I-TASSER results

I-TASSER results for job id Rv0128

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (259 residues)
MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQRAVLGLFGDDAWMSVT
ASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAAGVDIMLGGWHESMLDFVP
ILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIERHLAGGKVEDWLGYFLLHAS
FVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLHADRRGLVNQKRPQPGKRLFRAL
RRGELDSGTSTPATNYGSS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQRAVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAAGVDIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIERHLAGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLHADRRGLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS
Prediction	CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
Conf.Score	9876665677999999999989999999876676754433699999999986889999999999999999999999999986555557899999999999999999997556666546899999999999999999975755655567536789999999999789858999999999999999999999999998999999999999999999999987666666554445677777776666656778887667889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQRAVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAAGVDIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIERHLAGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLHADRRGLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS
Prediction	7455334441000000033013100200021332100200110020011003331220120111231121000001001322444322100000021322112211111322333332310000000001010003425735131010001023003200310244533400210001201330121012012324332011111222221111111234244236554554264144345445246445233453468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQRAVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAAGVDIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIERHLAGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLHADRRGLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS

3wdoA

0.10

0.09

0.90

MUSTER

LNRESGMVKGSFSKVLAEPRLLKLNFGIMCL----HMLLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA-----QTQFWQLVVGVQLFFVAFNLMEAL---------LPSLISKES-------PAGYTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPADIAANEALKVRLLETEGAEEEHIDSK

4ke2A

0.09

0.07

0.76

0.90

dPPAS

-------------------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP--------------------

3wdoA2

0.12

0.08

0.73

1.28

wdPPAS

--RESGMVKGSFSKVLA--------PRLLKL-GIMCLHLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA-----QTQFWQLVVGVQLFFVAFNLMEAL---------LPSLISKES--------AGYTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPY------------------------------------

3wdoA

0.11

0.10

0.90

1.02

wMUSTER

LNRESGMVKGSFSKVLAEPRLLKLNFGIMCL----HMLLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA-----QTQFWQLVVGVQLFFVAFNLMEAL---------LPSLISKES-------PAGYTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPYVLRIEIPADIAANEALKVRLLETEGVKAEEEHIDSK

3wdoA2

0.13

0.09

0.73

1.77

wPPAS

--RESGMVKGSFSKVLA--------PRLLKL-GIMCLHLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA-----QTQFWQLVVGVQLFFVAFNLMEAL---------LPSLISKES--------AGYTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVAST-------------------------------MKEP--PY---

4ke2A

0.09

0.07

0.76

1.53

dPPAS2

-------------------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP--------------------

3wdoA2

0.11

0.08

0.75

1.47

PPAS

--RESGMVKGSFSKVLAPRLLKLNFGIMCLHM-----LLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA-----QTQFWQLVVGVQLFFVAFNLMEAL---------LPSLISKES--------AGYTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPY------------------------------------

4w6vA1

0.13

0.11

0.85

0.94

Env-PPAS

TNTPGGRTFFGYPLSGLFLSEMWERFSFYGIRPLLILFMAATVFDGGMGLPR-EQASAIVGIFAGSMYLAALPGGLLADNWLG----QQRAVWYGSILIALGHLSIALSAFFGNDLFFIGLVFIVLGTGLFKTCISVMVGTLYKP--------------------GDARRDGGFSLFYMGINMGSFIAPLLSGWLLRTHGWHWGFGIGGIGMLVALLIFRGFAIPAMKRYDAEVGLDSSWNK----------PT-----

3wajA

0.09

0.98

0.88

MUSTER

ILGFNDHHIWEAFWQVSALGTFLLAY--RWKGHDLTARQMAYPVIAGITIGL--YVLSWGAGFIIAPIILAFMFFAFVLAGFVNADRKNLSLVAVVTFAVSALIYLPFAFNYPGFSTLLVLLGSAVIAAAFYQIEKWNDVGGLGRKGMPLAVIVLTALIMGLFFVLTAYRFLKRRSFPEMALLIWAIAMFIALWGQNRFAYYFAAVSAVYSALALSVVFDKLHFRVAFALLIALAAIYPTYILADAQSSYAGGPNKQDA

3wdoA2

0.09

0.07

0.76

0.83

dPPAS

--RESGMVKGSFSKVLAPRLLKLNFGIMCLHM-----LLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKR-KMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPA------------------GYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPY------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.87

