I-TASSER results

Input Sequence in FASTA format

>protein (194 residues)
MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYAG
EHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAVSVEAGDEQDRERMAPVIA
RAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEGAILLARVRRDLTPLDLVHRQ
LRNLLLAELPERSR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAVSVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEGAILLARVRRDLTPLDLVHRQLRNLLLAELPERSR
Prediction	CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
Conf.Score	96599999999999999989878899999999899956677768988999999999999999999998689999999999999999998568778968887777658899788899999999999999999999999985998656999999999999999999997699899999999999999997675559
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAVSVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEGAILLARVRRDLTPLDLVHRQLRNLLLAELPERSR
Prediction	86532540151025103534141010420163161333204323652222000000420253025105636512410220042025214655244110001001011545562234402520450153024103510464725673043003101223210101011352450043015103510563157578
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180

                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYFPGGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAVSVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEGAILLARVRRDLTPLDLVHRQLRNLLLAELPERSR

1sgmA

0.31

0.29

0.93

2.29

MUSTER

-GDSREKILHTASRLSQLQGYHATGLNQIVKESGAPKGSLYHFFPNGKEELAIEAVTYTGKIVEHLIQQSSDPVEAIQLFIKKTASQFDNTESIKGIPVGLLASETALIS-----EPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIMLSLTNKDKTPLLLIAEQIPVLVR--------

1sgmA

0.31

0.29

0.93

2.33

dPPAS

-GDSREKILHTASRLSQLQGYHATGLNQIVKESGAPKGSLYHFFPNGKEELAIEAVTYTGKIVEHLIQQSSDPVEAIQLFIKKTASQFDNTESIKGIPVGLLASETALIS-----EPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIMLSLTNKDKTPLLLIAEQIPVLVR--------

1sgmA

0.31

0.29

0.93

2.84

wdPPAS

-GDSREKILHTASRLSQLQGYHATGLNQIVKESGAPKGSLYHFFPNGKEELAIEAVTYTGKIVEHLIQQSSDPVEAIQLFIKKTASQFDNTESIKGIPVGLLASETALIS-----EPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIMLSLTNKDKTPLLLIAEQIPVLVR--------

1sgmA

0.31

0.29

0.92

2.62

wMUSTER

--DSREKILHTASRLSQLQGYHATGLNQIVKESGAPKGSLYHFFPNGKEELAIEAVTYTGKIVEHLIQQSSDPVEAIQLFIKKTASQFDNTESIKGIPVGLLASETALIS-----EPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIMLSLTNKDKTPLLLIAEQIPVLVR--------

1sgmA

0.32

0.29

0.93

3.11

wPPAS

-GDSREKILHTASRLSQLQGYHATGLNQIVKESGAPKGSLYHFFPNGKEELAIEAVTYTGKIVEHLIQQSSDPVEAIQLFIKKTASQFDNTESIKGIPVGLLASETALIS-----EPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIMLSLTNKDKTPLLLIAEQIPVLV--------R

1sgmA

0.31

0.29

0.93

3.54

dPPAS2

-GDSREKILHTASRLSQLQGYHATGLNQIVKESGAPKGSLYHFFPNGKEELAIEAVTYTGKIVEHLIQQSSDPVEAIQLFIKKTASQFDNTESIKGIPVGLLASETALIS-----EPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIMLSLTNKDKTPLLLIAEQIPVLVR--------

1sgmA

0.31

0.29

0.93

2.77

PPAS

-GDSREKILHTASRLSQLQGYHATGLNQIVKESGAPKGSLYHFFPNGKEELAIEAVTYTGKIVEHLIQQSSDPVEAIQLFIKKTASQFDNTESIKGIPVGLLASETALIS-----EPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIMLSLTNKDKTPLLLIAEQIPVLVR--------

4yzeA

0.18

0.17

0.94

3.83

Env-PPAS

-HDTREHLLATGEQLSLQRGFTGMGLSELLKTAEVPKGSFYHYFR-SKEAFGVAMLERHYAAYHQRLTELGNYRDRILAYYQQTLNQFSQHGTISGCLTVKLSAEVSDLS-----EDMRSAMDKGARGVIALLSQALENGRTFSGEPLQQAQVLYALWLGANLQAKISRSFEPLENALAHVKNIIATPAV----

