I-TASSER results

I-TASSER results for job id Rv0159c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (468 residues)
MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAADEVSSAAAALFSEYAR
ECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGSSGALGSVGMLSGNPLT
ALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTPEQWWPFIGNLSLDQSIAQGV
TLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINN
PNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMYTGQYDGYAHNPQYPLNILSDLNAF
MGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPLLQPIRAIPFVGTPIA
ELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVASALATGTVQGPQAALVSIGLLP
QSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALGSVARLIPPIA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTPEQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMYTGQYDGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVASALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALGSVARLIPPIA
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCHHHHHHHHCCCCHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
Conf.Score	976764579999999999999999999987665455555667765788999999999989999999999999999999999867776455455545555456777766666677777665566788888998875444444555567788886699867864478888888755689999999999999857899689999855889999999999977888899855489999868899988743457876567778888899999999758999976888778999865689999999999886567788887777876565567888986899995899985777888578876788875655355544689999999988788888887654578877766456889999877888888888888888888887778888888754334455677466478889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTPEQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMYTGQYDGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVASALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALGSVARLIPPIA
Prediction	311000102201000420340220031011100000020342221200200000002004201100320220133023112102212232332222311222212212222221223323423232133122332012213220012112222101021111000002314344124421530352044323453300000000001000300340173454541323200000000133220000021211200001131412113624020000000000000002100000011002100001023111234414542414134444020000001073000010022012024200310233032002101423324311213213314024213300311122043003312223432215221314424242414133242422211233224114203247
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCHHHHHHHHCCCCHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTPEQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMYTGQYDGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVASALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALGSVARLIPPIA

4ekjA

0.10

0.94

0.76

MUSTER

-ARVIDL---------DLRRAAGPVDRFFDLSIG------------SDYPGTLIREDSQAQLKTTVDELGFFHAIFHDVLGTVKDWTKIDQLYDALLAKGIKPFIELGFTPEAMKTSDQTIFYWKGNTSHPKLGPWRDLIDAFVYGVEEVRTWFFEVWNEPNLDGFWEKADQ-AAYFELYDVTARAIKAID-PSLRVGGPATA-GAAWVPEFLAHVKKSG----SAVDFVTTHTYGVFLDEKGVQDTKLSPSPDAVVGDQIEASAFPGLPLYFTEWSTSYTPRDSVHDSYVSAAYIVEKLRRVKGLVQAMSYWTYSDLFEEPGPPTAPFQGGFGLMNPQGIRKPSWFAYKYLNAIKGRELVCADDQVVAIVAYAWRQPDQKVSTKLHPASDVEPLKVLTSLKPGRYKDAYSAYIDMGSPTTLTQLQSLQALTEDRPEIEKALKVSGETVVDLPMRANDVVLIELEPLA

5gaoE

0.13

0.10

0.72

0.97

dPPAS

-----------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------------------AAAAAAAAAAA-----------AAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--

3ajaA

0.13

0.07

0.50

1.57

wdPPAS

------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHAADKQMSYNDSRAEGMRTTVKAMTDMNDPLTSYVIAGFSQGAVIAGDIASDIGN-GRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVENGQTATQWT---------LVENAPHP----------------------------------------------------------------------------------------------------------------------------

3ajaA

0.17

0.08

0.50

0.83

wMUSTER

------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLS-------LMSNISKPLAEQFGPRLQVYTTPYTAQFHNPFKQMSYNDSRAEGMRTTVKAMTDMNDPLTSYVIAGFSQGAVIAGDIASDIGN-GRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLS-VHALYNTPQFWVEN-----------GQT---------------------ATQWTLEWA----RNLVENA--------PHP-----------------------------------------------------------------------------------

