I-TASSER results

I-TASSER results for job id Rv0192

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (366 residues)
MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCWRCRGGPGRGSRRSRR
SRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAGPV
AGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIPPVP
GKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTITRNGV
VQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSDAVRID
NSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGTYNKNDG
AQDWQI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCWRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI
Prediction	CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCEEEHCCCCEEEEEEHCCCCCEEHCEHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCEEHCCCCCCEEEEEHCCCCCEEHCCEEEEEEHCCCCCCHHHHHHHEEEHCCCCCCCEEEEHCCCEEEEHCCCCCCCCCEEEHCCCCEEEEEEHCCCEEEEEHCCCCEEEEEHCCEEEEEEEEEHCCCCCCCCCCCEEEEEEEHCCCEEHCCCCCCCCCCCCCCCCCCCCCEEEHCCCCEEHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCCC
Conf.Score	998876555544555444444455777777778888888888887589975888777888888668866885678999779997665555788876688888888866789999778887655555556787755678866899688765789999689988689987544776589988667886797899974667899857875667857776758958999988987899998999999998765889999999876899999647667668877788999877777776568866995998578888565788888866667998999999998899958999889998887889988889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCWRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI
Prediction	625444542344443333413245344454563545444472445414031453256141655341415715144040427725516141474444142643043535140304154454545442423426433323030454420000000002054316325201530504154536241210444203032551144413132434424231403421001011440201002444101001000033465240230201011235422041431221343342131202000201320100000013234314331010001033710330052054402010202645144520111004
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCEEEHCCCCEEEEEEHCCCCCEEHCEHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCEEHCCCCCCEEEEEHCCCCCEEHCCEEEEEEHCCCCCCHHHHHHHEEEHCCCCCCCEEEEHCCCEEEEHCCCCCCCCCEEEHCCCCEEEEEEHCCCEEEEEHCCCCEEEEEHCCEEEEEEEEEHCCCCCCCCCCCEEEEEEEHCCCEEHCCCCCCCCCCCCCCCCCCCCCEEEHCCCCEEHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCCC
MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGCWRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI

4z7aA

0.28

0.24

0.87

2.59

MUSTER

-----------------------------------LAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLANVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYDGDIWDWAV

4z7aA

0.28

0.24

0.87

3.20

dPPAS

-----------------------------------LAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLANVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYDGDIWDWAV

4z7aA

0.28

0.24

0.87

4.30

wdPPAS

-----------------------------------LAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLRNVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYDGDIWDWAV

4z7aA

0.28

0.24

0.87

3.18

wMUSTER

------------------------------------AEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADARNVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYDGDIWDWAV

4z7aA

0.28

0.24

0.87

4.56

wPPAS

-----------------------------------LAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADARNVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYDGDIWDWAV

4z7aA

0.28

0.24

0.87

6.17

dPPAS2

-----------------------------------LAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLANVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYDGDIWDWAV

4z7aA

0.28

0.24

0.87

3.93

PPAS

-----------------------------------LAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLANVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSADGDIWDWAV

4z7aA

0.28

0.24

0.87

6.22

Env-PPAS

-----------------------------------LAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDERVHWRPREYYPAGTTVDVDAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLANVTRNGIHVVTEKYSDFYMSNPAAG-------YSHIHERWAVRISNNGEFIHANPMN------SNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSADGDIWDWAV

3vaeA

0.47

0.31

0.65

2.17

MUSTER

----------------------------------------------------------------------------------------------------------------------------RYTLNATAHLTMPYVMPGDGEVVGVGEPVAIRFDENIADRGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKPGTAVDVAEDNVQTHFTIGDEVIATADDNTKILTVRVNGEVVKSMPTSMGK--DSTPTANGIYIVGSRYKHIIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVFVHSAPWSVGAQGHTNTSHGL-NVSPSNAQWFYDHVKRGDIVEVVNTVGGLPGIDGLGDWNI

4jmnA

0.45

0.27

0.59

2.84

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------PIPGVASVSPANGAVVGVAHPVVVTFTTPVTDRRAVERSIRISTPHNTTGHFEWVASNVVRWVPHRYWPPHTRVSVGVQELTEGFETGDALIGVASISAHTFTVSRNGEVLRTMPASLGKP--SRPTPIGSFHAMSKERTVVMDSRTIGIPLNSSDGYLLTAHYAVRVTWSGVYVHSAPWSVNSQGYANVSHGCINLSPDNAAWYFDAVTVGDPIEVV-----------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.80

Estimated TM-score = 0.61±0.14

Estimated RMSD = 8.4±4.5Å

Download Model 2

C-score=-1.63

Download Model 3

C-score=-2.71

Download Model 4

C-score=-1.73

Download Model 5

C-score=-2.52

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4z7aA	0.815	2.02	0.283	0.869
2	3vaeA	0.576	2.54	0.458	0.628
3	4jmnA	0.517	2.47	0.417	0.571
4	4k73A	0.496	2.82	0.403	0.563
5	4xvoA	0.489	2.86	0.403	0.557
6	4f91B	0.420	6.40	0.028	0.667
7	1cwvA	0.419	6.18	0.052	0.661
8	4hu2A	0.411	3.04	0.257	0.478
9	2vzvA	0.392	7.12	0.048	0.683
10	4ak1A	0.380	4.47	0.039	0.500