Estimated TM-score = 0.49±0.15

Estimated RMSD = 10.1±4.6Å

Download Model 2

C-score=-3.35

Download Model 3

C-score=-3.55

Download Model 4

C-score=-4.22

Download Model 5

C-score=-1.92

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wdoA	0.751	2.51	0.099	0.842
2	4w6vA1	0.672	3.40	0.088	0.819
3	1pw4A2	0.651	3.19	0.110	0.795
4	4ybqA	0.649	3.58	0.088	0.807
5	4gbyA1	0.647	3.64	0.084	0.815
6	4ldsA	0.643	3.03	0.074	0.780
7	1pv6A2	0.642	3.34	0.063	0.799
8	4ikvA	0.642	3.06	0.101	0.764
9	3o7pA2	0.641	2.53	0.089	0.741
10	5c65A	0.634	3.97	0.102	0.826

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1qiyB	III	Rep, Mult	35,36,38
2	0.04	2	5d58A	78M	Rep, Mult	29,191,199,204
3	0.04	2	3ug6B	MG	Rep, Mult	40,54,58
4	0.04	2	3l1lA	ARG	Rep, Mult	42,43,46,99,100,103,104,107,205
5	0.04	2	4uvmA	78N	Rep, Mult	15,24,29,172
6	0.04	2	4jreD	GYP	Rep, Mult	28,180,183,184,203,204,207,208
7	0.02	1	5d58A	78M	Rep, Mult	100,104,198,199,202,205,209
8	0.02	1	2y5yA	TGA	Rep, Mult	132,136,181
9	0.02	1	5aymA	FE2	Rep, Mult	30,38,207,210,211
10	0.02	1	2q68A	CA	Rep, Mult	41,42
11	0.02	1	5d58A	78M	Rep, Mult	89,90,93,94,101,216,220
12	0.02	1	3ob6B	ARG	Rep, Mult	28,99,102
13	0.02	1	3qbmA	MG	Rep, Mult	50,53
14	0.02	1	4u4tA	ZN	Rep, Mult	19,222
15	0.02	1	2wsc2	CLA	Rep, Mult	184,191
16	0.02	1	5d59A	78M	Rep, Mult	13,24,171,172,175,179
17	0.02	1	3f3aA	TRP	Rep, Mult	187,190,191,195,199
18	0.02	1	5d58A	78M	Rep, Mult	100,209,212,213,216
19	0.02	1	3gjcA	NA	Rep, Mult	71,72,73,74,75,133
20	0.02	1	1fbmD	RTL	Rep, Mult	12,19

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1mhyB	0.407	4.44	0.046	0.552	1.14.13.25	105
2	0.060	1pfuA	0.383	5.22	0.089	0.587	6.1.1.10	33
3	0.060	2p0mA	0.407	5.65	0.069	0.649	1.13.11.33	NA
4	0.060	1q16A	0.411	5.86	0.047	0.679	1.7.99.4	NA
5	0.060	2zufA	0.392	5.78	0.049	0.633	6.1.1.19	74
6	0.060	7reqB	0.401	5.33	0.048	0.622	5.4.99.2	NA
7	0.060	1ogyI	0.391	6.30	0.047	0.695	1.7.99.4	NA
8	0.060	1qmgA	0.378	5.28	0.045	0.556	1.1.1.86	NA
9	0.060	3fg3A	0.435	4.73	0.055	0.625	4.2.1.92,1.13.11.40	NA
10	0.060	3fr8B	0.397	6.03	0.026	0.683	1.1.1.86	NA
11	0.060	3ee4A	0.395	4.01	0.085	0.521	1.17.4.1	NA
12	0.060	3dy5A	0.413	4.81	0.057	0.602	1.13.11.40,4.2.1.92	NA
13	0.060	3hf1B	0.375	4.05	0.070	0.498	1.17.4.1	NA
14	0.060	2b3xA	0.392	6.29	0.054	0.695	4.2.1.3	30
15	0.060	7reqD	0.402	5.39	0.048	0.625	5.4.99.2	189
16	0.060	3bicA	0.405	5.01	0.045	0.583	5.4.99.2	138,178
17	0.060	1pg0A	0.391	4.88	0.079	0.571	6.1.1.10	150
18	0.060	2yr4A	0.397	6.22	0.074	0.679	1.13.12.9	31,188
19	0.060	3bicB	0.406	5.12	0.035	0.595	5.4.99.2	127

