I-TASSER results

Input Sequence in FASTA format

>protein (229 residues)
MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVLLVVEGVAINFWLLRRD
SVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRDFNRDSREVVHLATGMAET
VASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLARRGVTAQAATLAAGVEAIGP
SAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGWLVLDVTPINAR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVLLVVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRDFNRDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLARRGVTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGWLVLDVTPINAR
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHCCCEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEHCCCEEEEEEEEEEEEHCCCCCCCCCEEEEEEEEEEHCCEEEEEEEHCCCCC
Conf.Score	9846677888888999999999999999986578999999999999988665567776566555678888647899999999999999998765456456789999999999999997887633788578899999997898999999999999999999979679999988899996599699999998898679989865456899999998897998666656789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVLLVVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRDFNRDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLARRGVTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGWLVLDVTPINAR
Prediction	7432010000110321020002100100311111000001000010123201100022240143143572320200000111111221221011213344453452244025204520330120337314531540363025612540362155025404756143404133101431366301000001103347654454422202010434644010441442668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHCCCEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEHCCCEEEEEEEEEEEEHCCCCCCCCCEEEEEEEEEEHCCEEEEEEEHCCCCC
MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVLLVVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRDFNRDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLARRGVTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGWLVLDVTPINAR

4i4kA

0.09

0.05

0.54

0.99

wPPAS

-------------------------------------------------------------------------------------------------STDSAPDAALAAVAALPARIVAAWADHDADRFADVFAE--TILPGLFRENIRTHAAAFAGPYKG----TRVIGSPIDARLLGDGIALLITEGGILAPGETEASGDGAVRASWLAVEQDGQWRLAAYQ--SPR

4ke2A

0.14

0.10

0.70

1.10

dPPAS2

ASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVAS------AAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------------------------------

4ke2A

0.19

0.16

0.83

1.07

PPAS

MN----PAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP----------------------------------

3wz4A

0.08

0.04

0.52

0.96

wPPAS

-------------------------------------------------------------------------------------------------------HQSDSAVLQWANQAAIAAFTYNFVNYRDELQASSGFFTDQFLGALEQS--NNLDAVKAKKLVVSAVATRAPIILQKGRYSWRVQPILVTYQSASEFTQ--QNNVVTLITRVSG-IGISQFVVGPA-

5d9rA

0.14

0.07

0.48

0.95

wPPAS

----------------------------------------------------------------------------------------------------------SEALARTAENIVSKWQKFGPD----RIEMLPEVLDGRMLKIWTDRAAETAQL-----TLLKLSVDSVTVSA-DGTRALVEATLEESAC-DLVHPENNTYTTRYEVFWSKSGWKITEGSVL---

3gzrA

0.13

0.07

0.50

0.95

wPPAS

-------------------------------------------------------------------------------------------------------GEGTDAIQALIQAYFTAWNTNA-------PERFAEIFWPD-RDQIVFAHTAFLKTIFKD---CKQELVTIEARTIAPGSALAVVTLIQDYVTPDGRQPRAHDRLTLLAVEREGVWRFIHGH-VNPD

4bwzA2

0.13

0.11

0.85

0.74

MUSTER

LKDILAVGKEAFLVAVLGVALPFLGGYLYGLEIFTLPALFLGTALVATSVGITAVLQELGVL------SRPYSRIILGAAVIDDVLGLIVLACVNGVALSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGA-------------VNEEEYAIVLFMVVFTT-------FAPFALKPLIAWTERE--------RAAK

4ke2A

0.15

0.13

0.85

0.88

dPPAS

NIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP----------------------------------

5ig4A

0.13

0.07

0.55

0.94

wdPPAS

-----------------------------------------------------------------------------------------------------TAKVREQEIIRLTQKLITSITTGDYDTYSKLVDPHVTCFEPFSNGNLVEGLEFHKFYFDNSKVPINTTILSPHVHVLGEDAACICYMRLTQSVNSSGEAKTLQQEETRVWQKKGGNWINVHFH--SGK

4bwzA2

0.13

0.11

0.84

0.77

wMUSTER

LKDILAVGKEAFLVAVLGVALPFLGGYLYGLEIFTLPALFLGTALVATSVGITAVLQELGVL---SRPYSRIILGAAVIDDVLGLIVLACVNGVASALASPVVLVAGTVVTVIAILGKVLGGFL----GALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGA-------------VNEEEYAIVLFMVVFTT-------FAPFAL---------KPLIAWTEERAAK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.76

