I-TASSER results

I-TASSER results for job id Rv0102

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (661 residues)
MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLVSGARRYAEAGNPYPGA
FVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAAAFRIHLLAERVSGLWLGL
AATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWIVAAICALVVATALRLYTRWL
GHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVFAVAFATLTGLKIAAALAGTTPS
RAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFARLGLLAGVILTSVWLFDCWRLLVR
PPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAPRFLTHAFTAWDVFLGYELPQPPTIAR
VLTVWRFDSLIGAAGVVLAIGYAAGFAALRRRGNSWPVGRLIAWLTGCAALVFTSGSGVR
AYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRVLPVTGDGRPPGAREWLTWLLHSR
VTTFLSHPITAFVLFVASPYIVYFTPLFDTFVRYHWGHEFMAIHFLVVGYLFYWAIIGID
PGPRRLPYPGRIGLLFAVMPFHAFFGIALMTMSSTVGATFYRSVNLPWLSSIIADQHLGG
GIAWSLTELPVIMVIVALVTQWARQDRRVASREDRHADSDYADDELEAYNAMLRELSRMR
R

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLVSGARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAAAFRIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWIVAAICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVFAVAFATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFARLGLLAGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAPRFLTHAFTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRRGNSWPVGRLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRVLPVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLFDTFVRYHWGHEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFGIALMTMSSTVGATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWARQDRRVASREDRHADSDYADDELEAYNAMLRELSRMRR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
Conf.Score	9999998888888888888876468999999999999999999757876656788998668899999999999999999999999999853488888777556889999999999999999999999999987887455566689999998758899999999999999999999756567999999999999999865778899986468999999999999999999999997655655678999999999999999999985565554688557799999999999999999999988877765677899999999999999998747899888888987777647888999877776645554699999999999999999999987578888999999999999999998687688888899999999999999999999998689999998677778888768899999876688999987999999999999999998999999985899999999999999999999976788888887689999999999999999999998698746777876688889999999999999999988999999999999999986788999999988765565899999999999987669
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLVSGARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAAAFRIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWIVAAICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVFAVAFATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFARLGLLAGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAPRFLTHAFTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRRGNSWPVGRLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRVLPVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLFDTFVRYHWGHEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFGIALMTMSSTVGATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWARQDRRVASREDRHADSDYADDELEAYNAMLRELSRMRR
Prediction	7536545444544444444110000000000000000100000001132121120010100000000000000000000000000100000023562313140110000000000000100010000000010021013103132013002314200000000010021011000001110010001102201210000000001320000000001111000110000000000122121100000000000000000000000201100002000000000000010000000000001231342200000000000011000000011043434434143220000120110010121011010001100100110210110000012244501100000000001011000000000000000000000000000000100000000000000011234232210120000001120000000010003222201200020000000000000000001000100210000000011113210000000000000110011000000000000100000030002030120001000000000021001001100000025345514441342446543521420140044037568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLVSGARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAAAFRIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWIVAAICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVFAVAFATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFARLGLLAGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAPRFLTHAFTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRRGNSWPVGRLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGPVTLALRVLPVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLFDTFVRYHWGHEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFGIALMTMSSTVGATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWARQDRRVASREDRHADSDYADDELEAYNAMLRELSRMRR

5ezmA

0.12

0.09

0.77

1.28

MUSTER

--------------------------------------------------------------------SAATGWVVLFVAVALVVWFVSL------DMRHLVGPDEGRYAEISREMFASGDWVTIRYNALKYFEKPPFHMWVTVVGYELFGLGEWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMW----------SVAAHFNTLDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTKG-------------LVGIALPGLVLVVYTLVTRDWGLWRRL--HLALGVVVMLVITVPWFYLVSVRN----------PEFPNFFFIHEHWQ-----RRSGSVFYFLPLVIGGFLPWAGIFPKLWTAMRA--RFRPALMAGIWAIAIFVFFSISRSK------------LPGYIVPVIPALGILAGVALDRLS---------------------PRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSFYRAYAVWVAVAFVVMLLGIAVARLLLRRGVLPSVAVYAMGMYLGFTVALLGHETVGRPASGADIAPQIAQKLTP-EMPLYGVQMLDHTLPFYLRHPLMMVGQADELTFGATVEPQRVDSFTKLWKNGQP--SPDTYLALAPTLARDWR