3ajaA

0.18

0.09

0.48

1.77

wPPAS

-----ADPDVMMVSI------GTWESSPTDDPFNPT-QFPLSLMSNISKPLAEQFG--------------------------------------------------------------------------------------------PDRLQVYTTPYTAQFHAADKQMSYNDSRAEGMRTTVKAMTDMNDPLTSYVIAGFSQGAVIAGDIASDIGN-GRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPALSALGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVEN-----------GQTA--LVENAPHP----------------------------------------------------------------------------------------------------------------------------

5gaoE

0.14

0.10

0.72

1.44

dPPAS2

-----------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----------------------AAAAAAAAAAAAAA----------AAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK------

5gaoE

0.14

0.10

0.72

1.36

PPAS

---------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------------------AAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK------

3hc7A1

0.18

0.07

0.39

1.06

Env-PPAS

--------------------------------------------------------------------------------------------------------------------SKPWLFTVHGTGQPDPLGPGLPADTARDVLDIY-------RWQPIGNYPAAA-FPMWPSVEKGVAELILQIELKLDPYADFAMAGYSQGAIVVGQVLKHHILPPTGRLHRHRLKKVIFWGNPMRQKGFAHSDEWIHPVAAPDILEDRLENEQYGFEVRDYAHDGDMYASIGDKWPHLY---NRYPAVEFLRQ----------------------------------------------------------------------------------------------------------------------------------------------------------------

5lo9A

0.11

0.10

0.95

0.72

MUSTER

----FERGRTLAEQGDAARGIVACAGADGGGDEALGAARLAGLEPAYLATQIERFRAGQRSHPVMSPWAERLTPVDIAAVSAYYGALAPASNAAAAGRALAETGDWPERDLPACVRCHGPGGVGAGAVFPPLAGQPYSYLLAQLQAWGTGRRHGEPMALMGAVAGRLDADEQRALAAYFATRPLARAEAASRFTPPSRDALPEGPLGEMVRLGARLFRHTNTDPRSAPHVGNDQTCAGCHLDNGRRADASPMWAAWVAYPAYRGKNQRVDTMAERIQGCFRYSMNAQVPETNGLVLDALQSYIFWLATGAPTGDTAMSGRGYPRLQPPAEGF--------------DRTRGAALYAEHCALCHGAEGELLVDGEVVFPPLWGPRSYNWGAGMHRVDTAAAFIAANDTVAWDVAAYINAHERPQDPRFDGSVERTAARFHASPFDLYGEPLGVDGAVLGQGV-------

3ajaA

0.14

0.07

0.48

0.74

dPPAS

------------------------------------------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFFAADKQMSYNDSRAEGMRTTVKAMTDMNDPLTSYVIAGFSQGAVIAGDIASDIGN-GRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAGLTMTGPRPGGFDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSPVHALYNTPQFWVENGQTATNAPHP-------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 3 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.41

Estimated TM-score = 0.54±0.15

Estimated RMSD = 10.5±4.6Å

Download Model 2

C-score=-1.76

Download Model 3

C-score=-3.28

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5lo9A	0.878	2.16	0.097	0.927
2	4v2kA	0.428	2.24	0.101	0.455
3	1l5jA	0.396	6.95	0.042	0.641
4	5k6lA	0.395	7.29	0.050	0.654
5	3zukA	0.392	6.81	0.056	0.622
6	3c3lA	0.391	6.86	0.056	0.611
7	3qmzA	0.390	7.35	0.047	0.647
8	4iuwA	0.389	6.79	0.059	0.611
9	1r1hA	0.387	6.87	0.043	0.618
10	4xqkA	0.385	6.81	0.048	0.598

