I-TASSER results

I-TASSER results for job id Rv0199

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (219 residues)
MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGIASTLLGVLSVAAVVLG
AMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDASLQRLHDGTVGQLNTDFDA
VVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAARPVVTTKLPPFATRTDSVLLV
ATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESIR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGIASTLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDASLQRLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAARPVVTTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESIR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHCCCCCCCCCEEEEEEEEEEEHCCEEEEHCCEHCC
Conf.Score	998888888877777788888777788878877778765467999999999999999999999987768899999999999999999999876886568999999998798699999999999999999997978999999899999758876544444556666667777765799999998765788888755789999999989989886667779
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGIASTLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDASLQRLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAARPVVTTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESIR
Prediction	655675566646665565655666666666465554432322100100000011212320111023234444445333402410241022011133730351044027313350364146316402510574634240413410022235544444444444444544544442210000113245555475544302020204547341203514438
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHCCCCCCCCCEEEEEEEEEEEHCCEEEEHCCEHCC
MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGIASTLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDASLQRLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAARPVVTTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESIR

3wz4A

0.13

0.07

0.55

1.24

wPPAS

-------------------------------------------------------------------------HQSDSAVLQWANQAAIAAFTYNFVNYRDELQASSGFFTDQFLGALEQS--NNLDAVKAKKLVVSAVATRAPIILQKG-------------------NGRYSWRVQPILVTYQSASEFT---QQNNVVTLITRVSG-IGISQFGPA-

4ke2A

0.13

0.11

0.88

1.38

dPPAS2

PAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------

4ke2A

0.14

0.12

0.88

1.21

PPAS

MNIDPAARAAAAAAASKAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------

5d9rA

0.09

0.05

0.58

1.04

Env-PPAS

-----------------------------------------------------------------SEALPRMDARTAENIVSKWQKIKSLAFGPDHR-----IEMLPEVLDGRMLKIWTDRAAETAQLG----LVYDYTLLKLSVDSVT-----------------VSADGTRALVEATLEESACLSDLVHPENRTYTTRYEVFWSKSGWKITEGSVL-

4i4kA

0.09

0.05

0.58

1.17

wPPAS

----------------------------------------------------------------STDSITSAPDAALAAVAALPARIVAAWADHDADRFADVFAE--TILPGLFRENIRTHAAAFAGPYKG----TRVIGSPIDARLLGDG----------------------IALLITEGGILAPGETEASGDGAVRASWLAVEQDGQWRLAAYQNSP

2nd4A

0.05

0.04

0.75

1.04

dPPAS2

-----------------------GENPSASNQLIQKKYVSWRDAADEANTQVAAHEAEIKEETLRQPGVVAAQQALDKANAIVGHDHEQAVK-----RAQEDYNTAYNEAYNTVRNRYIQVLQQKYIEAAKAQEANRTNEQRIADDIKAQTGKDVTVTKDENGNYVVKDEKGNVVATVDKDGKTVKADAKAG---------------------------

4ovmA

0.07

0.04

0.55

1.01

Env-PPAS

----------------------------------------------------------------------RDVTAVADVPRREA------WASNDASAFASLFAPDGTVLPGDVFQKGVDGIREFTKCYAGPYKGTSVFGVPIDVRFTGPD-----------------------TAILITQGGVAPGEHSVAPDKEIRATWVLGKRDGAWLVEAYSPVR

5d9rA

0.12

0.06

0.52

1.16

wPPAS

----------------------------------------------------------------------------SEALARTAENIVSKWQK-DHR-----IEMLPEVLDGRMLKIWTDRAAETAQL-----LVYDYTLLKLSVDSVT-----------------VSADGTRALVEATLEESAC-LVHPENNARTYTTRYEVFWSKSGWKITEGSVL-

3wz4A

0.11

0.06

0.58

1.02

dPPAS2

-------------------------------------------------------------------------HQSDSAVLQWANQAAIAAFTYNFVNYRDELQASSGFFTDQFLGALEQS--NNLDAVKAKKLVVSAVATRAPIILQKGVLNGRYSWRVQPILVTYQSASEFTQQNNVVTLITRVSTLNSPRGSQFVVGPA-----------------

5cnlA

0.08

0.05

0.54

1.16

wPPAS

------------------------------------------------------------------------GGPDRAQLAVWANEAIIATYTFDYKNYQQQKEIAKY--SIAYSKALNQS---LPEVVQKNAYFVNAVATEPPKLITLD---------------------PTHWQAIPILVVYKNPQYEQK--QNLKVVLGFTVASG-FSVTSLTPIS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.22

