I-TASSER results

I-TASSER results for job id Rv0227c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (421 residues)
MLRFAACGAIGLGAALLIAALLLSTYTTSRIAEIPLDIDATLISDGTGTALDSASLATEH
IVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKDSGLLLAIVDTVTLNRKTA
MAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFPFHTEKKTYPYFDPIAQKAFD
ANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSLYAGDEDGKVTTSAAMWGLPGDP
NEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYFARDPLKPEVTFADYQVTSTEETVE
SQVNAARDERDRLALWSRVLPITFTAAGLVALVGGGLFASFSLRTEGALMAASGDRDDHD
YRRGGFEEPVPGAEAETEKLPTQRPDFPREPSGSDPPRLGSAQPPPPPDAGHPDPGPPER
R

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLRFAACGAIGLGAALLIAALLLSTYTTSRIAEIPLDIDATLISDGTGTALDSASLATEHIVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKDSGLLLAIVDTVTLNRKTAMAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFPFHTEKKTYPYFDPIAQKAFDANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSLYAGDEDGKVTTSAAMWGLPGDPNEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYFARDPLKPEVTFADYQVTSTEETVESQVNAARDERDRLALWSRVLPITFTAAGLVALVGGGLFASFSLRTEGALMAASGDRDDHDYRRGGFEEPVPGAEAETEKLPTQRPDFPREPSGSDPPRLGSAQPPPPPDAGHPDPGPPERR
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHCCCCCEHCCCCCCCCCCEEHCCEEEEEEEEEEEEHCCCCCEEEEEEEEEEEHCCCCCCCCCEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHCCEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEHCCCCEEHCEEEEEEEEEHCCCCCCEEEEEEEEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9757999999999999999999999866765557898865788769985665555677875776555589999999985788988999985788865788887646778899999778888778887766655666667888888777765577799779998887666654545865657888777889989999999978766654567665555556777776556644448888888867899999888999997789957755786789986689987578999998789999999999999865666789999999999999999999999986556777777788888888888888888888888888888998888889999999998888888999999999999998889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLRFAACGAIGLGAALLIAALLLSTYTTSRIAEIPLDIDATLISDGTGTALDSASLATEHIVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKDSGLLLAIVDTVTLNRKTAMAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFPFHTEKKTYPYFDPIAQKAFDANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSLYAGDEDGKVTTSAAMWGLPGDPNEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYFARDPLKPEVTFADYQVTSTEETVESQVNAARDERDRLALWSRVLPITFTAAGLVALVGGGLFASFSLRTEGALMAASGDRDDHDYRRGGFEEPVPGAEAETEKLPTQRPDFPREPSGSDPPRLGSAQPPPPPDAGHPDPGPPERR
Prediction	7323000100020121212022021001430340214132121223511312324043752332461403343434235345533020201210332346444420311332000103113114343343443444342457424454514241110101241655613010110234130514446515525002020415426245224434244344444444242313214144555451303210304010100030030033434243203447354413103040413561054015304534420100011113112111210111012100112245543454645464453664456453454635266214751624676444554555546452448644644543758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHCCCCCEHCCCCCCCCCCEEHCCEEEEEEEEEEEEHCCCCCEEEEEEEEEEEHCCCCCCCCCEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHCCEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEHCCCCEEHCEEEEEEEEEHCCCCCCEEEEEEEEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MLRFAACGAIGLGAALLIAALLLSTYTTSRIAEIPLDIDATLISDGTGTALDSASLATEHIVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKDSGLLLAIVDTVTLNRKTAMAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFPFHTEKKTYPYFDPIAQKAFDANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSLYAGDEDGKVTTSAAMWGLPGDPNEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYFARDPLKPEVTFADYQVTSTEETVESQVNAARDERDRLALWSRVLPITFTAAGLVALVGGGLFASFSLRTEGALMAASGDRDDHDYRRGGFEEPVPGAEAETEKLPTQRPDFPREPSGSDPPRLGSAQPPPPPDAGHPDPGPPERR

4jrfA

0.11

0.10

0.94

0.79

MUSTER

DGREAYSVSVAHGT--------------QNVKEV-----LLALFDASDVCLETKTLATTDYILNVGGANKAGYDGKAFKPSATAKVLAVVSDKFKTACVASASGAVEQTLDEVTGTSKNNFINAGDNANGALVTANVKVVDGTTIPDVATAISEAQADRSIYVDNPD----GLKVPAGVTCTFGDWALNITNKSFPY-SEIVPAGGSTGADYRIDPNYELAGFDVSQFNYLKVADDGTLPADFSAADSKYCLENTAADAQTQAQTTSAVASAVYTPGSFTVGESWFRLLGVTYKTLADLQVVYNAAKAAGTADAAQTQVITLCDQFYARIAKAATAQGKAVGADFASITITELDDLKSGGEYSKPDAAAGETVGVEY-NILIHHDDAITATAHGKYG-KQPGTPWLPDTTNPTDPKDPGED