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	1	1agmA	MAN	Rep, Mult	446,447,448
2	0.04	1	3dd5B	DEP	Rep, Mult	127,169,203,204
3	0.04	1	5lo9A	HEC	Rep, Mult	47,51,54,114,117,118,128,129,130,132,139,140,144,147,152,155,159,160,163
4	0.04	1	1f8rC	UUU	Rep, Mult	332,335
5	0.04	1	2wieC	CVM	Rep, Mult	54,59
6	0.04	1	2wsc2	CLA	Rep, Mult	294,350
7	0.04	1	3c9hA	MG	Rep, Mult	171,173,375
8	0.04	1	1jdbE	GLN	Rep, Mult	38,39,40,47,48,51
9	0.04	1	1dlqB	LIO	Rep, Mult	18,21
10	0.04	1	1a9x2	III	Rep, Mult	40,44,49,50,53,80
11	0.04	1	2xquB	CVM	Rep, Mult	43,44
12	0.04	1	3dc7B	MG	Rep, Mult	295,296
13	0.04	1	3eqaA	MAN	Rep, Mult	151,445,446,447
14	0.04	1	1a9x1	III	Rep, Mult	207,208,210,211,303

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2j5wA	0.367	7.50	0.043	0.624	1.16.3.1	NA
2	0.060	3gm8A	0.374	7.26	0.056	0.615	3.2.1.-	NA
3	0.060	1itkB	0.361	7.40	0.045	0.611	1.11.1.6,1.11.1.7	NA
4	0.060	3gpbA	0.340	7.85	0.039	0.605	2.4.1.1	NA
5	0.060	1q2lA	0.348	7.15	0.066	0.564	3.4.24.55	NA
6	0.060	1dmtA	0.388	6.79	0.052	0.613	3.4.24.11	304
7	0.060	2dqmA	0.354	7.26	0.032	0.581	3.4.11.2	NA
8	0.060	2a4zA	0.357	7.12	0.036	0.575	2.7.1.153	301
9	0.060	2pdaA	0.349	7.67	0.040	0.600	1.2.7.1	223
10	0.060	1r1jA	0.388	6.73	0.060	0.609	3.4.24.11	NA
11	0.060	3epsA	0.349	7.14	0.034	0.564	2.7.11.5	213
12	0.060	2eabA	0.363	7.52	0.052	0.609	3.2.1.63	NA
13	0.060	2q1fA	0.348	7.59	0.043	0.596	4.2.2.21	NA
14	0.060	1ofdA	0.334	7.74	0.049	0.577	1.4.7.1	NA
15	0.060	1fa9A	0.338	7.68	0.049	0.581	2.4.1.1	NA
16	0.060	3dwbA	0.372	6.70	0.042	0.583	3.4.24.71	304
17	0.060	3l4uA	0.352	7.53	0.043	0.596	3.2.1.20,3.2.1.3	NA
18	0.060	2vdcA	0.352	7.45	0.032	0.594	1.4.1.13	NA
19	0.060	2je8B	0.351	7.29	0.040	0.583	3.2.1.25	161

