I-TASSER results

I-TASSER results for job id Rv0096

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (463 residues)
MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQLLGEVQASSWQGTAAT
QYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIAT
NFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPGGDAAD
TRLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYY
ASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLLPIAAALGPGDQWGANLAVAVTPAT
AAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSSGPKAGTKSPDTAAD
TLATAGAARPGLARAHRRKRSESGVGIRGYRDEFLDATATVDAATDVPAPANAAGSQGAG
TLGFAGTAPTTSGAAAGMVQLSSHSTSTTVPLLPTTWTTDAEQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPGGDAADTRLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLLPIAAALGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRDEFLDATATVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTVPLLPTTWTTDAEQ
Prediction	CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9998645555545799968899999999999999999999999999877567767869999999999999999999999999999999999999999987998899999999999999987666658899999999999999999999877677888888778889998778888776655555456645688899999887889999998876567665554455666666655555555677777655555445555555666555666666666666777776777777777777777888888888888888888888888887778787778888888888888888888888888888877788777777777777877778888777778888888888888888778788876676677888888887646657889988887888889999899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPGGDAADTRLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLLPIAAALGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRDEFLDATATVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTVPLLPTTWTTDAEQ
Prediction	7230002000102000000002000100220031022003102100011223311110000002002200300110023043103103000001110110113212011034100100100000000000030132034021300100111100000013314223222312444342242223323221310330142013012301320230122212132232112312222330321132122211222321311211101212212212222222111212121111110111011212112222112111122212111111112111110012110101122223334342343222222223334444444444444435444432142534344435344433311231011100012244643211110202435620200000001456678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCC
MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPGGDAADTRLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLLPIAAALGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRDEFLDATATVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTVPLLPTTWTTDAEQ

2g38B

0.27

0.10

0.37

1.36

MUSTER

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.10

0.37

1.49

dPPAS

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.10

0.37

2.90

wdPPAS

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.10

0.37

1.83

wMUSTER

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.10

0.37

4.32

wPPAS

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.10

0.37

3.29

dPPAS2

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.10

0.37

3.40

PPAS

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.10

0.37

3.64

Env-PPAS

EAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3p1uA

0.10

0.09

0.94

0.81

MUSTER

------------------NNEPRLASTLRGGLIIEGNVEQRLKPLQIDFYSQTVDGGGWGTKN---IQDDEWNNLVWEEYLKQIASINIVIRSLTEKYANT--IAFARIWRVYVHTLAAD-KFGPPFPAYEIVEANPP--YKSLKDIYDEYFRELDAAINGFNDSAQPIFSDAGIDLIYKNDVSKWKRFANSLRLRLAVREVDQEKCIAEANAAISSPAGLISDKADNAYPPKADGSWGQDYNYTFQITWSGPICSKSVEKLVTNIGGVAWPQGVVNQTSGVAVSSVHPEKVDPRAPKIFQPGIENGDWKGLVYGPKAEEANTGIYQSKQCAELGFIIKDGYPYKSRPYDLGFIAGDAKSGVTSEVDDYLTSTEKNEAGTSARYDDQQGAGNTLPRLDVAVYRDQAVYNNNDKDILKSANFIKRRYPTKESLINATEYEKGKSLGGKGDIVSTPLWWDKNSNY

5gaoE

0.20

0.14

0.69

0.92

dPPAS

------------------------------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAATT

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.69

Estimated TM-score = 0.40±0.14

Estimated RMSD = 13.7±4.0Å

Download Model 2

C-score=-2.85

Download Model 3

C-score=-2.62

Download Model 4

C-score=-3.85

Download Model 5

C-score=-2.80

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ehnA	0.853	2.95	0.068	0.929
2	3gzsA	0.761	3.70	0.074	0.875
3	3cghA	0.760	3.73	0.074	0.879
4	4pucA	0.757	3.78	0.085	0.877
5	4f7aA	0.756	3.63	0.094	0.875
6	4f53A	0.751	3.75	0.064	0.868
7	3sghA	0.748	3.78	0.087	0.868
8	4mruA	0.747	3.59	0.090	0.851
9	3p1uA	0.729	4.10	0.083	0.866
10	4q69A	0.654	4.47	0.077	0.808

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	4	1mz9E	VDY	Rep, Mult	147,151,154
2	0.03	2	1w5cB	CLA	Rep, Mult	144,151
3	0.03	2	2gm9A	3TH	Rep, Mult	85,89,92,102
4	0.03	2	6gpbA	GLC	Rep, Mult	78,79,81,82,95,98,99
5	0.03	2	1exvB	700	Rep, Mult	110,113,154,158
6	0.03	2	2zb2A	A46	Rep, Mult	40,42,43,71,75
7	0.02	1	1wauA	SO4	Rep, Mult	15,17,53
8	0.02	1	3ovnA	MPV	Rep, Mult	124,128
9	0.02	1	3k3wA	CA	Rep, Mult	126,134
10	0.02	1	3rj1A	SE	Rep, Mult	140,143
11	0.02	1	1ystM	BPH	Rep, Mult	94,97,98,101
12	0.02	1	2z3iD	BLS	Rep, Mult	54,56
13	0.02	1	1k4yA	MAN	Rep, Mult	153,157
14	0.02	1	3e1nE	UNK	Rep, Mult	158,188
15	0.02	1	1l7xA	700	Rep, Mult	80,82,110,114
16	0.02	1	2w0sB	BVP	Rep, Mult	21,25,28
17	0.02	1	2g38B	MN	Rep, Mult	146,149,150
18	0.02	1	3ehnA	NLC	Rep, Mult	36,54,58,68,251,253
19	0.02	1	3bd7A	CKB	Rep, Mult	57,65,67,69,72
20	0.02	1	3r6wA	NFZ	Rep, Mult	78,94,122

