATVEVTFGGFSARVRGGDVDIAVTGADTDPTVNGIMVGTNSIHHVRDGQVISLGTPRAGLRTYLAVRGGVCVEPVLGSRSYDVMSAIGPSPLRAGDVLPVGEHTDDYPELDQAPVAAIEEHLVELRVVPGPRDDWLVDPDALVHTIWMASNRSDRVGMRLQGRPLQHRWPDRQLPGEGVTRGAIQVPPNGLPVILGPDHPITGSYPVVGVITDEDIDKVAQIRPGQYVRLHWARPRSRLPGQGVTQAW

3mmlA

0.80

0.76

0.95

4.03

MUSTER

GTTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAEDVVELQVVPGPRDDWFVDPDILVRTNWLVTNRSDRVGRLVGP--LEYRNPDRQLPSEGATRGAIQVPPNGFPVILGPDHPVTGGYPVIGVVTEEDIDKLGQVRPGQTVRLHWAYPRR-----------

3mmlA

0.79

0.75

0.95

9.23

dPPAS

GTTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAEDVVELQVVPGPRDDWFVDPDILVRTNWLVTNRSDRVGRLVGPL--EYRNPDRQLPSEGATRGAIQVPPNGFPVILGPDHPVTGGYPVIGVVTEEDIDKLGQVRPGQTVRLHWAYPRR-----------

3mmlA

0.79

0.75

0.95

7.59

wdPPAS

GTTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAEDVVELQVVPGPRDDWFVDPDILVRTNWLVTNRSDRVGRLVGPL--EYRNPDRQLPSEGATRGAIQVPPNGFPVILGPDHPVTGGYPVIGVVTEEDIDKLGQVRPGQTVRLHWAYPRR-----------

3mmlA

0.80

0.75

0.95

4.50

wMUSTER

-TTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAEDVVELQVVPGPRDDWFVDPDILVRTNWLVTNRSDRVGRLVGPL--EYRNPDRQLPSEGATRGAIQVPPNGFPVILGPDHPVTGGYPVIGVVTEEDIDKLGQVRPGQTVRLHWAYPRR-----------

2q8uA

0.14

0.11

0.80

0.59

wPPAS

LKELKIL-----TS--DWGVTSW---TSSRPVDRREELKKALDKVV-----EEAEK----------REVD-LILLTG-DL---LHSRNNPSVVALH----DLLDY-LKRRTAP-VVVLPGLKLFGNFVTSISSDIT--VSFEPVKRGQKVRILP-------------FPYPKNEGDFRFFLESRLNKLY--EEALKKEDFAI----FGHFTVEGLA-REIIINRALIPSVAALGHIEIQKQGSLIRIFGEEADEKGA-VFVELKRGEPPRY-DASP-KTLYYKKIDTSALKSIRDFCRNF

3mmlA

0.79

0.75

0.95

13.72

dPPAS2

GTTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAEDVVELQVVPGPRDDWFVDPDILVRTNWLVTNRSDRVGRLVGPL--EYRNPDRQLPSEGATRGAIQVPPNGFPVILGPDHPVTGGYPVIGVVTEEDIDKLGQVRPGQTVRLHWAYPRR-----------

3mmlA

0.79

0.75

0.95

5.89

PPAS

GTTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAEDVVELQVVPGPRDDWFVDPDILVRTNWLVTNRSDRVGRLVGPLE--YRNPDRQLPSEGATRGAIQVPPNGFPVILGPDHPVTGGYPVIGVVTEEDIDKLGQVRPGQTVRLHWAYPRR-----------

2p0oA2

0.12

0.05

0.42

0.80

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------SERTAQFGYYHQTNQFLLEVA-----PSESRYLKRILGTHTNRLDAARDVLRSELATIESEQTEA------RPVGTVTIDNEGEIQVTLVDLPKDEKVNTITRIIDKDQTILPLIKAGNQFTLVTEG--TIENEFRKLNN-