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.428	2.24	0.10	0.46	4v2kA	GO:0009055 GO:0016491 GO:0020037 GO:0042597 GO:0046872 GO:0050338 GO:0055114
1	0.06	0.362	6.67	0.02	0.56	4fkeA	GO:0001525 GO:0001618 GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006
2	0.06	0.396	6.95	0.04	0.64	1l5jA	GO:0003723 GO:0003729 GO:0003730 GO:0003994 GO:0005829 GO:0006097 GO:0006099 GO:0006417 GO:0008152 GO:0016829 GO:0019629 GO:0046872 GO:0047456 GO:0051536 GO:0051539
3	0.06	0.384	6.78	0.07	0.61	4cthA	GO:0001822 GO:0002003 GO:0004175 GO:0004222 GO:0005737 GO:0005886 GO:0005887 GO:0005903 GO:0005925 GO:0006508 GO:0006518 GO:0008021 GO:0008233 GO:0008237 GO:0008238 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019233 GO:0030424 GO:0030425 GO:0042277 GO:0044306 GO:0045202 GO:0046449 GO:0046872 GO:0050435 GO:0070062 GO:0071345 GO:0071492 GO:0071493 GO:0090399
4	0.06	0.319	7.66	0.05	0.55	1acoA	GO:0003994 GO:0005506 GO:0005634 GO:0005739 GO:0006099 GO:0006101 GO:0008152 GO:0016829 GO:0043209 GO:0046872 GO:0051536 GO:0051539
5	0.06	0.389	6.79	0.06	0.61	4iuwA	GO:0004222 GO:0006508 GO:0008237
6	0.06	0.372	6.70	0.04	0.58	3dwbA	GO:0001666 GO:0001921 GO:0003100 GO:0004175 GO:0004222 GO:0005765 GO:0005768 GO:0005769 GO:0005886 GO:0006508 GO:0006915 GO:0007507 GO:0008217 GO:0008233 GO:0008237 GO:0009897 GO:0010613 GO:0010814 GO:0010815 GO:0010816 GO:0016020 GO:0016021 GO:0016485 GO:0016486 GO:0016787 GO:0017046 GO:0019229 GO:0030141 GO:0030819 GO:0031302 GO:0031410 GO:0031982 GO:0033093 GO:0034959 GO:0035994 GO:0042312 GO:0042447 GO:0042493 GO:0042733 GO:0042803 GO:0043583 GO:0045745 GO:0046686 GO:0046872 GO:0048471 GO:0060037 GO:0070062 GO:0070372
7	0.06	0.278	7.69	0.04	0.49	3ueqA	GO:0003824 GO:0005576 GO:0005975 GO:0016740 GO:0016757 GO:0047669
8	0.06	0.392	6.81	0.06	0.62	3zukA	GO:0004222 GO:0005618 GO:0005886 GO:0006508 GO:0008237 GO:0046872
9	0.06	0.258	7.63	0.05	0.45	4kp2A	GO:0003861 GO:0008152 GO:0008652 GO:0009098 GO:0016829 GO:0016836 GO:0046872 GO:0051536 GO:0051539
10	0.06	0.245	7.11	0.04	0.40	1k7wD	GO:0003824 GO:0004056 GO:0005212 GO:0006526 GO:0008652 GO:0016829 GO:0042450
11	0.06	0.254	6.75	0.04	0.40	4hjwC	GO:0001760 GO:0006568 GO:0016787 GO:0046872 GO:1904984
12	0.06	0.273	7.36	0.03	0.46	4kp1A	GO:0003861 GO:0008152 GO:0008652 GO:0009082 GO:0009097 GO:0009098 GO:0016829 GO:0016836 GO:0046872 GO:0047508 GO:0050075 GO:0051536 GO:0051539
13	0.06	0.284	7.83	0.02	0.49	3loyA
14	0.06	0.231	7.30	0.06	0.38	2zooA	GO:0005507 GO:0006807 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0050421 GO:0055114
15	0.06	0.219	6.96	0.02	0.35	3vmfB	GO:0005737 GO:0006412 GO:0006415 GO:0016149
16	0.06	0.213	7.08	0.07	0.35	3vqiB	GO:0005737 GO:0006810 GO:0006914 GO:0016020 GO:0034045
17	0.06	0.205	6.46	0.05	0.32	3ocdA	GO:0005506 GO:0005507 GO:0009055 GO:0016491 GO:0016669 GO:0016783 GO:0018192 GO:0019417 GO:0020037 GO:0042597 GO:0046872 GO:0046982 GO:0055114 GO:0070069
18	0.06	0.176	6.48	0.02	0.27	4pchB	GO:0005198 GO:0019028

Consensus prediction of GO terms

Molecular Function	GO:0043169
GO-Score	0.56
Biological Processes	GO:0006099	GO:0006417	GO:0043171	GO:0001525	GO:0046718	GO:0030154	GO:0019629	GO:0006097	GO:0050435	GO:0006101	GO:0090399	GO:0071493	GO:0002003	GO:0071345	GO:0019233	GO:0046449	GO:0001822	GO:0071492
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0042597	GO:0005829	GO:0005903	GO:0005634	GO:0008021	GO:0005739	GO:0043209	GO:0030424	GO:0044306	GO:0005887	GO:0030425	GO:0005925	GO:0070062
GO-Score	0.07	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.