I-TASSER results

I-TASSER results for job id Rv0207c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (242 residues)
MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVWDAPNLDMGLGSILGRR
PTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNIAPGSAEVVRPWVDALRNV
GFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASADGQAFRQPLEAVARSGTPVQ
VLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLTS
RV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVWDAPNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNIAPGSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASADGQAFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLTSRV
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHCCEEEHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
Conf.Score	99876677777777888888777788888888888887799999767655667777678998655868999999999987665445677666656788865688876654689999999897899768988888778899999999997788889998588667999999999979958999756777799998766577454454554467888778778878877788767899876579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVWDAPNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNIAPGSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASADGQAFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLTSRV
Prediction	45345534554455357454345524654445645442100000003211100120144325373221032004103631542345444453413000002135343520100030033130311324536664401420141044127441210000001153035104402756130000002211244035401411204413510443044251361476241141131023105648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHCCEEEHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVWDAPNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNIAPGSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASADGQAFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLTSRV

2qipA

0.17

0.11

0.63

1.17

MUSTER

--------------------------------QSDHKEKIAILVDVQNVYYTCREAYRSNFD------YNQFWYVATQ-----------EKEVVSAKAYAIAS--NDPKQRQFHHILRGVGFEVLKPYIQSAKGDWDVGITLDAIEIAP-DVDRVILVSGDG-DFSLLVERIQQRYKKVTVYGVPRLTSQTLIDCADNFVAIDDLL------------------------------------

2qipA

0.16

0.10

0.64

1.58

dPPAS

--------------------------------QSDHKEKIAILVDVQNVYYTCREAYRSNFD-------------YNQFWYVATQEKEVV----SAKAYAIAS--NDPKQRQFHHILRGVGFEVLKPRDGSAKGDWDVGITLDAIEIAP-DVDRVILVSGDGDFSLLVERIQQRYNKKVTVYGVPRLTSQTLIDCADNFVAIDDDFLL----------------------------------

2qipA

0.17

0.11

0.63

2.31

wdPPAS

--------------------------------QSDHKEKIAILVDVQNVYYTCREAYRSN------FDYNQFWYVATQEKEVV-----------SAKAYAIAS--NDPKQRQFHHILRGVGFEVLKPRDGSAKGDWDVGITLDAIEIAP-DVDRVILVSGDG-DFSLLVERIQQRYKKVTVYGVPRLTSQTLIDCADNFVAIDDL-------------------------------------

2qipA

0.17

0.11

0.63

1.45

wMUSTER

---------------------------------SDHKEKIAILVDVQNVYYTCREAYRSN------FDYNQFWYVATQEKEVV-----------SAKAYAI--ASNDPKQRQFHHILRGVGFEVLKPYIQSAKGDWDVGITLDAIEIAP-DVDRVILVSGDG-DFSLLVERIQQRYKKVTVYGVPRLTSQTLIDCADNFVAIDDLL------------------------------------

2qipA

0.17

0.11

0.63

2.27

wPPAS

--------------------------------QSDHKEKIAILVDVQNVYYTCREAYRSN------FDYNQFWYVATQEKEVV-----------SAKAYAIAS--NDPKQRQFHHILRGVGFEVLKPRDGSAKGDWDVGITLDAIEIAP-DVDRVILVSGDG-DFSLLVERIQQRYKKVTVYGVPRLTSQTLIDCADNFVAIDDL-------------------------------------

2qipA

0.17

0.11

0.63

3.96

dPPAS2

--------------------------------QSDHKEKIAILVDVQNVYYTCREAYRSNFD-------------YNQFWYVATQEKEVV----SAKAYAIAS--NDPKQRQFHHILRGVGFEVLKPRDGSAKGDWDVGITLDAIEIAP-DVDRVILVSGDG-DFSLLVERIQQRYKKVTVYGVPRLTSQTLIDCADNFVAIDDL-------------------------------------

2qipA

0.17

0.11

0.63

1.64

PPAS

--------------------------------QSDHKEKIAILVDVQNVYYTCREAYRSNFD------YNQFWYVATQEKEVV-----------SAKAYAIAS--NDPKQRQFHHILRGVGFEVLKPRDGSAKGDWDVGITLDAIEIAPD-VDRVILVSGDG-DFSLLVERIQQRYKKVTVYGVPRLTSQTLIDCADNFVAIDDD---L---------------------------------

2qipA

0.17

0.11

0.64

2.33

Env-PPAS

--------------------------------QSDHKEKIAILVDVQNVYYTCREAYRSNFD------YNQFWYVATQEKEVV-----------SAKAYAIAS--NDPKQRQFHHILRGVGFEVLKPRDGSAKGDWDVGITLDAIEIAPD-VDRVILVSGDG-DFSLLVERIQQRYKKVTVYGVPRLTSQTLIDCADNFVAIDDDF-LL---------------------------------

