I-TASSER results

I-TASSER results for job id Rv0093c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (282 residues)
MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATIDGMDCEVAREALSARL
DGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAESRPVVPPVGRLGIRRAPRR
QHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPTGAGTHLLNESTSWSIALGVI
MVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAVSTTRILTHLPVVIGAVLAIMVW
RSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWPTDGSAA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATIDGMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAESRPVVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPTGAGTHLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAVSTTRILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWPTDGSAA
Prediction	CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	987666677777655666664667765445677754665456677767999999999986699985559999999996999999999999999999986777899866777766557765444578999999999999999999999865545567787776455555578999999999999998545545689999999999999999999978777888999999999999999999758899998876667788788888877778888888888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATIDGMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAESRPVVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPTGAGTHLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAVSTTRILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWPTDGSAA
Prediction	733423432314430310141044111121443244345323545404063026102320243356444530450164055025115404402530461464544363255233544445443322011000000020113212211232321233332332211012011002001120010000113301000023113213132100200122313142011000112111000000124444444455444634414276365264443232464558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATIDGMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAESRPVVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPTGAGTHLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAVSTTRILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWPTDGSAA

5frfA

0.17

0.06

0.38

1.27

wdPPAS

-----------------------G--SHM-S---------AGEPHETDCSEILDHLYEFLDKEMPDSDAVKFEHHFEESSPCLEKYGLEQAVKKLVKRAGQDDVPGDLRAKVMGRLDLIRSGQSVP----------------------EHDVAAAPSSSAPQES----------------------------------------------------------------------------------------------------------------------

5frfA

0.16

0.06

0.38

1.59

wPPAS

-----------------------G--SHM-S---------AGEPHETDCSEILDHLYEFLDKEMPDSDAVKFEHHFEESSPCLEKYGLEQAVKKLVKRAGQDDVPGDLRAKVMGRLDLIRSGQSVPEHD----------------------VAAAPSSSAPQES----------------------------------------------------------------------------------------------------------------------

4ke2A

0.12

0.08

0.70

1.54

dPPAS2

-------------------------------------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------

1t33A

0.12

0.09

0.69

1.03

dPPAS2

MNIPTTTTKGFGEYHATTRDIAAGQNIA-------AITYYFGS-----------------------------------------KEDLYLACAQWIADFLGEKFRPHAEKAERLFSQPAPDRDAIRELILLACKNMIMLLTQEDTVNLSKFISREQLSPTSAYQLVHEQVIDPLHTHLTRLVAAYTGCDAILHTHALLGEVLAFRLGKETILLRTGQFDEEKAELIYQTVTCHIDLILHGLTQ---------------------------------------

2oerB

0.13

0.09

0.63

1.01

dPPAS2

--SSELEA------AVQVLAGAQRFTTARVAERAGSLYQYFPN--------------------------------------------KAAILFRLQSDEWRR-----TTRLLGEILEDTTRPPLERLRRLVLAFVRSECEEAAIRVALSDAAPLYRD-------ADEAREVKAEGARVFQAFLREALPEVAEAERSLAGDLLTTTLGAVGKQFSEQPRSEAEIERYAEALADLCAYLAALGER---------------------------------------

5cwiA

0.11

0.08

0.74

1.01

dPPAS2

------------------------------------------------------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEDIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEH--PNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACEQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKAR

5dlqB

0.07

1.00

0.81

MUSTER

VHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDYLAHGIEIEDSSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVRKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFSDQLASVGMLGRIAAEHCMPLLTSLLEERVTRLHGQLQRHQ-QDNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPEIIKHSSEVDINTTLQILGSPGEKASSIPGY

4ke2A

0.12

0.08

0.70

0.85

dPPAS

-------------------------------------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------

3hugB

0.16

0.04

0.22

0.83

wdPPAS

-------------------------------------------------HHYAMWDAAYVLGALSAADRREFEAHLAGCPECRGAVTELCGVPALLSQLDRDEVAAISESA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3e0sA

