I-TASSER results

I-TASSER results for job id Rv0204c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (412 residues)
MSHDAPARNLRQRVGALPRTRVGAPPAEGVPPRGKYWWLRWAVLAIVAIVLAIEVALGWD
QLAKAWVSLYRAKWWWLLAAVAAAGASMHSFAQIQRTLLKSAGVHVKQWRSEAAFYAANS
LSTTLPGGPVLSATFLLRQQRIWGASTVVASWQLVMSGVLQAVGLALLGLGGAFFLGAKN
NPFSLLFTLGGFVTLLLLAQAVASRPELIEGIGRRVLSWANSVRGRPADAGLPKWRETLM
QLESVSLGRRDLGVAFGWSLFNWIADVACLGFAAYAAGDHASVGGLAVAYAAARAVGTIP
LMPGGLLVVEAVLVPGLVSSGMPLPSAISAMLIYRLISWLLIAAIGWVVFFFMFRTESTA
DSDNDRDPPTDPNLRLVIQPQGTPCDDPVETTPQGPAPTPDLRPEGGETPPR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSHDAPARNLRQRVGALPRTRVGAPPAEGVPPRGKYWWLRWAVLAIVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGASMHSFAQIQRTLLKSAGVHVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGASTVVASWQLVMSGVLQAVGLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVASRPELIEGIGRRVLSWANSVRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLFNWIADVACLGFAAYAAGDHASVGGLAVAYAAARAVGTIPLMPGGLLVVEAVLVPGLVSSGMPLPSAISAMLIYRLISWLLIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLVIQPQGTPCDDPVETTPQGPAPTPDLRPEGGETPPR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9887666666555566666777888777776544456789999999999999999998658999999999889899999999999999999999999999979988699999999999999986888756788999988766588688999999999999999999999999998655554678999999999999999999998899999999999998887655578899999999999999865788999999999999999999999999998999999999999999999999845898667999999999998799989999999999999999999999999999997645555455555566776555667777888888778888888888887778899999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSHDAPARNLRQRVGALPRTRVGAPPAEGVPPRGKYWWLRWAVLAIVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGASMHSFAQIQRTLLKSAGVHVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGASTVVASWQLVMSGVLQAVGLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVASRPELIEGIGRRVLSWANSVRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLFNWIADVACLGFAAYAAGDHASVGGLAVAYAAARAVGTIPLMPGGLLVVEAVLVPGLVSSGMPLPSAISAMLIYRLISWLLIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLVIQPQGTPCDDPVETTPQGPAPTPDLRPEGGETPPR
Prediction	7545453563555454445444544446454543322001100002122222212102113033004103703010000000002101201020000002106350211100000000101111022110100000011135361310000000011333333132322221120023322121322333332222322111022231031001100210230242324300420340043033022312100000010011101100000000000213020000000122133112302311131120001000001240322100000012132113203330220100021344445553665464545354445565544654464456444463645666666468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSHDAPARNLRQRVGALPRTRVGAPPAEGVPPRGKYWWLRWAVLAIVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGASMHSFAQIQRTLLKSAGVHVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGASTVVASWQLVMSGVLQAVGLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVASRPELIEGIGRRVLSWANSVRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLFNWIADVACLGFAAYAAGDHASVGGLAVAYAAARAVGTIPLMPGGLLVVEAVLVPGLVSSGMPLPSAISAMLIYRLISWLLIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLVIQPQGTPCDDPVETTPQGPAPTPDLRPEGGETPPR

4wisA

0.10

0.98

1.07

MUSTER

VSSIQQSRPEFEWEHEAEDPITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGPYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMNYATVDAHDAALIQKQFVLNF---MTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTFSEKELPTREFQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQAEFLQRVREECTLEEYDVSGDYREMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISSRRPIPWRTDSIGPWLTALSFLSW----LGSITSSAIVYLCSSPLKAWGLLLSILFAEHFYLVVQLAVRFVLS-SPGLQKERKERFQTKKRLLQENLGQDAAAAPGIEHSEKITREALEEEARQASIEMFWQRQR