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2vdcA	0.358	7.48	0.043	0.603	1.4.1.13	NA
2	0.060	1ea0A	0.342	7.51	0.053	0.577	1.4.1.13	NA
3	0.060	3ig5A	0.360	7.32	0.041	0.603	6.3.2.2	NA
4	0.060	2wyhA	0.360	7.33	0.036	0.600	3.2.1.24	NA
5	0.060	2qllA	0.362	7.15	0.046	0.600	2.4.1.1	NA
6	0.060	3gzkA	0.359	7.18	0.052	0.588	3.2.1.4	NA
7	0.060	1i8qA	0.374	7.28	0.051	0.631	4.2.2.1	110
8	0.060	1fa9A	0.372	7.32	0.053	0.626	2.4.1.1	NA
9	0.060	1h54B	0.370	6.99	0.039	0.585	2.4.1.8	NA
10	0.060	1j0mA	0.374	7.20	0.049	0.618	4.2.2.12	NA
11	0.060	1fmiA	0.359	6.00	0.058	0.525	3.2.1.113	NA
12	0.060	2eabA	0.376	7.52	0.058	0.637	3.2.1.63	34
13	0.060	1e1yA	0.382	6.94	0.059	0.605	2.4.1.1	127
14	0.060	2qnoA	0.365	6.25	0.056	0.540	3.2.1.4	44
15	0.060	1w6jA	0.390	6.71	0.042	0.590	5.4.99.7	NA
16	0.060	1nxcA	0.362	6.54	0.040	0.542	3.2.1.113	106
17	0.060	3g4dA	0.359	6.87	0.030	0.570	4.2.3.13	NA
18	0.060	1f1sA	0.374	7.34	0.048	0.633	4.2.2.1	114,194
19	0.060	2jg0A	0.376	7.11	0.061	0.609	3.2.1.28	35

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.15	0.771	3.72	0.07	0.89	3cghA	GO:0046872
1	0.14	0.764	3.82	0.09	0.89	4pucB	GO:0046872
2	0.08	0.653	4.19	0.07	0.79	3mx3A	GO:0046872
3	0.06	0.251	6.34	0.06	0.37	4mpqA	GO:0003824 GO:0008152 GO:0016829
4	0.06	0.226	7.50	0.06	0.39	3nwrA	GO:0000287 GO:0015977 GO:0016984
5	0.06	0.216	7.27	0.04	0.36	4p3mB	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0035999
6	0.06	0.200	6.33	0.05	0.30	3io0A	GO:0005198
7	0.06	0.220	7.72	0.04	0.38	1p5hA	GO:0003824 GO:0005737 GO:0008152 GO:0008410 GO:0016740 GO:0033608 GO:0033611
8	0.06	0.160	5.69	0.05	0.22	1ou0B	GO:0009236 GO:0016993
9	0.06	0.169	5.43	0.06	0.23	4j8pA	GO:0000166 GO:0010181
10	0.06	0.130	4.06	0.09	0.16	3lhrB	GO:0003676 GO:0003677 GO:0003700 GO:0005634 GO:0006351 GO:0006355 GO:0008270 GO:0042552 GO:0043565 GO:0045892 GO:0046872
11	0.06	0.114	4.12	0.05	0.14	4bhxB	GO:0000122 GO:0000981 GO:0003676 GO:0003700 GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0006915 GO:0010468 GO:0046872
12	0.06	0.126	5.16	0.06	0.17	3gv1A
13	0.06	0.103	4.36	0.08	0.13	3wztE	GO:0003980 GO:0006486 GO:0016740 GO:0097359
14	0.06	0.112	4.64	0.05	0.14	1shmA
15	0.06	0.094	4.64	0.07	0.12	3ccdA	GO:0004674 GO:0005737 GO:0005829 GO:0006468 GO:0006810 GO:0008047 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0019197 GO:0043085 GO:0045819
16	0.06	0.081	3.98	0.04	0.10	2mgvA	GO:0008658
17	0.06	0.756	3.63	0.09	0.87	4f7aA
18	0.06	0.748	3.78	0.09	0.87	3sghA

Consensus prediction of GO terms

Molecular Function	GO:0046872
GO-Score	0.33
Biological Processes	GO:0015977
GO-Score	0.06
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.