I-TASSER results

I-TASSER results for job id Rv0160c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (502 residues)
MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGDEVSAATAALFSAYGR
EYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHALDTINAPIRTLLGRAPLSP
NGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVTDINKAFIQTLFPGAVSQGLF
TPEQFWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLALDNKVVAFGYSQSATIINNYINS
LMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDVPFNGATPANSPYPTHIYTA
QYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPELMATQVDNAVPLPTSPGYTGNTQYYM
FLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYADYGPGGNYADIPTPAGLFSIP
NPFAVTYYLIKGSLQAPYGAIVEIGVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQVT
LLSLMSGGLGNILHLIPPPVFT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGDEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHALDTINAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVTDINKAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLALDNKVVAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDVPFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPELMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHCEEHCCCCCCEEEEEEHCCCCCHHHHHHHHCCCCHHHHHHHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCC
Conf.Score	9767644799999999999999999999877546666666677656789999999999998889999999999999999998888765545555566666655566775455778888877788888887776677777766667788888888874555555544556788776567658865567778888887557899999999999999768999789998657899999999999876899987479999778999889754457875456789888899999999858999976887788999854689999999988876556678886657777555456577898589999599997888899869987578887565543443468899999888888888777788888788899888766445567888875677778887888888888888988765568887545555456665545678988789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGDEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHALDTINAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVTDINKAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLALDNKVVAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDVPFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPELMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT
Prediction	4110000012010004204402200310110001001211301111000000300120032010002100200220030011002111322121123232224132222231233232333223222223422322112222222224122212212112202211132212423242021010012012213313144023301520351045342463300000010000001300341154441423200000110232220001121201000001231422214514030000001100000002100000010000100001022112132731432232323434402000000107200001002301113410031024303200320143522443212111112103212023013301421142143103312333421233321412021230334140213343122121133302412520212347
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHCEEHCCCCCCEEEEEEHCCCCCHHHHHHHHCCCCHHHHHHHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCC
MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGDEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHALDTINAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVTDINKAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLALDNKVVAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDVPFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPELMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT

3w6qA

0.11

0.96

0.76

MUSTER

SPYLITDIDDWYLEQTNRIQLTLFVEALTVIQNRPLNDQLS------YFRLAGIHGAPWTEWDGVNYTFPTWHRVYVTLYEQVIYEAMLDFIKQNVPQNGKADWENEAKQWRL-ARFARHGDELRLPILVTMPMVKVLVPGQPGKQLSKPNPLYRFQMQTLMGTLERPYAITDLPFDKCQSTTKYGLLENYNAWADGGQNWLRANLALNEHPWYQNLDGWDSV--------PTLQDMTFRLLTTGGLNWGEFSSTRYDAPKN-WMNLEAIHNNVHNWVGGFMFSRPGRHDLKLWGAGHMSSVPVAAYDPIFWLHHCNIDRLTAIWQTVNSWFNDDKSKVSKDDDLRPFHRFCEKTRKVVFFRSDDV-IRKEISDLYGQRTKEVYKDFGEEDYILSIRYSRYALGGKPFQIGKDFYDARSQNFVGSVFNFSVLSVSQLPARLAVHYYKKQNKGEVPTPRYVVVNSQGKAEAEVKVE---VALHKTEGTFYDAPADYRRVADGK

5gaoE

0.13

0.09

0.67

0.88

dPPAS

--------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAA----------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAA---------------------AAAAAAAAAAAAAA---------AAAAAAAAAAAAAAAAAAAARAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------

3ajaA

0.15

0.07

0.46

1.61

wdPPAS

------------------------------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLGVTLIADGRRQMGVGQDVGPNPALSALGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVENGQTATQWTLE--------LVENAPHP---------------------------------------------------------------------------------------------------------------------------------------

5gjvF

0.11

0.10

0.92

0.75

wMUSTER

--F----PS-----AVTIKSWVDKMQEDLVTLAKTASG---------VHQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASVVYYNAKDQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGSTIVLNELNWTSLDDVFPSLLWQVFGSATGLYPASPWVKIDLYD------VRRRPWYIQGAASPKDMLILVDVSLTLKLIRTSVSEMLET--SDDDFVNVASFNSNAQDVSCFLVQANVRNKKVLNITAKGITDVSRANCNKIIMLFTDG---GEERAQEIFAKYNKDKKVVFTFSGQHNYDRGPIQWMA-------CENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNPNLQPPIGVGIPTINLRKRRPNVQNP---KSQEPVTLDFLDAELEN

3ajaA

0.17

0.08

0.45

1.83

wPPAS

------------------------------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLGVTLIADGRRQMGVGQDVGPNPALSALGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVEN------------GQTA--LVENAPHP---------------------------------------------------------------------------------------------------------------------------------------

