I-TASSER results

I-TASSER results for job id Rv0168

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (289 residues)
MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIGQIAHALRYYRKETLRL
IAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGNIGVEAFTGFFAALINVRI
AGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIKSISFLASTRIMAGLVVIIPL
YALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPDDVFWSFLEALIITAIVMVSHCY
YGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAALALYGVDPNFNLTV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIGQIAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGNIGVEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIKSISFLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPDDVFWSFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAALALYGVDPNFNLTV
Prediction	CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
Conf.Score	9988888888875789999999999999999999999999999999765556657999999999765544445456789999999999999999999999998976789999999999999999999999988756899999875456689999998999753457799999999999999999999999999999987499999999999997577899999999999999999999667957679855677887899999999999999999999995788876569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIGQIAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGNIGVEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIKSISFLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPDDVFWSFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAALALYGVDPNFNLTV
Prediction	8555554544344114203400410140033002102010200221221233234200310230123332312233013213322333232101101310341313310020102011103113200000002100100010021324421200331414303100002130122023311230331133002110111240311201310231142311330331133002000200011104144325201510120002000203331333122112233714036
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIGQIAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGNIGVEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIKSISFLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPDDVFWSFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAALALYGVDPNFNLTV

4ke2A

0.13

0.09

0.68

1.37

dPPAS2

-----MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAA---ATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------------

4bwzA2

0.14

0.10

0.70

1.00

PPAS

--------------------------------------------------------RLKDILAV--GKEAFLVAVLGVALPFLGGYLYGLEIGF-----------ETLPALFLGTALV-------TSVGITARVLQELSRPYSRIILGAAVIDDVLGLI----VLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGA---VNEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE----

5cwbA

0.12

0.08

0.68

1.03

dPPAS2

------------DECEEKARRVAEKVERLKRSGTSEDEIAEEVAREISEVIRTLKESSSYEVICECVARIVAEIVEALKRSGTSEDEIAEIVARVISEVIRTLKESGSSYEVICECVARIVAEIVEALKRSGTS-EDEIAEIVARVISEVIRTLKESGSS-------YEVIKECVQRIVEEIVEALKRSGTSEDEINEIVRRVKSEVERTLKESGS-------------------------------------------------------------------------

4bwzA2

0.12

0.08

0.67

1.01

dPPAS2

--------------------------------------------------------RLKDILAV--GKEAFLVAVLGVALPFLGGYLYGLEIGFETLPALFLGTALVATSVGITARVLQELGVLSRPYSRIILGAAVIDDVLGLIVLACVNGVAETGQELSALA------SPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAP------------RGEVGLIVAALGLKAGA------------VNEEEYAIVLFMVVFTTLFAPFALKP-------L

4rp8A2

0.12

0.11

0.93

0.86

MUSTER

------------GAISDTYASMMATIDRMGDAYSWVGYAVLLALALNICYVLLRRIT---IRTIMLTGHIMFQQAGLIAVTLFIFGYSMWTTIICTAILVSLY--WGITSNMMYKPTQEVTDGCGFSIGHQQQFASWIAYKVAPFLKKEEIDCAAIYSFAPVVWGFMWGTIGQLIAVGILVACGSSILIIPG-FIPMFFSNATIGVFANHFGGW--RAALKICLVMGMIEIFGCVWAVKLTGMSAWMGMSILAPPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAE

4ke2A

0.13

0.09

0.68

0.87

dPPAS

-----MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAA---ATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------------

4bwzA2

0.14

0.09

0.63

0.69

wdPPAS

--------------------------------------------------------RLKDILAV--GKEAFLVAVLGVALPFLGGYLYGLEIGF-----------ETLPALFLGTALV-SVGITARVLQELGVLSRPYSRIILGAAVIDDVLGLIVLAC--VNGVAET--PVVLVAGTVVTVIAILGKVLGGFLGALTQG-------------VRSALTVGCGMAPRGEVGLIVAALGLKAGA------------VNEEEYAIVLFMVVFTTLFAPFALKP-------L

4k1cA

0.13

0.11

0.91

0.80

wMUSTER

FQLSHTL-----AIIPLAAILANATEELADKAGNTIGGLLNATFGNAVELIVSIIALKKGQVRIVQASMLGSLLSNLLLVLGLCFIFGGYTAAQTMSSLLAIACA--IDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVEST--GLS---------------KTFIGLIVIPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGWMI---VPMTLNFST

