I-TASSER results

I-TASSER results for job id Rv0060

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (352 residues)
MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFTAYEKACKRGEVTIGKM
FVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRVIRELNIASVAVPPLGVGN
GGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVEGLRMTWGRAVILEAMRRYLQ
QRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFTPGRYGPYSERVRHLLQGMEGAF
TVGLGDGTARVLANQPISLTTKGTDAITDYLATDAAADRVSAAVDTVLRVIEGFEGPYGV
ELLASTHWVATREGAKEPATAAAAVRKWTKRKGRIYSDDRIGVALDRILMTA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFTAYEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRVIRELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVEGLRMTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFTPGRYGPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAAADRVSAAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGRIYSDDRIGVALDRILMTA
Prediction	CEEEEHCCCCCCCCCEEEHCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEHHHHHHHHHHHHHCCCCCCEEEHCCCCCCHHHHHHHHHHHHCHCEEHCCCCCCCCCCCCEEEHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
Conf.Score	9699987888888888998688998898647899999955999999999988899987799996888899869999769989999886999999999999999999996999767887889999999999999999978996899987899757777775567886577899999999986555554445788763457788999998788778667765789865789999999755444444567777778746897555899999999975777899999999999998547986478999999999985899999999999999999875799999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFTAYEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRVIRELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVEGLRMTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFTPGRYGPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAAADRVSAAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGRIYSDDRIGVALDRILMTA
Prediction	7142141201526030000000340310100000016303610530352166350420300002125152120000000132245553251024004300510573603100000000121403262003002400560550300111153474235335414133533220310442244433343323446123032310010034244624041353422110630340054044310222344455334443041256035304511563651640351053025005404234201000000000343643426401520460174256404571033005303758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEEHCCCCCCCCCEEEHCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEHHHHHHHHHHHHHCCCCCCEEEHCCCCCCHHHHHHHHHHHHCHCEEHCCCCCCCCCCCCEEEHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFTAYEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRVIRELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVEGLRMTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFTPGRYGPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAAADRVSAAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGRIYSDDRIGVALDRILMTA

3vfqA

0.14

0.13

0.94

1.16

MUSTER

VLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAPELQADCDQIVKREGLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKEN-------FQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKGSLVSPGGLQMLLVKEGVQNADVVVNSVPLDLVL-----SRGPLSKSLLEKAPELQEEL---DTVGQGVAVSMGTVLKTSSWNLDCRYVLGSTSSLKIMEDIIRECMEITESLS-------LKSIAFPAIGTGNLGAELIISEVFKFSSKNQLLHPHENIQAFSDEFARRA

3vfqA

0.14

0.12

0.92

1.30

wMUSTER

VLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAPELQADCDQIVKRERLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKENHCLKEIYLVDVSEKTVEAFAEAVKTVFKGSL---------VSPGGLQMLLVKEGVQNAKTDVV---VNSVPLDLVL-----SRGPLSKSLLEKAPELQEEL---DTVGQGVAVSMGTVLKTSSWNLDCRYVLGSTSSLKIMEDIIRECMEITESLSKSIAFPAIGT--------GNLGAELIISEVFKFSSKNQLLHPHENIQAFSDEFARRA

2dx6A

0.22

0.10

0.44

1.23

dPPAS

RIRVVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGG--PSIQEECDRIGKIRVGEAAVTGAGNLPVR-YVIHAAV--LGDEPASLETVRKATKSALEKAVELGLKTVAFPLLGTGVGGLPVEAVARVLEEIKKAPDTLEVTLYGYREEDAEAIRRAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3vfqA

0.11

0.10

0.93

1.13

dPPAS

VLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAELQADCDQIVKREGRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKENHCLKEIYLVDVSAEAVKTVFKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAG----------------PELQEELDTVGQGVAVSMGTSSWNLDCRYVLHVVANGSTSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGAELIISEVFKFSSKNQLKTLQEVHFLLH--------PSDHENIQAFSDEFARRA