3ajaA

0.15

0.07

0.45

1.52

dPPAS2

------------------------------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLGVTLIADGRRQMGVGQDVGPNPAGQGAGLTMTGPRPGGFDNRTNQICGSGDLICSAPFSVFNLPKTLETLSG--PVHALYNTPQFWVENGQTATQWTNAPHP----------------------------------------------------------------------------------------------------------------------------------------------------

3ajaA

0.16

0.07

0.47

1.37

PPAS

------------------------------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLGVTLIADGRRQMGVGQDVGPNPALSALGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVENGQTATQTLEWARN-----LVENAPHP---------------------------------------------------------------------------------------------------------------------------------------

3ajaA

0.16

0.08

0.47

1.18

Env-PPAS

------------------------------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLGVTLIADGRRQMGGPNPAGQGAEITLHELTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVENGQTATQTLEWARN-----LVENAPHP---------------------------------------------------------------------------------------------------------------------------------------

4ekjA

0.11

0.10

0.90

0.74

MUSTER

-ARVI------------------DLDLRRAAGPVDRFFDLSIGSDY---PGTLIREDSQAQLKTTVDELGFFHAIFHDVLGTVKIVYDWTKIDQLYDALLAKGI--KPFIELGFTPEAMKTSDQTIFYWKGNTSHPKLGPWR--------------DLIDAFVHHLRARYGVEEVRTWFFEVWNEPNLDGFWEKAD-QAAYFELYDVTARAIKAI-DPSLRVGGPATA-GAAWVPEFLAHVKKSGSA-VDFVTTHTYGVFLDEKGVQDTKLSPSPDAVVGDQIEASAFPGLPLYFTEWSTSYTPRDSVHDSYVSAAYIVEKLRRVKGLVQAMSYWTYSDLFEEPGPPT-APFQGGFGLMNPQGIRKPSWFAYKYLNAIKGRELVCADDQV-AIVAYAWRQPDQKVSNRPFYTKLHPASDVEPLKVLTSLKPGRYKDAYSAYIDMGSPTTLTESQL--QSLQALTEDRPEIEKALKVSGETVVDLPMRANDVVLIELEPLA--

3ajaA

0.15

0.07

0.45

0.78

dPPAS

------------------------------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLGVTLIADGRRQMGVGQDVGPNPAGQGAGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVENGQTATQWTNAPHP----------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.22

Estimated TM-score = 0.68±0.12

Estimated RMSD = 7.8±4.4Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3w6qA	0.893	2.83	0.101	0.964
2	4ouaB	0.736	3.94	0.078	0.865
3	4bedB	0.589	4.34	0.071	0.711
4	1lnlA	0.588	4.25	0.088	0.703
5	4bedA	0.588	4.38	0.097	0.707
6	3l6wA	0.578	4.35	0.070	0.695
7	2y9wA	0.568	3.38	0.105	0.643
8	1js8A	0.555	4.10	0.082	0.655
9	4z11A	0.537	5.44	0.086	0.711
10	2p3xA	0.433	4.45	0.097	0.524

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	6	4bedA	CUO	Rep, Mult	55,69,73,271,275,311,315
2	0.08	4	2y9xD	0TR	Rep, Mult	55,271,272,275,299,300,301,302,305,311
3	0.04	2	2wycA	3LA	Rep, Mult	51,54
4	0.04	2	2ll8A	PNS	Rep, Mult	45,48
5	0.02	1	3v4vA	0DU	Rep, Mult	158,185
6	0.02	1	1f8rC	UUU	Rep, Mult	355,358
7	0.02	1	1qbgB	FAD	Rep, Mult	293,294
8	0.02	1	4hd4B	CU	Rep, Mult	55,73,302
9	0.02	1	2efbA	PO4	Rep, Mult	235,237,243,375,376,377,378
10	0.02	1	2qqtA	NAG	Rep, Mult	210,213,216,235
11	0.02	1	2vn4A	MAN	Rep, Mult	486,487
12	0.02	1	2e9eB	NO3	Rep, Mult	5,318,319,320,366
13	0.02	1	3s6lA	ZN	Rep, Mult	45,73
14	0.02	1	2xqtE	CVM	Rep, Mult	62,65