4yzeA

0.18

0.96

2.16

MUSTER

-HDTREHLLATGEQLSLQRGFTGMGLSELLKTAEVPKGSFYHYFRS-KEAFGVAMLERHYAAYHQRLTELGNYRDRILAYYQQTLNQFSQHGTISGCLTVKLSAEVSDLS-EDMRSAMDKGARGVIALLSQALENGRENHSLTSGEPLQQAQVLYALWLGANLQAKISRSFEPLENALAHVKNIIATPAV----

3rd3A

0.20

0.19

0.94

2.23

dPPAS

--DTRQHLLDTGYRIMAVKGFSGVGLNEILQSAGVPKGSFYHYFK-SKEQFGQALLEDYFRVYLADMDQRLNARERLMSYWQKWLDNACPPCDEQRCLVVKLSAEVADLS-ESMRITLRDGSDGIIERLVGCLGQGRDDGSLAPCDARHMASALYQLWLGASLLSKLHRSPGPLETAMQTTRSLLE--------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 3 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.58

Estimated TM-score = 0.79±0.09

Estimated RMSD = 4.1±2.8Å

Download Model 2

C-score=-2.04

Download Model 3

C-score=-1.43

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1sgmA	0.906	0.83	0.311	0.928
2	4yzeA	0.820	2.22	0.143	0.933
3	3eupA	0.812	2.47	0.196	0.938
4	3bruA	0.806	2.17	0.176	0.902
5	3qbmA	0.790	2.67	0.315	0.928
6	3on4A	0.784	2.21	0.189	0.897
7	3dpjA	0.772	2.57	0.213	0.917
8	2g7sA	0.770	2.43	0.227	0.902
9	3rd3A	0.756	2.54	0.153	0.902
10	3g7rB	0.751	2.65	0.158	0.912

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	20	3q0uA	LL3	Rep, Mult	70,76,77,80,81,122,126,129,132,133,136,155,158,159,162,163,181
2	0.08	14	2uxhB	QUE	Rep, Mult	77,80,81,97,101,133,154,155,158,159,162
3	0.06	10	3frqA	ERY	Rep, Mult	13,17,63,66,80,103,125,126,156
4	0.05	7	1jt0D	QNA	Rep, Mult	3,4,34,35,36,37,41,42
5	0.05	9	1jusA	RHQ	Rep, Mult	56,60,63,66,87,88,93,96,99,125,162,163
6	0.03	4	1jt0C	QNA	Rep, Mult	24,25,26,37,40,47,48
7	0.02	3	3frqB	ERY	Rep, Mult	16,17,59,63,66,87,88,109,110,113,129,130,155,158,159
8	0.02	3	3btjB	DEQ	Rep, Mult	97,100,163,164
9	0.02	3	1zk80	III	Rep, Mult	119,145,148,149,152,153,155,156,159,160,161,163,164,166,167,168,179,180,183,184,186
10	0.02	3	2gbyA	BRN	Rep, Mult	102,126,130,156,159
11	0.01	1	1rkwA	PNT	Rep, Mult	59,62,63,66,80,84,87,88,93,129,155,158,159
12	0.01	2	3lsjB	COA	Rep, Mult	76,140,182,185,186
13	0.01	2	3btjB	DEQ	Rep, Mult	101,104,163,164
14	0.01	1	2eh3A	MG	Rep, Mult	75,78
15	0.01	1	2i10B	NPO	Rep, Mult	122,123,152
16	0.01	1	1bjyA	CTC	Rep, Mult	181,185
17	0.01	1	3qbmA	MG	Rep, Mult	104,107
18	0.01	1	2i10A	NPO	Rep, Mult	167,168,170
19	0.01	2	3lspA	QNA	Rep, Mult	25,26,27,31,41
20	0.01	1	2np5C	NDS	Rep, Mult	106,107,115,119