2dx6A

0.24

0.11

0.44

1.73

wdPPAS

RIRVVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRI---KIRVGEAAVTGAGNLPVRYVIHAAVLGD---EPASLETVRKATKSALEKAVELGLKTVAFPLLGTGVGGLPVEAVARVLEE-IKKAPDTLEVTLYGYREEDAEAIRRAL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3vfqA

0.13

0.12

0.94

1.66

PPAS

VLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAPELQADCDQIVKREGLLPGNATISKAGKLP-YHHVIHAVGPRWSGYEAPVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKEN-----FQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVL-----SRGPL-PELQEELDTVGQGVAVSMGTSSWNLDCRYVLHVVA------EWRNGSTSSLKIMEDIIRECMEITESLSKSIAFPAIGTGNLGFPKNIF--AELIISEVFKFSSKNQLLHPHENIQAFSDEFARRA

2dx6A

0.22

0.10

0.44

1.95

wPPAS

RIRVVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIG--KIRVGEAAVTGAGNLPV-RYVIHAAV--LGDEPASLETVRKATKSALEKAVELGLKTVAFPLLGTGVGGLPVEAVARVLEEIKKAPDTLEVTLYG-YREEDAEAIRRAL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3vfqA

0.11

0.10

0.92

1.68

wdPPAS

VLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKRRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKENHCLKEIYLVDVS----------------EKTVEAFAEAVKTVFKGSLVSPGGLQMLLVKEG-----VQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQ----GQGVAVSMGTVLKTSSWNLDCRYVLGSTSSLKIMEDIIRECMEITESLSKSIAFPAIGTGNLGFPKNIF--AELIISEVFKFSSKNQLLHDHENIQAFSDEFARRA

2dx6A

0.24

0.11

0.44

2.96

dPPAS2

RIRVVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGG--PSIQEECDRIGKIRVGEAAVTGAGNLPV-RYVIHAAV--LGDEPASLETVRKATKSALEKAVELGLKTVAFPLLGTGVGGLPVEAVARVLEEIKKAPDTLEVTLYG-YREEDAEAIRRAL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2dx6A

0.24

0.11

0.44

1.73

PPAS

RIRVVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGG--PSIQEECDRIGKIRVGEAAVTGAGNLPV-RYVIHAAV--LGDEPASLETVRKATKSALEKAVELGLKTVAFPLLGTGVGGLPVEAVARVLEEIKKAPDTLEVTLYG-YREEDAEAIRRAL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.83

Estimated TM-score = 0.49±0.15

Estimated RMSD = 10.8±4.6Å

Download Model 2

C-score=-3.14

Download Model 3

C-score=-2.51

Download Model 4

C-score=-3.52

Download Model 5

C-score=-4.56

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3vfqA	0.757	3.80	0.109	0.903
2	4guaA	0.530	4.60	0.141	0.673
3	4ksiA	0.506	5.27	0.071	0.710
4	2et6A	0.478	6.18	0.062	0.756
5	5d2eA	0.470	6.34	0.068	0.750
6	5ktkA	0.464	6.44	0.045	0.756
7	4zi6A	0.463	5.57	0.066	0.688
8	4j1qA	0.463	6.31	0.048	0.742
9	5g0iA	0.460	6.14	0.086	0.730
10	2fr0A	0.460	6.65	0.077	0.770

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.49	26	5cmsQ	APR	Rep, Mult	7,8,9,20,21,22,30,31,34,78,115,117,118,119,120,121,149
2	0.02	1	3jruB	CO3	Rep, Mult	92,93,95,96,116