5e1jA

0.06

0.05

0.90

1.11

dPPAS

LAEDGIGLPVEILDRYYFIFTRLDLIWSLNYFALLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLVHTFF-------PISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLY-------FRIAPYVRVIIFILSI----RELRDTLVLLSGMLGTYLNILALWMLFLLFASWIAFVMF---EDTQQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDKNQCIKLFEQLTNYEEFGLIFDELDDTRDFKINKDQAIALRFQKEYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVIGETATFIT-------PFSNGEWIRYLLLARMLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLNKKLFETELA--------EDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWW----SITYFVSFYVITILLLLNLVVAFVLEAFFTELDLEEEEK---------------------------

5ezmA

0.11

0.08

0.73

1.24

wdPPAS

--------------------------------------------------------------------SAATGWVVLFVAVALVVWFVSL---DMRHLVGPDEGRYAEISREMFASWVTPFHMWVTVVGYELFGLG-----------------EWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMW----------SVAAHFNTLDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTK--------------LVGIALPGLVLVVYTLVTRDWGLWRRL-----HLALGVVVMLVITVPWFYLVSVRNP-------EFPNFFFIHE-----HWQRRSGSVFYFLPLVIGGFLPWAGIFPKLWTAMRARFR-PALMAGIWAIAIFVFFSISRSKL-------------PGYIVPVIPALGILAGVALDRLS-------------------PRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSFYRAYAVWVAVAFVVMLLGIAVARLLL-------RRGVLPSVAVYAMGMYLGFTVALLGHETSGADIAPQIAQKLTP---MPL-------TLPFYLRHPLMMVGQADELTFGATVEPQRVDSFTKLWKNGQP--SPDTYLALAPTVARDWR

5ezmA

0.13

0.10

0.74

1.38

wMUSTER

--------------------------------------------------------------------SAATGWVVLFVAVALVVWFVSL------DMRHLVGPDEGRYAEISREMFAS-----VTIR---YNALKYFEHMWVTVVGYELFLGEWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMW----------SVAAHFNTLDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTK--------------LVGIALPGLVLVVYTLVTRDWGLWRRL--HLALGVVVMLVITVPWFYLVSVRN----------PEFPNFFFIHEHWQ-----RRSGSVFYFLPLVIGGFLPWAGIFPKLWTAMRARFR-PALMAGIWAIAIFVFFSISRSKL-------------PGYIVPVIPALGILAGVALDRL---------------------SPRSWGKQLIGMAIVAACGLLASPVVATL--IPNSFYRAYAVWVAVAFVVMLLGIAVARLLL------RRGVLPSVAVYAMGMYLGFTVALLGHETVSGADIAPQIAQKLTP-EMPLYGVQMLDHTLPFYLRHPLMMVGQADELTFGATVEPQRVDSFTKLWKNGQP--SPDTYLALAPTLARDWR

5ezmA

0.10

0.07

0.73

1.76

wPPAS

--------------------------------------------------------------------SAATGWVVLFVAVALVVWFVSL---DMRHLVGPDEGRYAEISREMFASWVTIRY----------NALKYFE---VTVVGYELFGLGEWQARLAVALSGLLGIGVSMMAAR-ARAAAFTGLALLAAPMWSVAAHFNT------------LDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTK--------------LVGIALPGLVLVVYTLVTRDWGLWRRL-----HLALGVVVMLVITVPWFYLVSVRNP-------EFPNFFFIHE-----HWQRRSGSVFYFLPLVIGGFLPWAGIFPKLWTAMRARFR-PALMAGIWAIAIFVFFSISRSKL-------------PGYIVPVIPALGILAGVALDRLS-------------------PRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSFYRAYAVWVAVAFVVMLLGIAVARLLL-------RRGVLPSVAVYAMGMYLGFTVALLGHET----VGRPASGAD----IAPQIAQKLTPTLPFYLRHPLMMV--DELTFGATVEPQRDVDSFTKLWKNGQP--SPDTYLALAPTVARDWR

5ezmA

0.11

0.08

0.70

1.61

dPPAS2

--------------------------------------------------------------------SAATGWVVLFVAVALVVWFVSL------DMRHLVGPDEGRYAEISREMFASPFHMWVTVVGYELFGLG-----------------EWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMW----------SVAAHFNTLDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTKG-------------LVGIALPGLVLVVYTLVTRDWGLWRRL--HLALGVVVMLVITVPWFYLVSVRN----------PEFPNFFFIHEHWQ-----RRSGSVFYFLPLVIGGFLPWAGIFPKLWTAMRARFR-PALMAGIWAIAIFVFFSISRSKL-------------PGYIVPVIPALGILAGVALDRL-------------------SPRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSFYRAYAVWVAVAFVVMLLGIAVARLLL-------RRGVLPSVAVYAMGMYLGFTVALLGHETSGADIAPQIAQKLTPQMLDH--------TLPFYLRHPLMMV----------GQADELTFGATVEPQRVVPD------VDSFTKLWKNGQ

