I-TASSER results

I-TASSER results for job id Rv0176

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (322 residues)
MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATMALTALTVPPGSAWRWL
CACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGSAIGPWRLLVRDLAHLVDT
LSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVIRRLTAAVALAAAGACASATA
VGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPETVQRDFERARSLATDRYRPQLSI
QQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFMQGERGTPPNQRYIQSTVRAIFQKS
RGQWRLDDLAVVMKPRQPTGEK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATMALTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGSAIGPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVIRRLTAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPETVQRDFERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFMQGERGTPPNQRYIQSTVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK
Prediction	CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEHCCCEEEEEEEEHCCCCCCCCCCCCCEEEEEEEEEHCCEEEEHCEEEHCCCCCCCCCC
Conf.Score	9888788887777777776776999999999999999999999999999647775578999999999999999999999855899988888787899689998889999999999999999999999998736888757888875755664566666666655545556667777777776666655566666778999999999987765578986556789999987888999999999999875676467899987899885599799999995556899988766558999999979978875557765788888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATMALTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGSAIGPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVIRRLTAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPETVQRDFERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFMQGERGTPPNQRYIQSTVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK
Prediction	6444356345445564543002101200032333203323333333211112333333233333323333332321110113311000020020000234453010100000221332123113302000000452110231003022223232332232333323321220321222322222222244333444434224304522542241527414530430362025602640362154245444444504122101331355301000000123455465533323030204436340204404303425466668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEHCCCEEEEEEEEHCCCCCCCCCCCCCEEEEEEEEEHCCEEEEHCEEEHCCCCCCCCCC
MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATMALTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGSAIGPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVIRRLTAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPETVQRDFERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFMQGERGTPPNQRYIQSTVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK

4ke2A

0.14

0.09

0.61

1.07

dPPAS2

-----------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAK-------------SIAAAAAMAAKDTAAAAASAAAAAVAS------AAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAA----TLEAAAAKAAATAVSAAAAAAAAAIAFAAAP--------------------------------------------------------------------------

4chvA

0.14

0.13

0.94

1.01

Env-PPAS

PGLLAVAALTIPDM-------SGRSRLALAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVLAVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGRVLANEARNLIGVTTLFGVVLFAVALEKFGSIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRAR-----TVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELAFFISGE----PRSATVSAATTVSLLSLH----SADFQMLCSSSPEIAEI

4yxzA

0.14

0.12

0.86

0.72

MUSTER

--ISVEELLKLAKAAYYSGTT--VEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGIS-VEELLKLAKAAYYSGTTVEEAYKL---ALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKL-----ISVEELLKLAEAAYYSG-TTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGIS--VEELLKLAEAAYYSGTTVEEAY-KLALKLGISVEELLKLAKAAYYSGTTVEEAYKLA-LKL---------------------------

5cwiA

0.10

0.07

0.72

0.69

dPPAS

-------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCI-------------KAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER---------------------------------------------------

3gzrA

0.12

0.04

0.38

0.81

wdPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEGTDAIQALIQAYFTAWNTNA-------PERFAEIFWPD-RDQIVFAHTAFLKTIFKDCKQELVTIEARTIAPGSALAVVTLIQDAYVTPDGRQPRDRLTLLAVEREGVWRFIHNTIVNPDADPVLRK

5fvmA

0.11

0.98

0.75

wMUSTER

RVSLQPNWRLENPDAILGSYA--WYKAWHNWALANFEVTSSLTQRIKDDKVPPTLNANDNFPPELVQRHVVPAIKGFFHSIALSQSSLQDTLRLTLWFKFGGIPEAAQAMHEGFGLIIDNWLEVIPQLISRIHQPNQTVSRSLLSLLLVYPLTVAIKSDSVSRQRAALSIIDKMRMHSPKLVNQAELVSDELIRVWHELWYEGLEDASRQFFGHNTEKMFATLEPLHEMLQNSFGRDLNDAYEWVLNYKRTKDINNLNQARISRKLPQLQTLDLAKDLELAVPGTYHAGKPIVRIT--HFEPVFTV--ISSKQRPR--SDGK

5d9rA

0.14

0.05

0.37

0.89

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEALDARTAENIVSKWQKIKSLAFGPDHR-----IEMLPEVLDGRMLKIWTDRAAETAQLGLTLLKLSVDSVTVSA-DGTRALVEATLEESALVHPENNVRTYTTRYEVFWSKSGWKITEGSVL----------

5cwiA

0.11

0.07

0.70

0.95

dPPAS2

-------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEH--------------------PNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER---------------------------------------------------

4ke2A

0.15

0.09

0.61

0.93

PPAS

-----------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSI-------AAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTA----------------NTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP--------------------------------------------------------------------------

