I-TASSER results

I-TASSER results for job id Rv0040c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (310 residues)
MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPVSAPATVPPVQNLTAL
PGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISGTLRDHLREKGVKLEAQ
RPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPA
EAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADK
YLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPAPAPGSAPVGLPGQAPGYPP
AGTLTPVPPR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPVSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR
Prediction	CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEHCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEEEEEEEHCCCCCHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCEEEEEEEEEEEHCCCCCEEEEEEEEHCCHHHHHHHHHHHHHHHHCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9865444445567789999888753479999988999999999988888888877788888888888999999999999988889999999999999999999999999999898656657899999855557999986789999997579997589999999858999997568999999998776889878886557888666788765788789875997887786699967899789999998566666666678899987575887578889999888888888888888888887766788999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPVSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR
Prediction	7453154030100010000000000123313353344524424335343432335414334343444444444443545534464444444455554443447230240056460444315477264040402304404427745123000000244667532010000000023603143007203410540541463645454143120110001145654323004210001375110000010213365245326204201530402056354434365362432413363443313232443368
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEHCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEEEEEEEHCCCCCHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEHCCEEEEEEEEEEEHCCCCCEEEEEEEEHCCHHHHHHHHHHHHHHHHCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPVSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR

4ol4A

1.00

0.57

2.21

MUSTER

------------------------------------------------------------------------------------------------PVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAH-------------------------------------

5gaoE

0.16

0.13

0.84

1.19

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------------------AAAAAAAAAAAAAAAAAAA---------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAR

4ol4A

1.00

0.57

3.00

dPPAS

------------------------------------------------------------------------------------------------PVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAH-------------------------------------

1mv3A

0.15

0.10

0.66

1.16

wPPAS

--------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQ---HD-----------------YTATDTD--ELQ-LK----AG-------------DVVLVIPFQN---------------------PEEQDEGWLMGVKESD------------KKLEKCR-GFPE---TERVP--

4ol4A

1.00

0.57

4.21

wdPPAS

------------------------------------------------------------------------------------------------PVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAH-------------------------------------

5gaoE

0.17

0.14

0.82

2.10

dPPAS2

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------------------AAAAAAAAAAAAAAA--------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAR

4ol4A

1.00

0.57

2.82

wMUSTER

-------------------------------------------------------------------------------------------------VTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAH-------------------------------------

5gaoE

0.14

0.99

1.57

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--AAAAAAAAAAARAAAAAAAAAAAAAAA--AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKK

4ol4A

1.00

0.57

4.27

wPPAS

------------------------------------------------------------------------------------------------PVTPAISGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAH-------------------------------------

1mv3A

0.14

0.09

0.67

1.19

wdPPAS

--------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQ---HD-----------------YTATDTDELQLK-------AG-------------DVVLVIPFQN---------------------PEEQDEGWLMGVKESDWNQHKKLEKCR---------GFPE---TERVP--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.11

Estimated TM-score = 0.28±0.09

Estimated RMSD = 16.6±2.9Å

Download Model 2

C-score=-3.84

Download Model 3

C-score=-3.48

Download Model 4

C-score=-3.10

Download Model 5

C-score=-4.48

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ol4A	0.533	1.79	0.966	0.571
2	3dx4A	0.418	6.08	0.036	0.661
3	3lydA	0.400	2.51	0.164	0.455
4	4a01A	0.393	5.82	0.061	0.616
5	2dkiA	0.388	5.98	0.050	0.613
6	4rthA	0.386	2.92	0.112	0.442
7	1m56A	0.386	6.47	0.060	0.645
8	2xb3A	0.386	2.91	0.133	0.445
9	3mk7A	0.385	6.45	0.061	0.648
10	5jm0A	0.384	6.16	0.024	0.610