5ezmA

0.10

0.08

0.75

1.81

PPAS

--------------------------------------------------------------------SAATGWVVLFVAVALVVWFVSL------DMRHLVGPDEGRYAEISREMFASGDWVTIRYN-----ALKYFE---VTVVGYELFLGEWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMWSVAAHFNT----------LDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTK--------------LVGIALPGLVLVVYTLVTRDWGLWRRL--HLALGVVVMLVITVPWFYLVSVR----------NPEFPNFFFIHEHWQRRS-----GSVFYFLPLVIGGFLPWAGIFPKLWTAMRA--RFRPALMAGIWAIAIFVFFSISRS-------------LPGYIVPVIPALGILAGVALDRLS-------------------PRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSFYRAYAVWVAVAFVVMLLGIAVARLLL-------RRGVLPSVAVYAMGMYLGFTVALLGHETSGADIAPQIAQKLTP-EMPLYGVQMLDHTLPFYLRPLMMVGQADELTFGATVEPQRDVDSFTKLWKNGQP--SPDTYLALAPTLARDWR

4zg4E

0.11

0.10

0.95

0.88

Env-PPAS

MAVAELYTQYNPEEVAKDYRVGDKVLRLLLELDYSVNPESLPPLRNPDILVGENLSYLHEPAVLHNLRIRFAESKLIYTYSGIILVA--MNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRNQSIIV--------SGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVLASNPITEAVGNAKTTRNDNSSRFEISFDEQN-QIIGANMSTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLFKEDFQMDVFKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLE---SGRVAQWLCPMTRPQAVNARDALAKKIYAHLFDFIVERINQQFSGKQHTFIFEQFCINYANEKLQQQFNMHVFKLEQEEYMKFYDNQPVIDLIEAKMG-ILELLDEECLLPHGTDENWLQKLYNNFVNPLFEKPRMSNTSFVIQHFVEYKCEGFLEKNRDTV-YDMLVEILRASKFHLCANFFQENRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEK-------LPFEFDSKRIVQQLRACGVLETIRISAQYIEFYSRYGILKQELSFVCKVVLHRLIQDSNQ-----Y-QFVAYLEKL-R

4ui9O

0.08

0.94

1.14

MUSTER

MSRTGEGAVSLVERRRQGPDITVSKLLKLIEESCPQLANSVQIRI-----KLMAEGELKDMEQFFDDLSDSFSGTEPEVVVGLFLRHMILA-LSFSQVFKYTALQQYFQSDENKKPLSQKQAEFFLSQQASLLKNDETKALTPASLQKELNNLLKFNP---FAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGYQQAELALQEAIRESNDHVCLQHCLSWLYVLYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQ--QAQMLLSMNSLEQQNNTESFA----VALCHLAELHAEQGCFAAASEVLKHLKPNSQHAQLWMLCDQKIQFDRAMNDGADSLVTGITALNSIEGVYRKAVVLQAQ-MSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRS--SPTIALPMLLQALALSKEYQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASY----DQPKKAEALEAAI-------ENLNEAKNYFAKVCKERIRDVVYFQARLYHTLTQERNRCAMLFRQLHQELPSVPL--INHL---------

5ezmA

0.11

0.08

0.77

1.11

dPPAS

--------------------------------------------------------------------SAATGWVVLFVAVALVVWFVSL------DMRHLVGPDEGRYAEISREMFASGDWVTIRYNALKYFEKPPFHMWVTVVGYELFGLGEWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMW----------SVAAHFNTLDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTKG---------------LVGIALPGLVLVVYTLVTRDWGLWRRLHLALGVVVMLVITVPWFYLVSVRN----------PEFPNFFFIHEHWQRR------SGSVFYFLPLVIGGFLPWAGIFPKLWTAMRARFRPALMAGIWAIAIFVFFSISRSKL-------------PGYIVPVIPALGILAGVALDRL---------------------SPRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSFYRAYAVWVAVAFVVMLLGIAVARLLLRRGVLPSVAVYAMGMYLGFTVALLGHETVGRPASGADIAPQIAQKLTP-EMPLYGVQMLDHTLPFYLRHPLMMVDELTFGATVEPQRVVPDVDSFTKLWKNGQPAMAVMSPDTYLALAPTLS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.33