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2acfB	0.400	2.17	0.144	0.435	2.7.7.48	22,30,32,58,119
2	0.060	2ji6A	0.401	6.29	0.065	0.636	4.1.1.8	25,27
3	0.060	1txzA	0.399	3.82	0.126	0.483	3.1.3.-	22,122
4	0.060	3kx2B	0.403	6.17	0.051	0.642	3.6.4.13	106,108
5	0.060	2w00B	0.391	6.71	0.037	0.668	3.1.21.3	29,111
6	0.060	2ewbA	0.418	5.71	0.115	0.628	3.4.11.1,3.4.11.5	29
7	0.060	2vz9B	0.420	6.37	0.053	0.679	2.3.1.85	NA
8	0.060	3h8eA	0.449	4.65	0.065	0.580	3.4.11.1	96
9	0.060	1larA	0.433	6.29	0.059	0.685	3.1.3.48	NA
10	0.060	3ij3A	0.389	7.01	0.053	0.679	3.4.11.1	NA
11	0.060	2x42A	0.395	6.24	0.047	0.617	3.2.1.21	95
12	0.060	2zuwC	0.412	6.63	0.043	0.668	2.4.1.211	NA
13	0.060	3c46B	0.344	7.23	0.036	0.625	2.7.7.6	107
14	0.060	2ji8A	0.401	6.35	0.058	0.639	4.1.1.8	NA
15	0.060	2jkbA	0.419	6.85	0.057	0.722	3.2.1.18,4.2.2.15	NA
16	0.060	2vz8B	0.419	6.40	0.057	0.679	2.3.1.85	NA
17	0.060	3ebgA	0.402	6.42	0.037	0.662	3.4.11.-	NA
18	0.060	1kwgA	0.406	6.22	0.061	0.631	3.2.1.23	76
19	0.060	2vz8A	0.416	6.45	0.045	0.676	2.3.1.85	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.25	0.420	2.30	0.14	0.46	1zr5A	GO:0000122 GO:0000182 GO:0000228 GO:0000784 GO:0000785 GO:0000786 GO:0000790 GO:0000793 GO:0000977 GO:0000979 GO:0001046 GO:0001558 GO:0001739 GO:0001740 GO:0003677 GO:0003682 GO:0005634 GO:0005694 GO:0005721 GO:0005730 GO:0006334 GO:0006342 GO:0007549 GO:0010385 GO:0016568 GO:0019216 GO:0019899 GO:0019901 GO:0030291 GO:0031490 GO:0031492 GO:0033128 GO:0034184 GO:0035098 GO:0040029 GO:0044212 GO:0045618 GO:0045814 GO:0045815 GO:0046982 GO:0051572 GO:0061086 GO:0061187 GO:0070062 GO:0071169 GO:0071901 GO:1901837 GO:1902750 GO:1904815
1	0.24	0.757	3.80	0.11	0.90	3vfqA	GO:0003950 GO:0005634 GO:0005737 GO:0006351 GO:0006355 GO:0016020 GO:0016740 GO:0016757
2	0.21	0.530	4.60	0.14	0.67	4guaA	GO:0000166 GO:0001172 GO:0003723 GO:0003824 GO:0003968 GO:0004386 GO:0004651 GO:0005524 GO:0005525 GO:0006351 GO:0006370 GO:0006396 GO:0006397 GO:0006508 GO:0008152 GO:0008168 GO:0008174 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0020002 GO:0030430 GO:0032259 GO:0033644 GO:0039523 GO:0039657 GO:0039690 GO:0039694 GO:0042025 GO:0044157 GO:0044174 GO:0044175 GO:0044176 GO:0044187 GO:0044188 GO:0080009 GO:0098507
3	0.20	0.435	1.93	0.15	0.47	5cb5A	GO:0001883 GO:0008428 GO:0016787 GO:0019213 GO:0019899 GO:0032074 GO:0042278 GO:0060701 GO:0061463 GO:1900231
4	0.16	0.390	2.59	0.17	0.43	3gqeA	GO:0000166 GO:0001172 GO:0003723 GO:0003824 GO:0003968 GO:0004386 GO:0004651 GO:0005524 GO:0005525 GO:0006351 GO:0006370 GO:0006396 GO:0006397 GO:0006508 GO:0008152 GO:0008168 GO:0008174 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0020002 GO:0030430 GO:0032259 GO:0033644 GO:0039523 GO:0039657 GO:0039694 GO:0042025 GO:0044157 GO:0044174 GO:0044175 GO:0044176 GO:0044187 GO:0044188 GO:0080009 GO:0098507
5	0.16	0.394	2.07	0.11	0.43	3ewqA	GO:0001172 GO:0003723 GO:0003968 GO:0004197 GO:0006508 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016787 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0036459 GO:0039503 GO:0039520 GO:0039548 GO:0039648 GO:0044220 GO:0046872
6	0.14	0.399	2.22	0.11	0.43	3v2bA	GO:0003950 GO:0005634 GO:0006351 GO:0006355 GO:0016740 GO:0016757
7	0.13	0.402	2.07	0.11	0.43	4abkA	GO:0003950 GO:0005634 GO:0005737 GO:0006351 GO:0006355 GO:0016020 GO:0016740 GO:0016757
8	0.11	0.420	2.23	0.10	0.46	2xd7C	GO:0000122 GO:0000784 GO:0000785 GO:0000786 GO:0000790 GO:0000977 GO:0001558 GO:0001740 GO:0003677 GO:0005634 GO:0005654 GO:0005694 GO:0006334 GO:0006342 GO:0007420 GO:0007549 GO:0016568 GO:0031490 GO:0035098 GO:0044212 GO:0045618 GO:0045814 GO:0046982 GO:0070062 GO:0071169 GO:1901837