5gaoE

0.11

0.09

0.77

1.11

dPPAS

---AAAAAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKK

5lgdA

0.11

0.08

0.69

1.29

wdPPAS

-QKTIKKQVV---------TIAFKNWVKT-----GTEVYRQFWI-----VQNPQEVNSSNIQVKQRGPYTYRVKENVTQDAEDNTVSFLQPNGAIFEGTEADNGLFNTADGVYKVF--NGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASF--PFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCFCTEKIISKNYISLPHFLYASPDVSEPIDGLNPNEEEHRYLDIEPITGFTLQKRLQVNLLVKPSEKIQVLRNYIVPILWLNETGTIGDEKANMFRSQV------------------------------------------------------------------------------------------------------------

4f7bA

0.14

0.09

0.68

0.75

wMUSTER

----------------IEKKIVLEAFDS---EKPPLPVYTQFYF-----VTNPEEIRGETPRVEEVGPYTYRELRNKANIQNGTTISAVSNKAYVFSVGDPKIDLIRTLFVTHTVD-YFGLFYEKNGTNDGDYVFLTGEDSITDKCNMINGTDGDSFH-PLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTS-DNAGFCIPEGNCLGSGVLNVSICKNGAPYQADERFAIEGMHPNQ-FVDINPLTGIILKKRFQINIYVKKLDDFVDIRTMVFPVMYLNESVHIDKETASRLKSMI------------------------------------------------------------------------------------------------------------

5lgdA

0.14

0.10

0.67

1.25

wPPAS

VKQ--------RG----------PYYRVRFLAKVTQDAEDNTVS-----IFEPLSVGTEADNFTVNLAVAAASHIYINKSKSSMFQVRTLRELL-YRDYPVTTGLFNTADGVYKVF--NGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASF--PFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDTEKIISKNCTSYGVLDISKCKEGRPASPDEPIDLNPNEEEHRYLDIEPITGFTLQKRLQVNLLVKPSEKIQVLK-YIVPILWLNETGTIGDEKANMFRSQV------------------------------------------------------------------------------------------------------------

5gaoE

0.11

0.09

0.77

2.13

dPPAS2

---AAAAAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKK

5gaoE

0.12

0.09

0.75

1.33

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------------AAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAA-----------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAAA---------------AAAAA---------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKK

2b5uA

0.13

0.96

0.99

Env-PPAS

SAGALSAAIADIMAALKLWGVALYGVLPSQIAKDPNMMSKIVTSLPADDITESPVSSLPLDK--ATVNVNVRVVDDVKDERQNISVVSGVPMSCPVVDAKPTERP---GVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPA---G----FTQGGNTRDAVIRFPK-DSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVY-NSRKSELDAANKTLADAIAEIKQFFAHDPMAGGHRM----WQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSSAMESRKKKEDKKREKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKSQHGELEGYRASDGQHLDPKTGNQLKGPDPKRN

2x9wA

0.11

0.10

0.90

0.78

MUSTER

TPRVDK------TPVNHQVGDVVEYEIV---TKIPALANANWSDRTEGLAFNKGTLEAGDYALTEVFDLKLTDAGLAKVNDQNAEKTVKITYSATLNDKAIVEVPESNDVTFNYGNNPDHGNTPKPNKPNENGDLTLTKTWVDATGAPIPAGAEATFD-----------LVNAQAGKVVQTVTLNTVTVNGLDEYKFVER---------SIKGYSADYQEITTAGEIAVKNWKDENP-KPLDPTEPKVVTYGKKFVKVN-DKDNRL---AGAEFVIANADNAGQYLARKAD-KVSQEEKQLVVTTKDALDRAVAAYNALTAQQQTQQEKEKVDKAQAAYNAAVIAANNAFEWVADKDNENVVKLVSDAQLAGT--EETKQPAG--ALLTSR-TATSYSATGQGIEYTAGSGKDDATKVVNK