4bwzA2

0.13

0.09

0.65

0.92

wPPAS

--------------------------------------------------------RLKDILAV--GKEAFLVAVLGVALPFLGGYLYGLEIGF-----------ETLPALFLGTALVTSVGITARVLQELGVLSRPYSRIILGAAVIDDVLGLIVLAC--VNGVAETGASPVVLVAGTVVTVIAILGKVLGGFLGALTQG------------VRSALTVGCGMAPRGEVGLIVAALGLKAGA------------VNEEEYAIVLFMVVFTTLFAPFALK------PLI

4yxxA

0.11

0.07

0.69

0.99

dPPAS2

-----VSLEQALKILKVAAELGTTVEEAVKRALKLKTKLLEQALKILEVAAELGTTVEEAVKRALKLKTKLGVSLEQALKILEVAAKLGVEEAVKRALKLKTKLGVSLEQALKILKVAAELG---TTVEEAVKRALKLKTKLGLEQALKILEVAAELGTT-----------VEEAVKRALKLKTKLLEQALKILEVAAKLGTTVEEAVKRALKLKTK------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.71

Estimated TM-score = 0.31±0.10

Estimated RMSD = 15.2±3.4Å

Download Model 2

C-score=-4.45

Download Model 3

C-score=-4.05

Download Model 4

C-score=-4.89

Download Model 5

C-score=-4.75

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4rp8A	0.723	4.30	0.091	0.952
2	2bmaA	0.493	5.03	0.030	0.716
3	1k89A	0.480	4.96	0.038	0.689
4	5ijzA	0.479	5.06	0.061	0.699
5	5aexA	0.476	5.77	0.087	0.744
6	4av3A	0.474	6.35	0.070	0.785
7	5aezA	0.473	5.87	0.087	0.747
8	3sboA	0.472	5.25	0.070	0.702
9	2nuuD	0.469	5.68	0.072	0.734
10	2b2jA	0.464	5.79	0.061	0.741

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	2h6bA	3C4	Rep, Mult	230,233
2	0.06	3	4v1fA	BQ1	Rep, Mult	223,226,227,230
3	0.04	2	3h3fD	ACT	Rep, Mult	223,226,227
4	0.04	2	3etgC	GWD	Rep, Mult	172,176,177,180,234
5	0.02	1	4z90A	4LE	Rep, Mult	228,232
6	0.02	1	1k9zA	ZN	Rep, Mult	141,226
7	0.02	1	3v2d2	MG	Rep, Mult	165,169
8	0.02	1	1r3nF	BIB	Rep, Mult	169,248
9	0.02	1	3bz1F	PL9	Rep, Mult	136,139
10	0.02	1	2wieA	CVM	Rep, Mult	275,279
11	0.02	1	3qmuA	XEG	Rep, Mult	96,253,258
12	0.02	1	3eteD	H3P	Rep, Mult	43,100,101,103
13	0.02	1	1zoyC	EPH	Rep, Mult	186,189
14	0.02	1	2aj4A	MG	Rep, Mult	69,161
15	0.02	1	3attA	MG	Rep, Mult	152,155
16	0.02	1	2npjA	IMD	Rep, Mult	125,126,203,205
17	0.02	1	1vs0A	MG	Rep, Mult	150,152
18	0.02	1	1hwyE	NAD	Rep, Mult	189,234,235,237,238,245,246