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.17	9	5dccB	58U	Rep, Mult	274,289,303,307,311,322,323,324,325,327
2	0.06	3	3cmvC	ANP	Rep, Mult	150,151,181
3	0.04	2	4qtfA	3V5	Rep, Mult	274,302,303,305,307,323,324,325
4	0.04	2	3psoA	ZN	Rep, Mult	307,325
5	0.04	2	1d4m1	MYR	Rep, Mult	343,344
6	0.02	1	3aruA	PNX	Rep, Mult	327,332,333,336
7	0.02	1	2xgfC	CO3	Rep, Mult	260,261,267
8	0.02	1	4afoB	CO	Rep, Mult	321,323
9	0.02	1	4k73A	CA	Rep, Mult	146,147,341
10	0.02	1	3as2A	POY	Rep, Mult	224,226,229,233,234,235
11	0.02	1	2h0bA	CA	Rep, Mult	227,231,247
12	0.02	1	3pyoL	MG	Rep, Mult	261,268
13	0.02	1	3turB	0JC	Rep, Mult	140,154,342,361

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2nztA	0.340	6.77	0.034	0.560	2.7.1.1	308
2	0.060	1jqmB	0.344	6.86	0.051	0.598	3.6.5.3	NA
3	0.060	1yq2A	0.364	6.84	0.047	0.609	3.2.1.23	NA
4	0.060	2vumB	0.293	7.16	0.042	0.514	2.7.7.6	NA
5	0.060	3btaA	0.371	6.54	0.020	0.601	3.4.24.69	337
6	0.060	3gm8A	0.340	6.99	0.051	0.593	3.2.1.-	245
7	0.060	3dnyT	0.253	7.12	0.064	0.445	3.6.5.3	300
8	0.060	3hz3A	0.347	7.15	0.027	0.615	2.4.1.5	225,238,240
9	0.060	2qf7A	0.363	7.48	0.039	0.672	6.4.1.1	NA
10	0.060	2e28A	0.339	6.82	0.056	0.568	2.7.1.40	329
11	0.060	2vdcA	0.362	7.13	0.048	0.639	1.4.1.13	NA
12	0.060	1edqA	0.371	6.90	0.069	0.645	3.2.1.14	NA
13	0.060	1f13A	0.349	6.64	0.053	0.571	2.3.2.13	307
14	0.060	1efgA	0.266	6.66	0.054	0.432	3.6.5.3	315
15	0.060	1darA	0.312	6.90	0.059	0.527	3.6.5.3	NA
16	0.060	1qhaA	0.279	7.11	0.074	0.494	2.7.1.1	227
17	0.060	1ordA	0.346	6.85	0.018	0.598	4.1.1.17	NA
18	0.060	3gtgB	0.353	6.95	0.016	0.612	2.7.7.6	NA
19	0.060	2je8B	0.363	7.28	0.037	0.658	3.2.1.25	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.43	0.815	2.02	0.28	0.87	4z7aA	GO:0016740
1	0.35	0.737	3.57	0.39	0.87	4qr7A	GO:0005886 GO:0008360 GO:0009252 GO:0016020 GO:0016740 GO:0016746 GO:0046872 GO:0071555
2	0.32	0.517	2.47	0.42	0.57	4jmnA	GO:0005576 GO:0006508 GO:0008360 GO:0009252 GO:0016740 GO:0016746 GO:0018104 GO:0042597 GO:0071555 GO:0071972
3	0.31	0.496	2.82	0.40	0.56	4k73A	GO:0008360 GO:0009252 GO:0016740 GO:0016746 GO:0071555
4	0.31	0.501	2.81	0.42	0.57	4xvoA	GO:0016740
5	0.10	0.310	4.04	0.19	0.37	4xxtA	GO:0004180 GO:0006508 GO:0016740 GO:0016787
6	0.08	0.319	4.21	0.15	0.40	4a52A	GO:0008360 GO:0009252 GO:0016740 GO:0016757 GO:0016787 GO:0030435 GO:0031160 GO:0071555
7	0.06	0.361	3.18	0.20	0.41	2hklA	GO:0016020 GO:0016021 GO:0016740
8	0.06	0.280	6.89	0.05	0.48	1d7fA	GO:0003824 GO:0005576 GO:0005975 GO:0016740 GO:0016757 GO:0030246 GO:0043169 GO:0043895 GO:0046872 GO:2001070
9	0.06	0.297	2.28	0.13	0.32	5bmqA	GO:0016020 GO:0016021 GO:0016740
10	0.06	0.298	2.90	0.11	0.33	4lzhA	GO:0016740
11	0.06	0.239	6.84	0.04	0.41	1rf4A	GO:0003824 GO:0003866 GO:0005737 GO:0008652 GO:0009073 GO:0009423 GO:0016740 GO:0016765
12	0.06	0.168	5.91	0.03	0.26	2c2pA	GO:0004844 GO:0006281 GO:0006285 GO:0008263 GO:0019104
13	0.06	0.102	4.55	0.03	0.14	1fm0D	GO:0000166 GO:0005829 GO:0006777
14	0.06	0.102	4.58	0.04	0.14	3ob9D	GO:0003677 GO:0005634 GO:0005654 GO:0006338 GO:0006342 GO:0006351 GO:0006355 GO:0016568 GO:0016575 GO:0035064 GO:0035267 GO:0043968 GO:0043984 GO:0072487
15	0.06	0.091	3.70	0.06	0.11	1whcA	GO:0000502 GO:0005634 GO:0005737 GO:0005783 GO:0005829 GO:0030425 GO:0031397 GO:0031593 GO:0031625 GO:0032435 GO:0034098 GO:0036435 GO:0043025 GO:0043130 GO:0051117 GO:0071796 GO:1903094 GO:1904293 GO:2000157

Consensus prediction of GO terms

Molecular Function	GO:0016746	GO:0046872	GO:0071972
GO-Score	0.69	0.35	0.32
Biological Processes	GO:0071555	GO:0008360	GO:0006508	GO:0018104
GO-Score	0.69	0.69	0.32	0.32
Cellular Component	GO:0005886	GO:0005576	GO:0042597
GO-Score	0.35	0.32	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.