0.10

0.09

0.91

0.73

wMUSTER

QLDAHASIHE---NVRRLLQFT----SIMEANEEGIRKDIDSEF-DF-IRRSRSILRLL--GVFDPEKTAWMLAGLRELGKRTNDLRDSDVYLLRREEYTSLLPPSLPALDPFFSDLEADKRLHHRQFCRYLTGREYSGFMTSLKEFIAEGELPDPETAPLAAEPTGDVAAKTIRKALKKVLVHGRSDADCKKLRYLLEFFASLFPPKATAQVLR---QMKTLQDNLGTFVDLTVQMEFLQSRLETISEAAAIGGLLTTL-------YRKREKVR----EHF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.75

Estimated TM-score = 0.31±0.10

Estimated RMSD = 15.3±3.4Å

Download Model 2

C-score=-4.14

Download Model 3

C-score=-4.36

Download Model 4

C-score=-4.18

Download Model 5

C-score=-4.26

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cwpA	0.464	4.99	0.063	0.667
2	5cwiA	0.458	5.08	0.093	0.663
3	1iduA	0.451	5.79	0.050	0.723
4	4he8L	0.440	6.13	0.047	0.734
5	5cwoA	0.440	5.40	0.079	0.667
6	1m56A	0.440	6.18	0.045	0.738
7	3mk7A	0.436	6.28	0.054	0.762
8	3ciaA	0.436	5.90	0.061	0.709
9	3o0rB	0.436	6.16	0.047	0.738
10	3kdpA	0.432	6.11	0.047	0.738

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.20	10	3oj6A	ZN	Rep, Mult	49,79,82
2	0.04	2	2qtsC	MAL	Rep, Mult	136,140
3	0.04	2	2dysO	CDL	Rep, Mult	131,135,138,139,142
4	0.02	1	1izlC	CLA	Rep, Mult	226,230
5	0.02	1	3dtuC	DXC	Rep, Mult	89,92,93,96,167,170
6	0.02	1	3mk7D	CA	Rep, Mult	57,65,69
7	0.02	1	3i9dW	MG	Rep, Mult	97,101
8	0.02	1	4jbeB	CA	Rep, Mult	74,78
9	0.02	1	2h6bA	3C4	Rep, Mult	142,145
10	0.02	1	3om3A	CA	Rep, Mult	55,58,62,64
11	0.02	1	3dtuC	DMU	Rep, Mult	86,89,90,93
12	0.02	1	1qprA	PPC	Rep, Mult	53,128
13	0.02	1	1s5lT	CLA	Rep, Mult	145,148
14	0.02	1	3luhB	5GP	Rep, Mult	116,120