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1hxgA	0.409	5.80	0.070	0.650	4.2.3.9,4.1.99.7	133
2	0.060	3b8cB	0.399	6.08	0.049	0.644	3.6.3.6	NA
3	0.060	1eulA	0.387	5.75	0.074	0.609	3.6.3.8	NA
4	0.060	1s1mB	0.416	6.19	0.054	0.675	6.3.4.2	NA
5	0.060	1gpeA	0.420	5.83	0.050	0.685	1.1.3.4	NA
6	0.060	1vncA	0.420	6.53	0.078	0.730	1.11.1.10	169,172,192,197
7	0.060	1bgvA	0.479	4.96	0.038	0.689	1.4.1.2	NA
8	0.060	2dkiA	0.397	6.50	0.060	0.699	1.14.13.23	279
9	0.060	1gtmA	0.407	5.61	0.047	0.616	1.4.1.3	218
10	0.060	1euzF	0.413	5.80	0.061	0.640	1.4.1.3	218
11	0.060	1iduA	0.421	6.43	0.086	0.727	1.11.1.10	NA
12	0.060	2bmaA	0.493	5.03	0.030	0.716	1.4.1.4	NA
13	0.060	1k8qA	0.401	6.00	0.074	0.661	3.1.1.3	NA
14	0.060	1aupA	0.467	5.17	0.043	0.689	1.4.1.2	NA
15	0.060	1hwxA	0.460	4.85	0.079	0.654	1.4.1.3	204
16	0.060	3b8cA	0.399	6.08	0.049	0.644	3.6.3.6	NA
17	0.060	1bvuA	0.406	5.56	0.051	0.613	1.4.1.3	NA
18	0.060	1hlgB	0.408	5.65	0.038	0.647	3.1.1.3	183
19	0.060	1u8vA	0.410	6.15	0.031	0.682	5.3.3.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.441	5.32	0.09	0.67	3aoeB	GO:0006520 GO:0016491 GO:0016639 GO:0055114
1	0.12	0.718	4.21	0.10	0.94	4rp9A	GO:0005886 GO:0006810 GO:0008643 GO:0009401 GO:0015882 GO:0016020 GO:0016021 GO:0034219 GO:0090585
2	0.07	0.493	5.03	0.03	0.72	2bmaA	GO:0006520 GO:0016491 GO:0016639 GO:0055114
3	0.07	0.489	5.07	0.03	0.71	2yfhE	GO:0004352 GO:0004354 GO:0005737 GO:0005829 GO:0006520 GO:0006537 GO:0016491 GO:0016639 GO:0019552 GO:0042802 GO:0055114
4	0.07	0.479	4.96	0.04	0.69	1bgvA	GO:0004352 GO:0006520 GO:0016491 GO:0016639 GO:0019552 GO:0055114
5	0.07	0.424	5.74	0.04	0.65	3r3jA	GO:0004354 GO:0006520 GO:0006537 GO:0016491 GO:0016639 GO:0020011 GO:0055114
6	0.07	0.461	4.74	0.07	0.65	5ijzK	GO:0004354 GO:0005737 GO:0006520 GO:0006537 GO:0016491 GO:0016639 GO:0055114
7	0.07	0.467	5.17	0.04	0.69	1aupA	GO:0004352 GO:0006520 GO:0016491 GO:0016639 GO:0019552 GO:0055114
8	0.07	0.470	5.46	0.07	0.71	4bhtA	GO:0004354 GO:0005737 GO:0005829 GO:0006520 GO:0006537 GO:0016491 GO:0016639 GO:0042802 GO:0055114
9	0.06	0.458	4.92	0.07	0.65	3etdA	GO:0000166 GO:0004352 GO:0004353 GO:0005524 GO:0005525 GO:0005739 GO:0005743 GO:0005759 GO:0006520 GO:0006538 GO:0006541 GO:0016491 GO:0055114 GO:0072350
10	0.06	0.407	5.61	0.05	0.62	1gtmA	GO:0004353 GO:0005737 GO:0006520 GO:0016491 GO:0016639 GO:0055114
11	0.06	0.415	5.71	0.04	0.64	3k8zA	GO:0004352 GO:0006520 GO:0016491 GO:0016639 GO:0055114
12	0.06	0.479	5.06	0.06	0.70	5ijzA	GO:0004354 GO:0005737 GO:0006520 GO:0006537 GO:0016491 GO:0016639 GO:0055114
13	0.06	0.385	6.21	0.06	0.64	2yfqB	GO:0004352 GO:0006520 GO:0016491 GO:0016639 GO:0019552 GO:0055114
14	0.06	0.406	5.56	0.05	0.61	1bvuA	GO:0004353 GO:0005737 GO:0006520 GO:0016491 GO:0016639 GO:0055114
15	0.06	0.317	5.16	0.06	0.47	3vpxB	GO:0006520 GO:0016491 GO:0016639 GO:0055114
16	0.06	0.412	5.55	0.05	0.62	1v9lA	GO:0000166 GO:0006520 GO:0016491 GO:0016639 GO:0055114
17	0.06	0.395	5.70	0.06	0.61	1lehA	GO:0006520 GO:0016491 GO:0016639 GO:0055114
18	0.06	0.411	5.32	0.04	0.60	3k92A	GO:0004352 GO:0006520 GO:0016491 GO:0016639 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0016638
GO-Score	0.58
Biological Processes	GO:0019752	GO:1901564	GO:0044238
GO-Score	0.58	0.58	0.50
Cellular Component	GO:0005886	GO:0016021	GO:0005829
GO-Score	0.12	0.12	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.