4n7wA

0.10

0.08

0.73

0.86

dPPAS

-------------------------------------MLVKITRLFPVWALLLSVAAYFR--PTTFTGIGPYVGPLLMLIMFAMGVTLRLDDFKRVLSRPAPVAAATFLHYLIMPLTAWILAMLFRMPPDLSAGMVLVGSVASGTAKGDVALSVTISAVSTLVGVFATPLLTRLYVDATISVDVVGMLKSILQIVVIPITAGLVIHHTFTKTVKRIEP-----YLPAMSMVCILAIISAVVAGSQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGFDESTCRTLAIEVGMQ-------------NSGLAATLGKIYFS-------PLAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE-------------------------------------------------

4n7wA

0.11

0.08

0.68

1.08

wdPPAS

---------------------------------MLVKITRLFPVWALLLSVAAYFRPTTFRLDDFKRVLS--RPAPVAAATFLHYLIMPLTAWILAMLFR-----MP-----PDLSAGMVLVGSVASGTASNVMIYLA---------GDVALSVTISAVSTLVGVFATPLLTRLYVDATISVDVVGMLKSILQIVVIPITAGLVIHHTFTKTVKRIEP-----YLPAMSMVCILAIISAVVAGSQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGFD-----ESTCRTLAIEVGM----------SGLAATLGKIYFS-------PLAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE-------------------------------------------------

4wisA

0.10

0.95

1.27

wMUSTER

VSSIQQSRPEFEWEHEAEDPITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGPYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMENYVDAHDAALIQKQFVLNFM--TSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTFSEKELPTR----FQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQEFLQRVREECTLEEYDVSGDYREMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISTDSIG--------PWLTALSFLSW----LGSITSSAIVYLCSSPLKAWGLLLSILFAEHFYLVVQLAVRFVLS--SPGLQKERKERFQTKKRLLQENLGQDAAAAPGIEHSEKITREALEEEARQASEMFWQRQR

4n7wA

0.12

0.08

0.66

1.68

wPPAS

---------------------------------MLVKITRLFPVWALLLSVAAYFRPTTFRLDDFKRVLS--RPAPVAAATFLHYLIMPLTAWILAMLFR-----MP-----PDLSAGMVLVGSVASGTA--SNVMIYLAK--G-----VALSVTISAVSTLVGVFATPLLTRLYVDATISVDVVGMLKSILQIVVIPITAGLVIHHTFTKTVKRIEP-------------------YLPAMSMVC--LAIISAVVAGSQSHIASVGFVVIIAVILH----NGIGLLSGYWGGKLFG----FD--VGMSGLAATLGKIYFS-------PLAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE-------------------------------------------------

4n7wA

0.10

0.07

0.69

1.34

dPPAS2

---------------------------------MLVKITRLFPVWALLLSVAAYFRPTTFRLDDFKRVLS--RPAPVAAATFLHYLIMPLTAWILAMLFRMP----------PDLSAGMVLVGSVASGT-----ASNVMIYLAKGDVALSVTISAVSTLVGVFATPLLTRLYV---DATISVDVVGMLKSILQIVVIPITAGLVIHHTFTKTVKRIEP-----YLPAMSMVCILAIISAVVAGSQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGFD-----ESTCRTLAIEVGMQN--------SGLAATLGKIYFS-------PLAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE-------------------------------------------------

4wgvA

0.07

0.06

0.82

1.54

PPAS

TVRLGIATGKDLAQMTRHFLS---------------KPVAIIFWIIAELAIIATDIAEVIGSAIALDLIFGIPLIVGALITVFDVFLLLFIMRFGFRKIEAI-----VGTLIFTVLAIFVFEVFISSPQLTDILNGFVPHKEIVTNQGILYIALGIIGATIMPHNLYLHSSIVQ-HDNEEKAQAIKYATIDSNLQLSIAFVVNCLLLTLGAALFFGTKTNDLGGFYDLYHALKTEPVLGATLGGVMSTLFAVALLASGQNSTITGTLAGQIVMEGFLRLSIPLITRSLAVIPVIICLIIFKGNSEKIEQLLVFSQVFLSIALPFSLIPLQLATSNFINKTWVNIISWTLIVILSGLNVY-----------------------------------------------------