Estimated TM-score = 0.44±0.14

Estimated RMSD = 13.7±4.0Å

Download Model 2

C-score=-2.44

Download Model 3

C-score=-4.17

Download Model 4

C-score=-4.25

Download Model 5

C-score=-2.70

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3c3lA	0.376	8.37	0.041	0.623
2	1kc7A	0.334	7.63	0.058	0.508
3	2j5wA	0.331	8.19	0.038	0.545
4	1jb0A	0.331	7.35	0.074	0.502
5	2c4mC	0.329	7.44	0.048	0.498
6	1kekA	0.327	8.02	0.060	0.532
7	3ikmD	0.327	7.94	0.031	0.522
8	2aw3A	0.326	7.57	0.034	0.495
9	1ygpA	0.326	7.54	0.033	0.493
10	1t3tA2	0.325	8.10	0.047	0.523

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	3	2c3oA	SF4	Rep, Mult	222,223,224,225,259,262,263,280,281
2	0.06	2	3kziK	CLA	Rep, Mult	442,443,446
3	0.06	2	3lw51	CLA	Rep, Mult	563,566,567
4	0.03	1	3d1lB	MPR	Rep, Mult	167,199,200
5	0.03	1	1txuA	MG	Rep, Mult	540,562
6	0.03	1	3g0kA	CA	Rep, Mult	603,608
7	0.03	1	2o01A	PQN	Rep, Mult	529,530,533,534,535
8	0.03	1	3venA	FE2	Rep, Mult	430,434,463,643
9	0.03	1	7insD	UNK	Rep, Mult	430,433
10	0.03	1	2o01A	SF4	Rep, Mult	225,227,229,256
11	0.03	1	1b0pA	SF4	Rep, Mult	228,232,233,248,249,250,251,255
12	0.03	1	2vl1B	III	Rep, Mult	273,274
13	0.03	1	5ezmA	MPG	Rep, Mult	75,190,193,548
14	0.03	1	5ezmA	MPG	Rep, Mult	88,92,560