4xzzA

0.08

0.07

0.89

0.90

Env-PPAS

--------------------LNASDRLLEIMRLYQKQGLEMVGQKLDSYLADKSFWAEELQNKDTDFGYYQNKQFLFVA-NKSKPSLEIENNMLKKINSVGSKKGDKTLELARITQKLERLDQYYGVLAFVTNYPN--LYDTLKKRTWVHGMPLNGDRNELNIENPLLSSYDKVLKGEKAFLITYEDKFFPSTKEELSMILSSLFQWKEAWARGDFERYMRFYNPNFTRYDGMKFNAFKEYKKRVFA-KNEKKNIAFSSINVIPNSQNKRLFYVVFDQDYKAYQHNKLSNSQKELYIEIENNQVSIIMEK------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.02

Estimated TM-score = 0.28±0.09

Estimated RMSD = 16.4±3.0Å

Download Model 2

C-score=-4.45

Download Model 3

C-score=-4.95

Download Model 4

C-score=-4.80

Download Model 5

C-score=-4.68

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cwiA	0.673	1.93	0.103	0.724
2	5cwoA	0.544	3.22	0.071	0.652
3	5cwpA	0.541	3.39	0.070	0.652
4	5cwfA	0.473	2.78	0.102	0.543
5	4fhmB	0.462	6.10	0.031	0.742
6	3op0A	0.460	5.23	0.073	0.652
7	1xmeA	0.452	5.99	0.052	0.708
8	5a9q1	0.451	6.00	0.032	0.714
9	1fbvA	0.450	5.29	0.063	0.646
10	3ayfA2	0.439	5.81	0.040	0.658

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	3d1lB	MPR	Rep, Mult	65,83,84
2	0.04	2	1swiC	BNZ	Rep, Mult	35,39
3	0.04	2	3uhoA	CA	Rep, Mult	26,29
4	0.04	2	3fyeA	DMU	Rep, Mult	28,30,71,72,75,76,79
5	0.02	1	1g6uA	TFA	Rep, Mult	86,87,88
6	0.02	1	1izlA	MN	Rep, Mult	6,21
7	0.02	1	3m50A	EBT	Rep, Mult	29,32,33
8	0.02	1	3i59A	N6S	Rep, Mult	75,78
9	0.02	1	4llhA	CM5	Rep, Mult	221,225
10	0.02	1	1m56D	PEH	Rep, Mult	39,46
11	0.02	1	3s8gA	OLC	Rep, Mult	40,44,116,120,124
12	0.02	1	3aouB	DCW	Rep, Mult	131,192,195,196
13	0.02	1	2dftB	MG	Rep, Mult	86,100
14	0.02	1	3dtuC	DXC	Rep, Mult	34,37,38,41,68,71
15	0.02	1	2a2zB	MG	Rep, Mult	86,152
16	0.02	1	2r9rB	PGW	Rep, Mult	208,212
17	0.02	1	1xrmA	III	Rep, Mult	64,67
18	0.02	1	3omiC	TRD	Rep, Mult	113,116,120
19	0.02	1	2pnqA	MG	Rep, Mult	100,101
20	0.02	1	2ymkA	ZN	Rep, Mult	141,145

