I-TASSER results

I-TASSER results for job id Rv0218

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (442 residues)
MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFGLVLLVALP
FVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLGLVIIPV
VLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYT
GHYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPG
EATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGRVVSPGDFPVNKTAAAA
GITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQRTARLPLACVEGWSAVRTWSGVPLAE
LALLAGVPAARSARVTSLQRGGAFGEAKLAANQIADPDALLALRVDGADLSLDHGYPARI
IVPALPGVHNTKWVAGIEFHKR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQRTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAARSARVTSLQRGGAFGEAKLAANQIADPDALLALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR
Prediction	CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCEEEEHCHHHHHHCCCEEEEEEEEEHCCCEEEEEEEEEEHHHHHHHHCCCCCCEEEEEEEHCCCCCCCCCCCHHHHHCCCEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCEEEEEEEEEEEHC
Conf.Score	9988888888888888865554445689988888656788778746788999999999999999999999997887667788777765667778899985677644578999999999999999988767877578887788889999999999999999999998877654578745689999999999999999998755556555455544445666666677777777777889877788899999999999999887666654577667665678888788988887777666778887788888599999655679858999985887699999887489678999886778999999799999859999997699887777788997599869999768956896679758999588665544568899999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQRTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAARSARVTSLQRGGAFGEAKLAANQIADPDALLALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR
Prediction	7645453464653231133014104632343243373042302101000000110120111000000000001105234333332210312213103200000100000000000000111200010001201523314301300000000102222320200000001211101000002031201001021100000200201210232222422433244444424445423414376231200100000000000000111142043235524332255431334311123222224103423165020203134442300152037034322302031024311203011010130064051654220000000021121001020320034000000001343024610000000002210000001023030358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCEEEEHCHHHHHHCCCEEEEEEEEEHCCCEEEEEEEEEEHHHHHHHHCCCCCCEEEEEEEHCCCCCCCCCCCHHHHHCCCEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCEEEEEEEEEEEHC
MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQRTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAARSARVTSLQRGGAFGEAKLAANQIADPDALLALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR

1xdqC

0.23

0.09

0.41

1.19

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KALEFSKPAAWQNNLPLTPADKVSGYNNFYEFGLDKADANAGSLKTDPWTLKISGEVAPLTLDHDDLTRRPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNKYVAFETIYAPEYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRE

1soxA

0.22

0.14

0.62

0.95

MUSTER

--------------------------------------------------------------------------------------------------------------------------------------SYPEYTREEVGPEERVWVTHGTDVFD-VTDFVE---LHPGGPDKILLA--GG-ALEPFWALYAVHGEPHVLELLQQYKVGELSPDEAPAPDAQDPFAGDPPRHPG-----------------------LRVNSQKPFNAEPPAELLAERFLTPNELFFTRNHLP----VPAVEPSSYRLRVDGPGGTLSLSLAELRSRPKHEVTATLQCAIGAISTARWGGARLRDVLLHAGFPEELHVCFEGLDADGAPYGASIPYGRALSPDVLLAYEMNGTELPRDHGFPVRVVVPGVVGARSVKWLRRVAVSPD

1xdqC

0.23

0.09

0.39

3.12

wdPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KALEFSKPAAWQNNLPLTPYNNFYELDKADPAANAGSLKTDPWTLKISGEVKPLTLDHDDLTRRPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAYVAFETIYAPKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRE

1soxA

0.22

0.14

0.61

1.23

wMUSTER

------------------------------------------------------------------------SYPEVGRHRSPEERV-------WVTHGTDVFDVT------------------------DFVELHPPDK------------ILLAA------G-----------------------ALEPFWALYAVHGEPHVLELLQQYKVGELSPDEAPAPDAQDPFAGDPPRHPG-----------------------LRVNSQKPFNAEPPAELLAERFLTPNELFFTRN----HLPVPAVEPSSYRLRVDGPGGTLSLSLAELRS-PKHEVTATLQCAIGAISTARWGGARLRDVLLHAGFPEELHVCFEGLDAGGAPYGASIPYGRALSPDVLLAYEMNGTELPRDHGFPVRVVVPGVVGARSVKWLRRVAVSPD

1xdqC

0.24

0.10

0.40

2.63

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KALPAAWQNNLPLTPADKVSGYNNFYEFGLADPAANAGSLKTDPWTLKISGEVKPLTLDHDDLTRRPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAYVAFETIYAPKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRE

1xdqC

0.24

0.10

0.40

3.75

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KALEFSKQNNLPLTPADKVSGYNNFYEFGLDKADANAGSLKTDPWTLKISGEVAPLTLDHDDLTRRPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNKYVAFETIYAPEYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRE