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1wmaA	0.428	4.35	0.041	0.624	1.1.1.184	NA
2	0.060	1aroP	0.396	5.52	0.046	0.696	2.7.7.6	NA
3	0.060	1syyA	0.431	5.34	0.063	0.701	1.17.4.1	NA
4	0.060	1lj8A	0.436	4.79	0.059	0.696	1.1.1.67	52
5	0.060	1xnyA	0.431	4.52	0.071	0.639	6.4.1.3	NA
6	0.060	1on3E	0.434	4.60	0.058	0.649	2.1.3.1	38
7	0.060	2zzgA	0.440	5.39	0.071	0.747	6.1.1.7	NA
8	0.060	2pulA	0.447	5.33	0.109	0.773	2.7.1.100	NA
9	0.060	1oqzB	0.429	5.36	0.054	0.727	3.5.1.93	22
10	0.060	2d0tB	0.471	5.19	0.018	0.794	1.13.11.52	95
11	0.060	2pffB	0.431	4.83	0.055	0.686	2.3.1.86	20
12	0.060	3c46B	0.375	6.06	0.056	0.701	2.7.7.6	NA
13	0.060	1i1iP	0.442	4.80	0.038	0.644	3.4.24.16	NA
14	0.060	3nztA	0.448	5.94	0.075	0.840	6.3.2.2	NA
15	0.060	2rd0A	0.400	4.59	0.021	0.603	2.7.1.153	NA
16	0.060	1n63B	0.428	5.92	0.060	0.789	1.2.99.2	NA
17	0.060	1uwkA	0.434	5.53	0.048	0.742	4.2.1.49	127
18	0.060	2o36A	0.439	4.72	0.027	0.629	3.4.24.15	159
19	0.060	2ztgA	0.433	5.32	0.037	0.732	6.1.1.7	25,47