3mmlA1

0.85

0.48

0.57

2.19

MUSTER

GTTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAE--------------------------------------------------------------------------------------------------------------------------------

3mmlA1

0.85

0.48

0.57

5.45

dPPAS

GTTLEVLRTGPLALVEDLGRPGLAH-GVTRSGAADRRSHTLANRLVANPGESATIEVTFGGFSARVCGGDVAIAVTGADTDPAVNGIPFGTNSIHHVHDGQVISLGAPHSGLRSYLAVRGGIDVTPVLGSRSYDV-SAIGPSPLRPGDVLPVGEHTDEFPELDQAPVAAIAE--------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.18

Estimated TM-score = 0.74±0.11

Estimated RMSD = 5.8±3.6Å

Download Model 2

C-score=-0.46

Download Model 3

C-score=-0.15

Download Model 4

C-score=-2.66

Download Model 5

C-score=-2.05

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3va7A	0.874	2.48	0.272	0.980
2	3mmlA	0.869	2.13	0.800	0.950
3	5dudA	0.856	2.34	0.335	0.947
4	3oepA	0.825	2.33	0.310	0.913
5	3ir7A	0.428	6.33	0.052	0.717
6	1is2A	0.423	6.19	0.045	0.693
7	5k3jA	0.421	6.27	0.031	0.703
8	4iibA	0.407	6.01	0.026	0.660
9	3zyzA	0.404	5.95	0.038	0.647
10	2z1qB	0.402	6.08	0.041	0.647

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	3	1ezmA	ZN	Rep, Mult	35,39,56
2	0.08	3	3owaA	FAD	Rep, Mult	42,45,46,53,56,114,115
3	0.05	2	2axtA	UNK	Rep, Mult	45,46
4	0.05	2	3n87G	N87	Rep, Mult	269,272,273
5	0.04	1	3va7A	BTI	Rep, Mult	231,237,239,245,252,255,256,257
6	0.03	1	3ir5A	SF4	Rep, Mult	21,23,27,29,30,31,135
7	0.03	1	3azeD	MN	Rep, Mult	273,274
8	0.03	1	1wd4A	AHR	Rep, Mult	238,239,241,242
9	0.03	1	1i5aA	MN	Rep, Mult	39,43
10	0.03	1	1u8vC	FAD	Rep, Mult	56,118,120
11	0.03	1	2z1qB	FAD	Rep, Mult	206,210,246,272,273,274
12	0.03	1	4qcvX	MG	Rep, Mult	14,57,113
13	0.03	1	3qq7A	CO	Rep, Mult	176,283