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	3fyeC	UNX	Rep, Mult	109,110,186,188
2	0.04	2	3v5mA	MA4	Rep, Mult	20,228,265
3	0.04	2	3dtuC	DXC	Rep, Mult	178,181,182,185,233
4	0.04	2	3dtuC	DMU	Rep, Mult	259,262,263,266
5	0.02	1	2yl8A	MN	Rep, Mult	145,178
6	0.02	1	4oxnB	2NV	Rep, Mult	121,271
7	0.02	1	2odjA	C8E	Rep, Mult	209,234
8	0.02	1	1v2bA	GLC	Rep, Mult	138,139,155,253,260
9	0.02	1	2gjmA	UUU	Rep, Mult	200,202
10	0.02	1	3bjeA	R1P	Rep, Mult	185,229
11	0.02	1	4h13A	8K6	Rep, Mult	13,287
12	0.02	1	2qtkB	C8E	Rep, Mult	213,245,246
13	0.02	1	3mjlA	2AI	Rep, Mult	185,189,208,303
14	0.02	1	1nqgA	C8E	Rep, Mult	213,232,243,245
15	0.02	1	2vn4A	MAN	Rep, Mult	103,104
16	0.02	1	3f7oA	HMB	Rep, Mult	216,218
17	0.02	1	1gfmA	C8E	Rep, Mult	151,168,245
18	0.02	1	3gyyA	ZN	Rep, Mult	137,257
19	0.02	1	3v65C	CA	Rep, Mult	193,238
20	0.02	1	3dtuA	TRD	Rep, Mult	184,187,191