9	0.11	0.425	2.25	0.14	0.46	4iqyA	GO:0005634 GO:0006974 GO:0007420 GO:0016787 GO:0016798 GO:0019213 GO:0042278 GO:0051725
10	0.11	0.397	2.21	0.14	0.43	3ewoA	GO:0001172 GO:0003723 GO:0003968 GO:0004197 GO:0006508 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016787 GO:0019079 GO:0019082 GO:0030430 GO:0033644 GO:0039520 GO:0044220 GO:0046872
11	0.11	0.422	2.35	0.12	0.46	4umlA	GO:0005765 GO:0032526
12	0.11	0.387	1.99	0.13	0.42	5hihA	GO:0001172 GO:0003676 GO:0003723 GO:0003968 GO:0004197 GO:0006508 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016787 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0036459 GO:0039502 GO:0039503 GO:0039520 GO:0039548 GO:0039579 GO:0039595 GO:0039648 GO:0039657 GO:0044220 GO:0046872
13	0.10	0.389	2.20	0.10	0.43	2vriA	GO:0001172 GO:0003723 GO:0003968 GO:0004197 GO:0006508 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016787 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0036459 GO:0039503 GO:0039520 GO:0039548 GO:0039648 GO:0044220 GO:0046872
14	0.09	0.430	2.17	0.14	0.47	5iitC	GO:0000122 GO:0000182 GO:0000228 GO:0000329 GO:0000784 GO:0000785 GO:0000786 GO:0000790 GO:0000793 GO:0000822 GO:0000977 GO:0000979 GO:0001046 GO:0001558 GO:0001739 GO:0001740 GO:0003677 GO:0003682 GO:0005634 GO:0005694 GO:0005721 GO:0005730 GO:0005773 GO:0005774 GO:0005783 GO:0006334 GO:0006342 GO:0006797 GO:0006799 GO:0007034 GO:0007549 GO:0008976 GO:0010385 GO:0016020 GO:0016021 GO:0016237 GO:0016310 GO:0016568 GO:0019216 GO:0019899 GO:0019901 GO:0030291 GO:0031310 GO:0031490 GO:0031492 GO:0033128 GO:0033254 GO:0034184 GO:0035098 GO:0040029 GO:0042144 GO:0044212 GO:0045618 GO:0045814 GO:0045815 GO:0046982 GO:0048016 GO:0051572 GO:0061086 GO:0061187 GO:0070062 GO:0071169 GO:0071901 GO:1901837 GO:1902750 GO:1904815
15	0.09	0.388	2.41	0.18	0.43	3gpgA	GO:0000166 GO:0001172 GO:0003723 GO:0003824 GO:0003968 GO:0004386 GO:0004651 GO:0005524 GO:0005525 GO:0006351 GO:0006370 GO:0006396 GO:0006397 GO:0006508 GO:0008152 GO:0008168 GO:0008174 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0020002 GO:0030430 GO:0032259 GO:0033644 GO:0039523 GO:0039657 GO:0039694 GO:0042025 GO:0044174 GO:0044175 GO:0044187 GO:0044188 GO:0080009 GO:0098507
16	0.08	0.408	2.58	0.13	0.45	5ailB	GO:0003950 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0006281 GO:0006302 GO:0006974 GO:0016020 GO:0016477 GO:0016740 GO:0060330
17	0.07	0.400	2.28	0.14	0.44	2acfD	GO:0000166 GO:0000175 GO:0001172 GO:0003676 GO:0003723 GO:0003725 GO:0003727 GO:0003968 GO:0004197 GO:0004386 GO:0004482 GO:0004483 GO:0004518 GO:0004519 GO:0004527 GO:0005524 GO:0006351 GO:0006370 GO:0006508 GO:0008168 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016788 GO:0016817 GO:0016896 GO:0019079 GO:0019082 GO:0019083 GO:0030430 GO:0030683 GO:0032259 GO:0033644 GO:0036265 GO:0036459 GO:0039502 GO:0039503 GO:0039519 GO:0039520 GO:0039549 GO:0039579 GO:0039595 GO:0039604 GO:0039644 GO:0039648 GO:0039657 GO:0039690 GO:0039694 GO:0039714 GO:0044172 GO:0044220 GO:0046872 GO:0071108 GO:0080009 GO:0090305 GO:0090503 GO:1990380 GO:2000158
18	0.07	0.391	2.38	0.10	0.43	3etiA	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0004197 GO:0004386 GO:0004518 GO:0004519 GO:0004527 GO:0005524 GO:0006351 GO:0006508 GO:0008168 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016896 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0032259 GO:0033644 GO:0036459 GO:0039503 GO:0039520 GO:0039548 GO:0039648 GO:0044172 GO:0044220 GO:0046872 GO:0090305 GO:0090503