Estimated TM-score = 0.35±0.12

Estimated RMSD = 13.1±4.1Å

Download Model 2

C-score=-3.75

Download Model 3

C-score=-5.00

Download Model 4

C-score=-4.55

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3k5bA	0.488	3.51	0.111	0.585
2	4ke2A	0.460	2.94	0.106	0.548
3	4i5sA	0.453	4.32	0.090	0.607
4	2w6dA	0.449	4.49	0.026	0.644
5	1sjjA	0.449	4.56	0.039	0.626
6	4ltbA	0.443	3.51	0.056	0.562
7	5ebzA3	0.442	4.09	0.070	0.571
8	1w27A	0.441	4.72	0.067	0.653
9	3p8cA	0.438	5.49	0.046	0.717
10	4aurA	0.433	4.50	0.045	0.598

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1t2kD	NUC	Rep, Mult	13,14,20,21,24
2	0.04	2	2a6eD	MG	Rep, Mult	205,207,210
3	0.04	2	4ev6D	MG	Rep, Mult	14,18
4	0.04	2	2w6dA	GDP	Rep, Mult	89,90,93,94,125
5	0.04	2	3r6nB	D1D	Rep, Mult	103,104,107,118,121
6	0.04	2	2onk2	III	Rep, Mult	105,106,107,108,110,111,112,120,124
7	0.04	2	4eotA	NUC	Rep, Mult	21,22,26,29,30,33
8	0.04	2	3a0bZ	CLA	Rep, Mult	54,57
9	0.02	1	1m34A	SF4	Rep, Mult	91,92
10	0.02	1	2p9i3	III	Rep, Mult	46,48,49,51,53,54,56,58
11	0.02	1	1zyrN	STD	Rep, Mult	45,48,49,53
12	0.02	1	2w6dB	CPL	Rep, Mult	94,95,128,129,131
13	0.02	1	3ojaB	MAN	Rep, Mult	29,32
14	0.02	1	3wmn2	BCL	Rep, Mult	44,48
15	0.02	1	2a69A	MG	Rep, Mult	215,216
16	0.02	1	1cb2A	MAN	Rep, Mult	112,116
17	0.02	1	3hd7F	GGG	Rep, Mult	71,74
18	0.02	1	3swfB	ZN	Rep, Mult	18,22

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3i9wA	0.393	4.83	0.056	0.552	2.7.13.3	120,137,214
2	0.060	3b8eC	0.393	4.90	0.056	0.575	3.6.3.9	84,144
3	0.060	2iw5A	0.380	5.42	0.034	0.626	1.-.-.-	NA
4	0.060	3a1cB	0.252	5.72	0.037	0.429	3.6.3.-	205
5	0.060	2nztA	0.363	5.30	0.038	0.562	2.7.1.1	NA
6	0.060	1o7hB	0.376	4.28	0.073	0.530	1.14.12.12	83,96
7	0.060	2np0A	0.322	5.09	0.034	0.493	3.4.24.69	NA
8	0.060	3btaA	0.396	5.93	0.040	0.690	3.4.24.69	NA
9	0.060	3errA	0.381	5.79	0.021	0.621	6.1.1.11	NA
10	0.060	3b8eA	0.368	5.88	0.074	0.644	3.6.3.9	NA
11	0.060	2vuaA	0.326	5.41	0.033	0.539	3.4.24.69	NA
12	0.060	3e99A	0.379	3.71	0.065	0.507	1.14.12.10	NA
13	0.060	1qhaA	0.351	5.48	0.034	0.566	2.7.1.1	NA
14	0.060	1mc0A	0.351	4.98	0.065	0.552	3.1.4.17	118
15	0.060	1y2mB	0.409	4.83	0.050	0.621	4.3.1.24	147
16	0.060	2uv8G	0.355	6.33	0.054	0.671	2.3.1.86	NA
17	0.060	3g61A	0.373	5.83	0.056	0.621	3.6.3.44	95,106,108
18	0.060	1serB	0.331	6.04	0.041	0.575	6.1.1.11	NA
19	0.060	3b8cB	0.385	5.10	0.055	0.598	3.6.3.6	111