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1u8vA	0.402	5.82	0.046	0.640	5.3.3.3	39
2	0.060	1is2A	0.423	6.19	0.045	0.693	1.3.3.6	NA
3	0.060	1aomB	0.381	6.14	0.097	0.627	1.7.99.1,1.7.2.1	95
4	0.060	2r0nA	0.380	6.05	0.037	0.617	1.3.99.7	58
5	0.060	1ivhA	0.386	6.16	0.030	0.630	1.3.99.10	169
6	0.060	2z1qB	0.402	6.08	0.041	0.647	1.3.99.3	209
7	0.060	1bucA	0.379	6.01	0.033	0.610	1.3.99.2	NA
8	0.060	1vcnA	0.377	6.16	0.085	0.617	6.3.4.2	NA
9	0.060	1udyA	0.385	6.03	0.025	0.623	1.3.99.3	NA
10	0.060	1ahpA	0.380	6.34	0.036	0.647	2.4.1.1	NA
11	0.060	2jifA	0.381	6.08	0.032	0.617	1.3.99.-	NA
12	0.060	1siqA	0.378	6.25	0.033	0.623	1.3.99.7	NA
13	0.060	1qksB	0.381	6.15	0.097	0.627	1.7.2.1	106
14	0.060	2yyjA	0.400	6.08	0.058	0.643	1.14.13.3	43
15	0.060	1vcmA	0.383	6.03	0.076	0.617	6.3.4.2	NA
16	0.060	2qllA	0.363	7.00	0.038	0.670	2.4.1.1	NA
17	0.060	3gpbA	0.362	6.88	0.054	0.647	2.4.1.1	NA
18	0.060	1rx0A	0.378	6.03	0.049	0.600	1.3.99.-	19
19	0.060	1q16A	0.428	6.37	0.055	0.720	1.7.99.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.79	0.879	2.16	0.80	0.96	3mmlE	GO:0004039 GO:0016787 GO:0016829
1	0.43	0.827	2.28	0.31	0.91	3opfB
2	0.20	0.874	2.48	0.27	0.98	3va7A	GO:0000166 GO:0003824 GO:0004039 GO:0004075 GO:0004847 GO:0005524 GO:0005737 GO:0016874 GO:0043419 GO:0046872
3	0.06	0.346	6.96	0.07	0.64	1bxrA	GO:0000050 GO:0000166 GO:0003824 GO:0004087 GO:0004088 GO:0005524 GO:0005829 GO:0005951 GO:0006221 GO:0006526 GO:0006807 GO:0008652 GO:0016597 GO:0016874 GO:0019856 GO:0044205 GO:0046872
4	0.06	0.272	7.25	0.06	0.51	4rcnB	GO:0003824 GO:0004075 GO:0005524 GO:0016874 GO:0046872
5	0.06	0.314	6.93	0.05	0.58	2qf7B	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
6	0.06	0.260	7.03	0.04	0.49	3u9sA	GO:0003824 GO:0004075 GO:0004485 GO:0005524 GO:0008300 GO:0046872 GO:1905202
7	0.06	0.312	6.85	0.01	0.57	4qshC	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
8	0.06	0.313	6.97	0.03	0.58	3n6rA	GO:0003824 GO:0004075 GO:0004658 GO:0005524 GO:0016874 GO:0019541 GO:0046872
9	0.06	0.274	6.81	0.02	0.49	2vpqB	GO:0003824 GO:0004075 GO:0005524 GO:0016874 GO:0046872
10	0.06	0.302	6.54	0.05	0.52	3n6rG	GO:0003824 GO:0004075 GO:0004658 GO:0005524 GO:0016874 GO:0019541 GO:0046872
11	0.06	0.272	6.73	0.04	0.49	4rcnA	GO:0003824 GO:0004075 GO:0005524 GO:0016874 GO:0046872
12	0.06	0.287	7.36	0.03	0.56	3u9sI	GO:0003824 GO:0004075 GO:0004485 GO:0005524 GO:0008300 GO:0046872 GO:1905202
13	0.06	0.273	7.04	0.03	0.52	3tw6B	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
14	0.06	0.328	3.19	0.09	0.39	2phcB
15	0.06	0.257	6.82	0.03	0.46	4qslG	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
16	0.06	0.312	7.03	0.05	0.57	2qf7A	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
17	0.06	0.277	6.81	0.04	0.50	1dv2A	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0005737 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0016874 GO:0045717 GO:0046872 GO:2001295
18	0.06	0.302	7.06	0.03	0.57	3floA	GO:0003677 GO:0003887 GO:0005634 GO:0005635 GO:0005658 GO:0006260 GO:0006270 GO:0006273 GO:0016233 GO:0046982 GO:0071897

Consensus prediction of GO terms

Molecular Function	GO:0004039	GO:0016829	GO:0032559	GO:0032550	GO:0035639	GO:0043169	GO:0016879
GO-Score	0.83	0.79	0.59	0.59	0.59	0.59	0.50
Biological Processes	GO:0019627	GO:0043605	GO:0044282	GO:1901565
GO-Score	0.39	0.39	0.39	0.39
Cellular Component	GO:0044424
GO-Score	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.