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3n58A	0.377	6.20	0.046	0.616	3.3.1.1	148
2	0.060	3fsnB	0.355	6.65	0.039	0.623	5.2.1.7	211,214,245
3	0.060	2vn4A	0.357	6.24	0.030	0.594	3.2.1.3	NA
4	0.060	3h9uC	0.371	6.31	0.005	0.616	3.3.1.1	NA
5	0.060	3bjuA	0.362	6.56	0.055	0.619	6.1.1.6	NA
6	0.060	1v8bA	0.378	6.19	0.055	0.616	3.3.1.1	NA
7	0.060	1a7aA	0.369	6.38	0.032	0.616	3.3.1.1	NA
8	0.060	3a2pA	0.362	6.19	0.058	0.590	3.5.2.12	NA
9	0.060	3lssB	0.369	5.92	0.026	0.581	6.1.1.11	NA
10	0.060	2dkiA	0.388	5.98	0.050	0.613	1.14.13.23	NA
11	0.060	1fftA	0.365	6.70	0.061	0.619	1.10.3.-	NA
12	0.060	3h0lA	0.359	6.13	0.062	0.581	6.3.5.-	211
13	0.060	2dq3A	0.357	6.04	0.050	0.581	6.1.1.11	NA
14	0.060	1m56A	0.386	6.47	0.060	0.645	1.9.3.1	192
15	0.060	1v8bC	0.379	6.20	0.046	0.616	3.3.1.1	NA
16	0.060	3d64B	0.315	6.26	0.066	0.513	3.3.1.1	148
17	0.060	1gz3A	0.341	6.53	0.032	0.571	1.1.1.38	NA
18	0.060	2ow6A	0.405	5.97	0.047	0.632	3.2.1.114	189
19	0.060	1peuA	0.368	6.35	0.033	0.610	1.17.4.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.54	0.533	1.79	0.97	0.57	4ol4A	GO:0005576
1	0.06	0.313	6.65	0.05	0.53	3bubA	GO:0000139 GO:0003824 GO:0004553 GO:0004559 GO:0004572 GO:0005783 GO:0005794 GO:0005795 GO:0005975 GO:0006013 GO:0006486 GO:0006487 GO:0006491 GO:0006517 GO:0008152 GO:0008270 GO:0015923 GO:0016020 GO:0016021 GO:0016063 GO:0016787 GO:0016798 GO:0030246 GO:0035010 GO:0046872
2	0.06	0.378	6.23	0.06	0.62	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
3	0.06	0.382	6.51	0.06	0.65	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
4	0.06	0.393	5.82	0.06	0.62	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
5	0.06	0.384	6.16	0.02	0.61	5jm0A	GO:0000329 GO:0003824 GO:0004553 GO:0004559 GO:0005773 GO:0005975 GO:0006013 GO:0006517 GO:0008152 GO:0008270 GO:0009313 GO:0015923 GO:0016787 GO:0016798 GO:0030246 GO:0044262 GO:0046872
6	0.06	0.291	5.60	0.06	0.45	1o7dD	GO:0003824 GO:0004553 GO:0004559 GO:0005764 GO:0005975 GO:0006013 GO:0006517 GO:0007611 GO:0008152 GO:0008270 GO:0015923 GO:0016787 GO:0016798 GO:0030246 GO:0046872
7	0.06	0.284	6.40	0.04	0.48	5bofA	GO:0000015 GO:0000287 GO:0004634 GO:0005576 GO:0005737 GO:0006096 GO:0009405 GO:0009986 GO:0016829 GO:0046872
8	0.06	0.315	6.77	0.02	0.55	3zlfA	GO:0000015 GO:0000287 GO:0004634 GO:0005576 GO:0005737 GO:0006096 GO:0009405 GO:0009986 GO:0016829 GO:0046872
9	0.06	0.293	6.01	0.05	0.47	4y25A	GO:0006810 GO:0009279 GO:0016020 GO:0016021 GO:0022891 GO:0044010 GO:0055085
10	0.06	0.289	6.59	0.06	0.50	2ybaB	GO:0000122 GO:0000281 GO:0003682 GO:0005634 GO:0005667 GO:0005700 GO:0006281 GO:0006334 GO:0006335 GO:0006342 GO:0006351 GO:0006355 GO:0007307 GO:0007346 GO:0007379 GO:0007517 GO:0008284 GO:0016568 GO:0016571 GO:0016573 GO:0016581 GO:0016584 GO:0016589 GO:0016590 GO:0031491 GO:0031497 GO:0031523 GO:0033186 GO:0035035 GO:0035097 GO:0035098 GO:0042054 GO:0042393 GO:0042766 GO:0042803 GO:0042826 GO:0046974 GO:0046976 GO:0048666 GO:0048812 GO:0048813 GO:0051567 GO:0061085 GO:0070615 GO:0070734 GO:0070822
11	0.06	0.289	6.37	0.03	0.49	3k5pA	GO:0004617 GO:0006564 GO:0008152 GO:0016491 GO:0016597 GO:0016616 GO:0051287 GO:0055114
12	0.06	0.289	5.75	0.04	0.44	3rd7B	GO:0006637 GO:0047617
13	0.06	0.220	6.27	0.04	0.37	1mzvA	GO:0000166 GO:0003999 GO:0009116 GO:0016740 GO:0016757
14	0.06	0.278	7.09	0.05	0.52	1opeA	GO:0005739 GO:0008152 GO:0008260 GO:0008410 GO:0016740 GO:0042803 GO:0046950 GO:0046952
15	0.06	0.258	7.01	0.03	0.47	3cg1A	GO:0005886 GO:0006810 GO:0016020 GO:0046872 GO:1901359
16	0.06	0.241	6.76	0.03	0.43	1o7dA	GO:0003824 GO:0004553 GO:0004559 GO:0005764 GO:0005975 GO:0006013 GO:0006517 GO:0007611 GO:0008152 GO:0008270 GO:0015923 GO:0016787 GO:0016798 GO:0030246 GO:0046872
17	0.06	0.231	5.98	0.03	0.38	1un2A	GO:0003756 GO:0015035 GO:0030288 GO:0042597 GO:0045454 GO:0055114 GO:0071236
18	0.06	0.238	6.82	0.04	0.42	3om8B	GO:0016787 GO:0042952 GO:0047570

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0015405	GO:0016462
GO-Score	0.47	0.36	0.36
Biological Processes	GO:0015672	GO:0006818
GO-Score	0.36	0.36
Cellular Component	GO:0005576	GO:0031224
GO-Score	0.54	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.