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.404	3.84	0.08	0.53	3v6iA	GO:0005524 GO:0006754 GO:0006810 GO:0006811 GO:0015991 GO:0015992 GO:0033178 GO:0042777 GO:0046933 GO:0046961
1	0.06	0.419	5.12	0.05	0.64	4i5sB	GO:0000155 GO:0000160 GO:0000166 GO:0005524 GO:0005622 GO:0006355 GO:0007165 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0023014
2	0.06	0.355	5.40	0.04	0.58	4gczB	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0007165 GO:0009399 GO:0009881 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0018298 GO:0023014 GO:0046872 GO:0050896
3	0.06	0.300	6.10	0.04	0.55	3ndaA	GO:0005615
4	0.06	0.322	4.17	0.03	0.43	4ctiD	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004721 GO:0004871 GO:0005524 GO:0005622 GO:0005886 GO:0005887 GO:0006470 GO:0007165 GO:0009898 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0023014 GO:0046777 GO:0047484
5	0.06	0.314	4.75	0.04	0.47	4bivA	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004871 GO:0005524 GO:0005622 GO:0005886 GO:0007165 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0023014 GO:0043708 GO:0046777
6	0.06	0.233	5.37	0.04	0.37	2zdxA	GO:0000166 GO:0002230 GO:0004672 GO:0004740 GO:0005524 GO:0005739 GO:0005743 GO:0005759 GO:0005975 GO:0006006 GO:0006468 GO:0006885 GO:0008286 GO:0009267 GO:0010510 GO:0010565 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0042304 GO:0042593 GO:0042594 GO:0045124 GO:0046320 GO:0071398 GO:0072593 GO:0098792 GO:2000811
7	0.06	0.260	5.51	0.02	0.43	3crlB	GO:0000166 GO:0004674 GO:0004740 GO:0005524 GO:0005739 GO:0005759 GO:0005967 GO:0005975 GO:0006006 GO:0006111 GO:0006468 GO:0006885 GO:0008286 GO:0010510 GO:0010565 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0031670 GO:0032403 GO:0042593 GO:0042803 GO:0045254 GO:0046982
8	0.06	0.271	5.39	0.05	0.43	3d36B
9	0.06	0.243	5.85	0.03	0.41	3d2rB	GO:0000166 GO:0002230 GO:0004672 GO:0004740 GO:0005524 GO:0005739 GO:0005743 GO:0005759 GO:0005975 GO:0006006 GO:0006468 GO:0006885 GO:0008286 GO:0009267 GO:0010510 GO:0010565 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0042304 GO:0042593 GO:0042594 GO:0045124 GO:0046320 GO:0071398 GO:0072593 GO:0098792 GO:2000811
10	0.06	0.260	5.68	0.04	0.44	1hynQ	GO:0003779 GO:0005215 GO:0005452 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006820 GO:0006821 GO:0006873 GO:0008022 GO:0008509 GO:0015106 GO:0015108 GO:0015301 GO:0015701 GO:0016020 GO:0016021 GO:0016323 GO:0019899 GO:0030018 GO:0030506 GO:0030863 GO:0042803 GO:0043495 GO:0051453 GO:0070062 GO:0072562 GO:1902476
11	0.06	0.272	5.56	0.03	0.45	1y8pA	GO:0000166 GO:0004672 GO:0004674 GO:0004740 GO:0005524 GO:0005739 GO:0005759 GO:0005975 GO:0006006 GO:0010510 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0035357 GO:0071333 GO:0071398 GO:0097411 GO:2000377
12	0.06	0.222	5.38	0.05	0.36	4kp4A	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004721 GO:0004871 GO:0005524 GO:0005622 GO:0005886 GO:0005887 GO:0006470 GO:0007165 GO:0009898 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0023014 GO:0046777 GO:0047484
13	0.06	0.231	5.62	0.03	0.37	3lmmD	GO:0005524
14	0.06	0.286	5.25	0.07	0.44	4lrxC	GO:0000166 GO:0003677 GO:0005524 GO:0006071 GO:0006351 GO:0006355 GO:0008134 GO:0043565
15	0.06	0.233	4.58	0.04	0.32	1l0oA	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0006468 GO:0010468 GO:0016301 GO:0016310 GO:0016740 GO:0016989 GO:0030435 GO:0030436 GO:0045892
16	0.06	0.248	5.71	0.05	0.42	3a0rA	GO:0000155 GO:0000160 GO:0000166 GO:0005524 GO:0005622 GO:0006355 GO:0007165 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0023014
17	0.06	0.221	6.59	0.05	0.42	4p7aA	GO:0000289 GO:0000712 GO:0000793 GO:0000794 GO:0000795 GO:0001673 GO:0002204 GO:0003682 GO:0003697 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0005712 GO:0006281 GO:0006298 GO:0006303 GO:0006974 GO:0007049 GO:0007060 GO:0007126 GO:0007129 GO:0007131 GO:0007140 GO:0007283 GO:0008630 GO:0016020 GO:0016321 GO:0016446 GO:0016447 GO:0016887 GO:0030983 GO:0032137 GO:0032389 GO:0032407 GO:0043060 GO:0045132 GO:0045141 GO:0045143 GO:0045190 GO:0045950 GO:0048477 GO:0051257
18	0.06	0.226	4.90	0.07	0.34	3cgzA	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004721 GO:0004871 GO:0005524 GO:0005622 GO:0005886 GO:0006470 GO:0007165 GO:0009405 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016787 GO:0018106 GO:0023014 GO:0040008 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0032550	GO:0035639	GO:0032559	GO:0038023	GO:0004673
GO-Score	0.57	0.57	0.57	0.36	0.36
Biological Processes	GO:0044710	GO:0006468	GO:0035556
GO-Score	0.36	0.36	0.36
Cellular Component	GO:0005623
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.