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.619	3.04	0.09	0.74	4tpgA	GO:0005215 GO:0005427 GO:0006810 GO:0006857 GO:0015197 GO:0015833 GO:0016020 GO:0016021 GO:0035672 GO:0042802
1	0.18	0.619	2.64	0.07	0.72	2xutA	GO:0005215 GO:0006810 GO:0006857 GO:0015197 GO:0015833 GO:0016020 GO:0016021
2	0.16	0.619	3.91	0.06	0.81	4uvmA	GO:0005215 GO:0006810 GO:0006857 GO:0015197 GO:0015833 GO:0016020 GO:0016021
3	0.08	0.651	3.19	0.11	0.80	1pw4A	GO:0005215 GO:0005886 GO:0006071 GO:0006810 GO:0015169 GO:0015315 GO:0015527 GO:0015793 GO:0015794 GO:0016020 GO:0016021 GO:0035435 GO:0055085
4	0.08	0.620	3.31	0.07	0.75	5a2nA	GO:0005215 GO:0005886 GO:0006810 GO:0006857 GO:0009414 GO:0009635 GO:0009734 GO:0010167 GO:0015112 GO:0015293 GO:0015706 GO:0016020 GO:0016021 GO:0042128 GO:0055085
5	0.08	0.592	3.64	0.06	0.75	4xnjA	GO:0005215 GO:0006810 GO:0006857 GO:0015197 GO:0015833 GO:0016020 GO:0016021 GO:0042802
6	0.08	0.639	3.17	0.08	0.78	4oh3A	GO:0005215 GO:0005886 GO:0006810 GO:0006857 GO:0009414 GO:0009635 GO:0009734 GO:0010167 GO:0015112 GO:0015293 GO:0015706 GO:0016020 GO:0016021 GO:0042128 GO:0055085
7	0.08	0.628	3.03	0.07	0.76	4oh3B	GO:0005215 GO:0005886 GO:0006810 GO:0006857 GO:0009414 GO:0009635 GO:0009734 GO:0010167 GO:0015112 GO:0015293 GO:0015706 GO:0016020 GO:0016021 GO:0042128 GO:0055085
8	0.07	0.637	3.55	0.07	0.81	2cfpA	GO:0005351 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015293 GO:0015528 GO:0015767 GO:0015992 GO:0016020 GO:0016021 GO:0030395 GO:0055085
9	0.07	0.624	3.45	0.08	0.76	4zp0A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015385 GO:0015386 GO:0016020 GO:0016021 GO:0030641 GO:0035725 GO:0046677 GO:0055085 GO:0071805
10	0.07	0.621	2.68	0.10	0.73	4q65A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006857 GO:0015031 GO:0015197 GO:0015333 GO:0015833 GO:0015992 GO:0016020 GO:0016021 GO:0042936 GO:0042938
11	0.07	0.642	3.06	0.10	0.76	4ikvA	GO:0005215 GO:0006810 GO:0006857 GO:0015197 GO:0015833 GO:0016020 GO:0016021
12	0.07	0.534	3.33	0.05	0.67	2gfpA	GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0015893 GO:0016020 GO:0016021 GO:0055085
13	0.06	0.354	6.31	0.07	0.63	4jevB	GO:0003824 GO:0003992 GO:0005737 GO:0005829 GO:0006520 GO:0006525 GO:0006526 GO:0008483 GO:0008652 GO:0009016 GO:0009085 GO:0009089 GO:0016740 GO:0030170 GO:0042802
14	0.06	0.310	6.23	0.05	0.54	3aqbD	GO:0000287 GO:0008299 GO:0009234 GO:0016740 GO:0016765 GO:0036423 GO:0046872
15	0.06	0.287	5.56	0.08	0.46	4r8zA	GO:0000160 GO:0005622 GO:0071111 GO:1900231 GO:2000147
16	0.06	0.331	5.39	0.06	0.52	1pquA	GO:0003942 GO:0004073 GO:0005737 GO:0006520 GO:0008652 GO:0009085 GO:0009086 GO:0009088 GO:0009089 GO:0009097 GO:0016491 GO:0016620 GO:0019877 GO:0046983 GO:0050661 GO:0051287 GO:0055114 GO:0071266
17	0.06	0.223	6.58	0.03	0.41	5i9qA	GO:0005198 GO:0016020 GO:0016021 GO:0016032 GO:0019012 GO:0019031 GO:0019062 GO:0020002 GO:0033644 GO:0039663 GO:0044174 GO:0044175 GO:0046718 GO:0055036
18	0.06	0.207	5.97	0.04	0.35	1t57A	GO:0000166 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0005515	GO:0015322
GO-Score	0.39	0.39
Biological Processes	GO:0006857	GO:0055085
GO-Score	0.49	0.39
Cellular Component	GO:0016021	GO:0071944
GO-Score	0.53	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.