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2qf7B	0.315	8.06	0.041	0.513	6.4.1.1	NA
2	0.060	3c46B	0.377	8.38	0.048	0.626	2.7.7.6	433
3	0.060	1b0pA	0.329	7.77	0.046	0.516	1.2.7.1	NA
4	0.060	2fhbA	0.307	7.62	0.049	0.477	3.2.1.41	NA
5	0.060	1fziA	0.314	7.23	0.052	0.472	1.14.13.25	NA
6	0.060	1mswD	0.292	8.81	0.048	0.510	2.7.7.6	NA
7	0.060	2rnpC	0.296	8.61	0.034	0.507	2.7.7.6	NA
8	0.060	1t3tA	0.311	8.10	0.034	0.501	6.3.5.3	550
9	0.060	2j5wA	0.331	8.19	0.038	0.545	1.16.3.1	NA
10	0.060	3bg3A	0.315	8.32	0.067	0.519	6.4.1.1	NA
11	0.060	2azdB	0.323	7.79	0.050	0.510	2.4.1.1	225
12	0.060	2ckjA	0.292	7.96	0.069	0.470	1.17.1.4,1.17.3.2	NA
13	0.060	1qleA	0.310	7.73	0.052	0.490	1.9.3.1	NA
14	0.060	2vdcF	0.280	7.82	0.043	0.436	1.4.1.13	83
15	0.060	2qf7A	0.320	8.05	0.041	0.519	6.4.1.1	NA
16	0.060	3b9jI	0.131	5.84	0.027	0.175	1.17.1.4,1.17.3.2	NA
17	0.060	1jqoA	0.317	7.56	0.039	0.489	4.1.1.31	NA
18	0.060	3b9jJ	0.206	5.95	0.065	0.277	1.17.1.4,1.17.3.2	NA
19	0.060	1br2A	0.305	8.13	0.046	0.499	3.6.1.32	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.376	8.40	0.04	0.62	3c46A	GO:0000166 GO:0003899 GO:0005524 GO:0005525 GO:0016740 GO:0016779 GO:0019012 GO:0032774 GO:0046872
1	0.06	0.332	7.56	0.05	0.50	1kblA	GO:0000166 GO:0003824 GO:0005524 GO:0006090 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872 GO:0050242
2	0.06	0.273	8.21	0.05	0.44	2x0sA	GO:0003824 GO:0005524 GO:0006090 GO:0016301 GO:0016310 GO:0016772 GO:0020015 GO:0046872 GO:0050242
3	0.06	0.258	8.33	0.06	0.43	3igyB	GO:0003824 GO:0004619 GO:0005737 GO:0006007 GO:0008152 GO:0016853 GO:0030145 GO:0046872
4	0.06	0.289	7.92	0.05	0.46	2gq3A	GO:0000287 GO:0003824 GO:0004474 GO:0005576 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006097 GO:0006099 GO:0015936 GO:0016740 GO:0030145 GO:0046872
5	0.06	0.255	8.81	0.04	0.44	1vbgA	GO:0000166 GO:0003824 GO:0005524 GO:0005737 GO:0006090 GO:0009507 GO:0009536 GO:0015979 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872 GO:0050242
6	0.06	0.250	8.08	0.05	0.40	2wqdA	GO:0003824 GO:0005737 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
7	0.06	0.273	7.49	0.04	0.42	1y2mB	GO:0003824 GO:0005737 GO:0006559 GO:0009698 GO:0009800 GO:0016829 GO:0016841 GO:0045548 GO:0052883
8	0.06	0.235	7.72	0.05	0.37	1m3eB	GO:0005739 GO:0008152 GO:0008260 GO:0008410 GO:0016740 GO:0042803 GO:0046950 GO:0046952
9	0.06	0.245	7.69	0.06	0.39	2kx9A	GO:0000287 GO:0003824 GO:0005737 GO:0005829 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0019197 GO:0046872
10	0.06	0.235	8.19	0.03	0.39	1jkiA	GO:0004512 GO:0005737 GO:0006021 GO:0006629 GO:0008654 GO:0016853
11	0.06	0.229	6.21	0.09	0.31	3jzdA	GO:0000166 GO:0016491 GO:0046872 GO:0055114
12	0.06	0.227	6.14	0.07	0.31	3iv7A	GO:0016491 GO:0018506 GO:0046872 GO:0055114
13	0.06	0.227	8.23	0.05	0.38	2e28A	GO:0000166 GO:0000287 GO:0003824 GO:0004743 GO:0005524 GO:0006096 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0030955 GO:0046872
14	0.06	0.228	8.35	0.07	0.38	2hroA	GO:0003824 GO:0005737 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
15	0.06	0.236	8.86	0.03	0.41	2olsA	GO:0000166 GO:0003824 GO:0005524 GO:0006090 GO:0006094 GO:0008986 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
16	0.06	0.218	7.60	0.04	0.33	1o9lB	GO:0005739 GO:0008152 GO:0008260 GO:0008410 GO:0016740 GO:0042803 GO:0046950 GO:0046952
17	0.06	0.219	7.75	0.04	0.34	1jkfA	GO:0004512 GO:0005737 GO:0006021 GO:0006629 GO:0008654 GO:0016853
18	0.06	0.214	7.60	0.04	0.34	5c2kA	GO:0000166 GO:0000281 GO:0000915 GO:0001669 GO:0003924 GO:0005096 GO:0005525 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005768 GO:0005789 GO:0005819 GO:0005829 GO:0005856 GO:0005874 GO:0005886 GO:0005925 GO:0005938 GO:0006810 GO:0006811 GO:0006890 GO:0007018 GO:0007049 GO:0007165 GO:0007179 GO:0007264 GO:0007266 GO:0007275 GO:0007283 GO:0007405 GO:0008017 GO:0008272 GO:0008289 GO:0009790 GO:0016020 GO:0016032 GO:0016477 GO:0017022 GO:0019886 GO:0019901 GO:0021762 GO:0030027 GO:0030036 GO:0030054 GO:0030154 GO:0030168 GO:0030334 GO:0030496 GO:0031234 GO:0031410 GO:0031532 GO:0031982 GO:0032154 GO:0032467 GO:0032956 GO:0033688 GO:0035385 GO:0035556 GO:0036089 GO:0038027 GO:0042346 GO:0042995 GO:0043014 GO:0043015 GO:0043123 GO:0043149 GO:0043296 GO:0043297 GO:0043542 GO:0043547 GO:0043931 GO:0044319 GO:0045666 GO:0046872 GO:0048010 GO:0048013 GO:0048015 GO:0048487 GO:0050771 GO:0050772 GO:0050919 GO:0051056 GO:0051233 GO:0051256 GO:0051301 GO:0051496 GO:0051988 GO:0060071 GO:0060193 GO:0061383 GO:0070062 GO:0071902 GO:0071944 GO:0072686 GO:0090051 GO:0090307 GO:0097149 GO:0097498 GO:1902766 GO:1903673 GO:2000145

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0035639	GO:0032559	GO:0032550
GO-Score	0.56	0.36	0.36	0.36
Biological Processes	GO:0006090	GO:0016310	GO:0032774	GO:0006007	GO:0015936	GO:0006097	GO:0006099
GO-Score	0.12	0.12	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0019012	GO:0020015	GO:0005576	GO:0005618	GO:0005829	GO:0005886
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.