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1mhsA	0.423	6.36	0.059	0.680	3.6.3.6	NA
2	0.060	3b9jJ	0.368	5.72	0.083	0.562	1.17.1.4,1.17.3.2	75,140
3	0.060	1xc6A	0.384	6.13	0.037	0.615	3.2.1.23	28
4	0.060	2g3mF	0.387	6.24	0.027	0.630	3.2.1.20	169
5	0.060	3b9jC	0.363	6.06	0.023	0.571	1.17.3.2,1.17.1.4	NA
6	0.060	3b8eA	0.432	5.96	0.046	0.671	3.6.3.9	NA
7	0.060	1xmeA	0.452	5.99	0.052	0.708	1.9.3.1	NA
8	0.060	1vncA	0.391	6.66	0.049	0.668	1.11.1.10	65,112,115
9	0.060	2ckjA	0.357	6.46	0.071	0.612	1.17.1.4,1.17.3.2	NA
10	0.060	1mo7A	0.238	5.63	0.026	0.363	3.6.3.9	134,182,197
11	0.060	3eifA	0.386	6.58	0.054	0.643	3.4.21.110	NA
12	0.060	1fbvA	0.450	5.29	0.063	0.646	6.3.2.19	NA
13	0.060	1mhyD	0.417	6.60	0.051	0.717	1.14.13.25	61
14	0.060	2zxqA	0.383	6.15	0.048	0.609	3.2.1.97	24,95
15	0.060	1fgjA	0.417	6.22	0.087	0.674	1.7.3.4	NA
16	0.060	2e1qA	0.354	6.39	0.062	0.590	1.17.3.2,1.17.1.4	NA
17	0.060	1qleA	0.423	5.85	0.049	0.646	1.9.3.1	NA
18	0.060	1m56A	0.424	5.87	0.049	0.649	1.9.3.1	NA
19	0.060	1kwgA	0.391	6.45	0.036	0.668	3.2.1.23	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.08	0.461	5.27	0.08	0.66	3op0A	GO:0001784 GO:0004842 GO:0004871 GO:0005154 GO:0005509 GO:0005634 GO:0007166 GO:0007175 GO:0008270 GO:0016567 GO:0016874 GO:0017124 GO:0023051 GO:0042059 GO:0042787 GO:0043407 GO:0046872 GO:0061630 GO:0070062
1	0.07	0.447	5.71	0.06	0.66	3zniA	GO:0000209 GO:0001784 GO:0004842 GO:0004871 GO:0005509 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006607 GO:0007165 GO:0007166 GO:0008270 GO:0009629 GO:0009725 GO:0016567 GO:0016874 GO:0019901 GO:0023051 GO:0045121 GO:0046872
2	0.07	0.462	6.10	0.03	0.74	4fhmB	GO:0005487 GO:0005634 GO:0005635 GO:0005643 GO:0006810 GO:0016973 GO:0031080 GO:0034399
3	0.07	0.450	5.29	0.06	0.65	1fbvA	GO:0001784 GO:0003700 GO:0004842 GO:0004871 GO:0005509 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0005913 GO:0006355 GO:0007166 GO:0007173 GO:0007179 GO:0008270 GO:0008543 GO:0014068 GO:0016020 GO:0016567 GO:0016600 GO:0016874 GO:0017124 GO:0019901 GO:0023051 GO:0042059 GO:0042787 GO:0043066 GO:0045742 GO:0046872 GO:0046875 GO:0048260 GO:0061630 GO:0098609 GO:0098641
4	0.06	0.448	5.54	0.05	0.65	3pfvB	GO:0000209 GO:0001784 GO:0004842 GO:0004871 GO:0005509 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006607 GO:0007165 GO:0007166 GO:0008270 GO:0009629 GO:0009725 GO:0016567 GO:0016874 GO:0019901 GO:0023051 GO:0045121 GO:0046872
5	0.06	0.423	4.88	0.08	0.57	3vrqA	GO:0001784 GO:0004842 GO:0004871 GO:0005154 GO:0005509 GO:0005634 GO:0007166 GO:0007175 GO:0008270 GO:0016567 GO:0016874 GO:0017124 GO:0023051 GO:0042059 GO:0042787 GO:0043407 GO:0046872 GO:0061630 GO:0070062
6	0.06	0.332	6.31	0.06	0.55	3gdeA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
7	0.06	0.317	6.15	0.06	0.52	3zwlD	GO:0001731 GO:0002183 GO:0002188 GO:0003743 GO:0005737 GO:0005852 GO:0006412 GO:0006413 GO:0006446 GO:0016282 GO:0033290 GO:0043614
8	0.06	0.449	6.18	0.04	0.73	4fhnB	GO:0005487 GO:0005634 GO:0005635 GO:0005643 GO:0006810 GO:0016973 GO:0031080 GO:0034399
9	0.06	0.439	6.41	0.06	0.72	4fhnD	GO:0005487 GO:0005634 GO:0005635 GO:0005643 GO:0006810 GO:0016973 GO:0031080 GO:0034399
10	0.06	0.295	6.43	0.04	0.48	2p5oB	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
11	0.06	0.302	6.18	0.03	0.49	4oc9D	GO:0003824 GO:0003961 GO:0006520 GO:0016740 GO:0016765 GO:0016829 GO:0030170 GO:0071266
12	0.06	0.241	6.28	0.03	0.39	2fncA	GO:0004175 GO:0005363 GO:0006511 GO:0015768 GO:0019773
13	0.06	0.240	6.94	0.03	0.43	1q20A	GO:0000103 GO:0004027 GO:0005634 GO:0005737 GO:0005783 GO:0005829 GO:0006629 GO:0008146 GO:0008202 GO:0016740 GO:0043231 GO:0050294 GO:0050427 GO:0070062
14	0.06	0.229	3.73	0.03	0.28	4iwbA	GO:0044780
15	0.06	0.271	5.48	0.04	0.41	5ekqD	GO:0009279 GO:0016020 GO:0043165 GO:0051205 GO:1990063
16	0.06	0.230	4.60	0.03	0.30	3uo2B	GO:0005739 GO:0005743 GO:0005758 GO:0005759 GO:0006457 GO:0006626 GO:0009060 GO:0016226 GO:0051087 GO:0051259
17	0.06	0.298	6.31	0.05	0.49	2ywcA	GO:0000166 GO:0003922 GO:0005524 GO:0006164 GO:0006177 GO:0006541 GO:0016462 GO:0016874
18	0.06	0.214	4.95	0.06	0.30	1ijxA	GO:0004930 GO:0005576 GO:0005615 GO:0007186 GO:0007275 GO:0008285 GO:0010721 GO:0014033 GO:0016021 GO:0016055 GO:0017147 GO:0030154 GO:0030178 GO:0030308 GO:0035567 GO:0042472 GO:0042813 GO:0043065 GO:0045600 GO:0060029 GO:0061037 GO:0061053 GO:0070367 GO:0090090 GO:0090103

Consensus prediction of GO terms

Molecular Function	GO:0019787	GO:0046914	GO:0045309	GO:0019900
GO-Score	0.49	0.49	0.49	0.37
Biological Processes	GO:0007165	GO:0032446
GO-Score	0.49	0.49
Cellular Component	GO:0043231	GO:0071944	GO:0044444
GO-Score	0.59	0.37	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.