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1i1iP	0.308	6.86	0.032	0.472	3.4.24.16	46
2	0.060	3gtgB	0.345	7.52	0.047	0.568	2.7.7.6	182,300
3	0.060	2d0gA	0.334	7.21	0.039	0.544	3.2.1.135	NA
4	0.060	2vr5A	0.345	7.29	0.051	0.556	3.2.1.-	NA
5	0.060	3b9jI	0.157	5.21	0.052	0.211	1.17.1.4,1.17.3.2	127,271
6	0.060	3czkA	0.337	7.57	0.051	0.564	3.2.1.48	90
7	0.060	1q16A	0.344	7.46	0.031	0.562	1.7.99.4	NA
8	0.060	1nx9A	0.328	6.89	0.025	0.514	3.1.1.43	NA
9	0.060	1z45A	0.346	7.47	0.084	0.568	5.1.3.2,5.1.3.3	NA
10	0.060	1bt1A	0.430	4.53	0.100	0.524	1.10.3.1	NA
11	0.060	2b4kA	0.320	7.60	0.043	0.528	3.1.1.43	58
12	0.060	1aorB	0.331	7.15	0.053	0.528	1.2.7.5	NA
13	0.060	3k1dA	0.330	7.15	0.047	0.528	2.4.1.18	323
14	0.060	3hhsA	0.338	5.49	0.057	0.438	1.14.18.1	377
15	0.060	2fhcA	0.335	7.62	0.040	0.558	3.2.1.41	231,279
16	0.060	1bf2A	0.335	7.59	0.042	0.548	3.2.1.68	NA
17	0.060	1h54B	0.332	7.32	0.051	0.534	2.4.1.8	NA
18	0.060	1fo4A	0.300	8.34	0.050	0.550	1.17.1.4	NA
19	0.060	2ckjA	0.292	7.91	0.040	0.500	1.17.1.4,1.17.3.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.888	2.75	0.10	0.96	3w6wA	GO:0004503 GO:0005634 GO:0008152 GO:0016491 GO:0046872 GO:0055114
1	0.20	0.893	2.83	0.10	0.96	3w6qA	GO:0004503 GO:0005634 GO:0008152 GO:0016491 GO:0046872 GO:0055114
2	0.15	0.588	4.25	0.09	0.70	1lnlA	GO:0005344 GO:0005576 GO:0005615 GO:0006810 GO:0008152 GO:0015671 GO:0016491 GO:0046872 GO:0055114
3	0.12	0.736	3.94	0.08	0.86	4ouaB	GO:0004503 GO:0008152 GO:0016491 GO:0046872 GO:0055114
4	0.07	0.587	4.22	0.08	0.71	3qjoA	GO:0008152 GO:0016491 GO:0046872 GO:0055114
5	0.07	0.568	3.38	0.10	0.64	2y9wA	GO:0004497 GO:0004503 GO:0008152 GO:0016491 GO:0042438 GO:0046872 GO:0055114
6	0.07	0.555	4.10	0.08	0.66	1js8A	GO:0005344 GO:0006810 GO:0008152 GO:0015671 GO:0016491 GO:0046872 GO:0055114
7	0.07	0.537	5.44	0.09	0.71	4z11A	GO:0004097 GO:0008152 GO:0016491 GO:0046148 GO:0046872 GO:0055114
8	0.06	0.433	4.45	0.10	0.52	2p3xA	GO:0004097 GO:0008152 GO:0009507 GO:0009536 GO:0009543 GO:0009579 GO:0016491 GO:0046148 GO:0046872 GO:0055114
9	0.06	0.430	4.53	0.10	0.52	1bt1A	GO:0004097 GO:0008152 GO:0009507 GO:0009536 GO:0009543 GO:0009579 GO:0016491 GO:0046872 GO:0055114
10	0.06	0.431	4.42	0.10	0.52	5ce9A	GO:0004097 GO:0004503 GO:0008152 GO:0016491 GO:0036263 GO:0046148 GO:0046872 GO:0055114
11	0.06	0.400	4.68	0.07	0.50	4j3rA	GO:0004097 GO:0008152 GO:0016491 GO:0046872 GO:0055114
12	0.06	0.395	4.17	0.09	0.47	4hd4A	GO:0008152 GO:0016491 GO:0046872 GO:0055114
13	0.06	0.391	4.20	0.11	0.47	3awtA	GO:0008152 GO:0016491 GO:0046872 GO:0055114
14	0.06	0.218	7.04	0.02	0.34	1gu6A	GO:0005506 GO:0005509 GO:0006807 GO:0016491 GO:0016966 GO:0019645 GO:0020037 GO:0030288 GO:0042128 GO:0042279 GO:0042597 GO:0046872 GO:0055114
15	0.06	0.219	6.84	0.06	0.34	4yb6A	GO:0000105 GO:0000166 GO:0000287 GO:0003879 GO:0005524 GO:0005737 GO:0008652 GO:0016740 GO:0016757 GO:0046872
16	0.06	0.183	6.40	0.04	0.27	2oy5O	GO:0009279 GO:0016020
17	0.06	0.177	6.76	0.04	0.28	3ckfA	GO:0009279
18	0.06	0.146	4.10	0.04	0.18	1gmzB	GO:0004623 GO:0005509 GO:0005576 GO:0006629 GO:0016042 GO:0016787 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0004503
GO-Score	0.56	0.44
Biological Processes	GO:0055114
GO-Score	0.56
Cellular Component	GO:0005634
GO-Score	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.