Estimated TM-score = 0.31±0.10

Estimated RMSD = 14.7±3.6Å

Download Model 2

C-score=-3.79

Download Model 3

C-score=-3.70

Download Model 4

C-score=-4.31

Download Model 5

C-score=-4.16

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cnlA	0.490	2.02	0.089	0.541
2	3soaA	0.485	4.52	0.087	0.672
3	3wz4A	0.484	1.85	0.115	0.528
4	4xzzA	0.473	4.22	0.072	0.642
5	4a01A	0.472	5.20	0.049	0.716
6	4o3vA	0.470	2.51	0.041	0.537
7	2cc3A	0.470	2.56	0.104	0.546
8	4mt1A	0.468	5.60	0.080	0.760
9	3pjzA	0.465	4.97	0.043	0.686
10	4lsoA	0.463	2.54	0.107	0.533

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	8	3ov4C	EQU	Rep, Mult	117,151,189,191,193,203,205,207,223,228
2	0.04	2	4f8hA	LMD	Rep, Mult	84,87
3	0.04	2	2c88A	NA	Rep, Mult	73,74,75,76
4	0.04	2	2q69A	CA	Rep, Mult	63,64,65
5	0.04	2	5ezmA	MPG	Rep, Mult	113,116
6	0.02	1	3attA	MG	Rep, Mult	53,67
7	0.02	1	3c9iE	XE	Rep, Mult	187,207
8	0.02	1	3b6cA	SDN	Rep, Mult	22,25,27,42,46,69,70,72
9	0.02	1	1dlmB	LIO	Rep, Mult	78,123
10	0.02	1	3ar3A	PTY	Rep, Mult	83,86,90,94
11	0.02	1	3k7tA	GP7	Rep, Mult	71,72
12	0.02	1	3udtB	MG	Rep, Mult	184,222
13	0.02	1	2vn9A	GVD	Rep, Mult	171,172,173,188,205,207,227
14	0.02	1	4akyA	4LL	Rep, Mult	121,122,123,124,148,158,191,205,225
15	0.02	1	3hxtA	MG	Rep, Mult	211,213