4jrfA

0.09

0.08

0.91

dPPAS

---------------------------------DGREAYSVSVAPKSGEHHGTADEQNVKEVLLALFDASDVCLETKTLATTDYILNVGGANKAGYDGKAFKVPACVASASWSAINGAVEQTLDEVTGTSKNNFINAGDNANPTNGALVTANVKVVDGTTIPDVATNPDGLKVPAGVTCTFGDWALNITNKSFPYSEIVPAGGSTGADYRIDPNYELAGFDVSQFNYLKVADDGTLPADFSAADSKYCLENTAADAQTQAQT----TSAVASAVYTPGSFTVGESWFRLLGVTYKTLADLQVVYNAAKAAGTADAAQTQVITLCDQFYARIAKAATAQGKAVGADFASITITELDDLKSGGEYSKPDAAAGETVGVEYNILIHHDDAITATAHGKYGVKQPGTPWLPDTTNPTDPKDPGED

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.53

Estimated TM-score = 0.42±0.14

Estimated RMSD = 13.1±4.2Å

Download Model 2

C-score=-2.56

Download Model 3

C-score=-3.29

Download Model 4

C-score=-3.42

Download Model 5

C-score=-3.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4jrfA	0.607	5.45	0.068	0.822
2	3btaA	0.375	6.69	0.035	0.596
3	4q2cA	0.374	7.53	0.050	0.658
4	1yq2A	0.372	6.89	0.050	0.603
5	4p9sA	0.368	6.70	0.066	0.591
6	1bxrA	0.364	7.19	0.049	0.611
7	1d0nA	0.363	7.24	0.037	0.611
8	2zwaB	0.363	7.03	0.051	0.603
9	2rdyA	0.362	6.71	0.041	0.580
10	1f31A	0.361	6.87	0.022	0.580

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1a9x1	III	Rep, Mult	299,300,303,304,320,321
2	0.04	2	3prqX	CLA	Rep, Mult	322,329
3	0.04	2	1aiyB	III	Rep, Mult	329,330
4	0.04	2	5d91A	8K6	Rep, Mult	316,324
5	0.04	2	1bpyA	MG	Rep, Mult	37,39
6	0.02	1	5klgA	6UC	Rep, Mult	330,333
7	0.02	1	1kf6O	CE1	Rep, Mult	21,26
8	0.02	1	1m56D	PEH	Rep, Mult	9,16
9	0.02	1	1wavL	III	Rep, Mult	161,163
10	0.02	1	1kj1D	MAN	Rep, Mult	163,165
11	0.02	1	2w95A	NGA	Rep, Mult	172,195
12	0.02	1	1jdbE	GLN	Rep, Mult	304,305,308,316,317
13	0.02	1	2ivzA	CA	Rep, Mult	188,189
14	0.02	1	1bpyA	MG	Rep, Mult	37,39,111
15	0.02	1	2r9rB	PGW	Rep, Mult	333,337
16	0.02	1	1eakC	III	Rep, Mult	151,154,156
17	0.02	1	1ucnB	CA	Rep, Mult	335,338
18	0.02	1	1mz9E	VDY	Rep, Mult	323,327,330
19	0.02	1	4ryoA	MPG	Rep, Mult	299,315,322