Consensus prediction of GO terms

Molecular Function	GO:0046983	GO:0031491	GO:0019900	GO:0001047	GO:0000976	GO:0001012	GO:0043566	GO:0004860	GO:0016763	GO:0008234	GO:0008174	GO:0004651	GO:0003723	GO:0004386	GO:0003968	GO:0005525	GO:0005524
GO-Score	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.48	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Biological Processes	GO:1901836	GO:0033127	GO:0040008	GO:0070199	GO:0000183	GO:1904814	GO:0045840	GO:0034093	GO:0006469	GO:0006629	GO:0031497	GO:0071168	GO:0045606	GO:1903828	GO:0016049	GO:0065004	GO:0071900	GO:0034182	GO:0006357	GO:0051240	GO:0016479	GO:0031935	GO:0045616	GO:0010628	GO:1901988	GO:1902749	GO:0006461	GO:0031061	GO:0051569	GO:0061085	GO:0034728	GO:0044034	GO:1900190	GO:0060700	GO:0072521	GO:0051346	GO:0044011	GO:0009116	GO:0080009	GO:0001172	GO:0039523	GO:0006508	GO:0006370	GO:0039694	GO:0098507
GO-Score	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.43	0.41	0.41	0.41	0.41	0.41	0.41	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Cellular Component	GO:0016020	GO:0031988	GO:0000805	GO:0044815	GO:1903561	GO:0031519	GO:0000775	GO:0000781	GO:0032993	GO:0035097	GO:0005720	GO:0042025	GO:0020002	GO:0044175	GO:0044188	GO:0044176
GO-Score	0.50	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.34	0.34	0.34	0.34	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.