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3ciaA	0.436	5.90	0.061	0.709	3.4.11.-	50
2	0.060	1vncA	0.450	5.92	0.046	0.731	1.11.1.10	19,21
3	0.060	2dqbA	0.430	5.10	0.049	0.614	3.1.5.1	120,138,177
4	0.060	3gvdI	0.396	5.32	0.096	0.603	2.3.1.30	NA
5	0.060	1fgjA	0.408	6.08	0.043	0.684	1.7.3.4	NA
6	0.060	1m56A	0.440	6.18	0.045	0.738	1.9.3.1	NA
7	0.060	2occN	0.401	6.87	0.056	0.738	1.9.3.1	201
8	0.060	1gw6A	0.428	5.95	0.043	0.702	3.3.2.6	NA
9	0.060	3b9jJ	0.334	6.31	0.045	0.560	1.17.1.4,1.17.3.2	89,91,94
10	0.060	3i4lA	0.419	5.74	0.087	0.677	3.6.3.14	53,135
11	0.060	1ssqD	0.388	5.33	0.071	0.592	2.3.1.30	63
12	0.060	3cskA	0.403	6.03	0.049	0.670	3.4.14.4	NA
13	0.060	3b8eC	0.403	6.21	0.057	0.702	3.6.3.9	84,180
14	0.060	3b9jC	0.312	6.30	0.044	0.535	1.17.3.2,1.17.1.4	NA
15	0.060	1fo4A	0.368	6.80	0.027	0.670	1.17.1.4	NA
16	0.060	3ixzA	0.428	5.87	0.062	0.706	3.6.3.10	NA
17	0.060	1pn0C	0.398	6.01	0.040	0.663	1.14.13.7	124
18	0.060	1eulA	0.407	5.81	0.047	0.649	3.6.3.8	NA
19	0.060	1dgjA	0.401	6.46	0.053	0.713	1.2.-.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.415	6.15	0.04	0.71	1occA	GO:0004129 GO:0005506 GO:0005739 GO:0005743 GO:0006119 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0045277 GO:0046872 GO:0055114 GO:0070469 GO:1902600
1	0.22	0.440	6.18	0.04	0.74	1m56A	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
2	0.07	0.451	5.79	0.05	0.72	1iduA	GO:0004601 GO:0005576 GO:0016491 GO:0016691 GO:0046872 GO:0055114 GO:0098869
3	0.07	0.426	6.24	0.04	0.73	1qleA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
4	0.06	0.394	6.90	0.04	0.73	1fftA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006811 GO:0009055 GO:0009060 GO:0009319 GO:0009486 GO:0015078 GO:0015453 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016682 GO:0019646 GO:0020037 GO:0046872 GO:0048039 GO:0055114 GO:0070469
5	0.06	0.441	6.13	0.05	0.74	4he8F	GO:0005886 GO:0008137 GO:0016020 GO:0016021 GO:0016491 GO:0042773 GO:0048038 GO:0055114
6	0.06	0.388	6.31	0.06	0.68	3eh3A	GO:0004129 GO:0005506 GO:0005886 GO:0006119 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
7	0.06	0.383	6.37	0.06	0.68	3w36B	GO:0004601 GO:0055114 GO:0098869
8	0.06	0.375	6.56	0.04	0.66	2yevA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015002 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0046872 GO:0055114 GO:0070469 GO:1902600
9	0.06	0.356	6.22	0.09	0.58	4he8I	GO:0005886 GO:0006810 GO:0008137 GO:0016020 GO:0016021 GO:0016491 GO:0042773 GO:0048038 GO:0050136 GO:0055114
10	0.06	0.360	6.60	0.04	0.65	4djaA	GO:0000166 GO:0000719 GO:0003677 GO:0003914 GO:0006281 GO:0006974 GO:0016829 GO:0018298 GO:0046872 GO:0051536 GO:0051539 GO:0071949
11	0.06	0.277	5.47	0.04	0.44	1tj7A	GO:0003824 GO:0004056 GO:0005737 GO:0005829 GO:0006526 GO:0008652 GO:0016829 GO:0042450 GO:0051262
12	0.06	0.328	6.19	0.04	0.54	2p5oB	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
13	0.06	0.264	6.08	0.04	0.43	3pgxA	GO:0016491 GO:0055114
14	0.06	0.324	7.06	0.04	0.60	3gdeA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
15	0.06	0.267	4.78	0.02	0.38	4iwbA	GO:0044780
16	0.06	0.254	5.34	0.08	0.38	2wgbB	GO:0003677 GO:0006351 GO:0006355
17	0.06	0.274	6.40	0.09	0.48	5ekqD	GO:0009279 GO:0016020 GO:0043165 GO:0051205 GO:1990063
18	0.06	0.230	6.10	0.05	0.39	3tswB	GO:0001825 GO:0005516 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005921 GO:0005923 GO:0007043 GO:0007605 GO:0014704 GO:0016020 GO:0016323 GO:0016324 GO:0016327 GO:0019904 GO:0030054 GO:0035329 GO:0043296 GO:0045177 GO:0046581 GO:0090557 GO:0098609 GO:0098641 GO:1901350

Consensus prediction of GO terms

Molecular Function	GO:0004129	GO:0005506	GO:0020037	GO:0005507
GO-Score	0.52	0.52	0.52	0.32
Biological Processes	GO:0009060	GO:1902600	GO:0006119
GO-Score	0.52	0.48	0.48
Cellular Component	GO:0019866	GO:0098803	GO:0031966	GO:0070069	GO:0016021	GO:0005886
GO-Score	0.58	0.58	0.58	0.58	0.52	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.