3nd0A

0.12

0.10

0.83

1.06

Env-PPAS

-------------------------------SLHPRTLVAAIVVGLITGVLGAGFKSAVNNMLQWRSQLAQIPPLAWLVTALISGGMVALSFWLMKRFAPDTSLPLVWQRVLPIKLVGGFLSLGAGMLIQMGGSIGQMTGGWFKAT-QENQRILIAVGAGAGLATAFAPLAGVALIGFRSQTLAYHSLLFGCVMATIILRMIRKRVPLDSLWMFIILGILFGVMGYTFNRGLFKVLDWFDRLPPLATKWKGFLLGSIIGILSLFPLPLTDNAVLWAFNSQSHFSTLILVFCGRFLLTLICYAIGGVSVAMARHFHLLFPSQIPRAPLTAILLTIEMYFVILPLLVTCLVASVVAEALGGKTVLLERTLAKQNR---------------------------------------

4wisA2

0.10

0.98

1.03

MUSTER

VSSIQQSRPEFEWEHEAEDPITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGPYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMNYATVDAHDAALIQKQFVLNF---MTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTFSEKELPTREFQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQAEFLQRVREECTLEEYDVSGDYREMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISSRRPIPWRTDSIGPWLTALSFLSW----LGSITSSAIVYLCSSPLKAWGLLLSILFAEHFYLVVQLAVRFVLS-SPGLQKERKERFQTKKRLLQENLGQDAAAAPGIEHSEKITREALEEEARQASIEMFWQRQR

5e1jA1

0.06

0.05

0.86

0.80

dPPAS

LNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLVHTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYFIAPYVRVIIFILSIRETLVLLSGMLGTYLNILALWMLFLLFASWIAFVMFEDTQQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGQRYRAFIATFITLIPSLMPYLGTIFC-VLCIYCSIGVQVFGGLNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGN-------WQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFTELDLEEEEK-------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.40

Estimated TM-score = 0.77±0.10

Estimated RMSD = 6.0±3.7Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4wisA	0.927	1.79	0.099	0.976
2	4a01A	0.419	6.59	0.059	0.658
3	5fvmA	0.405	6.89	0.073	0.665
4	4xqkA	0.405	6.66	0.048	0.638
5	4av3A	0.388	6.68	0.057	0.602
6	4jspB	0.385	6.60	0.054	0.619
7	3ffzA	0.385	6.94	0.042	0.626
8	5a22A	0.384	6.47	0.042	0.600
9	4bgdA	0.378	7.11	0.059	0.638
10	2x0sA3	0.377	5.67	0.067	0.546

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	2	1cm5B	NA	Rep, Mult	48,51,53,127,128
2	0.06	2	3rkoM	CA7	Rep, Mult	88,95,96,99
3	0.03	1	3ae6C	EPH	Rep, Mult	267,313,314,317
4	0.03	1	3prqI	CLA	Rep, Mult	350,354
5	0.03	1	2wsc2	CLA	Rep, Mult	306,355
6	0.03	1	3s7bA	BU3	Rep, Mult	21,37
7	0.03	1	3rkoC	LFA	Rep, Mult	114,117,121,125,126
8	0.03	1	2q67A	CA	Rep, Mult	298,299
9	0.03	1	4wisA	CA	Rep, Mult	201,234,237,266,270
10	0.03	1	2x2vH	DPV	Rep, Mult	288,296
11	0.03	1	1jb0M	CLA	Rep, Mult	80,84
12	0.03	1	1dlqB	LIO	Rep, Mult	309,312
13	0.03	1	3m6zB	MG	Rep, Mult	4,120,121,122
14	0.03	1	2r9rB	PGW	Rep, Mult	53,57
15	0.03	1	2eabA	CA	Rep, Mult	320,322,323,330