1xdqC

0.23

0.09

0.40

1.80

PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KALEAAWQNNLPLTPADKVSGYNNFYEFGLDKADANAGSLKTDPWTLKISGEVKPLTLDHDDLTRRPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNKYVAFETIYAPKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRE

4pw3A1

0.26

0.08

0.30

1.86

Env-PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVNTPPESILADRDGWKVEISGVKEPRTLTVAELKTLG-------------LVTAVIWSGVPLKAVVDALGGPAERFITGTGGEEDPKLLVVERSVPISNLDNVILAWEMNGRPLSLAHGGPLRMVVPGYSGVNNIKYVKAVAMTEV

1xdqC

0.24

0.10

0.40

0.90

MUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KALEFSKQNNLPLTPADKVSGYNNFYEFGLDKADANAGSLKTDPWTLKISGEVAPLTLDHDDLTR-PLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAYVAFETIYAPKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRE

4pw3A1

0.27

0.08

0.30

0.94

dPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVNTPPESILADRDGWKVEISGVKEPRTLTVAELKTL-------------GLVTAVIWSGVPLKAVVDALGGEGARFITGTGGEELPAGLVVERSVPISNLDNVILAWEMNGRPLSLAHGGPLRMVVPGYSGVNNIKYVKAVAMTEV

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.39

Estimated TM-score = 0.26±0.08

Estimated RMSD = 18.4±2.3Å

Download Model 2

C-score=-4.54

Download Model 3

C-score=-4.59

Download Model 4

C-score=-4.54

Download Model 5

C-score=-4.95

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1soxA	0.580	2.61	0.194	0.624
2	2xtsA	0.421	3.79	0.201	0.484
3	2bihA	0.419	2.95	0.139	0.464
4	2blfA	0.409	2.44	0.221	0.441
5	1ogpA	0.408	2.16	0.215	0.432
6	4pw3A	0.390	2.60	0.218	0.425
7	2x2hA	0.387	7.06	0.059	0.640
8	3c3lA	0.379	6.58	0.050	0.586
9	4r04A	0.371	7.29	0.056	0.622
10	1hn0A	0.370	7.48	0.045	0.636

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.34	25	1ogpF	MTQ	Rep, Mult	291,292,293,294,297,343,344,377,379,385,414,419,427,428,430,431,432,433
2	0.07	5	1xdqA	O	Rep, Mult	343,344,427,428
3	0.03	2	1soxA	HEM	Rep, Mult	104,136,137,192,193,196,198,199,203,204,207,208
4	0.01	1	1xdqA	MO	Rep, Mult	290,343,344,428
5	0.01	1	3c46A	2HP	Rep, Mult	363,367,368,370
6	0.01	1	1lm1A	F3S	Rep, Mult	414,415,416,418,419,420,421,431