3umgA

0.13

0.12

0.93

0.66

MUSTER

VPFRSPSTGRNVR-VDWRTGIATAVADYAARHQLEVDAVAFADRWRARYQPSMDAILSGARE---FVTLDILHRENLDFVLRESGIDPHDSGELDELARAWHVLTPWPDSVPGLTAIKAE-YIIGPL------SNGNTSLLLDMAKNAGIPWD-VIIGSDINQAYLRTAQVLGLHPGEVMLAAAHNGDLEAAHATGLATAFILRP----VEHGPHQTDDLAPT-GSWATDITDLAAQLRAGS

1zd4A1

0.16

0.13

0.85

0.70

dPPAS

LPAVFGVLGRTEEALALPRGLLNDAFQKGGPEG------------------ATTRLMKGEITLSQ--WIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAP----------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.60

Estimated TM-score = 0.41±0.14

Estimated RMSD = 11.8±4.5Å

Download Model 2

C-score=-2.61

Download Model 3

C-score=-2.94

Download Model 4

C-score=-2.96

Download Model 5

C-score=-2.76

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2qipA	0.589	1.93	0.161	0.636
2	3cb2A	0.518	4.33	0.108	0.731
3	3hkeD	0.514	4.47	0.060	0.736
4	4e69A	0.513	4.69	0.066	0.736
5	4af8A	0.513	4.37	0.080	0.715
6	1tubA	0.509	4.55	0.055	0.744
7	2amvA	0.508	5.15	0.050	0.793
8	1wz2A	0.505	5.41	0.047	0.810
9	3nv9A	0.503	4.40	0.051	0.698
10	4ofzA	0.503	4.56	0.039	0.727

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1tauA	ZN	Rep, Mult	45,48,137,161
2	0.06	3	3l8hA	MG	Rep, Mult	45,50,161
3	0.06	3	1ul1X	MG	Rep, Mult	45,101,135,137
4	0.06	3	2z8yO	XE	Rep, Mult	43,140,157,164
5	0.04	2	3nmtB	MG	Rep, Mult	161,162
6	0.04	2	1z2bB	VLB	Rep, Mult	144,148,154,155,156,157
7	0.02	1	4j7cD	ATP	Rep, Mult	68,203
8	0.02	1	3sxnD	COA	Rep, Mult	201,202
9	0.02	1	3ke6A	MN	Rep, Mult	45,161,204
10	0.02	1	4hx2A	1AX	Rep, Mult	36,151,152,153,175,176,177
11	0.02	1	3hkeB	T13	Rep, Mult	160,189,191,192
12	0.02	1	1id8A	DBI	Rep, Mult	50,75,157,158,160,182,183,200,203,208
13	0.02	1	1ampA	ZN	Rep, Mult	143,161,201
14	0.02	1	1cqpB	803	Rep, Mult	40,180,212,216

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3d64B	0.492	5.11	0.094	0.744	3.3.1.1	70,72,74
2	0.060	2yy7A	0.478	4.20	0.089	0.649	1.1.1.103	NA
3	0.060	1hlgA	0.460	4.87	0.074	0.711	3.1.1.3	NA
4	0.060	1fa9A	0.464	5.83	0.049	0.785	2.4.1.1	NA
5	0.060	1ileA	0.498	5.38	0.071	0.793	6.1.1.5	NA
6	0.060	3d64A	0.490	5.18	0.088	0.752	3.3.1.1	145
7	0.060	2i6aA	0.500	4.98	0.032	0.740	2.7.1.20	NA
8	0.060	1o0sA	0.484	5.59	0.077	0.785	1.1.1.38	NA
9	0.060	1eg7A	0.483	5.38	0.087	0.789	6.3.4.3	NA
10	0.060	3h9uC	0.489	5.03	0.074	0.736	3.3.1.1	139
11	0.060	1gqtB	0.486	4.58	0.094	0.686	2.7.1.15	NA
12	0.060	1gq2A	0.493	4.60	0.045	0.703	1.1.1.40	NA
13	0.060	1ffyA	0.499	5.42	0.056	0.814	6.1.1.5	NA
14	0.060	3g1uC	0.490	5.02	0.094	0.740	3.3.1.1	NA
15	0.060	3hmjA	0.496	4.87	0.074	0.740	2.3.1.86	NA
16	0.060	1fw8A	0.498	4.44	0.063	0.698	2.7.2.3	188,202,211,214
17	0.060	2a9yA	0.485	4.96	0.060	0.723	2.7.1.20	NA
18	0.060	2x42A	0.486	4.93	0.059	0.715	3.2.1.21	NA
19	0.060	1hlgB	0.460	4.87	0.074	0.711	3.1.1.3	142,165,169