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2v7oA	0.321	5.48	0.024	0.507	2.7.11.17	NA
2	0.060	1ethA	0.422	5.57	0.045	0.703	3.1.1.3	NA
3	0.060	2vf4X	0.420	5.22	0.041	0.677	2.6.1.16	119
4	0.060	2vxoB	0.433	5.91	0.058	0.760	6.3.5.2	NA
5	0.060	1eulA	0.440	5.66	0.032	0.729	3.6.3.8	NA
6	0.060	1lpaB	0.423	5.60	0.051	0.707	3.1.1.3	107,113
7	0.060	3ixzA	0.457	5.57	0.074	0.764	3.6.3.10	NA
8	0.060	2vk6A	0.422	5.49	0.057	0.672	3.2.1.18	NA
9	0.060	1oygA	0.455	5.01	0.036	0.707	2.4.1.10	NA
10	0.060	1f1uA	0.422	5.94	0.045	0.742	1.13.11.15	NA
11	0.060	1t3qB	0.430	5.82	0.086	0.738	1.3.99.17	NA
12	0.060	1ezmA	0.429	5.65	0.035	0.716	3.4.24.26	NA
13	0.060	1hplA	0.412	5.95	0.056	0.699	3.1.1.3	NA
14	0.060	1n1hA	0.430	5.01	0.034	0.668	2.7.7.48	119
15	0.060	1y9mA	0.378	5.48	0.051	0.611	3.2.1.80	NA
16	0.060	2gtqA	0.422	6.06	0.055	0.734	3.4.11.2	NA
17	0.060	1sqdA	0.436	5.79	0.063	0.755	1.13.11.27	132
18	0.060	3cskA	0.459	5.39	0.032	0.755	3.4.14.4	167
19	0.060	2j5wA	0.426	6.32	0.064	0.790	1.16.3.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.14	0.496	2.07	0.11	0.55	3wz4G	GO:0016020 GO:0016021
1	0.10	0.421	3.37	0.15	0.53	2ux0A	GO:0000082 GO:0000165 GO:0000166 GO:0004672 GO:0004674 GO:0004683 GO:0004723 GO:0005088 GO:0005516 GO:0005524 GO:0005654 GO:0005829 GO:0005886 GO:0006468 GO:0006470 GO:0006816 GO:0007275 GO:0007399 GO:0014733 GO:0016020 GO:0016301 GO:0016310 GO:0016529 GO:0016740 GO:0030073 GO:0030154 GO:0030666 GO:0033017 GO:0042803 GO:0043547 GO:0046777 GO:0051259 GO:0051924 GO:0060333 GO:0097481 GO:1900034 GO:1901897
2	0.08	0.419	3.14	0.10	0.52	5ig4E	GO:0000166 GO:0004672 GO:0004674 GO:0004683 GO:0005516 GO:0005524 GO:0006468 GO:0016301 GO:0016310 GO:0016740
3	0.07	0.485	4.52	0.09	0.67	3soaA	GO:0000082 GO:0000165 GO:0000166 GO:0002931 GO:0004672 GO:0004674 GO:0004683 GO:0005088 GO:0005516 GO:0005524 GO:0005634 GO:0005654 GO:0005739 GO:0005829 GO:0005886 GO:0006468 GO:0006816 GO:0007223 GO:0010666 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0030054 GO:0030666 GO:0035254 GO:0038166 GO:0042734 GO:0042803 GO:0043547 GO:0045202 GO:0046777 GO:0046928 GO:0048168 GO:0051092 GO:0051928 GO:0060333 GO:0097481 GO:1900034 GO:1902108
4	0.07	0.473	4.22	0.07	0.64	4xzzA	GO:0016740
5	0.06	0.447	3.40	0.15	0.57	5ig5F	GO:0000166 GO:0004672 GO:0004674 GO:0004683 GO:0005516 GO:0005524 GO:0006468 GO:0016301 GO:0016310 GO:0016740
6	0.06	0.416	3.12	0.11	0.51	2f86B	GO:0000165 GO:0000166 GO:0004672 GO:0004674 GO:0004683 GO:0005516 GO:0005524 GO:0005737 GO:0006468 GO:0010628 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0018107 GO:0030424 GO:0042995 GO:0043005 GO:0043204 GO:0044325 GO:0046872 GO:0072375 GO:1904115
7	0.06	0.410	3.32	0.09	0.51	5ig0A	GO:0000166 GO:0004672 GO:0004674 GO:0004683 GO:0005516 GO:0005524 GO:0006468 GO:0016301 GO:0016310 GO:0016740
8	0.06	0.423	3.19	0.11	0.53	3h51A	GO:0004683 GO:0005516 GO:0006468
9	0.06	0.414	3.16	0.09	0.52	2w2cH	GO:0000082 GO:0000165 GO:0000166 GO:0001558 GO:0001666 GO:0002026 GO:0002028 GO:0003254 GO:0004672 GO:0004674 GO:0004683 GO:0005088 GO:0005516 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006357 GO:0006468 GO:0006816 GO:0008016 GO:0010389 GO:0010613 GO:0010649 GO:0010666 GO:0010880 GO:0010881 GO:0014704 GO:0014911 GO:0016020 GO:0016301 GO:0016310 GO:0016529 GO:0016740 GO:0018105 GO:0018107 GO:0019871 GO:0030007 GO:0030315 GO:0030666 GO:0031432 GO:0031594 GO:0032469 GO:0033017 GO:0034704 GO:0035022 GO:0042383 GO:0042803 GO:0043025 GO:0043194 GO:0043234 GO:0043547 GO:0044325 GO:0046777 GO:0048471 GO:0048661 GO:0050998 GO:0051259 GO:0055119 GO:0060048 GO:0060314 GO:0060333 GO:0060341 GO:0061049 GO:0070374 GO:0071277 GO:0086003 GO:0086091 GO:0098901 GO:0098909 GO:1900034 GO:1901725 GO:1901844 GO:1901897 GO:1902306 GO:1902514 GO:2000650
10	0.06	0.288	5.86	0.05	0.48	3nr9B	GO:0000166 GO:0004672 GO:0004674 GO:0004712 GO:0004713 GO:0005524 GO:0005634 GO:0005654 GO:0006468 GO:0010033 GO:0010212 GO:0016301 GO:0016310 GO:0016607 GO:0016740 GO:0018108 GO:0032526 GO:0043484 GO:0045721 GO:0046777