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3btaA	0.343	7.18	0.021	0.578	3.4.24.69	54
2	0.060	1kblA	0.372	5.57	0.068	0.529	2.7.9.1	NA
3	0.060	3ihyC	0.336	6.74	0.041	0.544	2.7.1.137	98
4	0.060	2jg0A	0.343	6.55	0.024	0.546	3.2.1.28	NA
5	0.060	1y8bA	0.371	5.93	0.036	0.546	2.3.3.9	NA
6	0.060	2x0sA	0.357	6.88	0.052	0.568	2.7.9.1	NA
7	0.060	2vuaA	0.226	6.58	0.008	0.357	3.4.24.69	249,310,319
8	0.060	2pflA	0.363	6.74	0.032	0.583	2.3.1.54	NA
9	0.060	1dl2A	0.335	6.38	0.041	0.507	3.2.1.113	NA
10	0.060	1kc7A	0.353	6.16	0.068	0.529	2.7.9.1	NA
11	0.060	1h16A	0.369	6.54	0.046	0.585	2.3.1.54	NA
12	0.060	1eulA	0.248	6.99	0.038	0.410	3.6.3.8	NA
13	0.060	2x6fA	0.339	6.93	0.048	0.563	2.7.1.137,2.7.1.153,2.7.1.154	NA
14	0.060	1h54B	0.361	6.85	0.034	0.583	2.4.1.8	NA
15	0.060	1zjaA	0.332	6.48	0.041	0.507	5.4.99.11	NA
16	0.060	1lnsA	0.352	7.16	0.040	0.597	3.4.14.11	NA
17	0.060	1ayxA	0.338	6.42	0.029	0.524	3.2.1.3	NA
18	0.060	1vbgA	0.369	6.04	0.044	0.556	2.7.9.1	NA
19	0.060	1ej6A	0.346	6.68	0.054	0.551	2.7.7.50	186