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.486	4.58	0.09	0.69	1gqtB	GO:0000166 GO:0004747 GO:0005524 GO:0005737 GO:0005829 GO:0005975 GO:0006014 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0019303 GO:0046835 GO:0046872
1	0.16	0.450	5.05	0.06	0.69	2btqA	GO:0000166 GO:0003924 GO:0005200 GO:0005525 GO:0005874 GO:0007017
2	0.16	0.485	4.96	0.06	0.72	2a9yA	GO:0000166 GO:0004001 GO:0005524 GO:0006166 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0044209 GO:0046872
3	0.16	0.478	4.93	0.09	0.71	4u7xA	GO:0000166 GO:0004747 GO:0006014 GO:0008865 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0046835
4	0.07	0.514	4.51	0.07	0.74	4eb6B	GO:0000166 GO:0003924 GO:0005200 GO:0005525 GO:0005737 GO:0005856 GO:0005874 GO:0007017
5	0.07	0.459	4.90	0.05	0.68	5flzC	GO:0000166 GO:0000928 GO:0000930 GO:0003924 GO:0005200 GO:0005525 GO:0005634 GO:0005737 GO:0005816 GO:0005822 GO:0005824 GO:0005856 GO:0005874 GO:0007017 GO:0007020 GO:0030472 GO:0031122 GO:2000767
6	0.07	0.514	4.60	0.08	0.73	4e69B	GO:0000166 GO:0016301 GO:0016310 GO:0016740 GO:0016773
7	0.07	0.518	4.33	0.11	0.73	3cb2A	GO:0000086 GO:0000166 GO:0000212 GO:0000226 GO:0000242 GO:0000794 GO:0000930 GO:0003924 GO:0005200 GO:0005525 GO:0005737 GO:0005813 GO:0005814 GO:0005815 GO:0005827 GO:0005829 GO:0005856 GO:0005874 GO:0005876 GO:0005881 GO:0005929 GO:0007017 GO:0007020 GO:0031122 GO:0031252 GO:0031513 GO:0036064 GO:0045177 GO:0055037
8	0.07	0.420	5.07	0.07	0.63	3r3sA	GO:0000166 GO:0016491 GO:0046872 GO:0055114
9	0.07	0.449	5.08	0.05	0.68	4i4tA	GO:0000166 GO:0000226 GO:0003725 GO:0003924 GO:0005200 GO:0005525 GO:0005737 GO:0005856 GO:0005874 GO:0005881 GO:0007017 GO:0031625 GO:0043209 GO:0070062 GO:0071353
10	0.07	0.480	4.45	0.14	0.68	2rbcA	GO:0016301 GO:0016310 GO:0016740
11	0.07	0.473	4.91	0.07	0.71	3ljsB	GO:0000166 GO:0005524 GO:0016301 GO:0016310 GO:0016740 GO:0016773
12	0.07	0.482	4.55	0.08	0.68	3in1A	GO:0004747 GO:0006014 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0046835
13	0.07	0.461	5.02	0.06	0.69	1tz3A	GO:0000166 GO:0004747 GO:0006014 GO:0008715 GO:0008865 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0016787 GO:0046835
14	0.07	0.514	4.51	0.04	0.74	4ffbB	GO:0000070 GO:0000166 GO:0003924 GO:0005200 GO:0005525 GO:0005737 GO:0005816 GO:0005828 GO:0005856 GO:0005874 GO:0005880 GO:0005881 GO:0007017 GO:0030473 GO:0045143 GO:0045298 GO:0046677
15	0.07	0.444	5.71	0.07	0.72	2c49A	GO:0004747 GO:0006014 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0046835
16	0.07	0.478	4.40	0.07	0.68	2btqB	GO:0000166 GO:0003924 GO:0005200 GO:0005525 GO:0005874 GO:0007017
17	0.07	0.474	4.59	0.08	0.68	3ikhA	GO:0000166 GO:0004747 GO:0005524 GO:0005737 GO:0006014 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0019303 GO:0046835
18	0.07	0.459	4.91	0.04	0.69	1vm7A	GO:0004747 GO:0005524 GO:0005737 GO:0006014 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0019303 GO:0046835

Consensus prediction of GO terms

Molecular Function	GO:0005198	GO:0017111	GO:0032561	GO:0005524	GO:0046872	GO:0004747	GO:0019206	GO:0004396
GO-Score	0.43	0.43	0.43	0.35	0.35	0.35	0.32	0.32
Biological Processes	GO:0019323	GO:0046835	GO:0006014	GO:0006167	GO:0043174	GO:0032261
GO-Score	0.45	0.35	0.35	0.32	0.32	0.32
Cellular Component	GO:0044444	GO:0015630	GO:0099513
GO-Score	0.45	0.43	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.