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1k1xA	0.340	7.53	0.068	0.601	2.4.1.25	NA
2	0.060	1yq2A	0.372	6.89	0.050	0.603	3.2.1.23	NA
3	0.060	2ow6A	0.353	7.34	0.053	0.601	3.2.1.114	NA
4	0.060	1kitA	0.344	7.02	0.041	0.575	3.2.1.18	NA
5	0.060	2rioA	0.325	6.94	0.056	0.537	2.7.11.1	291
6	0.060	3fbvD	0.340	7.03	0.049	0.568	2.7.11.1,	291
7	0.060	1bglA	0.365	7.12	0.034	0.606	3.2.1.23	NA
8	0.060	2q1fA	0.354	7.24	0.036	0.606	4.2.2.21	NA
9	0.060	1hn0A	0.339	7.31	0.043	0.577	4.2.2.20	NA
10	0.060	1gytJ	0.343	7.50	0.045	0.606	3.4.11.1	NA
11	0.060	1bxrA	0.364	7.19	0.049	0.611	6.3.5.5	30
12	0.060	1h16A	0.360	7.25	0.045	0.611	2.3.1.54	NA
13	0.060	1llwA	0.345	7.45	0.049	0.606	1.4.7.1	NA
14	0.060	2c4mC	0.353	6.89	0.056	0.584	2.4.1.1	264
15	0.060	3btaA	0.375	6.69	0.035	0.596	3.4.24.69	NA
16	0.060	2azdB	0.348	7.55	0.031	0.608	2.4.1.1	195,263
17	0.060	1e1yA	0.357	7.41	0.034	0.618	2.4.1.1	NA
18	0.060	3gtgB	0.344	7.37	0.049	0.589	2.7.7.6	163
19	0.060	1kblA	0.311	7.47	0.039	0.534	2.7.9.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.616	5.55	0.06	0.84	4jrfA	GO:0046872
1	0.06	0.345	7.44	0.05	0.60	5bqnA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
2	0.06	0.353	6.71	0.02	0.56	3v0aB	GO:0004222 GO:0005576 GO:0006508 GO:0009405 GO:0050827 GO:0051609
3	0.06	0.353	6.51	0.07	0.55	4q98A	GO:0005198 GO:0007155 GO:0009289 GO:0009405
4	0.06	0.335	7.31	0.03	0.57	2np0A	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
5	0.06	0.378	6.67	0.04	0.60	3v0aA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
6	0.06	0.355	7.44	0.05	0.61	3ffzA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
7	0.06	0.351	6.68	0.02	0.56	3vuoA	GO:0004222 GO:0005576 GO:0006508 GO:0009405 GO:0050827 GO:0051609
8	0.06	0.267	7.63	0.05	0.48	3obrA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
9	0.06	0.271	7.71	0.04	0.48	2vxrA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016787 GO:0046872 GO:0050827 GO:0051609 GO:0071806
10	0.06	0.244	6.98	0.03	0.40	1a8dA	GO:0004222 GO:0005576 GO:0005829 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016787 GO:0030666 GO:0030669 GO:0046872 GO:0046929 GO:0050827 GO:0051609 GO:0071806
11	0.06	0.269	7.62	0.02	0.48	3rsjA	GO:0004222 GO:0005576 GO:0006508 GO:0008270 GO:0009405 GO:0050827 GO:0051609
12	0.06	0.262	8.16	0.05	0.50	3r4sA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033619 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0045955 GO:0046872 GO:0050827 GO:0051609
13	0.06	0.263	8.06	0.03	0.49	3azvA	GO:0004222 GO:0005576 GO:0006508 GO:0008270 GO:0009405 GO:0050827 GO:0051609
14	0.06	0.227	6.97	0.04	0.37	4oe8A	GO:0001916 GO:0002230 GO:0002323 GO:0002827 GO:0002860 GO:0002862 GO:0004896 GO:0005125 GO:0005126 GO:0005143 GO:0005576 GO:0005615 GO:0005737 GO:0007050 GO:0007166 GO:0008083 GO:0010033 GO:0010224 GO:0010535 GO:0016020 GO:0016477 GO:0019221 GO:0019233 GO:0019953 GO:0030101 GO:0032693 GO:0032700 GO:0032725 GO:0032729 GO:0032733 GO:0032735 GO:0032740 GO:0032760 GO:0032816 GO:0032819 GO:0032946 GO:0034105 GO:0034393 GO:0042035 GO:0042088 GO:0042093 GO:0042095 GO:0042102 GO:0042104 GO:0042164 GO:0042346 GO:0042510 GO:0042517 GO:0042520 GO:0042523 GO:0042802 GO:0042803 GO:0042832 GO:0043382 GO:0043514 GO:0044130 GO:0045078 GO:0045519 GO:0045672 GO:0045785 GO:0046982 GO:0048662 GO:0050671 GO:0050729 GO:0050829 GO:0051135 GO:0051142 GO:0051607 GO:0070743 GO:0071222 GO:0071346 GO:2000318 GO:2000330
15	0.06	0.238	7.66	0.03	0.42	3mppG	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016787 GO:0046872 GO:0050827 GO:0051609 GO:0071806
16	0.06	0.237	7.31	0.02	0.41	1z7hA	GO:0004222 GO:0005576 GO:0005829 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016787 GO:0030666 GO:0030669 GO:0046872 GO:0046929 GO:0050827 GO:0051609 GO:0071806
17	0.06	0.212	7.07	0.03	0.36	3debA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033619 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0045955 GO:0046872 GO:0050827 GO:0051609
18	0.06	0.238	7.00	0.02	0.39	3fieA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0004175	GO:0005102	GO:0008237
GO-Score	0.37	0.36	0.36	0.36
Biological Processes	GO:0051704	GO:0019538	GO:0051581
GO-Score	0.46	0.36	0.36
Cellular Component	GO:0005576	GO:0044231	GO:0044164	GO:0044156	GO:0016021	GO:0009289
GO-Score	0.18	0.12	0.12	0.12	0.12	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.