11	0.06	0.360	6.15	0.05	0.65	1qcfA	GO:0000166 GO:0002376 GO:0002522 GO:0002758 GO:0004672 GO:0004713 GO:0004715 GO:0005102 GO:0005524 GO:0005634 GO:0005737 GO:0005764 GO:0005794 GO:0005829 GO:0005856 GO:0005884 GO:0005886 GO:0005901 GO:0005925 GO:0006468 GO:0006887 GO:0006909 GO:0006954 GO:0007155 GO:0007169 GO:0007229 GO:0007498 GO:0008284 GO:0008360 GO:0016020 GO:0016023 GO:0016032 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0019221 GO:0030054 GO:0030133 GO:0030154 GO:0030838 GO:0031234 GO:0031410 GO:0031663 GO:0038083 GO:0038096 GO:0042995 GO:0043066 GO:0043299 GO:0045087 GO:0045728 GO:0046777 GO:0050690 GO:0050727 GO:0050764 GO:0051090 GO:0060333 GO:0071801 GO:2000251
12	0.06	0.338	5.37	0.05	0.54	3my0N	GO:0000166 GO:0001525 GO:0001701 GO:0001936 GO:0001937 GO:0001938 GO:0001946 GO:0001955 GO:0001974 GO:0002043 GO:0004672 GO:0004674 GO:0004675 GO:0004702 GO:0005024 GO:0005025 GO:0005524 GO:0005886 GO:0005887 GO:0006275 GO:0006355 GO:0006468 GO:0007162 GO:0007165 GO:0007178 GO:0007179 GO:0008015 GO:0008217 GO:0008285 GO:0009986 GO:0010596 GO:0010862 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016361 GO:0016740 GO:0019901 GO:0023014 GO:0030308 GO:0030336 GO:0030425 GO:0030509 GO:0030513 GO:0032332 GO:0032924 GO:0035313 GO:0043025 GO:0043535 GO:0043537 GO:0045602 GO:0045603 GO:0045766 GO:0045893 GO:0045944 GO:0046332 GO:0046872 GO:0048185 GO:0048514 GO:0050431 GO:0051291 GO:0051895 GO:0060836 GO:0060840 GO:0060841 GO:0061154 GO:0061298 GO:0071560 GO:0071773 GO:0098821 GO:2000279
13	0.06	0.290	5.78	0.07	0.48	4wb7A	GO:0000086 GO:0000166 GO:0001671 GO:0001707 GO:0001843 GO:0002027 GO:0002223 GO:0003091 GO:0004672 GO:0004674 GO:0004691 GO:0004712 GO:0005524 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005739 GO:0005794 GO:0005813 GO:0005829 GO:0005886 GO:0005913 GO:0005929 GO:0005952 GO:0006397 GO:0006457 GO:0006468 GO:0006986 GO:0007596 GO:0008284 GO:0010881 GO:0016020 GO:0016301 GO:0016310 GO:0016607 GO:0016740 GO:0018105 GO:0018107 GO:0019901 GO:0030544 GO:0031514 GO:0031588 GO:0031594 GO:0031625 GO:0032403 GO:0032781 GO:0034199 GO:0034237 GO:0034704 GO:0035584 GO:0042157 GO:0042995 GO:0043005 GO:0043234 GO:0043393 GO:0043457 GO:0044853 GO:0045667 GO:0046777 GO:0046827 GO:0048240 GO:0048471 GO:0050804 GO:0051082 GO:0051085 GO:0051087 GO:0051117 GO:0051447 GO:0051480 GO:0051966 GO:0055117 GO:0060314 GO:0061136 GO:0070062 GO:0070389 GO:0070613 GO:0071158 GO:0071333 GO:0071374 GO:0071377 GO:0071872 GO:0086064 GO:0090084 GO:0097225 GO:0097546 GO:0098609 GO:0098641 GO:1900034 GO:1901621 GO:1903779 GO:2000810
14	0.06	0.360	5.37	0.04	0.57	4nifA	GO:0000166 GO:0000287 GO:0004672 GO:0004674 GO:0004712 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006468 GO:0006915 GO:0007049 GO:0007165 GO:0016301 GO:0016310 GO:0016740 GO:0030307 GO:0035556 GO:0043027 GO:0043066 GO:0043154 GO:0043555 GO:0043620 GO:0045597 GO:0045944 GO:0046872 GO:0072574 GO:2000491
15	0.06	0.337	6.41	0.06	0.62	4y5sA	GO:0016491 GO:0051213 GO:0055114 GO:1902181
16	0.06	0.355	5.35	0.06	0.56	4d9uA	GO:0000166 GO:0000287 GO:0001501 GO:0002224 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006468 GO:0006915 GO:0007049 GO:0007165 GO:0007417 GO:0016301 GO:0016310 GO:0016740 GO:0019901 GO:0030307 GO:0032496 GO:0035556 GO:0043027 GO:0043066 GO:0043154 GO:0043555 GO:0043620 GO:0045597 GO:0045944 GO:0046872
17	0.06	0.328	6.20	0.02	0.59	1q8zB	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0006376 GO:0006468 GO:0006873 GO:0016301 GO:0016310 GO:0016740 GO:0030003 GO:0042307 GO:0042493
18	0.06	0.377	5.39	0.05	0.60	4ix3B	GO:0000166 GO:0004672 GO:0005524 GO:0006468

Consensus prediction of GO terms

Molecular Function	GO:0004674	GO:0035639	GO:0032550	GO:0032559	GO:0046983	GO:0042802	GO:0005085
GO-Score	0.45	0.45	0.45	0.45	0.31	0.31	0.31
Biological Processes	GO:0071346	GO:0034605	GO:0043087	GO:0019221	GO:0044772	GO:0023014	GO:0080135	GO:0035556	GO:0044843	GO:0051345	GO:0070838
GO-Score	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31
Cellular Component	GO:0031981	GO:0030139	GO:0098805	GO:0097458	GO:0098588	GO:0099572	GO:0030659	GO:0071944	GO:0060076
GO-Score	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv0200

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]