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	1soxA	0.580	2.61	0.194	0.624	1.8.3.1	NA
2	0.060	3ffzA	0.335	6.96	0.039	0.536	3.4.24.69	NA
3	0.060	1llwA	0.363	7.46	0.045	0.627	1.4.7.1	NA
4	0.060	2e8yA	0.336	7.27	0.058	0.566	3.2.1.41	290,413
5	0.060	2vr5A	0.338	7.00	0.025	0.550	3.2.1.-	NA
6	0.060	2q1fA	0.355	7.46	0.040	0.602	4.2.2.21	357
7	0.060	2p4eA	0.345	7.20	0.042	0.579	3.4.21.-	NA
8	0.060	2wanA	0.353	7.25	0.028	0.584	3.2.1.41	NA
9	0.060	2fahA	0.341	7.67	0.051	0.597	4.1.1.32	NA
10	0.060	3bpsA	0.332	7.00	0.064	0.543	3.4.21.-	NA
11	0.060	2jkpB	0.335	7.49	0.048	0.575	3.2.1.20	NA
12	0.060	2e9bA	0.357	7.07	0.030	0.584	3.2.1.41	NA
13	0.060	1j0mA	0.349	7.12	0.050	0.563	4.2.2.12	428
14	0.060	1l5jA	0.344	7.23	0.056	0.561	4.2.1.3	427
15	0.060	2vuaA	0.291	6.94	0.045	0.471	3.4.24.69	NA
16	0.060	1ojnA	0.335	6.81	0.035	0.536	4.2.2.1	NA
17	0.060	2zxqA	0.344	7.79	0.056	0.609	3.2.1.97	NA
18	0.060	1oqzB	0.339	7.38	0.080	0.575	3.5.1.93	438
19	0.060	1k32A	0.343	7.52	0.037	0.584	3.4.21.-	NA
20	0.060	1rw9A	0.336	6.67	0.033	0.525	4.2.2.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.16	0.580	2.61	0.19	0.62	1soxA	GO:0005739 GO:0005758 GO:0006790 GO:0008482 GO:0016491 GO:0020037 GO:0030151 GO:0042128 GO:0043546 GO:0046872 GO:0055114
1	0.07	0.421	3.79	0.20	0.48	2xtsA	GO:0016491 GO:0030151 GO:0042128 GO:0055114
2	0.06	0.409	2.44	0.22	0.44	2blfA	GO:0016491 GO:0030151 GO:0042128 GO:0055114
3	0.06	0.239	7.08	0.05	0.39	3rpmA	GO:0004553 GO:0004563 GO:0005576 GO:0005618 GO:0005975 GO:0008152 GO:0016020 GO:0016787 GO:0016798
4	0.06	0.251	7.40	0.05	0.42	1kbiA	GO:0003824 GO:0004460 GO:0005739 GO:0005743 GO:0005758 GO:0005829 GO:0006089 GO:0006626 GO:0010181 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0070469
5	0.06	0.419	2.95	0.14	0.46	2bihA	GO:0006809 GO:0016491 GO:0020037 GO:0030151 GO:0042128 GO:0043546 GO:0046872 GO:0050464 GO:0055114
6	0.06	0.408	2.16	0.21	0.43	1ogpA	GO:0005739 GO:0005777 GO:0005829 GO:0006790 GO:0008482 GO:0010477 GO:0015994 GO:0016491 GO:0030151 GO:0042128 GO:0046872 GO:0055114
7	0.06	0.212	7.02	0.04	0.35	3mjmA	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016812 GO:0019856 GO:0044205 GO:0046872
8	0.06	0.412	1.57	0.21	0.43	3hbgA	GO:0005739 GO:0005758 GO:0006790 GO:0008482 GO:0016491 GO:0020037 GO:0030151 GO:0042128 GO:0043546 GO:0046872 GO:0055114
9	0.06	0.242	6.95	0.05	0.39	3mcaA	GO:0000166 GO:0002181 GO:0002182 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0005829 GO:0006412 GO:0006414 GO:0006417 GO:0032790
10	0.06	0.390	2.60	0.22	0.43	4pw3A	GO:0008482 GO:0016491 GO:0030151 GO:0042128 GO:0055114
11	0.06	0.190	7.22	0.03	0.32	5c0xC	GO:0000176 GO:0000177 GO:0000178 GO:0000467 GO:0003723 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0006364 GO:0006396 GO:0006401 GO:0006402 GO:0016072 GO:0017091 GO:0034427 GO:0034473 GO:0034475 GO:0034476 GO:0043628 GO:0043928 GO:0070478 GO:0070481 GO:0070651 GO:0071028 GO:0071035 GO:0071038 GO:0071042 GO:0071051
12	0.06	0.336	2.98	0.21	0.37	1xdqC	GO:0016491 GO:0016667 GO:0016672 GO:0030091 GO:0030288 GO:0042128 GO:0042597 GO:0043546 GO:0046872 GO:0055114 GO:1901530
13	0.06	0.186	6.77	0.02	0.30	3p2mA	GO:0052689
14	0.06	0.191	6.61	0.06	0.31	1sgfG	GO:0004175 GO:0004252 GO:0005057 GO:0005615 GO:0005634 GO:0006508 GO:0007165 GO:0008083 GO:0008233 GO:0008236 GO:0016787 GO:0016811 GO:0043234 GO:0046872 GO:0070062
15	0.06	0.167	5.27	0.04	0.23	2j3wB
16	0.06	0.160	5.82	0.05	0.23	1c3gA	GO:0003677 GO:0005634 GO:0005737 GO:0006413 GO:0006457 GO:0007049 GO:0022627 GO:0035719 GO:0051082 GO:0051787 GO:0070843 GO:0071630
17	0.06	0.096	4.57	0.04	0.12	1aw3A	GO:0005737 GO:0005739 GO:0005783 GO:0005789 GO:0009055 GO:0016020 GO:0016021 GO:0019899 GO:0020037 GO:0031090 GO:0043231 GO:0046686 GO:0046872 GO:0055114 GO:0070062
18	0.06	0.092	4.57	0.01	0.12	2i89A	GO:0005739 GO:0005741 GO:0005743 GO:0008047 GO:0016020 GO:0016021 GO:0020037 GO:0043085 GO:0043231 GO:0045153 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0046914	GO:0046906	GO:0016670	GO:0050662
GO-Score	0.55	0.43	0.33	0.33
Biological Processes	GO:0071941	GO:0042126	GO:0055114
GO-Score	0.55	0.55	0.32
Cellular Component	GO:0031970	GO:0005740
GO-Score	0.43	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.