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.33	0.927	1.79	0.10	0.98	4wisA	GO:0016020 GO:0016021 GO:0046872
1	0.06	0.419	6.59	0.06	0.66	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
2	0.06	0.404	6.82	0.07	0.64	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
3	0.06	0.361	7.12	0.04	0.59	4yknA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
4	0.06	0.336	6.74	0.04	0.54	3ihyC	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
5	0.06	0.339	6.84	0.06	0.55	5dfzC	GO:0000166 GO:0000329 GO:0000407 GO:0004672 GO:0005524 GO:0005643 GO:0005768 GO:0005777 GO:0005794 GO:0006468 GO:0006810 GO:0006914 GO:0010008 GO:0015031 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030242 GO:0032968 GO:0034271 GO:0034272 GO:0036092 GO:0046854 GO:0048015 GO:0071561
6	0.06	0.340	6.84	0.04	0.56	4uwhA	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
7	0.06	0.387	6.82	0.07	0.63	4jsnB	GO:0000139 GO:0000166 GO:0001030 GO:0001031 GO:0001032 GO:0001156 GO:0001933 GO:0001934 GO:0001938 GO:0003007 GO:0003179 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005741 GO:0005764 GO:0005765 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0005942 GO:0005979 GO:0006109 GO:0006112 GO:0006207 GO:0006281 GO:0006468 GO:0006950 GO:0007050 GO:0007165 GO:0007281 GO:0007420 GO:0007569 GO:0007584 GO:0007616 GO:0008542 GO:0009791 GO:0010507 GO:0010592 GO:0010628 GO:0010831 GO:0010942 GO:0010976 GO:0012505 GO:0014042 GO:0014736 GO:0016020 GO:0016049 GO:0016236 GO:0016242 GO:0016301 GO:0016310 GO:0016605 GO:0016740 GO:0018105 GO:0018107 GO:0019901 GO:0019904 GO:0021510 GO:0030030 GO:0030163 GO:0030425 GO:0030838 GO:0031090 GO:0031295 GO:0031397 GO:0031529 GO:0031641 GO:0031669 GO:0031929 GO:0031931 GO:0031932 GO:0031998 GO:0032095 GO:0032868 GO:0032956 GO:0032991 GO:0035176 GO:0035264 GO:0040007 GO:0042060 GO:0042220 GO:0043022 GO:0043025 GO:0043087 GO:0043200 GO:0043231 GO:0043278 GO:0043610 GO:0044877 GO:0045429 GO:0045670 GO:0045727 GO:0045792 GO:0045859 GO:0045945 GO:0046777 GO:0046889 GO:0048015 GO:0048255 GO:0048661 GO:0048714 GO:0048738 GO:0050731 GO:0050769 GO:0050882 GO:0051219 GO:0051496 GO:0051534 GO:0051896 GO:0051897 GO:0055006 GO:0055013 GO:0060048 GO:0060135 GO:0060252 GO:0060999 GO:0061051 GO:0071456 GO:0090335 GO:0090559 GO:1900034 GO:1901216 GO:1901838 GO:1904000 GO:1904056 GO:1904058 GO:1904193 GO:1904197 GO:1904206 GO:1904213
8	0.06	0.328	7.04	0.03	0.55	5dxhA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
9	0.06	0.386	6.98	0.05	0.63	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
10	0.06	0.338	6.62	0.05	0.54	5dxtA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
11	0.06	0.289	6.32	0.06	0.44	4dziC	GO:0016787
12	0.06	0.348	6.67	0.06	0.56	2y3aA	GO:0000166 GO:0001935 GO:0001952 GO:0005524 GO:0005634 GO:0005730 GO:0005737 GO:0005886 GO:0005942 GO:0006874 GO:0006897 GO:0006914 GO:0007155 GO:0007156 GO:0009611 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0031526 GO:0035005 GO:0036092 GO:0040016 GO:0043560 GO:0045171 GO:0046854 GO:0046934 GO:0048015 GO:0060055
13	0.06	0.323	6.91	0.05	0.53	4ajwA	GO:0000166 GO:0001782 GO:0002250 GO:0002376 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006935 GO:0006954 GO:0007166 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030154 GO:0030335 GO:0035005 GO:0036092 GO:0042113 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0048872 GO:0050832
14	0.06	0.334	6.70	0.07	0.54	5dxuA	GO:0000166 GO:0001779 GO:0001816 GO:0002250 GO:0002376 GO:0002551 GO:0002679 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0005942 GO:0006468 GO:0006661 GO:0006935 GO:0006954 GO:0007165 GO:0010628 GO:0010818 GO:0014065 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030101 GO:0030154 GO:0030217 GO:0030335 GO:0030593 GO:0035004 GO:0035005 GO:0035747 GO:0035754 GO:0036092 GO:0042110 GO:0042113 GO:0042629 GO:0043303 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0050852 GO:0050853 GO:0060374 GO:0072672
15	0.06	0.329	6.72	0.03	0.52	4d0lE	GO:0000139 GO:0000166 GO:0004430 GO:0005524 GO:0005737 GO:0005739 GO:0005741 GO:0005768 GO:0005783 GO:0005794 GO:0005829 GO:0006661 GO:0006898 GO:0007165 GO:0012505 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0030867 GO:0046854 GO:0048015 GO:0048471 GO:0071889
16	0.06	0.266	6.21	0.02	0.40	4jlqA	GO:0000059 GO:0000060 GO:0005634 GO:0005737 GO:0005829 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0016032 GO:0031965 GO:0034399 GO:0043488 GO:0044822 GO:0070062 GO:0072372
17	0.06	0.310	6.95	0.05	0.50	4ovuA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
18	0.06	0.330	6.84	0.05	0.54	3qjzA	GO:0000166 GO:0001525 GO:0001816 GO:0001932 GO:0002250 GO:0002376 GO:0002407 GO:0002675 GO:0002679 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0005942 GO:0005944 GO:0006468 GO:0006661 GO:0006897 GO:0006935 GO:0006954 GO:0007186 GO:0007204 GO:0010818 GO:0010897 GO:0014065 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0030593 GO:0032252 GO:0033628 GO:0035004 GO:0035005 GO:0035747 GO:0036092 GO:0042098 GO:0042110 GO:0042629 GO:0043085 GO:0043303 GO:0043406 GO:0045087 GO:0046854 GO:0046875 GO:0046934 GO:0048015 GO:0051897 GO:0055118 GO:0070527 GO:0071320 GO:0072672 GO:0097284 GO:1903169 GO:2000270

Consensus prediction of GO terms

Molecular Function	GO:0046872
GO-Score	0.41
Biological Processes	GO:0015992	GO:0036092	GO:0046854	GO:0035725	GO:0043542	GO:0050852	GO:0045022	GO:2000811	GO:0001525	GO:0097009	GO:0034162	GO:0038096	GO:0031295	GO:0014066	GO:0032147	GO:0001889	GO:2000653	GO:0060612	GO:0040014	GO:0007173	GO:0044029	GO:0030168	GO:2000270	GO:0043524	GO:0038028	GO:0042149	GO:0000045	GO:0043201	GO:0048010	GO:0060048	GO:0010468	GO:0043491	GO:0043457	GO:0050708	GO:0050900	GO:0007032	GO:0033138	GO:0098779	GO:0038128	GO:0016485	GO:0032465	GO:0071333	GO:0038095	GO:0006006
GO-Score	0.12	0.12	0.12	0.07	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0016021
GO-Score	0.41

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.