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.46	0.809	2.65	0.31	0.95	3qbmA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
1	0.43	0.783	2.43	0.22	0.92	2g7sA	GO:0003677 GO:0006351 GO:0006355
2	0.42	0.906	0.83	0.31	0.93	1sgmA	GO:0003677 GO:0006351 GO:0006355
3	0.41	0.812	2.47	0.20	0.94	3eupA	GO:0003677 GO:0006351 GO:0006355
4	0.38	0.818	2.18	0.17	0.92	3bruA	GO:0003677 GO:0006351 GO:0006355
5	0.38	0.821	2.25	0.16	0.92	4l62A	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355
6	0.36	0.754	2.42	0.15	0.88	3knwA	GO:0003677 GO:0006351 GO:0006355
7	0.35	0.793	2.23	0.19	0.91	3on4A	GO:0003677 GO:0006351 GO:0006355
8	0.35	0.820	2.22	0.14	0.93	4yzeA	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355 GO:0045892
9	0.33	0.721	3.17	0.11	0.91	1jt0A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0045892
10	0.32	0.687	3.14	0.13	0.89	2zcnD	GO:0003677 GO:0006351 GO:0006355
11	0.32	0.683	3.22	0.13	0.89	4aciB	GO:0000287 GO:0003677 GO:0006351 GO:0006355 GO:0046872
12	0.31	0.682	3.39	0.14	0.90	5d18A	GO:0003677 GO:0006351 GO:0006355
13	0.30	0.661	3.86	0.13	0.92	3hggA	GO:0003677 GO:0006351 GO:0006355
14	0.29	0.675	3.69	0.13	0.90	2f07A	GO:0003677 GO:0006351 GO:0006355
15	0.29	0.655	3.47	0.09	0.89	3he0C	GO:0003677 GO:0006351 GO:0006355
16	0.29	0.743	2.99	0.18	0.92	4ichA	GO:0003677 GO:0006351 GO:0006355
17	0.29	0.713	3.06	0.11	0.90	3whcA	GO:0003677 GO:0005737 GO:0006351 GO:0006355 GO:0006629 GO:0006631 GO:0016042
18	0.28	0.640	3.54	0.11	0.85	2q24B	GO:0003677 GO:0006351 GO:0006355
19	0.28	0.636	3.78	0.08	0.87	3qkxA	GO:0003677 GO:0006351 GO:0006355
20	0.28	0.641	3.80	0.14	0.89	4pxiB	GO:0003677 GO:0006351 GO:0006355
21	0.27	0.638	3.67	0.10	0.89	3ppbA	GO:0003677 GO:0006351 GO:0006355
22	0.27	0.647	3.46	0.23	0.85	3bniA	GO:0003677 GO:0006351 GO:0006355
23	0.25	0.656	3.50	0.07	0.86	3vp5A	GO:0003677 GO:0006351 GO:0006355 GO:0046872
24	0.25	0.682	3.42	0.13	0.90	2hytA	GO:0003677 GO:0006351 GO:0006355
25	0.25	0.668	3.81	0.15	0.94	3vibC	GO:0003677 GO:0006351 GO:0006355
26	0.24	0.615	4.25	0.10	0.88	3vprA	GO:0003677 GO:0006351 GO:0006355 GO:0042802
27	0.24	0.676	3.79	0.11	0.92	3lwjA	GO:0003677 GO:0006351 GO:0006355
28	0.23	0.584	4.68	0.14	0.89	2of7A	GO:0003677 GO:0006351 GO:0006355
29	0.23	0.589	4.21	0.09	0.86	4w97A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0010468 GO:0019217
30	0.23	0.665	3.53	0.13	0.89	3mnlA	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355 GO:0042803
31	0.23	0.608	3.12	0.10	0.78	2qwtA	GO:0003677 GO:0006351 GO:0006355
32	0.22	0.615	3.93	0.14	0.87	3s5rA	GO:0003677 GO:0006351 GO:0006355
33	0.22	0.606	4.22	0.13	0.91	3cwrA	GO:0003677 GO:0006351 GO:0006355
34	0.22	0.697	3.12	0.11	0.90	3geuA	GO:0003677 GO:0006351 GO:0006355
35	0.21	0.673	3.24	0.20	0.87	2dg8B	GO:0003677 GO:0006351 GO:0006355
36	0.21	0.559	4.42	0.09	0.81	2np3B	GO:0003677 GO:0006351 GO:0006355
37	0.21	0.676	3.49	0.09	0.89	3f0cA	GO:0003677 GO:0006351 GO:0006355
38	0.21	0.648	3.69	0.11	0.91	2zb9A	GO:0003677 GO:0006351 GO:0006355
39	0.20	0.596	4.09	0.06	0.86	3ccyA	GO:0003677 GO:0006351 GO:0006355
40	0.19	0.549	4.40	0.10	0.81	2ibdA	GO:0003677 GO:0006351 GO:0006355
41	0.19	0.678	3.59	0.13	0.91	3angC	GO:0003677 GO:0006351 GO:0006355
42	0.19	0.692	3.70	0.13	0.95	3p9tA	GO:0003677 GO:0006351 GO:0006355
43	0.19	0.760	2.64	0.16	0.92	3g7rB	GO:0003677 GO:0003700 GO:0006351 GO:0006355
44	0.19	0.547	4.05	0.11	0.78	2iaiA	GO:0003677 GO:0006351 GO:0006355
45	0.19	0.618	3.69	0.07	0.86	3mvpA	GO:0003677 GO:0006351 GO:0006355
46	0.19	0.635	3.66	0.12	0.86	2y31A	GO:0003677 GO:0006351 GO:0006355 GO:0045892
47	0.18	0.709	3.27	0.14	0.91	3bhqA	GO:0003677 GO:0006351 GO:0006355
48	0.18	0.571	4.41	0.08	0.83	3b81A	GO:0003677 GO:0006351 GO:0006355
49	0.17	0.672	3.42	0.11	0.90	2id6A	GO:0003677 GO:0006351 GO:0006355
50	0.17	0.558	4.56	0.10	0.86	3dewA	GO:0003677 GO:0006351 GO:0006355 GO:0016020 GO:0016021
51	0.17	0.636	3.89	0.13	0.90	2genA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
52	0.16	0.644	3.90	0.07	0.91	4jykA	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355 GO:0045892 GO:0045893
53	0.16	0.593	4.01	0.16	0.85	4mxmA	GO:0003677 GO:0006351 GO:0006355
54	0.15	0.646	3.21	0.12	0.86	2eh3A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0046872
55	0.14	0.567	4.66	0.11	0.90	3nrgA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
56	0.11	0.577	4.42	0.08	0.85	4me9A	GO:0003677 GO:0006351 GO:0006355
57	0.10	0.682	3.22	0.16	0.89	2nx4A	GO:0003677 GO:0006351 GO:0006355
58	0.08	0.617	3.54	0.07	0.81	2raeA	GO:0003677 GO:0006351 GO:0006355
59	0.08	0.611	3.86	0.13	0.87	3aqtB	GO:0003677 GO:0006351 GO:0006355
60	0.07	0.650	3.99	0.14	0.91	3c07A	GO:0003677 GO:0006351 GO:0006355
61	0.07	0.611	3.97	0.08	0.85	3dcfA	GO:0003677 GO:0006351 GO:0006355

Consensus prediction of GO terms

Molecular Function	GO:0003677	GO:0003700
GO-Score	0.93	0.46
Biological Processes	GO:0006355
GO-Score	0.93
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv0196

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]